Aliases for GALNT6 Gene
- Polypeptide N-Acetylgalactosaminyltransferase 6 2 3 4 5
- Polypeptide GalNAc Transferase 6 2 3 4
- UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 6 (GalNAc-T6) 2 3
- UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 6 3 4
- Protein-UDP Acetylgalactosaminyltransferase 6 3 4
- Pp-GaNTase 6 3 4
External Ids for GALNT6 Gene
Previous GeneCards Identifiers for GALNT6 Gene
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]
GeneCards Summary for GALNT6 Gene
GALNT6 (Polypeptide N-Acetylgalactosaminyltransferase 6) is a Protein Coding gene. Among its related pathways are Metabolism and O-linked glycosylation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT3.
UniProtKB/Swiss-Prot Summary for GALNT6 Gene
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides.