GALR2 Gene (Protein Coding)

Galanin Receptor 2

GC17P076070
GIFtS:
41
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are me... See more...

Aliases for GALR2 Gene

Aliases for GALR2 Gene

  • Galanin Receptor 2 2 3 5
  • GALNR2 2 3 4
  • Galanin Receptor Type 2 3 4
  • GAL2-R 3 4
  • GALR-2 3 4
  • GALR2 5

External Ids for GALR2 Gene

Previous GeneCards Identifiers for GALR2 Gene

  • GC17U990138
  • GC17P074534
  • GC17P074668
  • GC17P074648
  • GC17P071582
  • GC17P074070
  • GC17P069499
  • GC17P076075

Summaries for GALR2 Gene

Entrez Gene Summary for GALR2 Gene

  • Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for GALR2 Gene

GALR2 (Galanin Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and galanin receptor activity. An important paralog of this gene is CXCR3.

UniProtKB/Swiss-Prot Summary for GALR2 Gene

  • Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).

Tocris Summary for GALR2 Gene

  • Galanin is widely distributed in the central and peripheral nervous systems and the endocrine system. Three different galanin receptors (GAL1-3) have been identified. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral conditions.

Gene Wiki entry for GALR2 Gene

Additional gene information for GALR2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GALR2 Gene

Genomics for GALR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GALR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J076070 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 600.7 +1.5 1457 3 SP1 GATAD2A PRDM10 ZNF629 REST NFKBIZ ZNF692 POLR2A RCOR2 BACH1 SRP68 GALR2 hsa-miR-5095-232 ZACN lnc-SRP68-1 NUP85 SRSF2 UNK GGA3 NT5C
GH17J076074 Promoter 1.1 EPDnew Ensembl 600.7 +3.9 3877 1 HNRNPL TEAD4 RBFOX2 EZH2 CTCF SPI1 MBD1 ARID4B NRF1 ZBTB6 GALR2 hsa-miR-5095-232 lnc-SRP68-1 SRP68 ZACN lnc-EXOC7-3 EXOC7
GH17J076077 Promoter/Enhancer 0.8 EPDnew ENCODE 600.4 +6.3 6307 0.2 EZH2 SPI1 ZBTB33 POLR2A GALR2 hsa-miR-5095-232 SRP68 ZACN lnc-EXOC7-3 EXOC7
GH17J075926 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 11.2 -143.8 -143776 1.9 CTCF ATF7 CREB1 POLR2A RAD21 HNF4A THAP11 ZNF143 ATF2 ZNF48 FBF1 GALR2 ZACN SRP68 ENSG00000267543 ENSG00000267426 MRPL38 lnc-SRP68-1
GH17J076207 Enhancer 0.8 Ensembl ENCODE 10.4 +138.0 137977 4 TCF12 YY1 SCRT2 CEBPB RUNX3 SCRT1 BCL11A POLR3A DPF2 ATF3 RNF157 UBE2O FOXJ1 EXOC7 GALR2 SRP68 ZACN AANAT PRPSAP1 ST6GALNAC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GALR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GALR2

Top Transcription factor binding sites by QIAGEN in the GALR2 gene promoter:
  • CREB
  • deltaCREB
  • MyoD
  • RREB-1
  • USF1

Genomic Locations for GALR2 Gene

Genomic Locations for GALR2 Gene
chr17:76,070,824-76,077,537
(GRCh38/hg38)
Size:
6,714 bases
Orientation:
Plus strand
chr17:74,070,875-74,073,622
(GRCh37/hg19)
Size:
2,748 bases
Orientation:
Plus strand

Genomic View for GALR2 Gene

Genes around GALR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALR2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GALR2 Gene

Proteins for GALR2 Gene

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  2. Protein
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  • Protein details for GALR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43603-GALR2_HUMAN
    Recommended name:
    Galanin receptor type 2
    Protein Accession:
    O43603
    Secondary Accessions:
    • A5JUU4
    • Q32MN8

