GALNTL6 Gene (Protein Coding)

Polypeptide N-Acetylgalactosaminyltransferase Like 6

GC04P171813
GIFtS:
36
See more...

Aliases for GALNTL6 Gene

Aliases for GALNTL6 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase Like 6 2 3 5
  • GALNT17 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase-Like 6 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 17 3 4
  • Putative Polypeptide N-Acetylgalactosaminyltransferase 17 3 4
  • Polypeptide N-Acetylgalactosaminyltransferase-Like 6 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 17 3 4
  • Polypeptide GalNAc Transferase-Like 6 2 3
  • Polypeptide GalNAc Transferase 17 3 4
  • Pp-GaNTase 17 3 4
  • EC 2.4.1.41 4 51
  • GalNAc-T6L 2 3
  • GalNAc-T17 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 20 3
  • GalNAc Transferase 17 3
  • GaNTase 17 3
  • GALNACT20 3
  • GALNTL6 5

External Ids for GALNTL6 Gene

Previous GeneCards Identifiers for GALNTL6 Gene

  • GC04P172972
  • GC04P172735
  • GC04P168485

Summaries for GALNTL6 Gene

GeneCards Summary for GALNTL6 Gene

GALNTL6 (Polypeptide N-Acetylgalactosaminyltransferase Like 6) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT10.

UniProtKB/Swiss-Prot Summary for GALNTL6 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.

Additional gene information for GALNTL6 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GALNTL6 Gene

Genomics for GALNTL6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GALNTL6 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04J171812 Promoter 1.3 EPDnew Ensembl CraniofacialAtlas 258.2 +1.5 1547 3.2 L3MBTL2 EZH2 RAD21 ZNF579 CBFA2T3 GALNTL6 HSALNG0038559 LOC441052 piR-50443-300
GH04J171853 Enhancer 0.2 Ensembl 5.9 +39.8 39847 0.6 GALNTL6 piR-50443-300 piR-37309-005
GH04J171852 Enhancer 0.2 FANTOM5 3.2 +40.8 40761 0.3 GALNTL6 piR-50443-300 piR-37309-005
GH04J171817 Enhancer 0.3 Ensembl 0.4 +5.1 5147 0.8 SPI1 LOC441052 GALNTL6 piR-50443-300
GH04J171879 Enhancer 0.4 Ensembl ENCODE 0.2 +68.0 68003 1.4 JUND piR-50443-300 GALNTL6 piR-37309-005
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GALNTL6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GALNTL6

Top Transcription factor binding sites by QIAGEN in the GALNTL6 gene promoter:
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-2
  • Ik-1
  • IRF-7A
  • NF-kappaB1
  • Pax-5
  • POU2F1
  • POU2F1a

Genomic Locations for GALNTL6 Gene

Latest Assembly
chr4:171,812,254-173,041,559
(GRCh38/hg38)
Size:
1,229,306 bases
Orientation:
Plus strand

Previous Assembly
chr4:172,734,555-173,962,710
(GRCh37/hg19 by Entrez Gene)
Size:
1,228,156 bases
Orientation:
Plus strand

chr4:172,733,405-173,962,710
(GRCh37/hg19 by Ensembl)
Size:
1,229,306 bases
Orientation:
Plus strand

Genomic View for GALNTL6 Gene

Genes around GALNTL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALNTL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALNTL6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GALNTL6 Gene

Proteins for GALNTL6 Gene

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  • Protein details for GALNTL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49A17-GLTL6_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase-like 6
    Protein Accession:
    Q49A17
    Secondary Accessions:
    • Q2L4S6

    Protein attributes for GALNTL6 Gene

    Size:
    601 amino acids
    Molecular mass:
    69788 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GALNTL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNTL6 Gene

Protein Expression for GALNTL6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for GALNTL6 Gene

Q49A17:
  • WREDIRPG
  • MAGGLFA
  • SPVTLYDCH
  • IVCPMID
  • IWGGEQYE
  • SLARNLKRVAE
  • FWELGGYD
  • AYRENGFNI
  • VLTFLDSH
  • AEYIYQRRPEYRHLS
  • LPNTSIIIPFHNEGW
  • SFKVWMCGG
  • FLDSHCE
  • QAGDAMRGAFDWEMYYKRIPIPPELQ
  • KREGLIR
  • PCSRVGH

