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This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Alterations in this gene may play a role in cancer progression and response to chemotherapy. [provided by RefSeq, Jun 2016]
GALNT14 (Polypeptide N-Acetylgalactosaminyltransferase 14) is a Protein Coding gene. Among its related pathways are Mucin type O-glycan biosynthesis and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT16.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
GO:0030246 | carbohydrate binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005794 | Golgi apparatus | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Mucin type O-glycan biosynthesis | ||
2 | Metabolism of proteins | ||
3 | O-linked glycosylation | ||
4 | Metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006486 | protein glycosylation | IEA | -- |
GO:0016266 | O-glycan processing | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Cisplatin | Approved | Pharma | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 3412 | ||
Fluorouracil | Approved | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor | 2338 | ||
Mitoxantrone | Approved, Investigational | Pharma | 299 | |||
Sorafenib | Approved, Investigational | Pharma | Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 779 | ||
Manganese | Approved | Nutra | 56 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Lactosamine |
|
13000-25-4 |
|
|||
UDP-N-acetyl-alpha-D-galactosamine |
|
|
||||
Uridine diphosphate-N-acetylgalactosamine |
|
7277-98-7 |
|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP8: |
ExUns: | 21b | · | 21c |
---|---|---|---|
SP1: | |||
SP2: | |||
SP3: | |||
SP4: | |||
SP5: | |||
SP6: | |||
SP7: | |||
SP8: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GALNT14 30 |
|
||
Dog (Canis familiaris) |
Mammalia | GALNT14 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GALNT14 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Galnt14 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Galnt14 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GALNT14 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GALNT14 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GALNT14 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GALNT14 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | galnt14 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | galnt14 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | pgant2 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | gly-4 31 |
|
ManyToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10774 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
777990 | Benign: not provided | 30,955,678(-) | G/A | SYNONYMOUS_VARIANT | |
782736 | Benign: not provided | 30,955,749(-) | G/A | INTRON_VARIANT | |
788391 | Benign: not provided | 30,912,229(-) | G/A | MISSENSE_VARIANT,SYNONYMOUS_VARIANT | |
788392 | Benign: not provided | 30,992,932(-) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
rs201118996 | Likely Pathogenic: Non-immune hydrops fetalis | 30,924,226(-) | G/A | NONSENSE,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1880n106 | CNV | deletion | 24896259 |
dgv690e199 | CNV | deletion | 23128226 |
esv1683223 | CNV | deletion | 17803354 |
esv22531 | CNV | loss | 19812545 |
esv2674441 | CNV | deletion | 23128226 |
esv2719868 | CNV | deletion | 23290073 |
esv2719869 | CNV | deletion | 23290073 |
esv2719870 | CNV | deletion | 23290073 |
esv2719871 | CNV | deletion | 23290073 |
esv2845014 | CNV | deletion | 24192839 |
esv3554489 | CNV | deletion | 23714750 |
esv3567 | CNV | loss | 18987735 |
esv3590211 | CNV | loss | 21293372 |
esv3590212 | CNV | loss | 21293372 |
esv3590213 | CNV | loss | 21293372 |
esv3590215 | CNV | loss | 21293372 |
nsv1071985 | CNV | deletion | 25765185 |
nsv1127717 | CNV | deletion | 24896259 |
nsv833659 | CNV | gain | 17160897 |
nsv955061 | CNV | deletion | 24416366 |
No disorders were found for GALNT14 Gene.