Aliases for GALNT14 Gene
Aliases for GALNT14 Gene
- Polypeptide N-Acetylgalactosaminyltransferase 14 2 3 3 5
- Polypeptide GalNAc Transferase 14 2 3 4
- UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 14 (GalNAc-T14) 2 3
- UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 14 3 4
- Protein-UDP Acetylgalactosaminyltransferase 14 3 4
- Pp-GaNTase 14 3 4
- UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase T10 3
External Ids for GALNT14 Gene
- HGNC: 22946
- Entrez Gene: 79623
- Ensembl: ENSG00000158089
- OMIM: 608225
- UniProtKB: Q96FL9
Previous GeneCards Identifiers for GALNT14 Gene
- GC02M031107
- GC02M031044
- GC02M030871
Summaries for GALNT14 Gene
-
This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Alterations in this gene may play a role in cancer progression and response to chemotherapy. [provided by RefSeq, Jun 2016]
GeneCards Summary for GALNT14 Gene
GALNT14 (Polypeptide N-Acetylgalactosaminyltransferase 14) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT16.
UniProtKB/Swiss-Prot for GALNT14 Gene
-
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.
Additional gene information for GALNT14 Gene
- Monarch Initiative
- Search for GALNT14 at DataMed
- Search for GALNT14 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT14 Gene
Genomics for GALNT14 Gene
GeneHancer (GH) Regulatory Elements for GALNT14 Gene
Promoters and enhancers for GALNT14 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J031137 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE | 654.9 | +23.5 | 23529 | 1.6 | SIN3A KLF14 ZNF2 ZNF335 GLIS2 ZNF143 EGR2 SMARCA5 ZNF202 SP3 | GALNT14 PIR55208 | |
| GH02J031332 | Enhancer | 1.1 | Ensembl ENCODE | 18 | -174.1 | -174066 | 7.4 | PKNOX1 FEZF1 GLI4 IRF4 ZNF213 ARID2 ZNF143 ATF7 FOS RUNX3 | GALNT14 ENSG00000234579 GC02P031291 GC02M031380 PIR52882 XDH | |
| GH02J031216 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 10.2 | -56.9 | -56932 | 4.1 | HDGF PKNOX1 BACH1 PAX8 EBF1 BATF ZIC2 IRF4 EED ETV6 | GALNT14 ENSG00000234579 CAPN14 RNA5SP90 GC02P031184 | |
| GH02J031283 | Enhancer | 0.6 | ENCODE dbSUPER | 17.5 | -122.0 | -122022 | 0.2 | JUND PKNOX1 FOS | EHD3 GALNT14 CAPN14 RPL21P70 PIR43580 | |
| GH02J031281 | Enhancer | 0.7 | ENCODE dbSUPER | 14.4 | -120.8 | -120766 | 2 | SRF GATA3 JUND JUN FOS | EHD3 GALNT14 CAPN14 RPL21P70 PIR43580 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GALNT14 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GALNT14 gene promoter:
-
- NRSF form 2
- NRSF form 1
- AREB6
- Nkx2-5
- CUTL1
- Chx10
- FOXO1
- FOXO1a
- GATA-1
- ZID
Regulatory Element Products
Genomic Locations for GALNT14 Gene
Genomic Locations for GALNT14 Gene
- chr2:30,910,465-31,161,688
- (GRCh38/hg38)
- Size:
- 251,224 bases
- Orientation:
- Minus strand
- chr2:31,133,333-31,378,068
- (GRCh37/hg19)
- Size:
- 244,736 bases
- Orientation:
- Minus strand
Genomic View for GALNT14 Gene
Genes around GALNT14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p23.1 by Entrez Gene
- 2p23.1 by HGNC
- 2p23.1 by Ensembl
GALNT14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GALNT14 Gene
Proteins for GALNT14 Gene
-
Protein details for GALNT14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96FL9-GLT14_HUMAN
- Recommended name:
- Polypeptide N-acetylgalactosaminyltransferase 14
- Protein Accession:
- Q96FL9
- B3KV89
- Q4ZG75
- Q53SU1
- Q53TJ0
- Q8IVI4
- Q9BRH1
- Q9H827
- Q9H9J8
Protein attributes for GALNT14 Gene
- Size:
- 552 amino acids
- Molecular mass:
- 64321 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB14795.1; Type=Miscellaneous discrepancy; Note=Chimeric at the C-terminus.; Evidence={ECO:0000305};
Protein Expression for GALNT14 Gene
Post-translational modifications for GALNT14 Gene
Other Protein References for GALNT14 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GALNT14
- Novus Biologicals Antibodies for GALNT14
-
Abcam antibodies for GALNT14
- Invitrogen Antibodies for GALNT14
- GeneTex GALNT14 Antibody for GALNT14
-
Boster Bio Antibodies for GALNT14
-
Santa Cruz Biotechnology (SCBT) Antibodies for GALNT14
Protein Products
