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Aliases for GAREM2 Gene

Aliases for GAREM2 Gene

  • GRB2 Associated Regulator Of MAPK1 Subtype 2 2 3 5
  • Family With Sequence Similarity 59, Member B 2 3
  • GRB2-Associated And Regulator Of MAPK1-Like 3 4
  • GRB2 Associated, Regulator Of MAPK1-Like 2 3
  • FAM59B 3 4
  • GAREML 3 4
  • GRB2-Associated And Regulator Of MAPK Protein-Like 3
  • GRB2-Associated And Regulator Of MAPK Protein 2 3
  • GRB2 Associated Regulator Of MAPK1 2 3
  • Protein FAM59B 3
  • KIAA2038 4

External Ids for GAREM2 Gene

Previous HGNC Symbols for GAREM2 Gene

  • FAM59B
  • GAREML

Summaries for GAREM2 Gene

GeneCards Summary for GAREM2 Gene

GAREM2 (GRB2 Associated Regulator Of MAPK1 Subtype 2) is a Protein Coding gene. An important paralog of this gene is GAREM1.

UniProtKB/Swiss-Prot for GAREM2 Gene

  • Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.

Additional gene information for GAREM2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAREM2 Gene

Genomics for GAREM2 Gene

GeneHancer (GH) Regulatory Elements for GAREM2 Gene

Promoters and enhancers for GAREM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I026172 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 -0.1 -53 0.5 NCOA6 MAZ RB1 L3MBTL2 SIN3A USF2 ZNF335 ZNF692 ADNP VEZF1 GAREM2 GC02M026166 GC02P026059
GH02I026171 Enhancer 0.7 ENCODE 550.8 -1.4 -1424 0.2 BCOR CTCF ARNT RAD21 BCL11B CHAMP1 CC2D1A ARID2 ZNF143 PRDM10 GAREM2 GC02M026166 GC02P026059
GH02I026342 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.2 +172.7 172679 6.3 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ADGRF3 SELENOI CAD ASXL2 TMEM214 GTF3C2-AS1 ENSG00000272148 AGBL5 KIF3C GAREM2
GH02I027049 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.1 +878.0 877978 3.2 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 AGBL5-AS1 GC02P027055 PIR54422 PIR59385 TRY-GTA2-1 AGBL5 IFT172 SUPT7L ZNF512 CAD
GH02I026242 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.6 +71.7 71724 5.5 CLOCK DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPARGC1A HADHA HADHB CAD TMEM214 DNMT3A ASXL2 ATRAID RPS2P15 GAREM2 LOC105374334
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GAREM2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GAREM2 Gene

Genomic Locations for GAREM2 Gene
chr2:26,173,091-26,202,529
(GRCh38/hg38)
Size:
29,439 bases
Orientation:
Plus strand
chr2:26,395,960-26,412,532
(GRCh37/hg19)

Genomic View for GAREM2 Gene

Genes around GAREM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAREM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAREM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAREM2 Gene

Proteins for GAREM2 Gene

  • Protein details for GAREM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q75VX8-GARE2_HUMAN
    Recommended name:
    GRB2-associated and regulator of MAPK protein 2
    Protein Accession:
    Q75VX8
    Secondary Accessions:
    • B5MC97
    • B7WNK9
    • Q8NF27
    • Q9UIK8

    Protein attributes for GAREM2 Gene

    Size:
    874 amino acids
    Molecular mass:
    92882 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC99057.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for GAREM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAREM2 Gene

Post-translational modifications for GAREM2 Gene

No Post-translational modifications

Other Protein References for GAREM2 Gene

No data available for DME Specific Peptides for GAREM2 Gene

Domains & Families for GAREM2 Gene

Gene Families for GAREM2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GAREM2 Gene

Suggested Antigen Peptide Sequences for GAREM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q75VX8

UniProtKB/Swiss-Prot:

GARE2_HUMAN :
  • Belongs to the GAREM family.
Family:
  • Belongs to the GAREM family.
genes like me logo Genes that share domains with GAREM2: view

