Aliases for GARRE1 Gene

Aliases for GARRE1 Gene

  • Granule Associated Rac And RHOG Effector 1 2 3
  • KIAA0355 2 3 4 5
  • Granule Associated Rac And RHOG Effector Protein 1 4
  • Uncharacterized Protein KIAA0355 3

External Ids for GARRE1 Gene

Previous HGNC Symbols for GARRE1 Gene

  • KIAA0355

Summaries for GARRE1 Gene

GeneCards Summary for GARRE1 Gene

GARRE1 (Granule Associated Rac And RHOG Effector 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for GARRE1 Gene

  • Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067).

Additional gene information for GARRE1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GARRE1 Gene

Genomics for GARRE1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GARRE1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GARRE1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GARRE1

Genomic Locations for GARRE1 Gene

Genomic Locations for GARRE1 Gene
chr19:34,254,552-34,355,571
(GRCh38/hg38)
Size:
101,020 bases
Orientation:
Plus strand
chr19:34,745,442-34,846,491
(GRCh37/hg19)
Size:
101,050 bases
Orientation:
Plus strand

Genomic View for GARRE1 Gene

Genes around GARRE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GARRE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GARRE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GARRE1 Gene

Proteins for GARRE1 Gene

  • Protein details for GARRE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15063-GRRE1_HUMAN
    Recommended name:
    Granule associated Rac and RHOG effector protein 1
    Protein Accession:
    O15063
    Secondary Accessions:
    • Q2M3W4

    Protein attributes for GARRE1 Gene

    Size:
    1070 amino acids
    Molecular mass:
    116020 Da
    Quaternary structure:
    • Interacts with AGO2 and TNRC6A.
    SequenceCaution:
    • Sequence=BAA20812.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for GARRE1 Gene

Post-translational modifications for GARRE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GARRE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GARRE1 Gene

Domains & Families for GARRE1 Gene

Gene Families for GARRE1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GARRE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GARRE1 Gene

GenScript: Design optimal peptide antigens:
  • KIAA0355 protein (A1A512_HUMAN)
genes like me logo Genes that share domains with GARRE1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GARRE1 Gene

Function for GARRE1 Gene

Molecular function for GARRE1 Gene

UniProtKB/Swiss-Prot Function:
Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067).

Phenotypes From GWAS Catalog for GARRE1 Gene

Gene Ontology (GO) - Molecular Function for GARRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 29395067
GO:0048365 Rac GTPase binding IPI 31871319
GO:1905762 CCR4-NOT complex binding IDA 29395067
genes like me logo Genes that share ontologies with GARRE1: view
genes like me logo Genes that share phenotypes with GARRE1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GARRE1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GARRE1 Gene

Localization for GARRE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GARRE1 Gene

Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GARRE1 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GARRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA 29395067
genes like me logo Genes that share ontologies with GARRE1: view

Pathways & Interactions for GARRE1 Gene

PathCards logo

SuperPathways for GARRE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GARRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016601 Rac protein signal transduction IDA 31871319
genes like me logo Genes that share ontologies with GARRE1: view

No data available for Pathways by source and SIGNOR curated interactions for GARRE1 Gene

Drugs & Compounds for GARRE1 Gene

No Compound Related Data Available

Transcripts for GARRE1 Gene

mRNA/cDNA for GARRE1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GARRE1

Alternative Splicing Database (ASD) splice patterns (SP) for GARRE1 Gene

No ASD Table

Relevant External Links for GARRE1 Gene

GeneLoc Exon Structure for
GARRE1

Expression for GARRE1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GARRE1

SOURCE GeneReport for Unigene cluster for GARRE1 Gene:

Hs.330073
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GARRE1 Gene

Orthologs for GARRE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GARRE1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KIAA0355 30 31
  • 99.38 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KIAA0355 30 31
  • 91.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KIAA0355 30 31
  • 91.09 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia 4931406P16Rik 30 31
  • 89.89 (n)
OneToOne
Garre1 17
Rat
(Rattus norvegicus)
Mammalia RGD1308428 30
  • 89.64 (n)
Oppossum
(Monodelphis domestica)
Mammalia KIAA0355 31
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0355 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KIAA0355 30 31
  • 74.92 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KIAA0355 31
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kiaa0355 30
  • 70.81 (n)
Str.19353 30
Zebrafish
(Danio rerio)
Actinopterygii KIAA0355 31
  • 64 (a)
OneToOne
Species where no ortholog for GARRE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GARRE1 Gene

ENSEMBL:
Gene Tree for GARRE1 (if available)
TreeFam:
Gene Tree for GARRE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GARRE1: view image

Paralogs for GARRE1 Gene

No data available for Paralogs for GARRE1 Gene

Variants for GARRE1 Gene

Additional dbSNP identifiers (rs#s) for GARRE1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GARRE1 Gene

Variant ID Type Subtype PubMed ID
esv3644205 CNV loss 21293372
esv3644206 CNV loss 21293372
nsv1121979 CNV deletion 24896259
nsv1143915 CNV deletion 24896259
nsv2468 CNV insertion 18451855
nsv474884 CNV novel sequence insertion 20440878
nsv474905 CNV novel sequence insertion 20440878
nsv474923 CNV novel sequence insertion 20440878
nsv475034 CNV novel sequence insertion 20440878
nsv475206 CNV novel sequence insertion 20440878
nsv475303 CNV novel sequence insertion 20440878
nsv475634 CNV novel sequence insertion 20440878
nsv476189 CNV novel sequence insertion 20440878
nsv478015 CNV novel sequence insertion 20440878
nsv480065 CNV novel sequence insertion 20440878
nsv480180 CNV novel sequence insertion 20440878
nsv509737 CNV insertion 20534489
nsv509738 CNV insertion 20534489
nsv961210 CNV duplication 23825009

Variation tolerance for GARRE1 Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GARRE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GARRE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GARRE1 Gene

Disorders for GARRE1 Gene

No disorders were found for GARRE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GARRE1 Gene

Publications for GARRE1 Gene

  1. Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. (PMID: 31871319) Bagci H … Côté JF (Nature cell biology 2020) 2 3 4
  2. High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. (PMID: 29395067) Youn JY … Gingras AC (Molecular cell 2018) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4
  4. Author Correction: Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. (PMID: 32042180) Bagci H … Côté JF (Nature cell biology 2020) 4
  5. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. (PMID: 30833792) Hubel P … Pichlmair A (Nature immunology 2019) 3

Products for GARRE1 Gene

Sources for GARRE1 Gene