GAPDH Gene (Protein Coding)

Glyceraldehyde-3-Phosphate Dehydrogenase

GC12P008971
GIFtS:
49
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde... See more...

Aliases for GAPDH Gene

Aliases for GAPDH Gene

  • Glyceraldehyde-3-Phosphate Dehydrogenase 2 3 4 5
  • Peptidyl-Cysteine S-Nitrosylase GAPDH 3 4
  • EC 1.2.1.12 4 51
  • GAPD 3 4
  • Epididymis Secretory Sperm Binding Protein Li 162eP 3
  • Oct1 Coactivator In S Phase, 38 Kd Component 3
  • Aging-Associated Gene 9 Protein 3
  • OCAS, P38 Component 3
  • HEL-S-162eP 3
  • EC 2.6.99.- 4
  • EC 1.2.1 51
  • GAPDH 5
  • G3PD 3

External Ids for GAPDH Gene

Previous HGNC Symbols for GAPDH Gene

  • GAPD

Previous GeneCards Identifiers for GAPDH Gene

  • GC12P006514
  • GC12P006643
  • GC12P006533
  • GC12P006553
  • GC12P006630
  • GC12P008161

Summaries for GAPDH Gene

Entrez Gene Summary for GAPDH Gene

  • This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for GAPDH Gene

GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) is a Protein Coding gene. Diseases associated with GAPDH include Aging and Schistosomiasis. Among its related pathways are Glucose metabolism and Cori Cycle. Gene Ontology (GO) annotations related to this gene include identical protein binding and NAD binding. An important paralog of this gene is GAPDHS.

UniProtKB/Swiss-Prot Summary for GAPDH Gene

  • Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.

Gene Wiki entry for GAPDH Gene

Additional gene information for GAPDH Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GAPDH Gene

Genomics for GAPDH Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GAPDH Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAPDH on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GAPDH

Top Transcription factor binding sites by QIAGEN in the GAPDH gene promoter:
  • GATA-2
  • N-Myc
  • NF-1
  • p53
  • PPAR-gamma1
  • PPAR-gamma2
  • TBP
  • TFIID

Genomic Locations for GAPDH Gene

Latest Assembly
chr12:6,534,512-6,538,374
(GRCh38/hg38)
Size:
3,863 bases
Orientation:
Plus strand

Previous Assembly
chr12:6,643,683-6,647,537
(GRCh37/hg19 by Entrez Gene)
Size:
3,855 bases
Orientation:
Plus strand

chr12:6,643,093-6,647,537
(GRCh37/hg19 by Ensembl)
Size:
4,445 bases
Orientation:
Plus strand

Genomic View for GAPDH Gene

Genes around GAPDH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAPDH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAPDH Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GAPDH Gene

Proteins for GAPDH Gene

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  • Protein details for GAPDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04406-G3P_HUMAN
    Recommended name:
    Glyceraldehyde-3-phosphate dehydrogenase
    Protein Accession:
    P04406
    Secondary Accessions:
    • E7EUT4
    • P00354
    • Q53X65

    Protein attributes for GAPDH Gene

    Size:
    335 amino acids
    Molecular mass:
    36053 Da
    Quaternary structure:
    • Homotetramer. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation. Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules. Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS1. Interacts with phosphorylated RPL13A; inhibited by oxidatively-modified low-densitity lipoprotein (LDL(ox)). Component of the GAIT complex. Interacts with FKBP6; leading to inhibit GAPDH catalytic activity.

    Three dimensional structures from OCA and Proteopedia for GAPDH Gene

    Alternative splice isoforms for GAPDH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAPDH Gene

Protein Expression for GAPDH Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for GAPDH Gene

