Aliases for GAS2 Gene
External Ids for GAS2 Gene
Previous GeneCards Identifiers for GAS2 Gene
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017]
GeneCards Summary for GAS2 Gene
GAS2 (Growth Arrest Specific 2) is a Protein Coding gene. Diseases associated with GAS2 include Gnathodiaphyseal Dysplasia and Trichothiodystrophy 1, Photosensitive. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Apoptotic Pathways in Synovial Fibroblasts. An important paralog of this gene is GAS2L1.
UniProtKB/Swiss-Prot Summary for GAS2 Gene
May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).