Aliases for GAS2L3 Gene

Aliases for GAS2L3 Gene

  • Growth Arrest Specific 2 Like 3 2 3 5
  • Growth Arrest-Specific Protein 2-Like 3 3 4
  • GAS2-Like Protein 3 3 4
  • G2L3 3

External Ids for GAS2L3 Gene

Previous GeneCards Identifiers for GAS2L3 Gene

  • GC12P099470
  • GC12P099471
  • GC12P100967
  • GC12P098028

Summaries for GAS2L3 Gene

GeneCards Summary for GAS2L3 Gene

GAS2L3 (Growth Arrest Specific 2 Like 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding and microtubule binding. An important paralog of this gene is MACF1.

UniProtKB/Swiss-Prot Summary for GAS2L3 Gene

  • Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network.

Additional gene information for GAS2L3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GAS2L3 Gene

Genomics for GAS2L3 Gene

GeneHancer (GH) Regulatory Elements for GAS2L3 Gene

Promoters and enhancers for GAS2L3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J100572 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 508.4 +1.5 1479 4.7 USF1 POLR2G SP1 JUND PHF8 FOS TEAD4 ZNF639 ZNF10 ZBTB10 GAS2L3 lnc-NR1H4-1 PIGAP1
GH12J100579 Promoter 0.3 EPDnew 500.7 +5.0 4994 0.1 ENSG00000257803 GAS2L3 PIGAP1 lnc-NR1H4-1
GH12J100593 Promoter/Enhancer 0.9 Ensembl ENCODE 6.1 +20.8 20755 2.8 TEAD1 ZKSCAN8 BCL6 HOMEZ FEZF1 SMARCA4 NFIL3 TEAD3 HNF4A HLF GAS2L3 HSALNG0093459 piR-53338-034
GH12J101051 Enhancer 1 Ensembl ENCODE 4.8 +478.8 478753 2.7 ZSCAN5C TCF12 NCOR1 RBAK JUND FOS ZNF639 ZNF10 ZNF423 TRIM28 ACTR6 ENSG00000257543 GAS2L3 ENSG00000258007 lnc-UTP20-2 SNX5P2 ANO4
GH12J100578 Enhancer 0.5 ENCODE 8.2 +5.7 5701 0.8 SKI FOXA2 SMAD4 HOMEZ RARA ZNF644 ENSG00000257803 PIGAP1 GAS2L3 piR-30188-047 lnc-NR1H4-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAS2L3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GAS2L3

Top Transcription factor binding sites by QIAGEN in the GAS2L3 gene promoter:
  • AP-4
  • CP2
  • Evi-1
  • GCNF-2
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Nkx6-1

Genomic Locations for GAS2L3 Gene

Genomic Locations for GAS2L3 Gene
chr12:100,573,646-100,628,288
(GRCh38/hg38)
Size:
54,643 bases
Orientation:
Plus strand
chr12:100,967,461-101,022,064
(GRCh37/hg19)
Size:
54,604 bases
Orientation:
Plus strand

Genomic View for GAS2L3 Gene

Genes around GAS2L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS2L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS2L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS2L3 Gene

Proteins for GAS2L3 Gene

  • Protein details for GAS2L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XJ1-GA2L3_HUMAN
    Recommended name:
    GAS2-like protein 3
    Protein Accession:
    Q86XJ1
    Secondary Accessions:
    • B2RCN2

    Protein attributes for GAS2L3 Gene

    Size:
    694 amino acids
    Molecular mass:
    75214 Da
    Quaternary structure:
    • Interacts (via CH domain) with F-actin (PubMed:21561867). Interacts (via C terminus) with microtubules (PubMed:21561867). Interacts with MAPRE1 (PubMed:24706950).

neXtProt entry for GAS2L3 Gene

Post-translational modifications for GAS2L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GAS2L3 Gene

Domains & Families for GAS2L3 Gene

Gene Families for GAS2L3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GAS2L3 Gene

Blocks:
  • Calponin-like actin-binding
  • Growth-arrest-specific protein 2
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GAS2L3 Gene

GenScript: Design optimal peptide antigens:
  • Growth arrest-specific protein 2-like 3 (GA2L3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86XJ1

UniProtKB/Swiss-Prot:

GA2L3_HUMAN :
  • The GAR domain modulates the binding strength to each cytoskeletal network.
  • Belongs to the GAS2 family.
Domain:
  • The GAR domain modulates the binding strength to each cytoskeletal network.
Family:
  • Belongs to the GAS2 family.
genes like me logo Genes that share domains with GAS2L3: view

Function for GAS2L3 Gene

Molecular function for GAS2L3 Gene

UniProtKB/Swiss-Prot Function:
Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network.

