GAS2L1 Gene (Protein Coding)

Growth Arrest Specific 2 Like 1

GC22P029306
GIFtS:
37
This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. This protein localizes to the proximal end of mature centrioles and links centrosomes to both microtubules and actin. Alternate splicing results in multiple transcript ... See more...

Aliases for GAS2L1 Gene

Aliases for GAS2L1 Gene

  • Growth Arrest Specific 2 Like 1 2 3 5
  • GAR22 2 3 4
  • Growth Arrest-Specific Protein 2-Like 1 3 4
  • GAS2-Related Protein On Chromosome 22 3 4
  • GAS2-Like Protein 1 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • GAS2L1 5

External Ids for GAS2L1 Gene

Previous GeneCards Identifiers for GAS2L1 Gene

  • GC22P026399
  • GC22P028027
  • GC22P029702
  • GC22P012667

Summaries for GAS2L1 Gene

Entrez Gene Summary for GAS2L1 Gene

  • This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. This protein localizes to the proximal end of mature centrioles and links centrosomes to both microtubules and actin. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2018]

GeneCards Summary for GAS2L1 Gene

GAS2L1 (Growth Arrest Specific 2 Like 1) is a Protein Coding gene. Among its related pathways are Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include microtubule binding and cytoskeletal adaptor activity. An important paralog of this gene is GAS2.

UniProtKB/Swiss-Prot Summary for GAS2L1 Gene

  • Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950).

Gene Wiki entry for GAS2L1 Gene

Additional gene information for GAS2L1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GAS2L1 Gene

Genomics for GAS2L1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GAS2L1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAS2L1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GAS2L1

Top Transcription factor binding sites by QIAGEN in the GAS2L1 gene promoter:
  • Evi-1
  • FOXL1
  • FOXO4
  • HFH-1
  • MAZR
  • NF-kappaB
  • NF-kappaB1
  • Pax-5
  • POU3F1
  • TBP

Genomic Locations for GAS2L1 Gene

Latest Assembly
chr22:29,306,582-29,312,787
(GRCh38/hg38)
Size:
6,206 bases
Orientation:
Plus strand

Previous Assembly
chr22:29,703,013-29,708,776
(GRCh37/hg19 by Entrez Gene)
Size:
5,764 bases
Orientation:
Plus strand

chr22:29,702,572-29,708,774
(GRCh37/hg19 by Ensembl)
Size:
6,203 bases
Orientation:
Plus strand

Genomic View for GAS2L1 Gene

Genes around GAS2L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS2L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS2L1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GAS2L1 Gene

Proteins for GAS2L1 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for GAS2L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99501-GA2L1_HUMAN
    Recommended name:
    GAS2-like protein 1
    Protein Accession:
    Q99501
    Secondary Accessions:
    • B5MCR7
    • Q53EN7
    • Q92640
    • Q9BUY9

    Protein attributes for GAS2L1 Gene

    Size:
    681 amino acids
    Molecular mass:
    72717 Da
    Quaternary structure:
    • Interacts with MAPRE1.

    Alternative splice isoforms for GAS2L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAS2L1 Gene

Protein Expression for GAS2L1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GAS2L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAS2L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAS2L1 Gene

Domains & Families for GAS2L1 Gene

Gene Families for GAS2L1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GAS2L1 Gene

InterPro:
Blocks:
  • Calponin-like actin-binding
  • Growth-arrest-specific protein 2
ProtoNet:

Suggested Antigen Peptide Sequences for GAS2L1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ36067 fis, clone TESTI2019308, highly similar to GAR22 PROTEIN (A0A5E8_HUMAN)
  • Growth arrest-specific protein 2-like 1 (GA2L1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99501

UniProtKB/Swiss-Prot:

GA2L1_HUMAN :
  • Belongs to the GAS2 family.
Family:
  • Belongs to the GAS2 family.
genes like me logo Genes that share domains with GAS2L1: view

Function for GAS2L1 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for GAS2L1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950).

Phenotypes From GWAS Catalog for GAS2L1 Gene

Gene Ontology (GO) - Molecular Function for GAS2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 24706950
GO:0008017 microtubule binding IEA,IBA 21873635
GO:0008093 cytoskeletal adaptor activity IEA,IBA 21873635
GO:0046966 thyroid hormone receptor binding IDA 19375645
GO:0051015 actin filament binding IBA 21873635
genes like me logo Genes that share ontologies with GAS2L1: view
genes like me logo Genes that share phenotypes with GAS2L1: view

Animal Models for GAS2L1 Gene

MGI Knock Outs for GAS2L1:
  • Gas2l1 Gas2l1<tm1.1(KOMP)Vlcg>

Animal Models for research

miRNA for GAS2L1 Gene

miRTarBase miRNAs that target GAS2L1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAS2L1

