Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GALNT6 Gene

Aliases for GALNT6 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 6 2 3 5
  • Polypeptide GalNAc Transferase 6 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 6 (GalNAc-T6) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 6 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 6 3 4
  • Pp-GaNTase 6 3 4
  • EC 2.4.1.41 4 56
  • GALNAC-T6 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine: Polypeptide N-Acetylgalactosaminyltransferase 6 3
  • GalNAc Transferase 6 3
  • GalNAcT6 3

External Ids for GALNT6 Gene

Previous GeneCards Identifiers for GALNT6 Gene

  • GC12M051903
  • GC12M051769
  • GC12M051463
  • GC12M050033
  • GC12M048778

Summaries for GALNT6 Gene

Entrez Gene Summary for GALNT6 Gene

  • This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]

GeneCards Summary for GALNT6 Gene

GALNT6 (Polypeptide N-Acetylgalactosaminyltransferase 6) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and O-linked glycosylation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT3.

UniProtKB/Swiss-Prot for GALNT6 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides.

Gene Wiki entry for GALNT6 Gene

Additional gene information for GALNT6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT6 Gene

Genomics for GALNT6 Gene

GeneHancer (GH) Regulatory Elements for GALNT6 Gene

Promoters and enhancers for GALNT6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I051387 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 565.2 +1.0 955 9.1 HDGF PKNOX1 ARNT SIN3A FEZF1 YBX1 ZNF2 IRF4 ZNF766 ZNF213 GALNT6 SLC4A8 BIN2 SLC11A2 CELA1 DAZAP2 CSRNP2
GH12I051368 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.3 +22.2 22181 4.4 FOXA2 PKNOX1 FEZF1 IRF4 YY1 ZNF766 ZNF143 FOS DEK JUNB GALNT6 CELA1 BIN2 SLC4A8 DAZAP2 CSRNP2 FIGNL2 SLC11A2
GH12I051424 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 12.2 -32.2 -32178 2 PKNOX1 ATF1 SIN3A ZNF2 GLIS2 ZNF143 FOS SP3 RXRA YY2 SLC4A8 ENSG00000271065 GALNT6 PIR56141 GC12P051454
GH12I051358 Enhancer 0.8 dbSUPER 21.5 +29.6 29620 9.6 HDAC1 RAD21 TCF12 ZNF121 GATA2 ZNF366 CREM ZBTB11 NFIC KLF16 GALNT6 SLC4A8 BIN2 CSRNP2 DAZAP2 SLC11A2 RNU6-1273P CELA1 POU6F1
GH12I051846 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE 10.2 -455.1 -455134 3.1 PKNOX1 MZF1 SIN3A ZNF335 GLIS2 EGR1 EGR2 SP3 ZBTB11 ZEB2 FIGNL2 LOC105369971 SLC4A8 ACVRL1 ENSG00000261586 RNU6-574P GALNT6 ANKRD33 SCN8A GC12P051835
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GALNT6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GALNT6 gene promoter:

Genomic Locations for GALNT6 Gene

Genomic Locations for GALNT6 Gene
chr12:51,351,247-51,392,867
(GRCh38/hg38)
Size:
41,621 bases
Orientation:
Minus strand
chr12:51,745,031-51,786,651
(GRCh37/hg19)

Genomic View for GALNT6 Gene

Genes around GALNT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALNT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALNT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT6 Gene

Proteins for GALNT6 Gene

  • Protein details for GALNT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCL4-GALT6_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 6
    Protein Accession:
    Q8NCL4
    Secondary Accessions:
    • Q8IYH4
    • Q9H6G2
    • Q9UIV5

    Protein attributes for GALNT6 Gene

    Size:
    622 amino acids
    Molecular mass:
    71159 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15297.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GALNT6 Gene

Selected DME Specific Peptides for GALNT6 Gene

Q8NCL4:
  • SFRVWQCGG
  • CLDVGENN
  • LGPDTRPPEC
  • TSVIIVFHNE
  • RLAEVWMD
  • CHGLGGNQ
  • AGGLFSI
  • WLEPLLARI
  • KHCFNAFASDRISL
  • LEIIPCS
  • LLKEIILVDD
  • ERKGLITARLLGA
  • FHNEAWS
  • GWLEPLL

Post-translational modifications for GALNT6 Gene

  • Glycosylation at isoforms=38, isoforms=86, and isoforms=476

Domains & Families for GALNT6 Gene

Gene Families for GALNT6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

Q8NCL4

UniProtKB/Swiss-Prot:

GALT6_HUMAN :
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNT6: view

Function for GALNT6 Gene

Molecular function for GALNT6 Gene

GENATLAS Biochemistry:
galactosamine
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides.

