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Aliases for GAS5 Gene

Subcategory (RNA class) for GAS5 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for GAS5 Gene

  • Growth Arrest Specific 5 2 3 5
  • Small Nucleolar RNA Host Gene (Non-Protein Coding) 2 2 3
  • Growth Arrest Specific 5 (Non-Protein Coding) 2 3
  • Growth Arrest Specific Transcript 5 3
  • Non-Protein Coding RNA 30 2
  • NCRNA00030 3
  • SNHG2 3

External Ids for GAS5 Gene

Previous GeneCards Identifiers for GAS5 Gene

  • GC01U990348
  • GC01M172108
  • GC01M172117
  • GC01M172125
  • GC01M172133
  • GC01M172142
  • GC01M172146
  • GC01M172157
  • GC01M172170
  • GC01M173843
  • GC01M173850
  • GC01M173855
  • GC01M173864
  • GC01M173874
  • GC01M173883
  • GC01M173892
  • GC01M173907
  • GC01M173919
  • GC01M173937
  • GC01M173947
  • GC01M173961
  • GC01M174061
  • GC01M173977
  • GC01M173985
  • GC01M173989
  • GC01M173997
  • GC01M174007
  • GC01M174021
  • GC01M174034
  • GC01M174047

Summaries for GAS5 Gene

Entrez Gene Summary for GAS5 Gene

  • This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]

GeneCards Summary for GAS5 Gene

GAS5 (Growth Arrest Specific 5) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with GAS5 include Inflammatory Bowel Disease and Autoimmune Disease.

Gene Wiki entry for GAS5 Gene

Additional gene information for GAS5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS5 Gene

Genomics for GAS5 Gene

GeneHancer (GH) Regulatory Elements for GAS5 Gene

Promoters and enhancers for GAS5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J173473 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 22.1 +391.9 391945 7.3 ZNF652 ZFX ELF3 MNT CBFA2T2 ZNF148 NKRF POLR2A MLLT1 ZNF121 PRDX6 LOC100506023 TNFSF4 KLHL20 GAS5 GAS5-AS1 DARS2 CENPL LOC101928673
GH01J173861 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.2 +2.1 2122 10.3 MTA3 ZFX SP1 ELF3 CBFA2T2 ZNF148 NKRF POLR2A MLLT1 GTF2F1 CENPL ZBTB37 GC01M174067 GC01M174080 GC01M174082 GC01M174083 GC01M174085 GC01M174086 GC01M174087 GC01M174091
GH01J174158 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 16.3 -290.9 -290874 4.5 HDGF ZFX ELF3 ZKSCAN8 CBFA2T2 ZNF148 MLLT1 ZNF121 POLR2A GTF2F1 RABGAP1L RABGAP1L-DT RC3H1 ANKRD45 GAS5 ZBTB37 GC01M174104
GH01J172902 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +962.2 962190 9 ZKSCAN8 ZNF148 GTF2F1 BACH1 MAFK TRIM24 ZNF639 SMARCA4 CAVIN1 CEBPG ENSG00000224000 KLHL20 TNFSF18 DNM3OS GAS5-AS1 ENSG00000224228 GAS5 AIMP1P2
GH01J173823 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7.9 +44.4 44381 3.8 ZFX CC2D1A ELF3 SIX5 ZNF148 NKRF MLLT1 ZNF121 CEBPG POLR2A DARS2 CENPL RC3H1 KLHL20 GAS5 ENSG00000252357
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAS5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GAS5 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • CREB
  • deltaCREB
  • Ik-2
  • IRF-1
  • LCR-F1
  • Pax-4a

Genomic Locations for GAS5 Gene

Genomic Locations for GAS5 Gene
chr1:173,858,559-173,868,882
(GRCh38/hg38)
Size:
10,324 bases
Orientation:
Minus strand
chr1:173,833,038-173,838,020
(GRCh37/hg19)
Size:
4,983 bases
Orientation:
Minus strand

Genomic View for GAS5 Gene

Genes around GAS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS5 Gene

Proteins for GAS5 Gene

No data available for DME Specific Peptides for GAS5 Gene

Domains & Families for GAS5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GAS5: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GAS5 Gene