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GAS2L1 Gene

Localization for GAS2L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS2L1 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Note=Colocalizes with the tips of microtubule plus ends. {ECO:0000269 PubMed:24706950}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAS2L1 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GAS2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IDA --
GO:0005884 colocalizes_with actin filament IMP 24706950
genes like me logo Genes that share ontologies with GAS2L1: view

Pathways & Interactions for GAS2L1 Gene

PathCards logo

SuperPathways for GAS2L1 Gene

SuperPathway Contained pathways
1 Ectoderm Differentiation
Ectoderm Differentiation
-
genes like me logo Genes that share pathways with GAS2L1: view

Pathways by source for GAS2L1 Gene

1 BioSystems pathway for GAS2L1 Gene
1 GeneTex pathway for GAS2L1 Gene

Gene Ontology (GO) - Biological Process for GAS2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA 21873635
GO:0001578 microtubule bundle formation IMP 24706950
GO:0007050 cell cycle arrest ISS 12584248
GO:0009267 cellular response to starvation ISS 12584248
GO:0010629 negative regulation of gene expression IDA --
genes like me logo Genes that share ontologies with GAS2L1: view

No data available for SIGNOR curated interactions for GAS2L1 Gene

Drugs & Compounds for GAS2L1 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for GAS2L1 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for GAS2L1 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAS2L1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for GAS2L1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7:
SP8: -

Relevant External Links for GAS2L1 Gene

GeneLoc Exon Structure for
GAS2L1

Expression for GAS2L1 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAS2L1 Gene

mRNA expression in normal human tissues for GAS2L1 Gene
mRNA expression by BioGPS for GAS2L1 GenemRNA expression by GTEx for GAS2L1 Gene

Protein differential expression in normal tissues from HIPED for GAS2L1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (45.5) and Testis (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GAS2L1 Gene



Protein tissue co-expression partners for GAS2L1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GAS2L1

SOURCE GeneReport for Unigene cluster for GAS2L1 Gene:

Hs.322852

Evidence on tissue expression from TISSUES for GAS2L1 Gene

  • Nervous system(4.7)
  • Blood(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with GAS2L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS2L1 Gene

Orthologs for GAS2L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAS2L1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GAS2L1 31
  • 98 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GAS2L1 30 31
  • 87.66 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia GAS2L1 30 31
  • 87.47 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Gas2l1 30 17 31
  • 83.36 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia GAS2L1 31
  • 31 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves LOC100859584 30
  • 58.93 (n)
GAS2L1 31
  • 26 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia GAS2L1 31
  • 30 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia gas2l1 30
  • 55.14 (n)
Zebrafish
(Danio rerio)
 Actinopterygii GAS2L1 31
  • 31 (a)
 OneToOne
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 40 (a)
 OneToMany
Species where no ortholog for GAS2L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GAS2L1 Gene

ENSEMBL:
Gene Tree for GAS2L1 (if available)
TreeFam:
Gene Tree for GAS2L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GAS2L1: view image

Paralogs for GAS2L1 Gene

Paralogs for GAS2L1 Gene

(2) SIMAP similar genes for GAS2L1 Gene using alignment to 6 proteins:

  • GA2L1_HUMAN
  • A0A5E8_HUMAN
  • B5MCR7_HUMAN
  • C9JFI0_HUMAN
  • C9JRR6_HUMAN
  • E7EQM6_HUMAN

Pseudogenes.org Pseudogenes for GAS2L1 Gene

genes like me logo Genes that share paralogs with GAS2L1: view

Variants for GAS2L1 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GAS2L1 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs34124440 - p.Ser490Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GAS2L1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GAS2L1 Gene

Variant ID Type Subtype PubMed ID
nsv829154 CNV gain 20364138
nsv829155 CNV loss 20364138
nsv834171 CNV loss 17160897

Variation tolerance for GAS2L1 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.26; 76.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAS2L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAS2L1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS2L1 Gene

Disorders for GAS2L1 Gene

Additional Disease Information for GAS2L1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for GAS2L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAS2L1 Gene

Publications for GAS2L1 Gene

  1. Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules. (PMID: 12584248) Goriounov D … Liem RK (Journal of cell science 2003) 2 3 4
  2. Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region. (PMID: 8975699) Zucman-Rossi J … Thomas G (Genomics 1996) 2 3 4
  3. GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins. (PMID: 24706950) Stroud MJ … Ballestrem C (Journal of cell science 2014) 3 4
  4. An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia. (PMID: 20537721) Saito A … Akiyama K (Psychiatry research 2011) 3 41
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

ExternalLinks

View latest publications for GAS2L1 gene in Mastermind

Products for GAS2L1 Gene

Sources for GAS2L1 Gene