Aliases for GAREM2 Gene

Aliases for GAREM2 Gene

  • GRB2 Associated Regulator Of MAPK1 Subtype 2 2 3 5
  • GRB2-Associated And Regulator Of MAPK Protein 2 3 4
  • Family With Sequence Similarity 59, Member B 2 3
  • GRB2-Associated And Regulator Of MAPK1-Like 3 4
  • GRB2 Associated, Regulator Of MAPK1-Like 2 3
  • KIAA2038 2 4
  • FAM59B 3 4
  • GAREML 3 4
  • GRB2-Associated And Regulator Of MAPK Protein-Like 3
  • GRB2 Associated Regulator Of MAPK1 2 3
  • Protein FAM59B 3
  • FLJ00375 2
  • GAREM2 5

External Ids for GAREM2 Gene

Previous HGNC Symbols for GAREM2 Gene

  • FAM59B

Summaries for GAREM2 Gene

GeneCards Summary for GAREM2 Gene

GAREM2 (GRB2 Associated Regulator Of MAPK1 Subtype 2) is a Protein Coding gene. Diseases associated with GAREM2 include Long-Chain 3-Hydroxyacyl-Coa Dehydrogenase Deficiency and 3-Hydroxyacyl-Coa Dehydrogenase Deficiency. An important paralog of this gene is GAREM1.

UniProtKB/Swiss-Prot Summary for GAREM2 Gene

  • Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GAREM2 Gene

Genomics for GAREM2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GAREM2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J026172 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 611.3 +1.1 1144 3.8 KDM1A ZNF692 ZIC2 ZFX NONO ZBTB20 EGR1 EZH2 HDAC2 ZBTB26 GAREM2 HADHA HADHB NONHSAG027276.2
GH02J026171 Enhancer 0.7 ENCODE 600.7 -1.4 -1421 0.2 CTCF ZBTB33 REST NR2C1 NKRF SMC3 ZBTB25 BCOR RAD21 NR2F1 GAREM2 lnc-HADHA-1 RAB10
GH02J026784 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 15.2 +613.3 613313 3.2 SP1 HNRNPL CREB1 GATAD2A ZBTB33 ZNF629 TFE3 RFX1 NFKBIZ KDM1A CENPA NONHSAG027291.2 ATRAID GTF3C2 EIF2B4 ASXL2 GPN1 ENSG00000234072 NRBP1 TMEM214
GH02J026342 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.2 +172.7 172682 6.3 SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 PRDM10 ZNF629 REST TFE3 ADGRF3 SELENOI lnc-HADHA-4 lnc-HADHA-5 CAD TMEM214 ENSG00000272148 KIF3C GAREM2 ATRAID
GH02J027049 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 12.1 +877.9 877913 4 RNF2 SP1 HNRNPL GATAD2A CTCF ARID3A TEAD4 PRDM10 ZNF629 TFE3 AGBL5-AS1 HSALNG0013764 TRY-GTA2-1 TRA-AGC8-1-001 piR-36241-001 piR-33423 AGBL5 SUPT7L IFT172 CAD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAREM2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GAREM2

Genomic Locations for GAREM2 Gene

Genomic Locations for GAREM2 Gene
29,442 bases
Plus strand
16,573 bases
Plus strand

Genomic View for GAREM2 Gene

Genes around GAREM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAREM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAREM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAREM2 Gene

Proteins for GAREM2 Gene

  • Protein details for GAREM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GRB2-associated and regulator of MAPK protein 2
    Protein Accession:
    Secondary Accessions:
    • B5MC97
    • B7WNK9
    • Q8NF27
    • Q9UIK8

    Protein attributes for GAREM2 Gene

    874 amino acids
    Molecular mass:
    92882 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC03435.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAC99057.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for GAREM2 Gene


neXtProt entry for GAREM2 Gene

Post-translational modifications for GAREM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAREM2 Gene

No data available for DME Specific Peptides for GAREM2 Gene

Domains & Families for GAREM2 Gene

Gene Families for GAREM2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GAREM2 Gene

  • Sterile alpha motif SAM

Suggested Antigen Peptide Sequences for GAREM2 Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM59B (FA59B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAREM family.
  • Belongs to the GAREM family.
genes like me logo Genes that share domains with GAREM2: view

Function for GAREM2 Gene

Molecular function for GAREM2 Gene

UniProtKB/Swiss-Prot Function:
Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.