- R&D Systems Proteins and Enzymes for GALNT14 (Polypeptide GalNac Transferase 14/GALNT14)
-
OriGene Purified Proteins for GALNT14
- Search Origene for MassSpec and Protein Over-expression Lysates for GALNT14
- Origene Custom Protein Services for GALNT14
- antibodies-online: Search results for 10 available GALNT14 Proteins ranked by validation data
- Compare Top GALNT14 Proteins
-
Quality Products:
- Search GeneTex for Proteins for GALNT14
-
Abcam proteins for GALNT14
Assay Products
No data available for DME Specific Peptides for GALNT14 Gene
Domains & Families for GALNT14 Gene
Gene Families for GALNT14 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for GALNT14 Gene
Suggested Antigen Peptide Sequences for GALNT14 Gene
Graphical View of Domain Structure for InterPro Entry
Q96FL9UniProtKB/Swiss-Prot:
GLT14_HUMAN :- There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
- Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
- Domain:
-
- There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
- The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
- Family:
-
- Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Function for GALNT14 Gene
Molecular function for GALNT14 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.
- UniProtKB/Swiss-Prot CatalyticActivity:
- UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
Enzyme Numbers (IUBMB) for GALNT14 Gene
Phenotypes From GWAS Catalog for GALNT14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity | TAS | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
| GO:0030246 | carbohydrate binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for GALNT14 Gene
- MGI mutant phenotypes for GALNT14:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GALNT14:
Animal Models for GALNT14 Gene
- MGI Knock Outs for GALNT14:
-
- Galnt14 Galnt14<tm1Lex>
Animal Model Products
-
Taconic Biosciences Mouse Models for GALNT14
- Cyagen custom Knockout/knockin (KOKI) mouse models for GALNT14
-
CRISPR Products
-
OriGene CRISPR knockouts for GALNT14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GALNT14
- genomics-online: gRNA clones - Search results for 128 available GALNT14 gene related products
- Overview of 128 available GALNT14 gene related products
- Applied Biological Materials CRISPR for GALNT14
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GALNT14
- GenScript: Design CRISPR guide RNA sequences for GALNT14
miRNA for GALNT14 Gene
- miRTarBase miRNAs that target GALNT14
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GALNT14
- Browse OriGene Inhibitory RNA Products For GALNT14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALNT14
- genomics-online: shRNA clones - Search results for 128 available GALNT14 gene related products
- Overview of 128 available GALNT14 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GALNT14
- VectorBuilder custom plasmid, inducible vectors for GALNT14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GALNT14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GALNT14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GALNT14
- Applied Biological Materials Clones for GALNT14
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
- ESI BIO PureStem ES-209, Meso-prx/latp Progenitor for GALNT14
-
Horizon Cell Lines for GALNT14
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GALNT14 Gene
Localization for GALNT14 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GALNT14 Gene
- Golgi apparatus membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| plasma membrane | 3 |
| extracellular | 1 |
| endoplasmic reticulum | 1 |
- Golgi apparatus (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IBA,IEA | -- |
| GO:0016020 | membrane | IEA,IBA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for GALNT14 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism of proteins | ||
| 2 | O-linked glycosylation | ||
| 3 | Metabolism | ||
| 4 | Mucin type O-glycan biosynthesis | ||
Pathways by source for GALNT14 Gene
4 Reactome pathways for GALNT14 Gene
2 KEGG pathways for GALNT14 Gene
