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Aliases for GAPDH Gene

Aliases for GAPDH Gene

  • Glyceraldehyde-3-Phosphate Dehydrogenase 2 3 4 5
  • Peptidyl-Cysteine S-Nitrosylase GAPDH 3 4
  • EC 1.2.1.12 4 56
  • GAPD 3 4
  • Epididymis Secretory Sperm Binding Protein Li 162eP 3
  • Oct1 Coactivator In S Phase, 38 Kd Component 3
  • Aging-Associated Gene 9 Protein 3
  • OCAS, P38 Component 3
  • HEL-S-162eP 3
  • EC 2.6.99.- 4
  • EC 1.2.1 56
  • G3PD 3

External Ids for GAPDH Gene

Previous HGNC Symbols for GAPDH Gene

  • GAPD

Previous GeneCards Identifiers for GAPDH Gene

  • GC12P006514
  • GC12P006643

Summaries for GAPDH Gene

Entrez Gene Summary for GAPDH Gene

  • This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for GAPDH Gene

GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) is a Protein Coding gene. Diseases associated with GAPDH include Fmr1-Related Disorders and Schistosomiasis. Among its related pathways are Glucose metabolism and Neuroscience. Gene Ontology (GO) annotations related to this gene include identical protein binding and NAD binding. An important paralog of this gene is GAPDHS.

UniProtKB/Swiss-Prot for GAPDH Gene

  • Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.

Gene Wiki entry for GAPDH Gene

Additional gene information for GAPDH Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAPDH Gene

Genomics for GAPDH Gene

GeneHancer (GH) Regulatory Elements for GAPDH Gene

Promoters and enhancers for GAPDH Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J006530 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 608.3 +2.7 2691 12.8 HDGF ZNF652 SP1 ZFX ELF3 CC2D1A CTCF ZNF148 NKRF POLR2A GAPDH ENSG00000269968 GPR162 ZNF384 CHD4 ENSG00000219410 ENSG00000247853 NOP2 NCAPD2 ATN1
GH12J006331 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -196.3 -196267 12.7 CC2D1A ZNF652 ZFX SP1 ELF3 MNT CBFA2T2 ZNF148 NKRF POLR2A TNFRSF1A NCAPD2 ENSG00000219410 NOP2 ZNF384 ENSG00000247853 CHD4 ING4 SPSB2 VAMP1
GH12J006492 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12 -40.4 -40351 3.7 SP1 ZFX CC2D1A ELF3 MNT NKRF POLR2A CEBPG GTF2F1 ZNF687 MRPL51 NCAPD2 TAPBPL NOP2 ZNF384 ENSG00000247853 ENSG00000219410 CHD4 ING4 VAMP1
GH12J006442 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 11.6 -88.9 -88909 6 SP1 NKRF CEBPG POLR2A ZNF687 CREM MLLT1 ZBED1 IKZF1 IKZF2 CD27 CD27-AS1 TAPBPL GAPDH ENSG00000255966 VAMP1 TNFRSF1A NCAPD2 SCARNA10 IFFO1
GH12J006468 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 -64.3 -64304 3.4 MTA3 ZFX SP1 ELF3 NKRF POLR2A ZNF121 CEBPG GTF2F1 CSDE1 VAMP1 TAPBPL NCAPD2 ZNF384 NOP2 ENSG00000219410 ING4 ENSG00000247853 CHD4 MRPL51
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAPDH on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GAPDH gene promoter:
  • GATA-2
  • N-Myc
  • NF-1
  • p53
  • PPAR-gamma1
  • PPAR-gamma2
  • TBP
  • TFIID

Genomic Locations for GAPDH Gene

Genomic Locations for GAPDH Gene
chr12:6,534,405-6,538,375
(GRCh38/hg38)
Size:
3,971 bases
Orientation:
Plus strand
chr12:6,643,093-6,647,537
(GRCh37/hg19)
Size:
4,445 bases
Orientation:
Plus strand

Genomic View for GAPDH Gene

Genes around GAPDH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAPDH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAPDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAPDH Gene

Proteins for GAPDH Gene

  • Protein details for GAPDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04406-G3P_HUMAN
    Recommended name:
    Glyceraldehyde-3-phosphate dehydrogenase
    Protein Accession:
    P04406
    Secondary Accessions:
    • E7EUT4
    • P00354
    • Q53X65

    Protein attributes for GAPDH Gene

    Size:
    335 amino acids
    Molecular mass:
    36053 Da
    Quaternary structure:
    • Homotetramer. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation. Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules. Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS. Interacts with phosphorylated RPL13A; inhibited by oxidatively-modified low-densitity lipoprotein (LDL(ox)). Component of the GAIT complex. Interacts with FKBP6; leading to inhibit GAPDH catalytic activity.