Post-translational modifications for GALNTL6 Gene

  • Glycosylation at Asn141 and Asn588
  • Modification sites at PhosphoSitePlus

Other Protein References for GALNTL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GALNTL6 Gene

Gene Families for GALNTL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GALNTL6 Gene

InterPro:
Blocks:
  • Ricin B lectin domain
  • Glycosyl transferase, family 2
ProtoNet:

Suggested Antigen Peptide Sequences for GALNTL6 Gene

GenScript: Design optimal peptide antigens:
  • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17 (GLTL6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q49A17

UniProtKB/Swiss-Prot:

GLTL6_HUMAN :
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNTL6: view

Function for GALNTL6 Gene

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  6. Cell Lines for research

Molecular function for GALNTL6 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41;.

Enzyme Numbers (IUBMB) for GALNTL6 Gene

Phenotypes From GWAS Catalog for GALNTL6 Gene

Gene Ontology (GO) - Molecular Function for GALNTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IEA,IDA 22186971
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNTL6: view
genes like me logo Genes that share phenotypes with GALNTL6: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALNTL6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GALNTL6 Gene

Localization for GALNTL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNTL6 Gene

Golgi apparatus membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GALNTL6 gene
Compartment Confidence
golgi apparatus 4
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
plasma membrane 0

Gene Ontology (GO) - Cellular Components for GALNTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GALNTL6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GALNTL6 Gene

Pathways & Interactions for GALNTL6 Gene

genes like me logo Genes that share pathways with GALNTL6: view

UniProtKB/Swiss-Prot Q49A17-GLTL6_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for GALNTL6 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000423313 for GALNTL6 Gene via STRING

GPS-Prot Interaction Network for GALNTL6

Gene Ontology (GO) - Biological Process for GALNTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0018215 protein phosphopantetheinylation IEA --
GO:0018243 protein O-linked glycosylation via threonine IDA 22186971
genes like me logo Genes that share ontologies with GALNTL6: view

No data available for SIGNOR curated interactions for GALNTL6 Gene

Drugs & Compounds for GALNTL6 Gene

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(3) Drugs for GALNTL6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 64
Uridine 5'-diphosphate Experimental Pharma 0
Calcium Nutra 6876

(3) Additional Compounds for GALNTL6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lactosamine
  • 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-Amino-2-deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
 13000-25-4
UDP-N-acetyl-alpha-D-galactosamine
  • (2R,3R,4R,5R,6R)-3-(Acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name)
  • UDP-GalNac
  • URIDINE-diphosphATE-N-acetylgalactosamine
  • (2R,3R,4R,5R,6R)-3-(Acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphoric acid (non-preferred name)
  • URIDINE-diphosphoric acid-N-acetylgalactosamine
Uridine diphosphate-N-acetylgalactosamine
  • Uridine diphosphoric acid-N-acetylgalactosamine
  • N-[2-({[({[3,4-dihydroxy-5-(4-hydroxy-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]ethanimidate
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
 7277-98-7
genes like me logo Genes that share compounds with GALNTL6: view

Transcripts for GALNTL6 Gene

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mRNA/cDNA for GALNTL6 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALNTL6

Alternative Splicing Database (ASD) splice patterns (SP) for GALNTL6 Gene

No ASD Table

Relevant External Links for GALNTL6 Gene

GeneLoc Exon Structure for
GALNTL6

Expression for GALNTL6 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GALNTL6 Gene

mRNA expression in normal human tissues for GALNTL6 Gene
mRNA expression by BioGPS for GALNTL6 GenemRNA expression by GTEx for GALNTL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNTL6 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.6), Brain - Substantia nigra (x5.1), and Brain - Anterior cingulate cortex (BA24) (x4.7).

Protein differential expression in normal tissues from HIPED for GALNTL6 Gene

This gene is overexpressed in Heart (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GALNTL6 Gene



Protein tissue co-expression partners for GALNTL6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GALNTL6

SOURCE GeneReport for Unigene cluster for GALNTL6 Gene:

Hs.386236

Evidence on tissue expression from TISSUES for GALNTL6 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with GALNTL6: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GALNTL6 Gene

