Aliases for GAP43 Gene
External Ids for GAP43 Gene
Previous GeneCards Identifiers for GAP43 Gene
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GAP43 Gene
GAP43 (Growth Associated Protein 43) is a Protein Coding gene. Diseases associated with GAP43 include Myositis Fibrosa and Developmental Coordination Disorder. Among its related pathways are Developmental Biology and L1CAM interactions. Gene Ontology (GO) annotations related to this gene include calmodulin binding. An important paralog of this gene is SPA17.
UniProtKB/Swiss-Prot Summary for GAP43 Gene
This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.