    Three dimensional structures from OCA and Proteopedia for GAPDH Gene

    Alternative splice isoforms for GAPDH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAPDH Gene

Selected DME Specific Peptides for GAPDH Gene

P04406:
  • GKLVING
  • GVNHEKY
  • FVKLISWYDNE
  • NVSVVDLT
  • IKWGDAGA
  • LAKVIHD
  • PELNGKL
  • AKAVGKV
  • SWYDNEFGYS
  • KTVDGPS
  • NGFGRIGR
  • VAINDPF
  • WRDGRGA
  • ITIFQERDP
  • TATQKTV
  • GPLKGIL
  • KAVGKVIP
  • GKLTGMAFRVP
  • CTTNCLAP
  • TGAAKAVG
  • YMVYMFQYDSTHGKF
  • GYSNRVV
  • NIIPASTGAAKAV
  • IVEGLMT
  • DAPMFVMGVN
  • GLMTTVH
  • ESTGVFT
  • AKYDDIK
  • LNDHFVKL
  • LKGILGY
  • RVPTANVS
  • AGIALND
  • EGLMTTVH
  • SNASCTT
  • LNGKLTG
  • ASEGPLKG
  • SNASCTTNCLAPL
  • VIISAPS
  • ISAPSADAPM
  • VSVVDLT

Post-translational modifications for GAPDH Gene

  • S-nitrosylation of Cys-152 leads to interaction with SIAH1, followed by translocation to the nucleus (By similarity). S-nitrosylation of Cys-247 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity.
  • ISGylated.
  • Sulfhydration at Cys-152 increases catalytic activity.
  • Oxidative stress can promote the formation of high molecular weight disulfide-linked GAPDH aggregates, through a process called nucleocytoplasmic coagulation. Such aggregates can be observed in vivo in the affected tissues of patients with Alzheimer disease or alcoholic liver cirrhosis, or in cell cultures during necrosis. Oxidation at Met-46 may play a pivotal role in the formation of these insoluble structures. This modification has been detected in vitro following treatment with free radical donor (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide. It has been proposed to destabilize nearby residues, increasing the likelihood of secondary oxidative damages, including oxidation of Tyr-45 and Met-105. This cascade of oxidations may augment GAPDH misfolding, leading to intermolecular disulfide cross-linking and aggregation.
  • Ubiquitination at isoforms=2107, posLast=55, isoforms=2162, posLast=145145, isoforms=2227, posLast=6666, posLast=194194, isoforms=261, isoforms=2263, isoforms=2219, and isoforms=286
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Antibody Products

  • Abcam antibodies for GAPDH

Domains & Families for GAPDH Gene

Gene Families for GAPDH Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GAPDH Gene

GenScript: Design optimal peptide antigens:
  • Glyceraldehyde-3-phosphate dehydrogenase (E7EU54_HUMAN)
  • Glyceraldehyde-3-phosphate dehydrogenase (E7EUT4_HUMAN)
  • Glyceraldehyde-3-phosphate dehydrogenase (E7EUT5_HUMAN)
  • Peptidyl-cysteine S-nitrosylase GAPDH (G3P_HUMAN)
  • Glyceraldehyde-3-phosphate dehydrogenase (Q0QET7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P04406

UniProtKB/Swiss-Prot:

G3P_HUMAN :
  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
  • Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Domain:
  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
Family:
  • Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
genes like me logo Genes that share domains with GAPDH: view

Function for GAPDH Gene

Molecular function for GAPDH Gene

UniProtKB/Swiss-Prot Function:
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = 3-phospho-D-glyceroyl phosphate + H(+) + NADH; Xref=Rhea:RHEA:10300, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57540, ChEBI:CHEBI:57604, ChEBI:CHEBI:57945, ChEBI:CHEBI:59776; EC=1.2.1.12; Evidence=. ;.

Enzyme Numbers (IUBMB) for GAPDH Gene

Phenotypes From GWAS Catalog for GAPDH Gene

Gene Ontology (GO) - Molecular Function for GAPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity NAS,IBA 3170585
GO:0005515 protein binding IPI 11724794
GO:0008017 microtubule binding ISS --
GO:0016491 oxidoreductase activity IEA --
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with GAPDH: view
genes like me logo Genes that share phenotypes with GAPDH: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for GAPDH - Now 50% OFF >
  • * GAPDH as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GAPDH tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for GAPDH

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAPDH Gene

Localization for GAPDH Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAPDH Gene

Cytoplasm, cytosol. Nucleus. Cytoplasm, perinuclear region. Membrane. Cytoplasm, cytoskeleton. Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAPDH gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 4
mitochondrion 3
extracellular 2
peroxisome 2
endoplasmic reticulum 2
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GAPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005811 lipid droplet IDA 14741744
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with GAPDH: view

Pathways & Interactions for GAPDH Gene

genes like me logo Genes that share pathways with GAPDH: view

UniProtKB/Swiss-Prot P04406-G3P_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.

Gene Ontology (GO) - Biological Process for GAPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization ISS --
GO:0006006 glucose metabolic process IEA --
GO:0006094 gluconeogenesis TAS --
GO:0006096 glycolytic process IBA 21873635
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with GAPDH: view

No data available for SIGNOR curated interactions for GAPDH Gene

Drugs & Compounds for GAPDH Gene

(73) Drugs for GAPDH Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
Copper Approved, Investigational Pharma Target 226
Xanthinol Approved, Withdrawn Pharma Target, cofactor 0
Phosphoric acid Approved Pharma 0
4-(2-Aminoethyl)Benzenesulfonyl Fluoride Experimental Pharma Target 0

(92) Additional Compounds for GAPDH Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Glyceric acid 1,3-biphosphate
  • 1,3-Biphosphoglycerate
  • 1,3-Biphosphoglyceric acid
  • 1,3-Bis-phosphoglycerate
  • 1,3-Bisphosphoglycerate
  • 1,3-Diphosphateglycerate
1981-49-3
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • beta-Nicotinamide adenine dinucleotide phosphate
  • NADP+
  • Nicotinamide adenine dinucleotide phosphate
  • Oxidized nicotinamide-adenine dinucleotide phosphate
  • TPN
53-59-8
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2

(1) ApexBio Compounds for GAPDH Gene

Compound Action Cas Number
CGP 3466B maleate GAPDH inhibitor 200189-97-5
genes like me logo Genes that share compounds with GAPDH: view

Transcripts for GAPDH Gene

Unigene Clusters for GAPDH Gene

Glyceraldehyde-3-phosphate dehydrogenase:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for GAPDH - Now 50% OFF >
  • * GAPDH as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GAPDH tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for GAPDH

Alternative Splicing Database (ASD) splice patterns (SP) for GAPDH Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9
SP1:
SP2: -
SP3: - - -
SP4: - - -
SP5: -
SP6:
SP7:

Relevant External Links for GAPDH Gene

GeneLoc Exon Structure for
GAPDH
ECgene alternative splicing isoforms for
GAPDH

Expression for GAPDH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAPDH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAPDH Gene

This gene is overexpressed in Muscle - Skeletal (x6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GAPDH Gene



Protein tissue co-expression partners for GAPDH Gene

NURSA nuclear receptor signaling pathways regulating expression of GAPDH Gene:

GAPDH

SOURCE GeneReport for Unigene cluster for GAPDH Gene:

Hs.544577

Evidence on tissue expression from TISSUES for GAPDH Gene

  • Blood(5)
  • Eye(5)
  • Intestine(5)
  • Kidney(5)
  • Liver(5)
  • Lung(5)
  • Muscle(5)
  • Skin(5)
  • Nervous system(5)
  • Heart(4.9)
  • Pancreas(4.9)
  • Stomach(4.8)
  • Bone(4.6)
  • Bone marrow(3.4)
  • Lymph node(3.2)
  • Adrenal gland(3.1)
  • Thyroid gland(3.1)
  • Spleen(3)
  • Gall bladder(2.6)
genes like me logo Genes that share expression patterns with GAPDH: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAPDH Gene

