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Aliases for GAS5 Gene

Subcategory (RNA class) for GAS5 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for GAS5 Gene

  • Growth Arrest Specific 5 (Non-Protein Coding) 2 3 5
  • Small Nucleolar RNA Host Gene (Non-Protein Coding) 2 2 3
  • Growth Arrest Specific Transcript 5 3
  • Non-Protein Coding RNA 30 2
  • NCRNA00030 3
  • SNHG2 3

External Ids for GAS5 Gene

Previous GeneCards Identifiers for GAS5 Gene

  • GC01U990348
  • GC01M172108
  • GC01M172117
  • GC01M172125
  • GC01M172133
  • GC01M172142
  • GC01M172146
  • GC01M172157
  • GC01M172170
  • GC01M173843
  • GC01M173850
  • GC01M173855
  • GC01M173864
  • GC01M173874
  • GC01M173883
  • GC01M173892
  • GC01M173907
  • GC01M173919
  • GC01M173937
  • GC01M173947
  • GC01M173961
  • GC01M173977
  • GC01M173985
  • GC01M173989
  • GC01M173997
  • GC01M174007

Summaries for GAS5 Gene

Entrez Gene Summary for GAS5 Gene

  • This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]

GeneCards Summary for GAS5 Gene

GAS5 (Growth Arrest Specific 5 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class.

Gene Wiki entry for GAS5 Gene

Additional gene information for GAS5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS5 Gene

Genomics for GAS5 Gene

GeneHancer (GH) Regulatory Elements for GAS5 Gene

Promoters and enhancers for GAS5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I173473 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 22.1 +392.1 392061 7.1 CLOCK DMAP1 YY1 E2F8 SP3 NFYC MEF2D ZNF610 ZNF585B GLIS1 PRDX6 LOC100506023 KLHL20 GAS5 GAS5-AS1 CENPL DARS2 LOC101928673
GH01I173861 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.3 +2.1 2122 10.3 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZBTB37 GC01M174031 GC01M174033 GC01M174034 GC01M174035 GC01M174036 SNORD44 SNORD75 SNORD78 SNORD80
GH01I174158 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 16.3 -290.5 -290462 3.7 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B RABGAP1L LOC102724601 RC3H1 ANKRD45 GAS5 ZBTB37 RNU7-78P GC01M174104
GH01I173714 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 +153.4 153444 2.3 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC SSRP1 KLHL20 RC3H1 DARS2 GAS5 GAS5-AS1 ANKRD45 RPS27P7
GH01I173823 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7.9 +44.3 44348 3 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC GLIS1 RCOR2 DARS2 CENPL RC3H1 KLHL20 ZBTB37 GAS5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GAS5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GAS5 gene promoter:

Genomic Locations for GAS5 Gene

Genomic Locations for GAS5 Gene
chr1:173,863,900-173,868,882
(GRCh38/hg38)
Size:
4,983 bases
Orientation:
Minus strand
chr1:173,833,038-173,838,020
(GRCh37/hg19)

Genomic View for GAS5 Gene

Genes around GAS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS5 Gene

Proteins for GAS5 Gene

Post-translational modifications for GAS5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for GAS5 Gene

Domains & Families for GAS5 Gene

Gene Families for GAS5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GAS5: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GAS5 Gene

Function for GAS5 Gene

Animal Model Products

miRNA for GAS5 Gene

miRTarBase miRNAs that target GAS5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAS5 Gene

Localization for GAS5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAS5 gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GAS5 Gene

Pathways & Interactions for GAS5 Gene

No Data Available

Interacting Proteins for GAS5 Gene

Gene Ontology (GO) - Biological Process for GAS5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAS5 Gene

Drugs & Compounds for GAS5 Gene

No Compound Related Data Available

Transcripts for GAS5 Gene

mRNA/cDNA for GAS5 Gene

(29) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

  • Addgene plasmids for GAS5

Alternative Splicing Database (ASD) splice patterns (SP) for GAS5 Gene

No ASD Table

Relevant External Links for GAS5 Gene

GeneLoc Exon Structure for
GAS5
ECgene alternative splicing isoforms for
GAS5

Expression for GAS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAS5 Gene

mRNA differential expression in normal tissues according to GTEx for GAS5 Gene

This gene is overexpressed in Pancreas (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of GAS5 Gene:

GAS5

SOURCE GeneReport for Unigene cluster for GAS5 Gene:

Hs.531856
genes like me logo Genes that share expression patterns with GAS5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS5 Gene

Orthologs for GAS5 Gene

Evolution for GAS5 Gene

ENSEMBL:
Gene Tree for GAS5 (if available)
TreeFam:
Gene Tree for GAS5 (if available)

No data available for Orthologs for GAS5 Gene

Paralogs for GAS5 Gene

No data available for Paralogs for GAS5 Gene

Variants for GAS5 Gene

Sequence variations from dbSNP and Humsavar for GAS5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000056001 -- 173,867,389(-) G/A intron_variant
rs1000127752 -- 173,867,669(-) A/G intron_variant
rs1000247329 -- 173,868,599(-) C/T upstream_transcript_variant
rs1000390155 -- 173,863,801(-) A/G downstream_transcript_variant
rs1000450082 -- 173,868,415(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GAS5 Gene

Variant ID Type Subtype PubMed ID
esv2758978 CNV loss 17122850
nsv831926 CNV gain+loss 17160897

Additional Variant Information for GAS5 Gene

Human Gene Mutation Database (HGMD)
GAS5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAS5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GAS5 Gene

Disorders for GAS5 Gene

Additional Disease Information for GAS5

No disorders were found for GAS5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAS5 Gene

Publications for GAS5 Gene

  1. A long non-coding RNA signature in glioblastoma multiforme predicts survival. (PMID: 23726844) Zhang XQ … Leung GK (Neurobiology of disease 2013) 2 3 58
  2. Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes. (PMID: 9819378) Smith CM … Steitz JA (Molecular and cellular biology 1998) 2 3 58
  3. Serum HOTAIR and GAS5 levels as predictors of survival in patients with glioblastoma. (PMID: 28926136) Shen J … Zhao H (Molecular carcinogenesis 2018) 3 58
  4. Negative regulation of lncRNA GAS5 by miR-196a inhibits esophageal squamous cell carcinoma growth. (PMID: 29170131) Wang K … Bai Y (Biochemical and biophysical research communications 2018) 3 58
  5. LncRNA GAS5 suppresses the tumorigenesis of cervical cancer by downregulating miR-196a and miR-205. (PMID: 28671039) Yang W … Jiang L (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58

Products for GAS5 Gene

  • Addgene plasmids for GAS5

Sources for GAS5 Gene

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