Phenotypes From GWAS Catalog for GAS2L3 Gene

Gene Ontology (GO) - Molecular Function for GAS2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 21561867
GO:0005515 protein binding IPI,IEA 24571573
GO:0008017 microtubule binding IDA 21561867
genes like me logo Genes that share ontologies with GAS2L3: view
genes like me logo Genes that share phenotypes with GAS2L3: view

Animal Models for GAS2L3 Gene

MGI Knock Outs for GAS2L3:
  • Gas2l3 Gas2l3<tm1d(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GAS2L3 Gene

Localization for GAS2L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS2L3 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Localizes to microtubule and actin cytoskeletons. {ECO:0000269 PubMed:21561867, ECO:0000269 PubMed:24706950}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAS2L3 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for GAS2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0015629 actin cytoskeleton IDA 21561867
GO:0015630 microtubule cytoskeleton IDA 21561867
genes like me logo Genes that share ontologies with GAS2L3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GAS2L3 Gene

Pathways & Interactions for GAS2L3 Gene

PathCards logo

SuperPathways for GAS2L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GAS2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IDA 21561867
GO:0030036 actin cytoskeleton organization IDA 21561867
genes like me logo Genes that share ontologies with GAS2L3: view

No data available for Pathways by source and SIGNOR curated interactions for GAS2L3 Gene

Drugs & Compounds for GAS2L3 Gene

No Compound Related Data Available

Transcripts for GAS2L3 Gene

mRNA/cDNA for GAS2L3 Gene

4 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAS2L3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: -
SP2: - - - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6:

Relevant External Links for GAS2L3 Gene

GeneLoc Exon Structure for
GAS2L3

Expression for GAS2L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAS2L3 Gene

mRNA differential expression in normal tissues according to GTEx for GAS2L3 Gene

This gene is overexpressed in Nerve - Tibial (x22.1).

Protein differential expression in normal tissues from HIPED for GAS2L3 Gene

This gene is overexpressed in Serum (65.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GAS2L3 Gene



Protein tissue co-expression partners for GAS2L3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GAS2L3

SOURCE GeneReport for Unigene cluster for GAS2L3 Gene:

Hs.20575

mRNA Expression by UniProt/SwissProt for GAS2L3 Gene:

Q86XJ1-GA2L3_HUMAN
Tissue specificity: Expressed in the pancreas, heart, liver, placenta, brain, skeletal muscle, kidney and lung.
genes like me logo Genes that share expression patterns with GAS2L3: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS2L3 Gene

Orthologs for GAS2L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GAS2L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAS2L3 31 30
  • 99.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GAS2L3 31 30
  • 87.28 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gas2l3 17 31 30
  • 80.59 (n)
rat
(Rattus norvegicus)
Mammalia Gas2l3 30
  • 79.7 (n)
dog
(Canis familiaris)
Mammalia GAS2L3 31 30
  • 76.19 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GAS2L3 31
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAS2L3 31
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves GAS2L3 31 30
  • 63.63 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAS2L3 31
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gas2l3 30
  • 61.23 (n)
zebrafish
(Danio rerio)
Actinopterygii gas2l3 31
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea D2096.11 31
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4664 31
  • 48 (a)
OneToMany
Species where no ortholog for GAS2L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GAS2L3 Gene

ENSEMBL:
Gene Tree for GAS2L3 (if available)
TreeFam:
Gene Tree for GAS2L3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GAS2L3: view image

Paralogs for GAS2L3 Gene

(1) SIMAP similar genes for GAS2L3 Gene using alignment to 4 proteins:

  • GA2L3_HUMAN
  • F8VSB7_HUMAN
  • G3V1N3_HUMAN
  • H0YIT6_HUMAN
genes like me logo Genes that share paralogs with GAS2L3: view

Variants for GAS2L3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GAS2L3 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs11834625 - p.Leu461Ser
rs17030365 - p.Pro500Thr

Additional dbSNP identifiers (rs#s) for GAS2L3 Gene

Structural Variations from Database of Genomic Variants (DGV) for GAS2L3 Gene

Variant ID Type Subtype PubMed ID
esv28430 CNV gain 19812545
nsv478596 CNV novel sequence insertion 20440878

Variation tolerance for GAS2L3 Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAS2L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAS2L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS2L3 Gene

Disorders for GAS2L3 Gene

Additional Disease Information for GAS2L3

No disorders were found for GAS2L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAS2L3 Gene

Publications for GAS2L3 Gene

  1. GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins. (PMID: 24706950) Stroud MJ … Ballestrem C (Journal of cell science 2014) 3 4 54
  2. Characterization of G2L3 (GAS2-like 3), a new microtubule- and actin-binding protein related to spectraplakins. (PMID: 21561867) Stroud MJ … Ballestrem C (The Journal of biological chemistry 2011) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54

Products for GAS2L3 Gene

Sources for GAS2L3 Gene