Orthologs for GALNTL6 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNTL6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GALNTL6 30 31
  • 99.72 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia GALNTL6 31
  • 95 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia GALNTL6 31
  • 95 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia GALNTL6 30 31
  • 94.18 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Galntl6 30 17 31
  • 91.24 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Galntl6 30
  • 90.68 (n)
Cow
(Bos Taurus)
 Mammalia GALNTL6 30 31
  • 88.8 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves GALNTL6 30 31
  • 84.08 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia GALNTL6 31
  • 91 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia galntl6 30
  • 79.53 (n)
Zebrafish
(Danio rerio)
 Actinopterygii GALNTL6 31
  • 82 (a)
 OneToOne
si:ch211-15e22.3 30
  • 74.44 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta pgant6 31
  • 40 (a)
 ManyToMany
pgant4 31
  • 38 (a)
 ManyToMany
pgant8 31
  • 33 (a)
 ManyToMany
CG31776 31
  • 32 (a)
 ManyToMany
Worm
(Caenorhabditis elegans)
 Secernentea gly-10 31
  • 38 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 54 (a)
 OneToMany
Species where no ortholog for GALNTL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GALNTL6 Gene

ENSEMBL:
Gene Tree for GALNTL6 (if available)
TreeFam:
Gene Tree for GALNTL6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GALNTL6: view image

Paralogs for GALNTL6 Gene

Paralogs for GALNTL6 Gene

(23) SIMAP similar genes for GALNTL6 Gene using alignment to 3 proteins:

  • GLTL6_HUMAN
  • D6RCP4_HUMAN
  • I6L9C1_HUMAN
genes like me logo Genes that share paralogs with GALNTL6: view

Variants for GALNTL6 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GALNTL6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GALNTL6 Gene