P04406:
  • GKLVING
  • GVNHEKY
  • FVKLISWYDNE
  • NVSVVDLT
  • IKWGDAGA
  • LAKVIHD
  • PELNGKL
  • AKAVGKV
  • SWYDNEFGYS
  • KTVDGPS
  • NGFGRIGR
  • VAINDPF
  • WRDGRGA
  • ITIFQERDP
  • TATQKTV
  • GPLKGIL
  • KAVGKVIP
  • GKLTGMAFRVP
  • CTTNCLAP
  • TGAAKAVG
  • YMVYMFQYDSTHGKF
  • GYSNRVV
  • NIIPASTGAAKAV
  • IVEGLMT
  • DAPMFVMGVN
  • GLMTTVH
  • ESTGVFT
  • AKYDDIK
  • LNDHFVKL
  • LKGILGY
  • RVPTANVS
  • AGIALND
  • EGLMTTVH
  • SNASCTT
  • LNGKLTG
  • ASEGPLKG
  • SNASCTTNCLAPL
  • VIISAPS
  • ISAPSADAPM
  • VSVVDLT

Post-translational modifications for GAPDH Gene

  • S-nitrosylation of Cys-152 leads to interaction with SIAH1, followed by translocation to the nucleus (By similarity). S-nitrosylation of Cys-247 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity.
  • ISGylated.
  • Sulfhydration at Cys-152 increases catalytic activity.
  • Oxidative stress can promote the formation of high molecular weight disulfide-linked GAPDH aggregates, through a process called nucleocytoplasmic coagulation. Such aggregates can be observed in vivo in the affected tissues of patients with Alzheimer disease or alcoholic liver cirrhosis, or in cell cultures during necrosis. Oxidation at Met-46 may play a pivotal role in the formation of these insoluble structures. This modification has been detected in vitro following treatment with free radical donor (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide. It has been proposed to destabilize nearby residues, increasing the likelihood of secondary oxidative damages, including oxidation of Tyr-45 and Met-105. This cascade of oxidations may augment GAPDH misfolding, leading to intermolecular disulfide cross-linking and aggregation.
  • Succination of Cys-152 and Cys-247 by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits glyceraldehyde-3-phosphate dehydrogenase activity. Fumarate concentration as well as succination of cysteine residues in GAPDH is significantly increased in muscle of diabetic mammals. It was proposed that the S-(2-succinyl)cysteine chemical modification may be a useful biomarker of mitochondrial and oxidative stress in diabetes and that succination of GAPDH and other thiol proteins by fumarate may contribute to the metabolic changes underlying the development of diabetes complications.
  • Glycosylation at Asn149 and Asn239
  • Ubiquitination at Lys5, Lys61, Lys66, Lys84, Lys86, Lys107, Lys139, Lys145, Lys162, Lys186, Lys194, Lys215, Lys219, Lys227, Lys263, and Lys334
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for GAPDH Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for GAPDH

Domains & Families for GAPDH Gene

Gene Families for GAPDH Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GAPDH Gene

InterPro:
Blocks:
  • Glyceraldehyde 3-phosphate dehydrogenase
ProtoNet:

Suggested Antigen Peptide Sequences for GAPDH Gene

GenScript: Design optimal peptide antigens:
  • Glyceraldehyde-3-phosphate dehydrogenase (E7EU54_HUMAN)
  • Glyceraldehyde-3-phosphate dehydrogenase (E7EUT4_HUMAN)
  • Glyceraldehyde-3-phosphate dehydrogenase (E7EUT5_HUMAN)
  • Peptidyl-cysteine S-nitrosylase GAPDH (G3P_HUMAN)
  • Glyceraldehyde-3-phosphate dehydrogenase (Q0QET7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P04406

UniProtKB/Swiss-Prot:

G3P_HUMAN :
  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
  • Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Domain:
  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
Family:
  • Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
genes like me logo Genes that share domains with GAPDH: view

Function for GAPDH Gene

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  6. Cell Lines for research

Molecular function for GAPDH Gene

UniProtKB/Swiss-Prot Function:
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH; Xref=Rhea:RHEA:10300, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57540, ChEBI:CHEBI:57604, ChEBI:CHEBI:57945, ChEBI:CHEBI:59776; EC=1.2.1.12; Evidence={ECO:0000255|PROSITE-ProRule:PRU10009, ECO:0000269|PubMed:3170585};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Glyceraldehyde-3-phosphate dehydrogenase activity is inhibited by fumarate, via the formation of S-(2-succinyl)cysteine residues.