Function for GAS5 Gene

Phenotypes From GWAS Catalog for GAS5 Gene

Animal Model Products

CRISPR Products

miRNA for GAS5 Gene

miRTarBase miRNAs that target GAS5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAS5 Gene

Localization for GAS5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAS5 gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GAS5 Gene

Pathways & Interactions for GAS5 Gene

PathCards logo

SuperPathways for GAS5 Gene

No Data Available

Interacting Proteins for GAS5 Gene

Gene Ontology (GO) - Biological Process for GAS5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAS5 Gene

Drugs & Compounds for GAS5 Gene

No Compound Related Data Available

Transcripts for GAS5 Gene

mRNA/cDNA for GAS5 Gene

(17) Additional mRNA sequences :
(31) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(25) RNA Central transcripts :

Unigene Clusters for GAS5 Gene

Growth arrest-specific 5 (non-protein coding):
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAS5 Gene

No ASD Table

Relevant External Links for GAS5 Gene

GeneLoc Exon Structure for
GAS5
ECgene alternative splicing isoforms for
GAS5

Expression for GAS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAS5 Gene

mRNA differential expression in normal tissues according to GTEx for GAS5 Gene

This gene is overexpressed in Pancreas (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of GAS5 Gene:

GAS5

SOURCE GeneReport for Unigene cluster for GAS5 Gene:

Hs.531856
genes like me logo Genes that share expression patterns with GAS5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS5 Gene

Orthologs for GAS5 Gene

Evolution for GAS5 Gene

ENSEMBL:
Gene Tree for GAS5 (if available)
TreeFam:
Gene Tree for GAS5 (if available)

No data available for Orthologs for GAS5 Gene

Paralogs for GAS5 Gene

No data available for Paralogs for GAS5 Gene

Variants for GAS5 Gene

Sequence variations from dbSNP and Humsavar for GAS5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000056001 -- 173,867,389(-) G/A intron_variant
rs1000127752 -- 173,867,669(-) A/G intron_variant
rs1000247329 -- 173,868,599(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000390155 -- 173,863,801(-) A/G downstream_transcript_variant
rs1000450082 -- 173,868,415(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GAS5 Gene

Variant ID Type Subtype PubMed ID
esv2758978 CNV loss 17122850
nsv831926 CNV gain+loss 17160897

Additional Variant Information for GAS5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAS5
Human Gene Mutation Database (HGMD)
GAS5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GAS5 Gene

Disorders for GAS5 Gene

MalaCards: The human disease database

(43) MalaCards diseases for GAS5 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease
  • inflammatory bowel diseases
autoimmune disease
  • autoimmune hypersensitivity disease
malignant pleural mesothelioma
  • malignant mesothelioma of pleura
osteoarthritis
  • kashin-beck disease
b-cell lymphomas
  • b-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search GAS5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GAS5

genes like me logo Genes that share disorders with GAS5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAS5 Gene

Publications for GAS5 Gene

  1. A long non-coding RNA signature in glioblastoma multiforme predicts survival. (PMID: 23726844) Zhang XQ … Leung GK (Neurobiology of disease 2013) 2 3 58
  2. Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes. (PMID: 9819378) Smith CM … Steitz JA (Molecular and cellular biology 1998) 2 3 58
  3. LncRNA GAS5 regulates redox balance and dysregulates the cell cycle and apoptosis in malignant melanoma cells. (PMID: 30569211) Chen L … Zhu Y (Journal of cancer research and clinical oncology 2019) 3 58
  4. Role of the Long Non-Coding RNA Growth Arrest-Specific 5 in Glucocorticoid Response in Children with Inflammatory Bowel Disease. (PMID: 28722800) Lucafò M … De Iudicibus S (Basic & clinical pharmacology & toxicology 2018) 3 58
  5. Serum HOTAIR and GAS5 levels as predictors of survival in patients with glioblastoma. (PMID: 28926136) Shen J … Zhao H (Molecular carcinogenesis 2018) 3 58

Products for GAS5 Gene

Sources for GAS5 Gene

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