Variant ID Type Subtype PubMed ID
dgv1042e214 CNV gain 21293372
dgv130e203 CNV gain+loss 21179565
dgv1546e212 CNV loss 25503493
dgv1547e212 CNV loss 25503493
dgv1548e212 CNV gain 25503493
dgv157n73 CNV deletion 24416366
dgv181n6 CNV deletion 16902084
dgv2946n106 CNV deletion 24896259
dgv2947n106 CNV deletion 24896259
dgv341e215 CNV deletion 23714750
dgv46n50 CNV loss 21212237
dgv5476n100 CNV gain 25217958
dgv5477n100 CNV gain 25217958
dgv5478n100 CNV gain 25217958
dgv910n67 CNV loss 20364138
dgv9391n54 CNV loss 21841781
dgv9392n54 CNV gain 21841781
dgv9393n54 CNV loss 21841781
dgv9394n54 CNV loss 21841781
dgv9395n54 CNV gain 21841781
dgv9396n54 CNV gain 21841781
dgv98n16 CNV deletion 17901297
dgv992e199 CNV deletion 23128226
esv1004880 CNV deletion 20482838
esv1008745 CNV deletion 20482838
esv1011260 CNV deletion 20482838
esv1235967 CNV deletion 17803354
esv1531442 CNV insertion 17803354
esv2033228 CNV deletion 18987734
esv2097954 CNV deletion 18987734
esv2285591 CNV deletion 18987734
esv2322806 CNV deletion 18987734
esv2421402 CNV deletion 20811451
esv2421911 CNV deletion 20811451
esv2435425 CNV deletion 19546169
esv2439458 CNV loss 19546169
esv2546113 CNV deletion 19546169
esv2565726 CNV deletion 19546169
esv2607011 CNV loss 19546169
esv2661236 CNV deletion 23128226
esv2661339 CNV deletion 23128226
esv2661674 CNV deletion 23128226
esv2666802 CNV deletion 23128226
esv2667074 CNV deletion 23128226
esv2728753 CNV deletion 23290073
esv2728754 CNV deletion 23290073
esv2728755 CNV deletion 23290073
esv2728756 CNV deletion 23290073
esv2728757 CNV deletion 23290073
esv2728758 CNV deletion 23290073
esv274870 CNV gain+loss 21479260
esv27951 CNV loss 19812545
esv28615 CNV gain+loss 19812545
esv3297273 CNV deletion 24192839
esv33022 CNV gain 17666407
esv3305270 CNV mobile element insertion 20981092
esv33205 CNV loss 17666407
esv3347798 CNV insertion 20981092
esv3440082 CNV duplication 20981092
esv3450996 CNV insertion 20981092
esv3565009 CNV deletion 23714750
esv3565011 CNV deletion 23714750
esv3565014 CNV deletion 23714750
esv3565018 CNV deletion 23714750
esv3565020 CNV deletion 23714750
esv3575792 CNV gain 25503493
esv3603175 CNV loss 21293372
esv3603176 CNV loss 21293372
esv3603178 CNV gain 21293372
esv3603179 CNV loss 21293372
esv3603180 CNV loss 21293372
esv3603182 CNV loss 21293372
esv3603184 CNV loss 21293372
esv3603185 CNV loss 21293372
esv3603186 CNV loss 21293372
esv3603187 CNV gain 21293372
esv3603188 CNV loss 21293372
esv3603191 CNV loss 21293372
esv3603192 CNV loss 21293372
esv3603194 CNV loss 21293372
esv3603195 CNV loss 21293372
esv3603200 CNV loss 21293372
esv3603201 CNV loss 21293372
esv3603202 CNV loss 21293372
esv3603205 CNV gain 21293372
esv4052 CNV loss 18987735
esv8153 CNV loss 19470904
esv8497 CNV loss 19470904
nsv1017091 CNV gain 25217958
nsv1018930 CNV loss 25217958
nsv1019896 CNV gain 25217958
nsv1021388 CNV loss 25217958
nsv1025388 CNV loss 25217958
nsv1029351 CNV gain 25217958
nsv10611 CNV loss 18304495
nsv10612 CNV loss 18304495
nsv10613 CNV gain+loss 18304495
nsv1071631 CNV deletion 25765185
nsv1072980 CNV deletion 25765185
nsv1114604 CNV deletion 24896259
nsv1114605 CNV deletion 24896259
nsv1152502 CNV deletion 26484159
nsv1153765 CNV deletion 26484159
nsv1161175 OTHER complex 26073780
nsv263 CNV deletion 15895083
nsv289404 CNV deletion 16902084
nsv289548 CNV deletion 16902084
nsv289632 CNV deletion 16902084
nsv290804 CNV insertion 16902084
nsv291048 CNV deletion 16902084
nsv433470 CNV loss 18776910
nsv436418 CNV deletion 17901297
nsv437950 CNV loss 16468122
nsv442931 CNV loss 18776908
nsv4605 CNV deletion 18451855
nsv4606 CNV insertion 18451855
nsv4607 CNV deletion 18451855
nsv4608 CNV deletion 18451855
nsv461838 CNV gain 19166990
nsv499494 CNV loss 21111241
nsv508332 CNV deletion 20534489
nsv508333 CNV deletion 20534489
nsv513180 CNV loss 21212237
nsv514272 CNV loss 21397061
nsv514273 CNV loss 21397061
nsv519578 CNV loss 19592680
nsv520744 CNV gain 19592680
nsv525324 CNV loss 19592680
nsv527739 CNV loss 19592680
nsv596171 CNV loss 21841781
nsv596173 CNV gain 21841781
nsv596197 CNV loss 21841781
nsv596202 CNV loss 21841781
nsv596203 CNV gain+loss 21841781
nsv596205 CNV loss 21841781
nsv596209 CNV loss 21841781
nsv596210 CNV gain 21841781
nsv596211 CNV gain 21841781
nsv596214 CNV gain+loss 21841781
nsv596216 CNV loss 21841781
nsv596221 CNV gain 21841781
nsv819440 CNV loss 19587683
nsv819975 CNV loss 19587683
nsv820239 CNV loss 19587683
nsv821526 CNV deletion 20802225
nsv822836 CNV loss 20364138
nsv822837 CNV loss 20364138
nsv822838 CNV loss 20364138
nsv830152 CNV loss 17160897
nsv830153 CNV loss 17160897
nsv955638 CNV deletion 24416366
nsv964345 CNV deletion 23825009
nsv967813 CNV duplication 23825009
nsv968039 CNV duplication 23825009

Variation tolerance for GALNTL6 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 26.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GALNTL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GALNTL6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GALNTL6 Gene

Disorders for GALNTL6 Gene

Additional Disease Information for GALNTL6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for GALNTL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALNTL6 Gene

Publications for GALNTL6 Gene

  1. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl GR … Lerman C (Archives of general psychiatry 2008) 3 41
  2. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  3. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  4. UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. (PMID: 22186971) Raman J … Tabak LA (Glycobiology 2012) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

ExternalLinks

View latest publications for GALNTL6 gene in Mastermind

Products for GALNTL6 Gene

Sources for GALNTL6 Gene