This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem ... See more...

Aliases for GALNT4 Gene

Aliases for GALNT4 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 4 2 3 4 5
  • Polypeptide GalNAc Transferase 4 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 4 (GalNAc-T4) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 4 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 4 3 4
  • Pp-GaNTase 4 3 4
  • EC 2.4.1.41 4 51
  • GalNAc-T4 2 4
  • GALNAC-T4 3
  • GALNACT4 3
  • GALNT4 5

External Ids for GALNT4 Gene

Previous GeneCards Identifiers for GALNT4 Gene

  • GC12M089334
  • GC12M090360
  • GC12M089849
  • GC12M088419
  • GC12M088415
  • GC12M089913

Summaries for GALNT4 Gene

Entrez Gene Summary for GALNT4 Gene

  • This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon. Fusion transcripts, which combine part of this gene with the 5' exons of the neighboring POC1B (POC1 centriolar protein homolog B) gene, also exist. [provided by RefSeq, Dec 2010]

GeneCards Summary for GALNT4 Gene

GALNT4 (Polypeptide N-Acetylgalactosaminyltransferase 4) is a Protein Coding gene. Diseases associated with GALNT4 include Nephrotic Syndrome, Type 3 and Corneal Dystrophy, Posterior Amorphous. Among its related pathways are O-linked glycosylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is POC1B-GALNT4.

UniProtKB/Swiss-Prot Summary for GALNT4 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GALNT4 Gene

Genomics for GALNT4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GALNT4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GALNT4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GALNT4

Top Transcription factor binding sites by QIAGEN in the GALNT4 gene promoter:
  • CUTL1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • NRSF form 1
  • NRSF form 2
  • POU2F1
  • POU2F1a

Genomic Locations for GALNT4 Gene

Latest Assembly
chr12:89,519,412-89,524,796
(GRCh38/hg38)
Size:
5,385 bases
Orientation:
Minus strand

Previous Assembly
chr12:89,913,189-89,918,573
(GRCh37/hg19 by Entrez Gene)
Size:
5,385 bases
Orientation:
Minus strand

chr12:89,913,185-89,920,039
(GRCh37/hg19 by Ensembl)
Size:
6,855 bases
Orientation:
Minus strand

Genomic View for GALNT4 Gene

Genes around GALNT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALNT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALNT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT4 Gene

Proteins for GALNT4 Gene

  • Protein details for GALNT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4A0-GALT4_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 4
    Protein Accession:
    Q8N4A0
    Secondary Accessions:
    • B2R775
    • B4DMX6
    • O00208

    Protein attributes for GALNT4 Gene

    Size:
    578 amino acids
    Molecular mass:
    66666 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GALNT4 Gene

    Alternative splice isoforms for GALNT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNT4 Gene

Selected DME Specific Peptides for GALNT4 Gene

Q8N4A0:
  • SFRVWQCGG
  • RAAEVWMD
  • MAGGLFA
  • VVCPVID
  • AEVWMDEYK
  • LLKEIILVDD
  • PTMAGGL
  • WGGENLE
  • GWLEPLL

Post-translational modifications for GALNT4 Gene

  • Glycosylation at Asn471
  • Modification sites at PhosphoSitePlus

Other Protein References for GALNT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GALNT4 Gene

Gene Families for GALNT4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GALNT4 Gene

InterPro:
Blocks:
  • Ricin B lectin domain
  • Glycosyl transferase, family 2
ProtoNet:

Suggested Antigen Peptide Sequences for GALNT4 Gene

GenScript: Design optimal peptide antigens:
  • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4 (GALT4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N4A0

UniProtKB/Swiss-Prot:

GALT4_HUMAN :
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNT4: view

Function for GALNT4 Gene

Molecular function for GALNT4 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Evidence={ECO:0000269|PubMed:10984485, ECO:0000269|PubMed:29208955, ECO:0000269|PubMed:9804815};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Evidence={ECO:0000269|PubMed:10984485, ECO:0000269|PubMed:29208955, ECO:0000269|PubMed:9804815};.
GENATLAS Biochemistry:
galactosamine :UDP-N-acetyl alpha D polypeptide T4 transferase,widely expressed,possessing substrate specificity for fibronectin (fetal or plasma),widely expressed

Enzyme Numbers (IUBMB) for GALNT4 Gene

Phenotypes From GWAS Catalog for GALNT4 Gene

Gene Ontology (GO) - Molecular Function for GALNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IEA,IDA 9804815
GO:0005515 protein binding IPI 32814053
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0030145 manganese ion binding IDA 29208955
genes like me logo Genes that share ontologies with GALNT4: view
genes like me logo Genes that share phenotypes with GALNT4: view

Animal Models for GALNT4 Gene

MGI Knock Outs for GALNT4:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALNT4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GALNT4 Gene

Localization for GALNT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT4 Gene

Golgi apparatus membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GALNT4 gene
Compartment Confidence
extracellular 4
golgi apparatus 4
plasma membrane 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GALNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 colocalizes_with Golgi apparatus IDA 12506059
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 12506059
genes like me logo Genes that share ontologies with GALNT4: view

Pathways & Interactions for GALNT4 Gene

genes like me logo Genes that share pathways with GALNT4: view

UniProtKB/Swiss-Prot Q8N4A0-GALT4_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for GALNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0016266 O-glycan processing TAS --
GO:0018215 protein phosphopantetheinylation IEA --
GO:0018242 protein O-linked glycosylation via serine IDA 9804815
GO:0018243 protein O-linked glycosylation via threonine IDA 9804815
genes like me logo Genes that share ontologies with GALNT4: view

No data available for SIGNOR curated interactions for GALNT4 Gene

Drugs & Compounds for GALNT4 Gene

(6) Drugs for GALNT4 Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Edetic Acid Approved, Vet_approved Pharma 165
Pentetic acid Approved Pharma 165
Manganese Approved Nutra 64
Uridine 5'-diphosphate Experimental Pharma 0
Liver Extracts Pharma 6128

(3) Additional Compounds for GALNT4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lactosamine
  • 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-Amino-2-deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
13000-25-4
UDP-N-acetyl-alpha-D-galactosamine
  • (2R,3R,4R,5R,6R)-3-(Acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name)
  • UDP-GalNac
  • URIDINE-diphosphATE-N-acetylgalactosamine
  • (2R,3R,4R,5R,6R)-3-(Acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphoric acid (non-preferred name)
  • URIDINE-diphosphoric acid-N-acetylgalactosamine
Uridine diphosphate-N-acetylgalactosamine
  • Uridine diphosphoric acid-N-acetylgalactosamine
  • N-[2-({[({[3,4-dihydroxy-5-(4-hydroxy-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]ethanimidate
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT4: view

Transcripts for GALNT4 Gene

mRNA/cDNA for GALNT4 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALNT4

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT4 Gene

No ASD Table

Relevant External Links for GALNT4 Gene

GeneLoc Exon Structure for
GALNT4

Expression for GALNT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GALNT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GALNT4 Gene

This gene is overexpressed in Nasal epithelium (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GALNT4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GALNT4

mRNA Expression by UniProt/SwissProt for GALNT4 Gene:

Q8N4A0-GALT4_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in mucous cells.

Evidence on tissue expression from TISSUES for GALNT4 Gene

  • Nervous system(4.1)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with GALNT4: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GALNT4 Gene

Orthologs for GALNT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GALNT4 30
  • 99.6 (n)
Cow
(Bos Taurus)
Mammalia GALNT4 30
  • 88.68 (n)
Rat
(Rattus norvegicus)
Mammalia Galnt4 30
  • 86.33 (n)
Mouse
(Mus musculus)
Mammalia Galnt4 30 17 31
  • 85.76 (n)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 76 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 74 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 76 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia galnt4 30
  • 71.6 (n)
Zebrafish
(Danio rerio)
Actinopterygii poc1bl 30 31
  • 67.65 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta GalNAc-T1 32
  • 39 (a)
CG2103 32
  • 37 (a)
CG7297 32
  • 31 (a)
CG7579 32
  • 31 (a)
CG7304 32
  • 30 (a)
Worm
(Caenorhabditis elegans)
Secernentea Y39E4B.12a 32
  • 47 (a)
Y39E4B.12b 32
  • 46 (a)
Y39E4B.12c 32
  • 46 (a)
Y47D3A.23 32
  • 37 (a)
Y45F10D.3 32
  • 36 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4670 31
  • 61 (a)
OneToMany
Species where no ortholog for GALNT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GALNT4 Gene

ENSEMBL:
Gene Tree for GALNT4 (if available)
TreeFam:
Gene Tree for GALNT4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GALNT4: view image

Paralogs for GALNT4 Gene

Variants for GALNT4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GALNT4 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs139995124 Benign: not provided 89,523,004(-) G/T
NM_003774.5(GALNT4):c.1546C>A (p.Gln516Lys)
MISSENSE_VARIANT,INTRON
rs188465081 Benign: not provided 89,523,764(-) A/T
NM_003774.5(GALNT4):c.786T>A (p.Asn262Lys)
MISSENSE_VARIANT,INTRON
rs863223348 Likely Pathogenic: Childhood-Onset Schizophrenia 89,523,356(-) G/A
NM_003774.5(GALNT4):c.1194C>T (p.Asn398=)
SYNONYMOUS_VARIANT,INTRON
rs17853610 - p.Asp51Gly
rs2230281 - p.Ile270Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GALNT4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GALNT4 Gene

Variant ID Type Subtype PubMed ID
nsv832479 CNV gain 17160897

Variation tolerance for GALNT4 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.98; 84.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GALNT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GALNT4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT4 Gene

Disorders for GALNT4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GALNT4 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GALNT4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GALNT4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GALNT4 Gene

Publications for GALNT4 Gene

  1. Genetic polymorphisms in platelet-related proteins and coronary artery disease: investigation of candidate genes, including N-acetylgalactosaminyltransferase 4 (GALNT4) and sulphotransferase 1A1/2 (SULT1A1/2). (PMID: 18259693) O'Halloran AM … Shields DC (Journal of thrombosis and thrombolysis 2009) 3 23 41
  2. Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat. (PMID: 9804815) Bennett EP … Clausen H (The Journal of biological chemistry 1998) 2 3 4
  3. The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences. (PMID: 29208955) de Las Rivas M … Hurtado-Guerrero R (Nature communications 2017) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The lectin domain of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-T4 directs its glycopeptide specificities. (PMID: 10984485) Hassan H … Clausen H (The Journal of biological chemistry 2000) 3 4

Products for GALNT4 Gene

Sources for GALNT4 Gene