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This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. This protein localizes to the proximal end of mature centrioles and links centrosomes to both microtubules and actin. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2018]
GAS2L1 (Growth Arrest Specific 2 Like 1) is a Protein Coding gene. Among its related pathways are Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include microtubule binding and cytoskeletal adaptor activity. An important paralog of this gene is GAS2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA,IPI | 24706950 |
GO:0008017 | microtubule binding | IEA,IBA | 21873635 |
GO:0008093 | cytoskeletal adaptor activity | IEA,IBA | 21873635 |
GO:0046966 | thyroid hormone receptor binding | IDA | 19375645 |
GO:0051015 | actin filament binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001725 | stress fiber | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005856 | cytoskeleton | IEA | -- |
GO:0005874 | microtubule | IDA | -- |
GO:0005884 | colocalizes_with actin filament | IMP | 24706950 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Ectoderm Differentiation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000226 | microtubule cytoskeleton organization | IBA | 21873635 |
GO:0001578 | microtubule bundle formation | IMP | 24706950 |
GO:0007050 | cell cycle arrest | ISS | 12584248 |
GO:0009267 | cellular response to starvation | ISS | 12584248 |
GO:0010629 | negative regulation of gene expression | IDA | -- |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||
SP8: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GAS2L1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GAS2L1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GAS2L1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gas2l1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GAS2L1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LOC100859584 30 |
|
||
GAS2L1 31 |
|
OneToOne | |||
Lizard (Anolis carolinensis) |
Reptilia | GAS2L1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gas2l1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | GAS2L1 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs34124440 | - |
p.Ser490Gly |
No disorders were found for GAS2L1 Gene.