Enzyme Numbers (IUBMB) for GAPDH Gene

Phenotypes From GWAS Catalog for GAPDH Gene

Gene Ontology (GO) - Molecular Function for GAPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA,NAS 3170585
GO:0005515 protein binding IPI 11724794
GO:0008017 microtubule binding ISS --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GAPDH: view
genes like me logo Genes that share phenotypes with GAPDH: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAPDH

Clone products for research

  • Addgene plasmids for GAPDH

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAPDH Gene

Localization for GAPDH Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAPDH Gene

Cytoplasm, cytosol. Nucleus. Cytoplasm, perinuclear region. Membrane. Cytoplasm, cytoskeleton. Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAPDH gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 4
peroxisome 3
endoplasmic reticulum 3
endosome 3
lysosome 3
golgi apparatus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
  • Vesicles (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GAPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,ISS --
GO:0005737 cytoplasm ISS --
GO:0005811 lipid droplet IDA 14741744
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with GAPDH: view

Pathways & Interactions for GAPDH Gene

genes like me logo Genes that share pathways with GAPDH: view

Pathways by source for GAPDH Gene

1 GeneGo (Thomson Reuters) pathway for GAPDH Gene
  • Glycolysis and gluconeogenesis (short map)
1 Qiagen pathway for GAPDH Gene
  • Huntington's Disease Pathway
2 Cell Signaling Technology pathways for GAPDH Gene

UniProtKB/Swiss-Prot P04406-G3P_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.

SIGNOR curated interactions for GAPDH Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GAPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization ISS --
GO:0001819 positive regulation of cytokine production IDA 22832495
GO:0006006 glucose metabolic process IEA --
GO:0006094 gluconeogenesis TAS --
GO:0006096 glycolytic process IBA 21873635
genes like me logo Genes that share ontologies with GAPDH: view

Drugs & Compounds for GAPDH Gene

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(73) Drugs for GAPDH Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
Copper Approved, Investigational Pharma Target 271
Xanthinol Approved, Withdrawn Pharma Target, cofactor 0
NADPH Experimental Pharma 0
4-(2-Aminoethyl)Benzenesulfonyl Fluoride Experimental Pharma Target 0

(90) Additional Compounds for GAPDH Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glyceraldehyde 3-phosphate
  • (2R)-2-Hydroxy-3-(phosphonooxy)-propanal
  • Glyceraldehyde 3-phosphate
  • Glyceraldehyde 3-phosphoric acid
  • Glyceraldehyde-3-phosphoric acid
  • D-Glyceraldehyde 3-phosphoric acid
 591-57-1
Glyceric acid 1,3-biphosphate
  • (R)-2-Hydroxy-3-(phosphonooxy)-1-monoanhydride with phosphoric propanoic acid
  • 1,3-Bisphospho-D-glycerate
  • 3-Phospho-D-glyceroyl phosphate
  • D-Glycerate 1,3-diphosphate
  • (R)-2-Hydroxy-3-(phosphonooxy)-1-monoanhydride with phosphoric propanoate
 38168-82-0
Hydrogen Ion
  • H+
  • H(+)
  • Hydron
  • Hydrogen cation
  • Proton

(1) ApexBio Compounds for GAPDH Gene

Compound Action Cas Number
CGP 3466B maleate GAPDH inhibitor 200189-97-5
genes like me logo Genes that share compounds with GAPDH: view

Drug products for research

Transcripts for GAPDH Gene

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mRNA/cDNA for GAPDH Gene

7 REFSEQ mRNAs :
42 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAPDH

Clone products for research

  • Addgene plasmids for GAPDH

Alternative Splicing Database (ASD) splice patterns (SP) for GAPDH Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9
SP1:
SP2: -
SP3: - - -
SP4: - - -
SP5: -
SP6:
SP7:

Relevant External Links for GAPDH Gene

GeneLoc Exon Structure for
GAPDH

Expression for GAPDH Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAPDH Gene

mRNA expression in normal human tissues for GAPDH Gene
mRNA expression by BioGPS for GAPDH GenemRNA expression by GTEx for GAPDH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAPDH Gene

This gene is overexpressed in Muscle - Skeletal (x6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GAPDH Gene



Protein tissue co-expression partners for GAPDH Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GAPDH

SOURCE GeneReport for Unigene cluster for GAPDH Gene:

Hs.544577

Evidence on tissue expression from TISSUES for GAPDH Gene

  • Heart(5)
  • Lung(5)
  • Nervous system(5)
  • Eye(5)
  • Skin(5)
  • Kidney(5)
  • Liver(5)
  • Blood(5)
  • Muscle(5)
  • Intestine(5)
  • Pancreas(5)
  • Stomach(4.9)
  • Bone(4.8)
  • Bone marrow(4.1)
  • Lymph node(3.9)
  • Spleen(3.8)
  • Adrenal gland(3.7)
  • Thyroid gland(3.6)
  • Gall bladder(3.4)
  • Urine(2.3)
genes like me logo Genes that share expression patterns with GAPDH: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAPDH Gene

Orthologs for GAPDH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GAPDH Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GAPDH 30 31
  • 99.6 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia GAPDH 30 31
  • 91.27 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GAPDH 30 31
  • 90.86 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Gapdh 30
  • 89.66 (n)
Mouse
(Mus musculus)
 Mammalia Gapdh 30 17
  • 89.56 (n)
Gm12117 31
  • 79 (a)
 OneToOne
Gapdh-ps15 17
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 86 (a)
 OneToMany
-- 31
  • 80 (a)
 OneToMany
-- 31
  • 78 (a)
 OneToMany
-- 31
  • 72 (a)
 OneToMany
-- 31
  • 68 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves GAPDH 30
  • 83.73 (n)
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia gapdh 30
  • 78.95 (n)
Zebrafish
(Danio rerio)
 Actinopterygii gapdh 30
  • 77.91 (n)
-- 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.1292 30
Fruit Fly
(Drosophila melanogaster)
 Insecta Gapdh1 30
  • 72.42 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP009623 30
  • 71.11 (n)
Worm
(Caenorhabditis elegans)
 Secernentea gpd-3 30
  • 70.86 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes TDH3 30 33
  • 62.11 (n)
TDH1 33
TDH2 33
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F20988g 30
  • 60.47 (n)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.7665 30
Soybean
(Glycine max)
 eudicotyledons Gma.5505 30
Rice
(Oryza sativa)
 Liliopsida Os08g0126300 30
  • 67.76 (n)
Os.22781 30
Bread mold
(Neurospora crassa)
 Ascomycetes NCU01528 30
  • 72.34 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes gpd3 30
  • 69.25 (n)
Species where no ortholog for GAPDH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GAPDH Gene

ENSEMBL:
Gene Tree for GAPDH (if available)
TreeFam:
Gene Tree for GAPDH (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GAPDH: view image

Paralogs for GAPDH Gene

Paralogs for GAPDH Gene

(3) SIMAP similar genes for GAPDH Gene using alignment to 3 proteins:

  • G3P_HUMAN
  • E7EUT5_HUMAN
  • Q0QET7_HUMAN

Pseudogenes.org Pseudogenes for GAPDH Gene

genes like me logo Genes that share paralogs with GAPDH: view

Variants for GAPDH Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GAPDH Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs1062429 - p.Lys251Asn
rs45541435 - p.Ala22Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GAPDH Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GAPDH Gene

Variant ID Type Subtype PubMed ID
esv2745477 CNV deletion 23290073
esv2759876 CNV gain 17122850
esv3628408 CNV gain 21293372
nsv475237 CNV novel sequence insertion 20440878
nsv557255 CNV loss 21841781
nsv826208 CNV gain 20364138
nsv8896 CNV gain 18304495
nsv983266 CNV duplication 23825009

Variation tolerance for GAPDH Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAPDH Gene

Human Gene Mutation Database (HGMD)
GAPDH
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAPDH

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAPDH Gene

Disorders for GAPDH Gene

MalaCards: The human disease database

(139) MalaCards diseases for GAPDH Gene - From: COP and GCD

Disorder Aliases PubMed IDs
aging
schistosomiasis
  • bilharzia
alzheimer disease
  • ad
cataract 4, multiple types
  • ctrct4
cataract 34, multiple types
  • ctrct34
- elite association - COSMIC cancer census association via MalaCards
Search GAPDH in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GAPDH

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GAPDH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAPDH Gene

Publications for GAPDH Gene