Free for academic non-profit institutions. Other users need a Commercial license

GAPLINC Gene(RNA Gene)

Gastric Adenocarcinoma Associated, Positive CD44 Regulator, Long Intergenic Non-Coding RNA

GCID:
GC18P003467
GIFtS:
14
Genes Participants
UDN Logo

Aliases for GAPLINC Gene

Subcategory (RNA class) for GAPLINC Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for GAPLINC Gene

  • Gastric Adenocarcinoma Associated, Positive CD44 Regulator, Long Intergenic Non-Coding RNA 2 3 5
  • Gastric Adenocarcinoma Predictive Long Intergenic Noncoding RNA 2 3
  • Long Intergenic Non-Protein Coding RNA 1540 2 3
  • LncRNA-Uc002kmd.1 3
  • TCONS_00026238 3
  • RP11-838N2.4 3
  • LINC01540 3

External Ids for GAPLINC Gene

Previous HGNC Symbols for GAPLINC Gene

  • LINC01540

Summaries for GAPLINC Gene

GeneCards Summary for GAPLINC Gene

GAPLINC (Gastric Adenocarcinoma Associated, Positive CD44 Regulator, Long Intergenic Non-Coding RNA) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with GAPLINC include Gastric Cancer and Glioblastoma.

Additional gene information for GAPLINC Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAPLINC Gene

Genomics for GAPLINC Gene

GeneHancer (GH) Regulatory Elements for GAPLINC Gene

Promoters and enhancers for GAPLINC Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH18J003465 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 600.7 +0.3 310 2.2 ZNF148 IKZF1 LEF1 ZNF766 FOSL1 JUN BRF2 VEZF1 PRDM10 NANOG GAPLINC DLGAP1-AS1 MYL12B LOC105371965 GC18P003299
GH18J003445 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.4 -13.2 -13248 14.4 ZNF652 SP1 ZFX CC2D1A CTCF ELF3 MNT NKRF POLR2A MLLT1 TGIF1 METTL4 DLGAP1-AS1 RPL21P127 GAPLINC BOD1P1 GC18P003299
GH18J003468 Promoter/Enhancer 1.2 Ensembl dbSUPER 0.7 +2.7 2651 0.2 CBFA2T2 ZNF148 TRIM24 SMARCA4 ATF1 ATF7 LEF1 EP300 ATF2 VEZF1 DLGAP1-AS1 MYL12B GAPLINC LOC105371965 GC18P003299
GH18J003461 Enhancer 0.8 Ensembl ENCODE dbSUPER 0.7 -3.4 -3392 1.9 POLR2A ZC3H8 ZNF26 METTL4 ENSG00000266783 GAPLINC LOC105371965 BOD1P1 GC18P003299
GH18J003480 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +15.1 15063 2.6 CTCF RAD21 SMARCA4 PRDM10 REST HDAC1 CTBP1 HDAC2 MEF2D POLR2A LOC105371965 GAPLINC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAPLINC on UCSC Golden Path with GeneCards custom track

Genomic Locations for GAPLINC Gene

Genomic Locations for GAPLINC Gene
chr18:3,466,250-3,478,978
(GRCh38/hg38)
Size:
12,729 bases
Orientation:
Plus strand
chr18:3,466,248-3,478,976
(GRCh37/hg19)
Size:
12,729 bases
Orientation:
Plus strand

Genomic View for GAPLINC Gene

Genes around GAPLINC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAPLINC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAPLINC Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GAPLINC Gene

Proteins for GAPLINC Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for GAPLINC Gene

No Post-translational modifications

No data available for DME Specific Peptides for GAPLINC Gene

Domains & Families for GAPLINC Gene

Gene Families for GAPLINC Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GAPLINC: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GAPLINC Gene

Function for GAPLINC Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for GAPLINC Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAPLINC Gene

Localization for GAPLINC Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GAPLINC Gene

Pathways & Interactions for GAPLINC Gene

GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards
PathCards logo

SuperPathways for GAPLINC Gene

No Data Available

Interacting Proteins for GAPLINC Gene

Gene Ontology (GO) - Biological Process for GAPLINC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAPLINC Gene

Drugs & Compounds for GAPLINC Gene

Products:

  1. Drug
GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards
No Compound Related Data Available

Transcripts for GAPLINC Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GAPLINC Gene

(3) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(6) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for GAPLINC Gene

No ASD Table

Relevant External Links for GAPLINC Gene

GeneLoc Exon Structure for
GAPLINC
ECgene alternative splicing isoforms for
GAPLINC

Expression for GAPLINC Gene

Products:

  1. Primer
  2. Gene Expression Assay
GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards

NURSA nuclear receptor signaling pathways regulating expression of GAPLINC Gene:

GAPLINC
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAPLINC Gene

Orthologs for GAPLINC Gene

Evolution for GAPLINC Gene

ENSEMBL:
Gene Tree for GAPLINC (if available)
TreeFam:
Gene Tree for GAPLINC (if available)

No data available for Orthologs for GAPLINC Gene

Paralogs for GAPLINC Gene

No data available for Paralogs for GAPLINC Gene

Variants for GAPLINC Gene

Products:

  1. SNP Genotyping and Copy Number Assay
VarElect - NGS phenotyper. Rapid prioritization of variants from NGS data powered by 100+ GeneCards sources

Sequence variations from dbSNP and Humsavar for GAPLINC Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000153729 -- 3,466,047(+) C/T upstream_transcript_variant
rs1000302133 -- 3,477,471(+) C/A/T intron_variant
rs1000352760 -- 3,472,208(+) AA/ intron_variant
rs1000377313 -- 3,465,836(+) A/G upstream_transcript_variant
rs1000503065 -- 3,479,008(+) T/C downstream_transcript_variant

Additional Variant Information for GAPLINC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAPLINC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for GAPLINC Gene

Disorders for GAPLINC Gene

MalaCards: The human disease database

(4) MalaCards diseases for GAPLINC Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • gastric cancer, somatic
glioblastoma
  • glioblastoma multiforme
colorectal cancer
  • crc
gastric adenocarcinoma
  • adenocarcinoma of stomach
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GAPLINC

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GAPLINC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAPLINC Gene

Publications for GAPLINC Gene

  1. Long Non-Coding RNA ucoo2kmd.1 Regulates CD44-Dependent Cell Growth by Competing for miR-211-3p in Colorectal Cancer. (PMID: 26974151) Wu X … Zhu H (PloS one 2016) 2 3 58
  2. Hypoxia Promotes Gastric Cancer Malignancy Partly through the HIF-1α Dependent Transcriptional Activation of the Long Non-coding RNA GAPLINC. (PMID: 27729869) Liu L … Tian Z (Frontiers in physiology 2016) 2 3 58
  3. Long noncoding RNA GAPLINC regulates CD44-dependent cell invasiveness and associates with poor prognosis of gastric cancer. (PMID: 25277524) Hu Y … Fang JY (Cancer research 2014) 2 3 58
  4. Exosome-mediated transfer of lncRNA RP11‑838N2.4 promotes erlotinib resistance in non-small cell lung cancer. (PMID: 29845246) Zhang W … Qian W (International journal of oncology 2018) 3 58
  5. GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma. (PMID: 30177521) Liao S … Wang C (Bioscience reports 2018) 3 58

ExternalLinks

View latest publications for GAPLINC gene in Mastermind

Products for GAPLINC Gene

Sources for GAPLINC Gene

Content
Loading form....