Function for GAREM2 Gene

Molecular function for GAREM2 Gene

UniProtKB/Swiss-Prot Function:
Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.
genes like me logo Genes that share phenotypes with GAREM2: view

Animal Model Products

miRNA for GAREM2 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAREM2 Gene

Localization for GAREM2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAREM2 gene
Compartment Confidence
extracellular 5
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GAREM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 23376485
genes like me logo Genes that share ontologies with GAREM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GAREM2 Gene

Pathways & Interactions for GAREM2 Gene

SuperPathways for GAREM2 Gene

No Data Available

Interacting Proteins for GAREM2 Gene

Gene Ontology (GO) - Biological Process for GAREM2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAREM2 Gene

Drugs & Compounds for GAREM2 Gene

No Compound Related Data Available

Transcripts for GAREM2 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAREM2 Gene

No ASD Table

Relevant External Links for GAREM2 Gene

GeneLoc Exon Structure for
GAREM2
ECgene alternative splicing isoforms for
GAREM2

Expression for GAREM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAREM2 Gene:

GAREM2

Evidence on tissue expression from TISSUES for GAREM2 Gene

  • Nervous system(4.3)
  • Spleen(4.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAREM2 Gene

Orthologs for GAREM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAREM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM59B 33
  • 98.5 (n)
GAREML 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAREML 33 34
  • 89.93 (n)
cow
(Bos Taurus)
Mammalia FAM59B 33
  • 87.95 (n)
GAREML 34
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gareml 33 34
  • 85.6 (n)
Garem2 16
rat
(Rattus norvegicus)
Mammalia Gareml 33
  • 84.45 (n)
oppossum
(Monodelphis domestica)
Mammalia GAREML 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAREML 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM59B 33
  • 70.32 (n)
GAREML 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gareml 33
  • 65.06 (n)
zebrafish
(Danio rerio)
Actinopterygii gareml 33 34
  • 61.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
OneToMany
Species where no ortholog for GAREM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAREM2 Gene

ENSEMBL:
Gene Tree for GAREM2 (if available)
TreeFam:
Gene Tree for GAREM2 (if available)

Paralogs for GAREM2 Gene

Paralogs for GAREM2 Gene

genes like me logo Genes that share paralogs with GAREM2: view

Variants for GAREM2 Gene

Sequence variations from dbSNP and Humsavar for GAREM2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1015478070 uncertain-significance, LCHAD Deficiency, Mitochondrial trifunctional protein deficiency 26,190,845(+) G/A genic_downstream_transcript_variant, intron_variant
rs1049987 likely-benign, LCHAD Deficiency, Mitochondrial trifunctional protein deficiency 26,190,948(+) C/G/T genic_downstream_transcript_variant, intron_variant
rs1057516217 likely-pathogenic, pathogenic, Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency, not provided 26,193,774(+) T/C genic_downstream_transcript_variant, intron_variant
rs1057516233 likely-pathogenic, Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency 26,201,321(+) C/G genic_downstream_transcript_variant, intron_variant
rs1057516350 likely-pathogenic, Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency 26,191,481(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GAREM2 Gene

Variant ID Type Subtype PubMed ID
nsv524918 CNV gain 19592680
nsv520638 CNV loss 19592680
nsv2648 CNV deletion 18451855
nsv1144893 CNV deletion 24896259
nsv1071583 CNV deletion 25765185
esv33316 CNV loss 17666407
esv22083 CNV loss 19812545

Variation tolerance for GAREM2 Gene

Gene Damage Index Score: 2.03; 37.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAREM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAREM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAREM2 Gene

Disorders for GAREM2 Gene

No disorders were found for GAREM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAREM2 Gene

Publications for GAREM2 Gene

  1. A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling. (PMID: 24003223) Taniguchi T … Konishi H (The Journal of biological chemistry 2013) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 58
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 58

Products for GAREM2 Gene

Sources for GAREM2 Gene

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