Enzyme Numbers (IUBMB) for GALNT6 Gene

Gene Ontology (GO) - Molecular Function for GALNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT6: view
genes like me logo Genes that share phenotypes with GALNT6: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GALNT6 Gene

Localization for GALNT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GALNT6 gene
Compartment Confidence
golgi apparatus 5
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GALNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA 12506059
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 12506059
genes like me logo Genes that share ontologies with GALNT6: view

Pathways & Interactions for GALNT6 Gene

genes like me logo Genes that share pathways with GALNT6: view

Pathways by source for GALNT6 Gene

UniProtKB/Swiss-Prot Q8NCL4-GALT6_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for GALNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006493 protein O-linked glycosylation TAS 10464263
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with GALNT6: view

No data available for SIGNOR curated interactions for GALNT6 Gene

Drugs & Compounds for GALNT6 Gene

(3) Drugs for GALNT6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Manganese Approved Nutra 37
Uridine-5'-Diphosphate Experimental Pharma 0

(3) Additional Compounds for GALNT6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lactosamine
  • 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-Amino-2-deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
13000-25-4
UDP-N-acetyl-alpha-D-galactosamine
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT6: view

Transcripts for GALNT6 Gene

Unigene Clusters for GALNT6 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h ^ 8 ^ 9 ^ 10 ^
SP1: - - - - - -
SP2: - - -
SP3: - - - - - -
SP4: -
SP5:
SP6: - - - - - - - - -
SP7: - - - - -
SP8: -
SP9: - -
SP10: - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - -
SP13:

ExUns: 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for GALNT6 Gene

GeneLoc Exon Structure for
GALNT6
ECgene alternative splicing isoforms for
GALNT6

Expression for GALNT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GALNT6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNT6 Gene

This gene is overexpressed in Stomach (x4.3).

Protein differential expression in normal tissues from HIPED for GALNT6 Gene

This gene is overexpressed in Stomach (34.6), Lung (14.7), and Salivary gland (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GALNT6 Gene



Protein tissue co-expression partners for GALNT6 Gene

NURSA nuclear receptor signaling pathways regulating expression of GALNT6 Gene:

GALNT6

SOURCE GeneReport for Unigene cluster for GALNT6 Gene:

Hs.505575

mRNA Expression by UniProt/SwissProt for GALNT6 Gene:

Q8NCL4-GALT6_HUMAN
Tissue specificity: Expressed in placenta and trachea. Weakly expressed in brain and pancreas. Expressed in fibroblast. Weakly or not expressed in lung, liver, muscle, kidney, spleen, thymus, prostate, testis, ovary, intestine, colon, leukocyte, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland and bone marrow.

Evidence on tissue expression from TISSUES for GALNT6 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with GALNT6: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GALNT6 Gene

Orthologs for GALNT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNT6 33 34
  • 96.57 (n)
dog
(Canis familiaris)
Mammalia GALNT6 33 34
  • 90.12 (n)
cow
(Bos Taurus)
Mammalia GALNT6 33 34
  • 89.17 (n)
rat
(Rattus norvegicus)
Mammalia Galnt6 33
  • 86.98 (n)
mouse
(Mus musculus)
Mammalia Galnt6 33 16 34
  • 86.87 (n)
chicken
(Gallus gallus)
Aves GALNT6 33 34
  • 74.83 (n)
lizard
(Anolis carolinensis)
Reptilia GALNT6 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt6 33
  • 68.77 (n)
zebrafish
(Danio rerio)
Actinopterygii galnt6 33 34
  • 66.5 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11246 33
fruit fly
(Drosophila melanogaster)
Insecta GalNAc-T1 35
  • 40 (a)
CG7297 35
  • 33 (a)
CG7304 35
  • 32 (a)
CG7579 35
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea Y39E4B.12b 35
  • 45 (a)
Y39E4B.12c 35
  • 45 (a)
Y39E4B.12a 35
  • 44 (a)
Y47D3A.23 35
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
Species where no ortholog for GALNT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT6 Gene

ENSEMBL:
Gene Tree for GALNT6 (if available)
TreeFam:
Gene Tree for GALNT6 (if available)

Paralogs for GALNT6 Gene

Variants for GALNT6 Gene

Sequence variations from dbSNP and Humsavar for GALNT6 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000074213 -- 51,367,524(-) G/A intron_variant
rs1000135512 -- 51,362,924(-) C/G intron_variant
rs1000260094 -- 51,372,635(-) C/G intron_variant
rs1000289636 -- 51,372,949(-) G/A/T intron_variant
rs1000300256 -- 51,361,136(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GALNT6 Gene

Variant ID Type Subtype PubMed ID
nsv832408 CNV gain 17160897
nsv476302 CNV novel sequence insertion 20440878
esv2745883 CNV deletion 23290073

Variation tolerance for GALNT6 Gene

Residual Variation Intolerance Score: 18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GALNT6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GALNT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT6 Gene

Disorders for GALNT6 Gene

Additional Disease Information for GALNT6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GALNT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALNT6 Gene

Publications for GALNT6 Gene

  1. Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy. (PMID: 10464263) Bennett EP … Clausen H (The Journal of biological chemistry 1999) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma. (PMID: 18854599) Gomes J … Reis CA (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009) 3 22 58
  4. Prognostic utility of glycosyltransferase expression in breast cancer. (PMID: 19287074) Patani N … Mokbel K (Cancer genomics & proteomics 2008) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for GALNT6 Gene

Sources for GALNT6 Gene

Content
Loading form....