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Aliases for GAS2L2 Gene

Aliases for GAS2L2 Gene

  • Growth Arrest Specific 2 Like 2 2 3 5
  • GAS2-Related Protein On Chromosome 17 3 4
  • GAS2-Like Protein 2 3 4
  • GAR17 3 4
  • Growth Arrest-Specific Protein 2-Like 2 4

External Ids for GAS2L2 Gene

Previous GeneCards Identifiers for GAS2L2 Gene

  • GC17M034218
  • GC17M031095
  • GC17M034071
  • GC17M030256

Summaries for GAS2L2 Gene

Entrez Gene Summary for GAS2L2 Gene

  • The protein encoded by this gene appears to crosslink microtubules and microfilaments and may be part of the cytoskeleton. This gene is mainly expressed in skeletal muscle. [provided by RefSeq, Jul 2011]

GeneCards Summary for GAS2L2 Gene

GAS2L2 (Growth Arrest Specific 2 Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include microtubule binding and cytoskeletal adaptor activity. An important paralog of this gene is DST.

UniProtKB/Swiss-Prot for GAS2L2 Gene

  • Seems to be involved in the cross-linking of microtubules and microfilaments.

Additional gene information for GAS2L2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS2L2 Gene

Genomics for GAS2L2 Gene

GeneHancer (GH) Regulatory Elements for GAS2L2 Gene

Promoters and enhancers for GAS2L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J035763 Promoter/Enhancer 1.6 EPDnew ENCODE 611.8 -11.5 -11457 2.9 ZNF473 ZFX CTCF NKRF RERE ZNF687 ZSCAN21 TFE3 NCOA6 ZBTB7A C17orf50 GAS2L2 LIG3 ZNF830 AP2B1 SNHG30 CCT6B RAD51D GC17P035762 MMP28
GH17J035747 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 613.4 +3.4 3432 6.2 CC2D1A CTCF ZNF148 SP7 EGR1 RAD21 GLIS2 ARID2 ZNF600 ZIC2 GAS2L2 C17orf50 MMP28 HEATR9 GC17P035742 TAF15
GH17J035807 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.6 -55.9 -55851 4.4 SP1 CTCF ELF3 ZFX SIX5 NKRF POLR2A MLLT1 CEBPG GTF2F1 ENSG00000270829 TAF15 C17orf50 GAS2L2 LIG3 MMP28 HEATR9 RDM1 AP2B1 ENSG00000270894
GH17J035878 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 11.5 -126.1 -126096 3.3 SP1 MLLT1 POLR2A ZNF687 RELA CREM SMARCA4 ZBED1 IKZF1 DPF2 CCL5 C17orf50 TAF15 GAS2L2 ENSG00000270240 LOC105371744
GH17J035895 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -145.6 -145581 8.1 ZNF148 ZNF687 BACH1 TRIM24 SP7 PRDM1 MLLT1 ZNF680 IKZF1 PKNOX1 C17orf50 CCL5 GAS2L2 TAF15 HEATR9 SLFN12L SLFN14 GC17M035909 GC17M035888 PIR57610
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAS2L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GAS2L2 gene promoter:
  • c-Ets-1
  • c-Myc
  • HOXA3
  • LCR-F1
  • Max1
  • Nkx2-5
  • Nkx3-1 v1
  • NRSF form 1
  • NRSF form 2
  • POU2F1

Genomic Locations for GAS2L2 Gene

Genomic Locations for GAS2L2 Gene
9,235 bases
Minus strand
8,368 bases
Minus strand

Genomic View for GAS2L2 Gene

Genes around GAS2L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS2L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS2L2 Gene

Proteins for GAS2L2 Gene

  • Protein details for GAS2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GAS2-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8NHY4

    Protein attributes for GAS2L2 Gene

    880 amino acids
    Molecular mass:
    96520 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GAS2L2 Gene


neXtProt entry for GAS2L2 Gene

Post-translational modifications for GAS2L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAS2L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAS2L2 Gene

Domains & Families for GAS2L2 Gene

Gene Families for GAS2L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GAS2L2 Gene

Suggested Antigen Peptide Sequences for GAS2L2 Gene

GenScript: Design optimal peptide antigens:
  • Growth arrest-specific protein 2-like 2 (GA2L2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAS2 family.
  • Belongs to the GAS2 family.
genes like me logo Genes that share domains with GAS2L2: view

Function for GAS2L2 Gene

Molecular function for GAS2L2 Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in the cross-linking of microtubules and microfilaments.

