This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem ... See more...

Aliases for GALNT6 Gene

Aliases for GALNT6 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 6 2 3 4 5
  • Polypeptide GalNAc Transferase 6 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 6 (GalNAc-T6) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 6 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 6 3 4
  • Pp-GaNTase 6 3 4
  • EC 2.4.1.41 4 51
  • GalNAc-T6 2 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine: Polypeptide N-Acetylgalactosaminyltransferase 6 3
  • GalNAc Transferase 6 3
  • GALNAC-T6 3
  • GalNAcT6 3
  • GALNT6 5

External Ids for GALNT6 Gene

Previous GeneCards Identifiers for GALNT6 Gene

  • GC12M051903
  • GC12M051769
  • GC12M051463
  • GC12M050033
  • GC12M048778

Summaries for GALNT6 Gene

Entrez Gene Summary for GALNT6 Gene

  • This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]

GeneCards Summary for GALNT6 Gene

GALNT6 (Polypeptide N-Acetylgalactosaminyltransferase 6) is a Protein Coding gene. Among its related pathways are Mucin type O-glycan biosynthesis and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT3.

UniProtKB/Swiss-Prot Summary for GALNT6 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides.

Gene Wiki entry for GALNT6 Gene

Additional gene information for GALNT6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GALNT6 Gene

Genomics for GALNT6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GALNT6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J051387 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 615.1 +1.0 955 9.1 CEBPG CREB1 PRDM10 ZNF629 ZNF512 LEF1 IKZF1 ZNF692 POLR2A TARDBP GALNT6 SLC4A8 lnc-CELA1-2 BIN2 SLC11A2 CELA1 DAZAP2 CSRNP2
GH12J051379 Promoter/Enhancer 0.5 EPDnew dbSUPER 600.4 +13.0 13028 0.1 GALNT6 CELA1 SLC4A8 lnc-CELA1-2
GH12J051368 Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 19.3 +22.2 22181 4.4 SP1 PRDM10 REST ZNF629 ZNF512 LEF1 IKZF1 ZNF692 BACH1 DDX20 GALNT6 CELA1 BIN2 SLC4A8 DAZAP2 CSRNP2 FIGNL2 SLC11A2
GH12J051424 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.2 -32.2 -32158 2 SP1 CTCF RFX1 LARP7 ZNF143 POLR2A PATZ1 REST ZNF501 ZNF341 SLC4A8 ENSG00000271065 LOC107984508 GALNT6 SCN8A
GH12J051846 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.2 -455.5 -455541 4 HNRNPL ZIC2 RBFOX2 PATZ1 ZNF600 ZNF341 ZNF148 ZNF561 CTCF KLF9 FIGNL2 FIGNL2-DT lnc-KRT80-14 lnc-KRT80-5 SLC4A8 ACVRL1 ENSG00000261586 RNU6-574P GALNT6 ANKRD33
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GALNT6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GALNT6

Top Transcription factor binding sites by QIAGEN in the GALNT6 gene promoter:
  • AML1a
  • ATF6
  • C/EBPbeta
  • En-1
  • MZF-1
  • p53
  • POU2F1
  • POU2F1a

Genomic Locations for GALNT6 Gene

Genomic Locations for GALNT6 Gene
chr12:51,351,247-51,392,867
(GRCh38/hg38)
Size:
41,621 bases
Orientation:
Minus strand
chr12:51,745,031-51,786,651
(GRCh37/hg19)
Size:
41,621 bases
Orientation:
Minus strand

Genomic View for GALNT6 Gene

Genes around GALNT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALNT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALNT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT6 Gene

Proteins for GALNT6 Gene

  • Protein details for GALNT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCL4-GALT6_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 6
    Protein Accession:
    Q8NCL4
    Secondary Accessions:
    • Q8IYH4
    • Q9H6G2
    • Q9UIV5

    Protein attributes for GALNT6 Gene

    Size:
    622 amino acids
    Molecular mass:
    71159 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15297.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GALNT6 Gene