Orthologs for GAPDH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GAPDH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAPDH 35 34
  • 99.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GAPDH 35 34
  • 91.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GAPDH 35 34
  • 90.86 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gapdh 34
  • 89.66 (n)
mouse
(Mus musculus)
Mammalia Gapdh 34
  • 89.56 (n)
Gm12117 35
  • 79 (a)
OneToOne
Gapdh-ps15 17
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 80 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves GAPDH 34
  • 83.73 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gapdh 34
  • 78.95 (n)
zebrafish
(Danio rerio)
Actinopterygii gapdh 34
  • 77.91 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1292 34
fruit fly
(Drosophila melanogaster)
Insecta Gapdh1 34
  • 72.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009623 34
  • 71.11 (n)
worm
(Caenorhabditis elegans)
Secernentea gpd-2 34
  • 70.86 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TDH3 34
  • 62.11 (n)
TDH1 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20988g 34
  • 60.47 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7665 34
soybean
(Glycine max)
eudicotyledons Gma.5505 34
rice
(Oryza sativa)
Liliopsida Os08g0126300 34
  • 67.76 (n)
Os.22781 34
bread mold
(Neurospora crassa)
Ascomycetes NCU01528 34
  • 72.34 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpd3 34
  • 69.25 (n)
Species where no ortholog for GAPDH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GAPDH Gene

ENSEMBL:
Gene Tree for GAPDH (if available)
TreeFam:
Gene Tree for GAPDH (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GAPDH: view image

Paralogs for GAPDH Gene

Paralogs for GAPDH Gene

(3) SIMAP similar genes for GAPDH Gene using alignment to 3 proteins:

  • G3P_HUMAN
  • E7EUT5_HUMAN
  • Q0QET7_HUMAN
genes like me logo Genes that share paralogs with GAPDH: view

Variants for GAPDH Gene

Sequence variations from dbSNP and Humsavar for GAPDH Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000456643 -- 6,536,400(+) G/A/C intron_variant
rs1001147308 -- 6,536,368(+) C/T intron_variant
rs1001428291 -- 6,536,152(+) G/A/T intron_variant
rs1001439727 -- 6,538,703(+) A/G downstream_transcript_variant
rs1001754507 -- 6,538,862(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GAPDH Gene

Variant ID Type Subtype PubMed ID
esv2745477 CNV deletion 23290073
esv2759876 CNV gain 17122850
esv3628408 CNV gain 21293372
nsv475237 CNV novel sequence insertion 20440878
nsv557255 CNV loss 21841781
nsv826208 CNV gain 20364138
nsv8896 CNV gain 18304495
nsv983266 CNV duplication 23825009

Variation tolerance for GAPDH Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAPDH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAPDH
Human Gene Mutation Database (HGMD)
GAPDH

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAPDH Gene

Disorders for GAPDH Gene

MalaCards: The human disease database

(19) MalaCards diseases for GAPDH Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fmr1-related disorders
schistosomiasis
  • katayama fever
retinitis pigmentosa 49
  • rp49
sleeping sickness
  • african sleeping sickness
baylisascariasis
  • infection by baylisascaris
- elite association - COSMIC cancer census association via MalaCards
Search GAPDH in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GAPDH

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GAPDH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAPDH Gene

Publications for GAPDH Gene

  1. FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor. (PMID: 19001379) Jarczowski F … Edlich F (The Journal of biological chemistry 2009) 3 4 23 58
  2. Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase. (PMID: 16239728) Ismail SA … Park HW (Acta crystallographica. Section D, Biological crystallography 2005) 3 4 23 58
  3. Subcellular localization of human glyceraldehyde-3-phosphate dehydrogenase is independent of its glycolytic function. (PMID: 12829261) Mazzola JL … Sirover MA (Biochimica et biophysica acta 2003) 3 4 23 58
  4. Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene. (PMID: 3170585) Ercolani L … Alexander M (The Journal of biological chemistry 1988) 2 3 4 58
  5. Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase. (PMID: 25086035) Samson AL … Medcalf RL (The Journal of biological chemistry 2014) 3 4 58

Products for GAPDH Gene