UniProtKB/Swiss-Prot Q96FL9-GLT14_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for GALNT14 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| C1GALT1 | ||
| C1GALT1C1 | ||
| MUC5B | ||
| MUC7 | ||
| ST6GALNAC1 |
GPS-Prot Interaction Network for GALNT14
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IEA | -- |
| GO:0009312 | oligosaccharide biosynthetic process | IBA | -- |
| GO:0016266 | O-glycan processing | TAS | -- |
| GO:0018242 | protein O-linked glycosylation via serine | IBA | -- |
| GO:0018243 | protein O-linked glycosylation via threonine | IBA | -- |
No data available for SIGNOR curated interactions for GALNT14 Gene
Drugs & Compounds for GALNT14 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cisplatin | Approved | Pharma | Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 | 2906 | ||
| Fluorouracil | Approved | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor | 1970 | ||
| Mitoxantrone | Approved, Investigational | Pharma | 275 | |||
| calcium | Approved | Nutra | 0 | |||
| Manganese | Approved | Nutra | 37 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Lactosamine |
|
13000-25-4 |
|
|||
| UDP-N-acetyl-alpha-D-galactosamine |
|
|
||||
| Uridine diphosphate-N-acetylgalactosamine |
|
7277-98-7 |
|
Drug Products
Transcripts for GALNT14 Gene
mRNA/cDNA for GALNT14 Gene
- (8) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (124) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000324589 2169 bps (uc002rns.4)
- ENST00000349752 2733 bps (uc002rnr.4)
- ENST00000406653 2496 bps (uc002rnq.4)
- ENST00000475320 844 bps (uc061hwb.1)
- ENST00000486564 1045 bps (uc061hwc.1)
Unigene Clusters for GALNT14 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GALNT14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GALNT14
- genomics-online: gRNA clones - Search results for 128 available GALNT14 gene related products
- Overview of 128 available GALNT14 gene related products
- Applied Biological Materials CRISPR for GALNT14
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GALNT14
- GenScript: Design CRISPR guide RNA sequences for GALNT14
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GALNT14
- Browse OriGene Inhibitory RNA Products For GALNT14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALNT14
- genomics-online: shRNA clones - Search results for 128 available GALNT14 gene related products
- Overview of 128 available GALNT14 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GALNT14
- VectorBuilder custom plasmid, inducible vectors for GALNT14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GALNT14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GALNT14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GALNT14
- Applied Biological Materials Clones for GALNT14
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 21b | · | 21c |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: |
Expression for GALNT14 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
- Eye (Sensory Organs)
-
Spinal Cord (Nervous System)
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for GALNT14 Gene
This gene is overexpressed in Whole Blood (x10.2), Kidney - Cortex (x9.6), and Esophagus - Mucosa (x5.1).
This gene is overexpressed in Skin (60.3) and Peripheral blood mononuclear cells (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GALNT14 Gene
NURSA nuclear receptor signaling pathways regulating expression of GALNT14 Gene:
GALNT14SOURCE GeneReport for Unigene cluster for GALNT14 Gene:
Hs.468058mRNA Expression by UniProt/SwissProt for GALNT14 Gene:
Q96FL9-GLT14_HUMAN
Tissue specificity:
Detected in renal tubules (at protein level). Highly expressed in fetal and adult kidney. Widely expressed at low level. Weakly expressed in whole brain, cerebellum, thymus, lung, mammary gland, liver, stomach, small intestine, colon, pancreas, spleen, bladder, uterus, placenta, testis, ovary, skeletal muscle, leukocyte, B-cell, bone marrow, fetal brain, fetal thymus, fetal lung, fetal liver, fetal small intestine, fetal spleen, fetal skeletal and fetus. Detected in renal tubules (at protein level).
Evidence on tissue expression from TISSUES for GALNT14 Gene
- Nervous system(4.7)
- Eye(4.2)
- Stomach(4.1)
- Kidney(3.7)
Primer Products
-
OriGene qPCR primer pairs and template standards for GALNT14
-
OriGene qPCR primer pairs for GALNT14
- genomics-online: primer clones - Search results for 128 available GALNT14 gene related products
- Overview of 128 available GALNT14 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GALNT14 Gene
Orthologs for GALNT14 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GALNT14 33 |
|
||
| dog (Canis familiaris) |
Mammalia | GALNT14 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GALNT14 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Galnt14 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Galnt14 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GALNT14 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GALNT14 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GALNT14 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GALNT14 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | galnt14 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | galnt14 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | pgant2 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | gly-4 34 |
|
ManyToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10774 34 |
|
OneToMany |
- Species where no ortholog for GALNT14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for GALNT14 Gene
- ENSEMBL:
- Gene Tree for GALNT14 (if available)
- TreeFam:
- Gene Tree for GALNT14 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GALNT14: view image
Paralogs for GALNT14 Gene
Paralogs for GALNT14 Gene
(23) SIMAP similar genes for GALNT14 Gene using alignment to 5 proteins:
- GLT14_HUMAN
- F5H263_HUMAN
- H7C168_HUMAN
- H7C1E3_HUMAN
- J3KQQ5_HUMAN
Variants for GALNT14 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs201118996 | likely-pathogenic, Non-immune hydrops fetalis | 30,924,226(-) | G/A | coding_sequence_variant, intron_variant, non_coding_transcript_variant, stop_gained | |
| rs1000000004 | -- | 31,032,286(-) | T/C | intron_variant | |
| rs1000001129 | -- | 31,012,765(-) | A/G | intron_variant | |
| rs1000013900 | -- | 31,067,320(-) | C/A | intron_variant | |
| rs1000014359 | -- | 30,948,915(-) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1880n106 | CNV | deletion | 24896259 |
| dgv690e199 | CNV | deletion | 23128226 |
| esv1683223 | CNV | deletion | 17803354 |
| esv22531 | CNV | loss | 19812545 |
| esv2674441 | CNV | deletion | 23128226 |
| esv2719868 | CNV | deletion | 23290073 |
| esv2719869 | CNV | deletion | 23290073 |
| esv2719870 | CNV | deletion | 23290073 |
| esv2719871 | CNV | deletion | 23290073 |
| esv2845014 | CNV | deletion | 24192839 |
| esv3554489 | CNV | deletion | 23714750 |
| esv3567 | CNV | loss | 18987735 |
| esv3590211 | CNV | loss | 21293372 |
| esv3590212 | CNV | loss | 21293372 |
| esv3590213 | CNV | loss | 21293372 |
| esv3590215 | CNV | loss | 21293372 |
| nsv1071985 | CNV | deletion | 25765185 |
| nsv1127717 | CNV | deletion | 24896259 |
| nsv833659 | CNV | gain | 17160897 |
| nsv955061 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.65;
86.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GALNT14 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT14 Gene
Disorders for GALNT14 Gene
Additional Disease Information for GALNT14
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GALNT14 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALNT14 Gene
Publications for GALNT14 Gene
- Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14. (PMID: 12507512) Wang H … Narimatsu H (Biochemical and biophysical research communications 2003) 2 3 4 58
- Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa JR … Partners in Prevention HSV/HIV Transmission Study Team (PloS one 2011) 3 44 58
- Development of immunohistochemistry assays to assess GALNT14 and FUT3/6 in clinical trials of dulanermin and drozitumab. (PMID: 20179215) Stern HM … Ashkenazi A (Clinical cancer research : an official journal of the American Association for Cancer Research 2010) 3 4 58
- N-Acetylgalactosaminyltransferase-14 as a potential biomarker for breast cancer by immunohistochemistry. (PMID: 20356418) Wu C … Zhu M (BMC cancer 2010) 3 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
Products for GALNT14 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for GALNT14
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- ESI BIO PureStem ES-209, Meso-prx/latp Progenitor for GALNT14
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- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for GALNT14
- Cyagen custom Knockout/knockin (KOKI) mouse models for GALNT14
- VectorBuilder custom plasmid, inducible vectors for GALNT14
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
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- Addgene plasmids for GALNT14
- antibodies-online: Search results for 62 available GALNT14 Antibodies ranked by validation data
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- antibodies-online: Search results for 10 available GALNT14 Proteins ranked by validation data
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- Quality Products:
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- Santa Cruz Biotechnology (SCBT) Antibodies for GALNT14
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- Horizon Cell Lines for GALNT14
- genomics-online: cdna clones - Search results for 128 available GALNT14 gene related products
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- Overview of 128 available GALNT14 gene related products
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- Overview of 128 available GALNT14 gene related products
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GALNT14
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- Boster Bio Antibodies for GALNT14
- Browse Boster Bio ELISA Kits
Sources for GALNT14 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt