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This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem ... See more...
Aliases for GALNT4 Gene
Aliases for GALNT4 Gene
- Polypeptide N-Acetylgalactosaminyltransferase 4 2 3 4 5
- Polypeptide GalNAc Transferase 4 2 3 4
- UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 4 (GalNAc-T4) 2 3
- UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 4 3 4
- Protein-UDP Acetylgalactosaminyltransferase 4 3 4
External Ids for GALNT4 Gene
- HGNC: 4126
- Entrez Gene: 8693
- Ensembl: ENSG00000257594
- OMIM: 603565
- UniProtKB: Q8N4A0
Previous GeneCards Identifiers for GALNT4 Gene
- GC12M089334
- GC12M090360
- GC12M089849
- GC12M088419
- GC12M088415
- GC12M089913
Summaries for GALNT4 Gene
-
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon. Fusion transcripts, which combine part of this gene with the 5' exons of the neighboring POC1B (POC1 centriolar protein homolog B) gene, also exist. [provided by RefSeq, Dec 2010]
GeneCards Summary for GALNT4 Gene
GALNT4 (Polypeptide N-Acetylgalactosaminyltransferase 4) is a Protein Coding gene. Diseases associated with GALNT4 include Nephrotic Syndrome, Type 3. Among its related pathways are Mucin type O-glycan biosynthesis and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is POC1B-GALNT4.
UniProtKB/Swiss-Prot Summary for GALNT4 Gene
-
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG.
Additional gene information for GALNT4 Gene
- HGNC(4126)
- Entrez Gene(8693)
- Ensembl(ENSG00000257594)
- OMIM(603565)
- UniProtKB(Q8N4A0)
- Open Targets Platform(ENSG00000257594)
- Search for GALNT4 at DataMed
- Search for GALNT4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GALNT4 Gene
Genomics for GALNT4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GALNT4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GALNT4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GALNT4
- Top Transcription factor binding sites by QIAGEN in the GALNT4 gene promoter:
-
- CUTL1
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
- NRSF form 1
- NRSF form 2
- POU2F1
- POU2F1a
Genomic Locations for GALNT4 Gene
Genomic Locations for GALNT4 Gene
- chr12:89,519,412-89,524,796
- (GRCh38/hg38)
- Size:
- 5,385 bases
- Orientation:
- Minus strand
- chr12:89,913,185-89,920,039
- (GRCh37/hg19)
- Size:
- 6,855 bases
- Orientation:
- Minus strand
Genomic View for GALNT4 Gene
Genes around GALNT4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q21.33 by HGNC
- 12q21.33 by Entrez Gene
- 12q21.33 by Ensembl
GALNT4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GALNT4 Gene
Proteins for GALNT4 Gene
-
Protein details for GALNT4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N4A0-GALT4_HUMAN
- Recommended name:
- Polypeptide N-acetylgalactosaminyltransferase 4
- Protein Accession:
- Q8N4A0
- B2R775
- B4DMX6
- O00208
Protein attributes for GALNT4 Gene
- Size:
- 578 amino acids
- Molecular mass:
- 66666 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
- No Data Available
Protein Expression for GALNT4 Gene
Selected DME Specific Peptides for GALNT4 Gene
- Q8N4A0:
-
- SFRVWQCGG
- RAAEVWMD
- MAGGLFA
- VVCPVID
- AEVWMDEYK
- LLKEIILVDD
- PTMAGGL
- WGGENLE
- GWLEPLL
Post-translational modifications for GALNT4 Gene
Other Protein References for GALNT4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GALNT4
-
Abcam antibodies for GALNT4
- Invitrogen Antibodies for GALNT4 (AFLGC-GALNT4)
Protein Products
-
OriGene Purified Proteins for GALNT4
- Search Origene for MassSpec and Protein Over-expression Lysates for GALNT4
- Origene Custom Protein Services for GALNT4
- antibodies-online: Show 5 available GALNT4 Proteins ranked by validation data
- Compare Top GALNT4 Proteins
-
Quality Products:
-
Abcam proteins for GALNT4
Domains & Families for GALNT4 Gene
Gene Families for GALNT4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for GALNT4 Gene
- InterPro:
- Blocks:
-
- Ricin B lectin domain
- Glycosyl transferase, family 2
- ProtoNet:
Suggested Antigen Peptide Sequences for GALNT4 Gene
- GenScript: Design optimal peptide antigens:
-
- UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4 (GALT4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8N4A0UniProtKB/Swiss-Prot:
GALT4_HUMAN :- There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
- Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
- Domain:
-
- There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
- The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates.
- Family:
-
- Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Function for GALNT4 Gene
Molecular function for GALNT4 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Evidence={ECO:0000269|PubMed:10984485, ECO:0000269|PubMed:29208955, ECO:0000269|PubMed:9804815};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Evidence={ECO:0000269|PubMed:10984485, ECO:0000269|PubMed:29208955, ECO:0000269|PubMed:9804815};.
- GENATLAS Biochemistry:
- galactosamine :UDP-N-acetyl alpha D polypeptide T4 transferase,widely expressed,possessing substrate specificity for fibronectin (fetal or plasma),widely expressed
Enzyme Numbers (IUBMB) for GALNT4 Gene
Phenotypes From GWAS Catalog for GALNT4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity | IEA,IDA | 9804815 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
| GO:0030145 | manganese ion binding | IDA | 29208955 |
| GO:0030246 | carbohydrate binding | IEA | -- |
Phenotypes for GALNT4 Gene
- MGI mutant phenotypes for GALNT4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GALNT4:
Animal Models for GALNT4 Gene
- MGI Knock Outs for GALNT4:
-
- Galnt4 Galnt4<tm1Tabk>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GALNT4 - Select products 50% OFF >
- * GALNT4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GALNT4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GALNT4
-
Santa Cruz Biotechnology (SCBT) CRISPR for GALNT4
miRNA for GALNT4 Gene
- miRTarBase miRNAs that target GALNT4
-
- hsa-miR-2113 (MIRT067465)
- hsa-miR-1250-3p (MIRT067466)
- hsa-miR-1256 (MIRT067467)
- hsa-miR-365a-3p (MIRT275123)
- hsa-miR-365b-3p (MIRT275124)
- hsa-miR-126-5p (MIRT328572)
- hsa-miR-4477b (MIRT502412)
- hsa-miR-3157-3p (MIRT502413)
- hsa-miR-18b-3p (MIRT502414)
- hsa-miR-2115-3p (MIRT502415)
- hsa-miR-4295 (MIRT502416)
- hsa-miR-454-3p (MIRT502417)
- hsa-miR-3666 (MIRT502418)
- hsa-miR-301b-3p (MIRT502419)
- hsa-miR-301a-3p (MIRT502420)
- hsa-miR-130b-3p (MIRT502421)
- hsa-miR-130a-3p (MIRT502422)
- hsa-miR-519c-3p (MIRT502423)
- hsa-miR-519b-3p (MIRT502424)
- hsa-miR-519a-3p (MIRT502425)
- hsa-miR-651-3p (MIRT502426)
- hsa-miR-6844 (MIRT557702)
- hsa-miR-6847-3p (MIRT557703)
- hsa-miR-153-5p (MIRT557704)
- hsa-miR-944 (MIRT557705)
- hsa-miR-4282 (MIRT557706)
- hsa-miR-218-5p (MIRT557707)
- hsa-miR-3611 (MIRT567467)
- hsa-miR-4289 (MIRT567468)
- hsa-miR-3910 (MIRT567469)
- hsa-miR-3714 (MIRT567470)
- hsa-miR-124-3p (MIRT567471)
- hsa-miR-506-3p (MIRT567472)
- mmu-miR-1958 (MIRT595326)
- mmu-miR-743a-3p (MIRT595327)
- mmu-miR-743b-3p (MIRT595328)
- mmu-miR-291a-3p (MIRT595329)
- mmu-miR-295-3p (MIRT595330)
- mmu-miR-302d-3p (MIRT595331)
- mmu-miR-302b-3p (MIRT595332)
- mmu-miR-294-3p (MIRT595333)
- mmu-miR-302a-3p (MIRT595334)
- mmu-miR-302c-3p (MIRT595335)
- hsa-miR-9-5p (MIRT734029)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GALNT4
- Browse OriGene Inhibitory RNA Products For GALNT4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALNT4
Clone Products
- Applied Biological Materials (abm): Clones for GALNT4 - Select products 50% OFF >
- * GALNT4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GALNT4
- Addgene plasmids for GALNT4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GALNT4
Cell Line Products
-
Horizon Cell Lines for GALNT4
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GALNT4 Gene
Localization for GALNT4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GALNT4 Gene
- Golgi apparatus membrane. Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| golgi apparatus | 4 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005794 | colocalizes_with Golgi apparatus | IDA | 12506059 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0048471 | perinuclear region of cytoplasm | IDA | 12506059 |
Pathways & Interactions for GALNT4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Mucin type O-glycan biosynthesis | ||
| 2 | Metabolism of proteins | ||
| 3 | O-linked glycosylation | ||
| 4 | Metabolism | ||
Pathways by source for GALNT4 Gene
1 BioSystems pathway for GALNT4 Gene
4 Reactome pathways for GALNT4 Gene
3 KEGG pathways for GALNT4 Gene
UniProtKB/Swiss-Prot Q8N4A0-GALT4_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for GALNT4 Gene
GPS-Prot Interaction Network for GALNT4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IEA | -- |
| GO:0016266 | O-glycan processing | TAS | -- |
| GO:0018242 | protein O-linked glycosylation via serine | IDA | 9804815 |
| GO:0018243 | protein O-linked glycosylation via threonine | IDA | 9804815 |
No data available for SIGNOR curated interactions for GALNT4 Gene
Drugs & Compounds for GALNT4 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Lactosamine |
|
13000-25-4 |
|
|||
| UDP-N-acetyl-alpha-D-galactosamine |
|
|
||||
| Uridine diphosphate-N-acetylgalactosamine |
|
7277-98-7 |
|
Transcripts for GALNT4 Gene
mRNA/cDNA for GALNT4 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000529983 5385 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GALNT4 - Select products 50% OFF >
- * GALNT4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GALNT4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GALNT4
-
Santa Cruz Biotechnology (SCBT) CRISPR for GALNT4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GALNT4
- Browse OriGene Inhibitory RNA Products For GALNT4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALNT4
Clone Products
- Applied Biological Materials (abm): Clones for GALNT4 - Select products 50% OFF >
- * GALNT4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GALNT4
- Addgene plasmids for GALNT4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GALNT4
Relevant External Links for GALNT4 Gene
- GeneLoc Exon Structure for
- GALNT4
Expression for GALNT4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
-
Colon (Gastrointestinal Tract)
-
Intestine (Gastrointestinal Tract)
This gene is overexpressed in Nasal epithelium (63.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GALNT4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GALNT4
mRNA Expression by UniProt/SwissProt for GALNT4 Gene:
Q8N4A0-GALT4_HUMAN
Tissue specificity:
Ubiquitous. Highly expressed in mucous cells.
Evidence on tissue expression from TISSUES for GALNT4 Gene
- Nervous system(4.2)
- Kidney(4.2)
Primer Products
-
OriGene qPCR primer pairs for GALNT4
-
OriGene qPCR primer pairs and template standards for GALNT4
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GALNT4 Gene
Orthologs for GALNT4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GALNT4 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | GALNT4 30 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Galnt4 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Galnt4 30 17 31 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | galnt4 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | poc1bl 30 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | GalNAc-T1 32 |
|
|
|
| CG2103 32 |
|
|
|||
| CG7297 32 |
|
|
|||
| CG7579 32 |
|
|
|||
| CG7304 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | Y39E4B.12a 32 |
|
|
|
| Y39E4B.12b 32 |
|
|
|||
| Y39E4B.12c 32 |
|
|
|||
| Y47D3A.23 32 |
|
|
|||
| Y45F10D.3 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4670 31 |
|
OneToMany |
- Species where no ortholog for GALNT4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for GALNT4 Gene
- ENSEMBL:
- Gene Tree for GALNT4 (if available)
- TreeFam:
- Gene Tree for GALNT4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GALNT4: view image
Paralogs for GALNT4 Gene
Paralogs for GALNT4 Gene
(24) SIMAP similar genes for GALNT4 Gene using alignment to 2 proteins:
- GALT4_HUMAN
- L8EA58_HUMAN
Variants for GALNT4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GALNT4 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 717686 | Benign: not provided | 89,523,764(-) | A/T | MISSENSE_VARIANT,INTRON_VARIANT | |
| 773664 | Benign: not provided | 89,523,004(-) | G/T | MISSENSE_VARIANT,INTRON_VARIANT | |
| rs863223348 | Likely Pathogenic: Childhood-Onset Schizophrenia | 89,523,356(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| rs17853610 | - | p.Asp51Gly | |||
| rs2230281 | - | p.Ile270Thr |
Residual Variation Intolerance Score:
36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.98;
84.08% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GALNT4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GALNT4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT4 Gene
Disorders for GALNT4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| nephrotic syndrome, type 3 |
|
|
Search GALNT4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GALNT4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GALNT4 Gene
Publications for GALNT4 Gene
- Genetic polymorphisms in platelet-related proteins and coronary artery disease: investigation of candidate genes, including N-acetylgalactosaminyltransferase 4 (GALNT4) and sulphotransferase 1A1/2 (SULT1A1/2). (PMID: 18259693) O'Halloran AM … Shields DC (Journal of thrombosis and thrombolysis 2009) 3 23 41
- Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat. (PMID: 9804815) Bennett EP … Clausen H (The Journal of biological chemistry 1998) 2 3 4
- The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences. (PMID: 29208955) de Las Rivas M … Hurtado-Guerrero R (Nature communications 2017) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- The lectin domain of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-T4 directs its glycopeptide specificities. (PMID: 10984485) Hassan H … Clausen H (The Journal of biological chemistry 2000) 3 4
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Products for GALNT4 Gene
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