Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008] See more...

Aliases for GAS1 Gene

Aliases for GAS1 Gene

  • Growth Arrest Specific 1 2 3 5
  • Growth Arrest-Specific Protein 1 3 4
  • Growth Arrest-Specific Gene-1 2 3
  • GAS-1 3 4
  • GAS1 5

External Ids for GAS1 Gene

Previous GeneCards Identifiers for GAS1 Gene

  • GC09M080603
  • GC09M081412
  • GC09M083114
  • GC09M085016
  • GC09M086788
  • GC09M088749
  • GC09M089559
  • GC09M059383

Summaries for GAS1 Gene

Entrez Gene Summary for GAS1 Gene

  • Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAS1 Gene

GAS1 (Growth Arrest Specific 1) is a Protein Coding gene. Diseases associated with GAS1 include Septopreoptic Holoprosencephaly and Midline Interhemispheric Variant Of Holoprosencephaly. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Signaling by GPCR.

UniProtKB/Swiss-Prot Summary for GAS1 Gene

  • Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.

Gene Wiki entry for GAS1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GAS1 Gene

Genomics for GAS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GAS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J086941 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.8 1796 8.1 SP1 ZNF600 ZNF580 CEBPA ZNF10 ZSCAN16 POLR2A ZIC2 ZBTB10 YY1 GAS1RR GAS1 HSALNG0072435 HSALNG0072436 piR-38457 TUT7
GH09J087140 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 13.8 -193.3 -193318 1 ZNF580 ATF2 ZNF10 ZIC2 FEZF1 ZNF639 ZEB1 ZNF843 PRDM6 GLI4 GAS1 LINC02893 GAS1RR piR-33614-278 HSALNG0072441 HSALNG0072443 lnc-GAS1-4 DAPK1
GH09J086982 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 11.4 -36.2 -36195 3.4 ZNF600 ZNF10 CEBPB FEZF1 ZNF639 ZNF341 ZEB1 EP300 ZNF610 STAT3 GAS1RR GAS1 LINC02893 piR-33614-277 piR-38580-383 DAPK1
GH09J086562 Enhancer 1 Ensembl ENCODE dbSUPER 12.8 +384.0 384021 1.6 ZNF600 FEZF1 PRDM6 ZBTB1 JUND SP7 ZNF561 ZNF792 ZBTB12 ZNF629 GAS1 lnc-NAA35-10 RF00017-7091 HSALNG0072405 TUT7
GH09J086738 Enhancer 0.9 Ensembl ENCODE 12.8 +209.0 209005 0.6 ZNF580 KLF16 PRDM6 GLI4 ZSCAN5A ZNF2 ZNF189 PKNOX1 SCRT1 CBLL2 GAS1 GAS1RR HSALNG0072415 HSALNG0072416 TUT7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAS1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GAS1

Top Transcription factor binding sites by QIAGEN in the GAS1 gene promoter:
  • C/EBPalpha
  • E2F
  • E2F-1
  • FOXF2
  • NF-kappaB
  • NF-kappaB1
  • RFX1
  • STAT1
  • USF-1
  • USF1

Genomic Locations for GAS1 Gene

Latest Assembly
chr9:86,944,362-86,947,506
(GRCh38/hg38)
Size:
3,145 bases
Orientation:
Minus strand

Previous Assembly
chr9:89,559,277-89,562,421
(GRCh37/hg19 by Entrez Gene)
Size:
3,145 bases
Orientation:
Minus strand

chr9:89,559,279-89,562,104
(GRCh37/hg19 by Ensembl)
Size:
2,826 bases
Orientation:
Minus strand

Genomic View for GAS1 Gene

Genes around GAS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS1 Gene

Proteins for GAS1 Gene

  • Protein details for GAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54826-GAS1_HUMAN
    Recommended name:
    Growth arrest-specific protein 1
    Protein Accession:
    P54826
    Secondary Accessions:
    • B9EGM4
    • Q6B086

    Protein attributes for GAS1 Gene

    Size:
    345 amino acids
    Molecular mass:
    35693 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GAS1 Gene

Post-translational modifications for GAS1 Gene

  • Glycosylation at Asn117
  • Ubiquitination at Lys192
  • Modification sites at PhosphoSitePlus

Other Protein References for GAS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAS1 Gene

Domains & Families for GAS1 Gene

Gene Families for GAS1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for GAS1 Gene

InterPro:

Suggested Antigen Peptide Sequences for GAS1 Gene

GenScript: Design optimal peptide antigens:
  • Growth arrest-specific protein 1 (GAS1_HUMAN)
genes like me logo Genes that share domains with GAS1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GAS1 Gene

Function for GAS1 Gene

Molecular function for GAS1 Gene

UniProtKB/Swiss-Prot Function:
Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.
GENATLAS Biochemistry:
growth arrest specific gene 1,45kDa,predominantly expressed in lung and heart

Phenotypes From GWAS Catalog for GAS1 Gene

Gene Ontology (GO) - Molecular Function for GAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21357679
genes like me logo Genes that share ontologies with GAS1: view
genes like me logo Genes that share phenotypes with GAS1: view

Human Phenotype Ontology for GAS1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GAS1 Gene

MGI Knock Outs for GAS1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAS1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GAS1 Gene

Localization for GAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS1 Gene

Cell membrane. Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAS1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 8127893
GO:0031225 anchored component of membrane IEA --
GO:0046658 anchored component of plasma membrane ISS --
genes like me logo Genes that share ontologies with GAS1: view