Phenotypes From GWAS Catalog for GAREM2 Gene

genes like me logo Genes that share phenotypes with GAREM2: view

Animal Model Products

CRISPR Products

miRNA for GAREM2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAREM2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAREM2 Gene

Localization for GAREM2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAREM2 gene
Compartment Confidence
nucleus 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GAREM2 Gene

Pathways & Interactions for GAREM2 Gene

PathCards logo

SuperPathways for GAREM2 Gene

No Data Available

Interacting Proteins for GAREM2 Gene

Gene Ontology (GO) - Biological Process for GAREM2 Gene


No data available for Pathways by source and SIGNOR curated interactions for GAREM2 Gene

Drugs & Compounds for GAREM2 Gene

No Compound Related Data Available

Transcripts for GAREM2 Gene

mRNA/cDNA for GAREM2 Gene

5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAREM2

Alternative Splicing Database (ASD) splice patterns (SP) for GAREM2 Gene

No ASD Table

Relevant External Links for GAREM2 Gene

GeneLoc Exon Structure for

Expression for GAREM2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GAREM2

Evidence on tissue expression from TISSUES for GAREM2 Gene

  • Nervous system(2.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAREM2 Gene

Orthologs for GAREM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAREM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM59B 30
  • 98.5 (n)
  • 98 (a)
(Canis familiaris)
Mammalia GAREML 30 31
  • 89.93 (n)
(Bos Taurus)
Mammalia FAM59B 30
  • 87.95 (n)
  • 73 (a)
(Mus musculus)
Mammalia Gareml 30 31
  • 85.6 (n)
Garem2 17
(Rattus norvegicus)
Mammalia Gareml 30
  • 84.45 (n)
(Monodelphis domestica)
Mammalia GAREML 31
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia GAREML 31
  • 61 (a)
(Gallus gallus)
Aves FAM59B 30
  • 70.32 (n)
  • 63 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gareml 30
  • 65.06 (n)
(Danio rerio)
Actinopterygii gareml 30 31
  • 61.36 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
Species where no ortholog for GAREM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GAREM2 Gene

Gene Tree for GAREM2 (if available)
Gene Tree for GAREM2 (if available)
Evolutionary constrained regions (ECRs) for GAREM2: view image

Paralogs for GAREM2 Gene

Paralogs for GAREM2 Gene

genes like me logo Genes that share paralogs with GAREM2: view

Variants for GAREM2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GAREM2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
651987 Pathogenic: Mitochondrial trifunctional protein deficiency; Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency 26,194,614(+) TG/T FRAMESHIFT_VARIANT
657134 Uncertain Significance: Mitochondrial trifunctional protein deficiency; Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency 26,191,327(+) C/A MISSENSE_VARIANT
659825 Uncertain Significance: Mitochondrial trifunctional protein deficiency; Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency 26,193,690(+) A/C MISSENSE_VARIANT
668557 Benign: not provided 26,192,020(+) C/T INTRON_VARIANT
673764 Benign: not provided 26,201,515(+) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for GAREM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GAREM2 Gene

Variant ID Type Subtype PubMed ID
esv22083 CNV loss 19812545
esv33316 CNV loss 17666407
nsv1071583 CNV deletion 25765185
nsv1144893 CNV deletion 24896259
nsv2648 CNV deletion 18451855
nsv520638 CNV loss 19592680
nsv524918 CNV gain 19592680

Variation tolerance for GAREM2 Gene

Gene Damage Index Score: 2.03; 37.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAREM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAREM2 Gene

Disorders for GAREM2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GAREM2 Gene - From: GeneCards

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with GAREM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAREM2 Gene

Publications for GAREM2 Gene

  1. A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling. (PMID: 24003223) Taniguchi T … Konishi H (The Journal of biological chemistry 2013) 2 3
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3

Products for GAREM2 Gene

Sources for GAREM2 Gene