Aliases for GALNT3 Gene
- Polypeptide N-Acetylgalactosaminyltransferase 3 2 3 4 5
- Polypeptide GalNAc Transferase 3 2 3 4
- UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 3 (GalNAc-T3) 2 3
- UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 3 3 4
- Protein-UDP Acetylgalactosaminyltransferase 3 3 4
- Pp-GaNTase 3 3 4
External Ids for GALNT3 Gene
Previous GeneCards Identifiers for GALNT3 Gene
This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities. [provided by RefSeq, Jul 2008]
GeneCards Summary for GALNT3 Gene
GALNT3 (Polypeptide N-Acetylgalactosaminyltransferase 3) is a Protein Coding gene. Diseases associated with GALNT3 include Tumoral Calcinosis, Hyperphosphatemic, Familial, 1 and Hyperphosphatemia. Among its related pathways are Signaling by activated point mutants of FGFR3 and Signaling by FGFR2. Gene Ontology (GO) annotations related to this gene include calcium ion binding and transferase activity, transferring glycosyl groups. An important paralog of this gene is GALNT6.
UniProtKB/Swiss-Prot Summary for GALNT3 Gene
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis.