Aliases for GALR1 Gene
External Ids for GALR1 Gene
Previous HGNC Symbols for GALR1 Gene
Previous GeneCards Identifiers for GALR1 Gene
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]
GeneCards Summary for GALR1 Gene
GALR1 (Galanin Receptor 1) is a Protein Coding gene. Diseases associated with GALR1 include Chromosome 18Q Deletion Syndrome and Arboleda-Tham Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and neuropeptide binding. An important paralog of this gene is GALR3.
UniProtKB/Swiss-Prot Summary for GALR1 Gene
Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Galanin is widely distributed in the central and peripheral nervous systems and the endocrine system. Three different galanin receptors (GAL1-3) have been identified. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral conditions.