Pathways & Interactions for GAS1 Gene

PathCards logo

SuperPathways for GAS1 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
2 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
3 ERK Signaling
.61
.61
.58
.51
.49
4 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
5 CREB Pathway
.68
.68
.63
.50
genes like me logo Genes that share pathways with GAS1: view

Pathways by source for GAS1 Gene

1 KEGG pathway for GAS1 Gene
54 Qiagen pathways for GAS1 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

SIGNOR curated interactions for GAS1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for GAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IEA --
GO:0008589 regulation of smoothened signaling pathway ISS --
GO:0010955 negative regulation of protein processing IMP 21357679
GO:0035924 cellular response to vascular endothelial growth factor stimulus IEP 15070677
genes like me logo Genes that share ontologies with GAS1: view

Drugs & Compounds for GAS1 Gene

(1) Additional Compounds for GAS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GAS1: view

Transcripts for GAS1 Gene

mRNA/cDNA for GAS1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAS1

Alternative Splicing Database (ASD) splice patterns (SP) for GAS1 Gene

No ASD Table

Relevant External Links for GAS1 Gene

GeneLoc Exon Structure for
GAS1

Expression for GAS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAS1 Gene

mRNA differential expression in normal tissues according to GTEx for GAS1 Gene

This gene is overexpressed in Uterus (x6.1) and Adipose - Visceral (Omentum) (x4.4).

Protein differential expression in normal tissues from HIPED for GAS1 Gene

This gene is overexpressed in Pancreatic juice (27.2), Gallbladder (13.2), and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GAS1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GAS1

SOURCE GeneReport for Unigene cluster for GAS1 Gene:

Hs.65029

Evidence on tissue expression from TISSUES for GAS1 Gene

  • Liver(4.3)
  • Skin(2.4)
  • Muscle(2.2)
  • Intestine(2.1)
  • Heart(2.1)
  • Nervous system(2.1)
  • Kidney(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeleton
Regions:
Head and neck:
  • brain
  • eye
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • pharynx
  • pituitary gland
  • skull
  • tooth
General:
  • skin
genes like me logo Genes that share expression patterns with GAS1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GAS1 Gene

Orthologs for GAS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GAS1 29 30
  • 98.16 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GAS1 29 30
  • 93.29 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GAS1 29 30
  • 91.72 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gas1 29 16 30
  • 84.5 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gas1 29
  • 84.35 (n)
Oppossum
(Monodelphis domestica)
Mammalia GAS1 30
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GAS1 30
  • 68 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GAS1 30
  • 62 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gas1 29
  • 72.62 (n)
Str.10719 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.16153 29
Zebrafish
(Danio rerio)
Actinopterygii gas1a 29 30
  • 63.47 (n)
OneToMany
gas1b 30
  • 46 (a)
OneToMany
Species where no ortholog for GAS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GAS1 Gene

ENSEMBL:
Gene Tree for GAS1 (if available)
TreeFam:
Gene Tree for GAS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GAS1: view image
Alliance of Genome Resources:
Additional Orthologs for GAS1

Paralogs for GAS1 Gene

No data available for Paralogs for GAS1 Gene

Variants for GAS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GAS1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs1041660363 Likely Benign: not provided 86,946,468(-) G/C
NM_002048.3(GAS1):c.312C>G (p.Arg104=)
SYNONYMOUS
rs1246966375 Likely Benign: not provided 86,946,591(-) G/A
NM_002048.3(GAS1):c.189C>T (p.Tyr63=)
SYNONYMOUS
rs1442633125 Likely Benign: not provided 86,946,603(-) C/T
NM_002048.3(GAS1):c.177G>A (p.Pro59=)
SYNONYMOUS
rs1462430843 Benign: not provided 86,945,787(-) G/C
NM_002048.3(GAS1):c.993C>G (p.Thr331=)
SYNONYMOUS
rs150545553 Benign: not provided 86,946,039(-) C/T
NM_002048.3(GAS1):c.741G>A (p.Glu247=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GAS1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GAS1 Gene

Variant ID Type Subtype PubMed ID
dgv12781n54 CNV loss 21841781
esv29661 CNV loss 19812545
nsv1077160 CNV deletion 25765185
nsv1119600 CNV deletion 24896259
nsv1122240 CNV deletion 24896259

Variation tolerance for GAS1 Gene

Gene Damage Index Score: 0.37; 8.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAS1 Gene

Human Gene Mutation Database (HGMD)
GAS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAS1
Leiden Open Variation Database (LOVD)
GAS1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS1 Gene

Disorders for GAS1 Gene

MalaCards: The human disease database

(17) MalaCards diseases for GAS1 Gene - From: ORP, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search GAS1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GAS1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GAS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAS1 Gene

Publications for GAS1 Gene

  1. Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene. (PMID: 8127893) Del Sal G … Schneider C (Proceedings of the National Academy of Sciences of the United States of America 1994) 3 4 22
  2. Localization of the human growth arrest-specific gene (GAS1) to chromosome bands 9q21.3-q22, a region frequently deleted in myeloid malignancies. (PMID: 8307588) Evdokiou A … Cowled PA (Genomics 1993) 2 3 22
  3. Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study. (PMID: 21901158) Irvin MR … Arnett DK (PloS one 2011) 3 40
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 40
  5. Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin. (PMID: 20050020) Rittié L … Fisher GJ (Aging cell 2009) 3 22

Products for GAS1 Gene

Sources for GAS1 Gene