Selected DME Specific Peptides for GALNT6 Gene

Q8NCL4:
  • SFRVWQCGG
  • CLDVGENN
  • LGPDTRPPEC
  • TSVIIVFHNE
  • RLAEVWMD
  • CHGLGGNQ
  • AGGLFSI
  • WLEPLLARI
  • KHCFNAFASDRISL
  • LEIIPCS
  • LLKEIILVDD
  • ERKGLITARLLGA
  • FHNEAWS
  • GWLEPLL

Post-translational modifications for GALNT6 Gene

  • Glycosylation at Thr38, Asn86, and Asn476
  • Modification sites at PhosphoSitePlus

Domains & Families for GALNT6 Gene

Gene Families for GALNT6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GALNT6 Gene

InterPro:
Blocks:
  • Ricin B lectin domain
  • Glycosyl transferase, family 2
ProtoNet:

Suggested Antigen Peptide Sequences for GALNT6 Gene

GenScript: Design optimal peptide antigens:
  • UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 6 (D7UNW5_HUMAN)
  • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6 (GALT6_HUMAN)
  • UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) (Q24JS2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NCL4

UniProtKB/Swiss-Prot:

GALT6_HUMAN :
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNT6: view

Function for GALNT6 Gene

Molecular function for GALNT6 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Evidence={ECO:0000269|PubMed:10464263};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Evidence={ECO:0000269|PubMed:10464263};.
GENATLAS Biochemistry:
galactosamine:UDP-N-acetyl-alpha-D-polypeptide T6,catalyzing the initial reaction in O-linked (mucin type) oligosaccharide biosynthesis,expressed in fibroblast cell,highly homolog to GALNT3 and possessing the same substrate specificity for oncofetal fribronectin

Enzyme Numbers (IUBMB) for GALNT6 Gene

Phenotypes From GWAS Catalog for GALNT6 Gene

Gene Ontology (GO) - Molecular Function for GALNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity TAS,IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT6: view
genes like me logo Genes that share phenotypes with GALNT6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALNT6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GALNT6 Gene

Localization for GALNT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT6 Gene

Golgi apparatus membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GALNT6 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 2
extracellular 2
nucleus 2
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GALNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA 12506059
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 12506059
genes like me logo Genes that share ontologies with GALNT6: view

Pathways & Interactions for GALNT6 Gene

genes like me logo Genes that share pathways with GALNT6: view

UniProtKB/Swiss-Prot Q8NCL4-GALT6_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for GALNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006493 protein O-linked glycosylation TAS 10464263
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with GALNT6: view

No data available for SIGNOR curated interactions for GALNT6 Gene

Drugs & Compounds for GALNT6 Gene

(3) Drugs for GALNT6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 56
Uridine 5'-diphosphate Experimental Pharma 0
Calcium Nutra 6556

(3) Additional Compounds for GALNT6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lactosamine
  • 2-amino-2-Deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-amino-2-Deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
13000-25-4
UDP-N-acetyl-alpha-D-galactosamine
  • (2R,3R,4R,5R,6R)-3-(acetylamino)-4,5-Dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name)
  • URIDINE-diphosphATE-N-acetylgalactosamine
  • (2R,3R,4R,5R,6R)-3-(acetylamino)-4,5-Dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphoric acid (non-preferred name)
  • UDP-N-Acetyl-a-D-galactosamine
  • UDP-N-Acetyl-α-D-galactosamine
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT6: view

Transcripts for GALNT6 Gene

mRNA/cDNA for GALNT6 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALNT6

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h ^ 8 ^ 9 ^ 10 ^
SP1: - - - - - -
SP2: - - -
SP3: - - - - - -
SP4: -
SP5:
SP6: - - - - - - - - -
SP7: - - - - -
SP8: -
SP9: - -
SP10: - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - -
SP13:

ExUns: 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for GALNT6 Gene

GeneLoc Exon Structure for
GALNT6

Expression for GALNT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GALNT6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNT6 Gene

This gene is overexpressed in Stomach (x4.3).