Phenotypes From GWAS Catalog for GAS2L2 Gene

Gene Ontology (GO) - Molecular Function for GAS2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with GAS2L2: view
genes like me logo Genes that share phenotypes with GAS2L2: view

Animal Models for GAS2L2 Gene

MGI Knock Outs for GAS2L2:
  • Gas2l2 Gas2l2<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for GAS2L2 Gene

miRTarBase miRNAs that target GAS2L2

Clone Products

  • Applied Biological Materials (abm): Clones for GAS2L2 - Now 50% OFF >
  • * GAS2L2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GAS2L2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GAS2L2 Gene

Localization for GAS2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS2L2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAS2L2 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GAS2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with GAS2L2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GAS2L2 Gene

Pathways & Interactions for GAS2L2 Gene

PathCards logo

SuperPathways for GAS2L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GAS2L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for GAS2L2 Gene

Drugs & Compounds for GAS2L2 Gene

No Compound Related Data Available

Transcripts for GAS2L2 Gene

mRNA/cDNA for GAS2L2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for GAS2L2 Gene

Growth arrest-specific 2 like 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for GAS2L2 - Now 50% OFF >
  • * GAS2L2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GAS2L2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for GAS2L2 Gene

No ASD Table

Relevant External Links for GAS2L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GAS2L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAS2L2 Gene

mRNA differential expression in normal tissues according to GTEx for GAS2L2 Gene

This gene is overexpressed in Fallopian Tube (x8.6) and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for GAS2L2 Gene

This gene is overexpressed in Heart (35.8) and Adipocyte (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GAS2L2 Gene

Protein tissue co-expression partners for GAS2L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAS2L2 Gene:


SOURCE GeneReport for Unigene cluster for GAS2L2 Gene:


mRNA Expression by UniProt/SwissProt for GAS2L2 Gene:

Tissue specificity: Expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with GAS2L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS2L2 Gene

Orthologs for GAS2L2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for GAS2L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GAS2L2 34
  • 99.02 (n)
(Bos Taurus)
Mammalia GAS2L2 34
  • 81.41 (n)
(Canis familiaris)
Mammalia GAS2L2 34
  • 78.91 (n)
(Mus musculus)
Mammalia Gas2l2 17 34
  • 76.36 (n)
(Rattus norvegicus)
Mammalia LOC100912215 34
  • 75.34 (n)
Species where no ortholog for GAS2L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAS2L2 Gene

Gene Tree for GAS2L2 (if available)
Gene Tree for GAS2L2 (if available)
Evolutionary constrained regions (ECRs) for GAS2L2: view image

Paralogs for GAS2L2 Gene

(2) SIMAP similar genes for GAS2L2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GAS2L2: view

Variants for GAS2L2 Gene

Sequence variations from dbSNP and Humsavar for GAS2L2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs145313062 uncertain-significance, not specified 35,745,876(-) C/T coding_sequence_variant, missense_variant
rs1000531601 -- 35,745,580(-) C/A coding_sequence_variant, missense_variant
rs1000770382 -- 35,754,837(-) A/G upstream_transcript_variant
rs1001591251 -- 35,748,809(-) G/A intron_variant
rs1001807562 -- 35,744,507(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GAS2L2 Gene

Variant ID Type Subtype PubMed ID
esv1004453 CNV deletion 20482838
esv3892999 CNV loss 25118596
nsv517530 CNV loss 19592680

Variation tolerance for GAS2L2 Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.59; 91.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAS2L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS2L2 Gene

Disorders for GAS2L2 Gene

Additional Disease Information for GAS2L2

No disorders were found for GAS2L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAS2L2 Gene

Publications for GAS2L2 Gene

  1. Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules. (PMID: 12584248) Goriounov D … Liem RK (Journal of cell science 2003) 2 3 4 58
  2. GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins. (PMID: 24706950) Stroud MJ … Ballestrem C (Journal of cell science 2014) 3 58
  3. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z … Gao Y (Journal of proteome research 2012) 3 58
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for GAS2L2 Gene

Sources for GAS2L2 Gene

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