Aliases for GAS2L1 Gene
External Ids for GAS2L1 Gene
Previous GeneCards Identifiers for GAS2L1 Gene
This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. This protein localizes to the proximal end of mature centrioles and links centrosomes to both microtubules and actin. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2018]
GeneCards Summary for GAS2L1 Gene
GAS2L1 (Growth Arrest Specific 2 Like 1) is a Protein Coding gene. Among its related pathways are Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include microtubule binding and cytoskeletal adaptor activity. An important paralog of this gene is ASPM.
UniProtKB/Swiss-Prot Summary for GAS2L1 Gene
Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950).