Protein differential expression in normal tissues from HIPED for GALNT6 Gene

This gene is overexpressed in Stomach (34.6), Lung (14.7), and Salivary gland (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GALNT6 Gene



Protein tissue co-expression partners for GALNT6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GALNT6

SOURCE GeneReport for Unigene cluster for GALNT6 Gene:

Hs.505575

mRNA Expression by UniProt/SwissProt for GALNT6 Gene:

Q8NCL4-GALT6_HUMAN
Tissue specificity: Expressed in placenta and trachea. Weakly expressed in brain and pancreas. Expressed in fibroblast. Weakly or not expressed in lung, liver, muscle, kidney, spleen, thymus, prostate, testis, ovary, intestine, colon, leukocyte, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland and bone marrow.

Evidence on tissue expression from TISSUES for GALNT6 Gene

  • Kidney(4.3)
  • Intestine(2.6)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with GALNT6: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GALNT6 Gene

Orthologs for GALNT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GALNT6 30 31
  • 96.57 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GALNT6 30 31
  • 90.12 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GALNT6 30 31
  • 89.17 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Galnt6 30
  • 86.98 (n)
Mouse
(Mus musculus)
Mammalia Galnt6 30 17 31
  • 86.87 (n)
OneToOne
Chicken
(Gallus gallus)
Aves GALNT6 30 31
  • 74.83 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GALNT6 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia galnt6 30
  • 68.77 (n)
Zebrafish
(Danio rerio)
Actinopterygii galnt6 30 31
  • 66.5 (n)
OneToOne
-- 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11246 30
Fruit Fly
(Drosophila melanogaster)
Insecta GalNAc-T1 32
  • 40 (a)
CG7297 32
  • 33 (a)
CG7304 32
  • 32 (a)
CG7579 32
  • 30 (a)
Worm
(Caenorhabditis elegans)
Secernentea Y39E4B.12b 32
  • 45 (a)
Y39E4B.12c 32
  • 45 (a)
Y39E4B.12a 32
  • 44 (a)
Y47D3A.23 32
  • 37 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
Species where no ortholog for GALNT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GALNT6 Gene

ENSEMBL:
Gene Tree for GALNT6 (if available)
TreeFam:
Gene Tree for GALNT6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GALNT6: view image

Paralogs for GALNT6 Gene

(25) SIMAP similar genes for GALNT6 Gene using alignment to 12 proteins:

  • GALT6_HUMAN
  • D7UNW5_HUMAN
  • Q24JS2_HUMAN
  • S4R310_HUMAN
  • S4R345_HUMAN
  • S4R355_HUMAN
  • S4R370_HUMAN
  • S4R396_HUMAN
  • S4R3A9_HUMAN
  • S4R3L4_HUMAN
  • S4R3M3_HUMAN
  • S4R3S5_HUMAN
genes like me logo Genes that share paralogs with GALNT6: view

Variants for GALNT6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GALNT6 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
770231 Benign: not provided 51,359,233(-) C/T MISSENSE_VARIANT
783662 Benign: not provided 51,379,368(-) C/G MISSENSE_VARIANT
784301 Benign: not provided 51,377,316(-) C/T SYNONYMOUS_VARIANT
785406 Benign: not provided 51,355,799(-) G/A INTRON_VARIANT
rs747300 - p.Val423Ile

Additional dbSNP identifiers (rs#s) for GALNT6 Gene

Structural Variations from Database of Genomic Variants (DGV) for GALNT6 Gene

Variant ID Type Subtype PubMed ID
esv2745883 CNV deletion 23290073
nsv476302 CNV novel sequence insertion 20440878
nsv832408 CNV gain 17160897

Variation tolerance for GALNT6 Gene

Residual Variation Intolerance Score: 18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GALNT6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GALNT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT6 Gene

Disorders for GALNT6 Gene

Additional Disease Information for GALNT6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for GALNT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALNT6 Gene

Publications for GALNT6 Gene

  1. Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy. (PMID: 10464263) Bennett EP … Clausen H (The Journal of biological chemistry 1999) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma. (PMID: 18854599) Gomes J … Reis CA (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009) 3 23
  4. Prognostic utility of glycosyltransferase expression in breast cancer. (PMID: 19287074) Patani N … Mokbel K (Cancer genomics & proteomics 2008) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for GALNT6 Gene

Sources for GALNT6 Gene