Aliases for GAS2L2 Gene
External Ids for GAS2L2 Gene
Previous GeneCards Identifiers for GAS2L2 Gene
The protein encoded by this gene appears to crosslink microtubules and microfilaments and may be part of the cytoskeleton. This gene is mainly expressed in skeletal muscle. [provided by RefSeq, Jul 2011]
GeneCards Summary for GAS2L2 Gene
GAS2L2 (Growth Arrest Specific 2 Like 2) is a Protein Coding gene. Diseases associated with GAS2L2 include Ciliary Dyskinesia, Primary, 41 and Primary Ciliary Dyskinesia. Gene Ontology (GO) annotations related to this gene include microtubule binding and cytoskeletal adaptor activity. An important paralog of this gene is SYNE2.
UniProtKB/Swiss-Prot Summary for GAS2L2 Gene
Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity). Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704).