    Protein attributes for GALR2 Gene

    Size:
    387 amino acids
    Molecular mass:
    41700 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GALR2 Gene

Post-translational modifications for GALR2 Gene

  • Glycosylation at Asn2 and Asn11
  • Modification sites at PhosphoSitePlus

Other Protein References for GALR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GALR2 Gene

Domains & Families for GALR2 Gene

Gene Families for GALR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for GALR2 Gene

InterPro:
Blocks:
  • Galanin receptor signature
  • Galanin 2 receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for GALR2 Gene

GenScript: Design optimal peptide antigens:
  • Galanin receptor type 2 (GALR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43603

UniProtKB/Swiss-Prot:

GALR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GALR2: view

Function for GALR2 Gene

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Molecular function for GALR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).
GENATLAS Biochemistry:
galanin receptor 2,G protein coupled receptor superfamily,binding GALN with high affinity,expressed in several region of brain as will as peripheral tissues,coupling to phospholipase C and elevation of intracellular calcium levels

Phenotypes From GWAS Catalog for GALR2 Gene

Gene Ontology (GO) - Molecular Function for GALR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004966 galanin receptor activity TAS,IDA 9832121
GO:0005515 protein binding IPI 23597562
GO:0008528 G protein-coupled peptide receptor activity IBA 21873635
GO:0017046 peptide hormone binding IPI 9832121
genes like me logo Genes that share ontologies with GALR2: view
genes like me logo Genes that share phenotypes with GALR2: view

Animal Models for GALR2 Gene

MGI Knock Outs for GALR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for GALR2

CRISPR Products

miRNA for GALR2 Gene

miRTarBase miRNAs that target GALR2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GALR2 Gene

Localization for GALR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALR2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GALR2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GALR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0005929 cilium IDA 28154160
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GALR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GALR2 Gene

Pathways & Interactions for GALR2 Gene

genes like me logo Genes that share pathways with GALR2: view

SIGNOR curated interactions for GALR2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for GALR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 9480833
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway TAS 9480833
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS,IBA 21873635
genes like me logo Genes that share ontologies with GALR2: view

Drugs & Compounds for GALR2 Gene

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(65) Drugs for GALR2 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
M40 Pharma Antagonist 0
M617 Pharma Agonist 0
M871 Pharma Antagonist 0
Galanin (1-15) (porcine, rat) Pharma Galanin receptor agonist peptide 0
Galanin (1-29) (rat, mouse) Pharma Non-selective galanin receptor agonist 0

(4) Additional Compounds for GALR2 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
galanin (10-29) (rat/mouse)
Agonist
galanin(2?àó29) (rat/mouse)
Agonist, Full agonist

(5) Tocris Compounds for GALR2 Gene

Compound Action Cas Number
Galanin (1-15) (porcine, rat) Galanin receptor agonist peptide 112747-70-3
Galanin (1-29) (rat, mouse) Non-selective galanin receptor agonist 114547-31-8
Galanin (1-30) (human) Endogenous galanin receptor agonist 119418-04-1
Galanin (2-29) (rat) Selective GAL2 peptide agonist 141696-11-9
Galnon Non-selective galanin receptor agonist 475115-35-6

(11) ApexBio Compounds for GALR2 Gene

Compound Action Cas Number
AR-M 1896 Selective GAL2 agonist 367518-31-8
Galanin (1-15) (porcine, rat) 112747-70-3
Galanin (1-29) (rat, mouse) 114547-31-8
Galanin (1-30) (human) 119418-04-1
Galanin (2-29) (rat) 141696-11-9
Galanin (porcine) 88813-36-9
Galnon 475115-35-6
M 1145 1172089-00-7
M40 143896-17-7
M617 860790-38-1
M871 908844-75-7
genes like me logo Genes that share compounds with GALR2: view

Drug Products

Transcripts for GALR2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GALR2 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALR2

Alternative Splicing Database (ASD) splice patterns (SP) for GALR2 Gene

No ASD Table

Relevant External Links for GALR2 Gene

GeneLoc Exon Structure for
GALR2

Expression for GALR2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GALR2 Gene

mRNA expression in normal human tissues for GALR2 Gene
mRNA expression by GTEx for GALR2 GenemRNA expression by BioGPS for GALR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALR2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x20.1), Colon - Sigmoid (x13.6), and Colon - Transverse (x6.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GALR2

SOURCE GeneReport for Unigene cluster for GALR2 Gene:

Hs.666366

mRNA Expression by UniProt/SwissProt for GALR2 Gene:

O43603-GALR2_HUMAN
Tissue specificity: Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.

Evidence on tissue expression from TISSUES for GALR2 Gene

  • Nervous system(4.6)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with GALR2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GALR2 Gene

Orthologs for GALR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GALR2 30 31
  • 99.31 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GALR2 30 31
  • 89.03 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia GALR2 30 31
  • 89.01 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Galr2 30
  • 86.65 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia GALR2 31
  • 86 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Galr2 30 17 31
  • 85.21 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves GALR2 30 31
  • 72.75 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia GALR2 31
  • 62 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia galr2 30
  • 67.59 (n)
Str.12152 30
Zebrafish
(Danio rerio)
 Actinopterygii si:ch211-250n8.2 30
  • 67.79 (n)
GALR2 31
  • 60 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta GPRALS2 30
  • 54.67 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta AlstR 30 31 32
  • 47.64 (n)
 ManyToMany
AR-2 31
  • 27 (a)
 ManyToMany
Worm
(Caenorhabditis elegans)
 Secernentea npr-9 30 31
  • 43.84 (n)
 OneToMany
ZK455.3 32
  • 33 (a)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 33 (a)
 OneToMany
Species where no ortholog for GALR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GALR2 Gene

ENSEMBL:
Gene Tree for GALR2 (if available)
TreeFam:
Gene Tree for GALR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GALR2: view image

Paralogs for GALR2 Gene

Paralogs for GALR2 Gene

(15) SIMAP similar genes for GALR2 Gene using alignment to 1 proteins:

  • GALR2_HUMAN
genes like me logo Genes that share paralogs with GALR2: view

Variants for GALR2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GALR2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
710117 Benign: not provided 76,077,274(+) A/C MISSENSE_VARIANT
739873 Likely Benign: not provided 76,075,234(+) C/A SYNONYMOUS_VARIANT
775336 Benign: not provided 76,076,943(+) G/A MISSENSE_VARIANT
788155 Likely Benign: not provided 76,077,013(+) G/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for GALR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GALR2 Gene

Variant ID Type Subtype PubMed ID
nsv2142 CNV insertion 18451855
nsv509674 CNV insertion 20534489
nsv833546 CNV loss 17160897

Variation tolerance for GALR2 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GALR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GALR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALR2 Gene

Disorders for GALR2 Gene

Additional Disease Information for GALR2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for GALR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALR2 Gene

Publications for GALR2 Gene

  1. Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor. (PMID: 9685625) Fathi Z … Zimanyi IA (Brain research. Molecular brain research 1998) 2 3 4 23
  2. Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3. (PMID: 9832121) Kolakowski LF … O'Dowd BF (Journal of neurochemistry 1998) 2 3 4 23
  3. Alcoholism is associated with GALR3 but not two other galanin receptor genes. (PMID: 17083333) Belfer I … Enoch MA (Genes, brain, and behavior 2007) 3 23 41
  4. Cloning and expression of the human galanin receptor GalR2. (PMID: 9480833) Bloomquist BT … Cornfield LJ (Biochemical and biophysical research communications 1998) 3 4 23
  5. Cloning and characterization of the human galanin GALR2 receptor. (PMID: 9880084) Borowsky B … Gerald C (Peptides 1998) 3 4 23

ExternalLinks

View latest publications for GALR2 gene in Mastermind

Products for GALR2 Gene

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Sources for GALR2 Gene