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This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Alterations in thi... See more...
Aliases for GALNT14 Gene
Aliases for GALNT14 Gene
- Polypeptide N-Acetylgalactosaminyltransferase 14 2 3 4 5
- Polypeptide GalNAc Transferase 14 2 3 4
- UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 14 (GalNAc-T14) 2 3
- UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 14 3 4
- Protein-UDP Acetylgalactosaminyltransferase 14 3 4
- Pp-GaNTase 14 3 4
- EC 2.4.1.41 4 51
External Ids for GALNT14 Gene
- HGNC: 22946
- Entrez Gene: 79623
- Ensembl: ENSG00000158089
- OMIM: 608225
- UniProtKB: Q96FL9
Previous GeneCards Identifiers for GALNT14 Gene
- GC02M031107
- GC02M031044
- GC02M030871
- GC02M030910
Summaries for GALNT14 Gene
-
This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Alterations in this gene may play a role in cancer progression and response to chemotherapy. [provided by RefSeq, Jun 2016]
GeneCards Summary for GALNT14 Gene
GALNT14 (Polypeptide N-Acetylgalactosaminyltransferase 14) is a Protein Coding gene. Among its related pathways are Mucin type O-glycan biosynthesis and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT16.
UniProtKB/Swiss-Prot Summary for GALNT14 Gene
-
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.
Additional gene information for GALNT14 Gene
- HGNC(22946)
- Entrez Gene(79623)
- Ensembl(ENSG00000158089)
- OMIM(608225)
- UniProtKB(Q96FL9)
- Open Targets Platform(ENSG00000158089)
- Monarch Initiative
- Search for GALNT14 at DataMed
- Search for GALNT14 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GALNT14 Gene
Genomics for GALNT14 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GALNT14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GALNT14 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GALNT14
- Top Transcription factor binding sites by QIAGEN in the GALNT14 gene promoter:
-
- AREB6
- Chx10
- CUTL1
- FOXO1
- FOXO1a
- GATA-1
- Nkx2-5
- NRSF form 1
- NRSF form 2
- ZID
Genomic Locations for GALNT14 Gene
Genomic Locations for GALNT14 Gene
- chr2:30,888,518-31,155,202
- (GRCh38/hg38)
- Size:
- 266,685 bases
- Orientation:
- Minus strand
- chr2:31,133,333-31,378,068
- (GRCh37/hg19)
- Size:
- 244,736 bases
- Orientation:
- Minus strand
Genomic View for GALNT14 Gene
Genes around GALNT14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p23.1 by HGNC
- 2p23.1 by Entrez Gene
- 2p23.1 by Ensembl
GALNT14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GALNT14 Gene
Proteins for GALNT14 Gene
-
Protein details for GALNT14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96FL9-GLT14_HUMAN
- Recommended name:
- Polypeptide N-acetylgalactosaminyltransferase 14
- Protein Accession:
- Q96FL9
- B3KV89
- Q4ZG75
- Q53SU1
- Q53TJ0
- Q8IVI4
- Q9BRH1
- Q9H827
- Q9H9J8
Protein attributes for GALNT14 Gene
- Size:
- 552 amino acids
- Molecular mass:
- 64321 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB14795.1; Type=Miscellaneous discrepancy; Note=Chimeric at the C-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 1]: Major isoform.
- [Isoform 3]: Minor isoform.
Protein Expression for GALNT14 Gene
Selected DME Specific Peptides for GALNT14 Gene
- Q96FL9:
-
- VVCPVID
- VGHVFRK
- AEVWMDEYK
- CGGSLEI
- FLDSHCE
- WYLENIYP
- MDIWGGEN
- CQSFKWYL
- PCSRVGH
Post-translational modifications for GALNT14 Gene
Other Protein References for GALNT14 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GALNT14
- Novus Biologicals Antibodies for GALNT14
-
Abcam antibodies for GALNT14
- Invitrogen Antibodies for GALNT14 (AFLGC-Galnt14)
-
Biorbyt antibodies for GALNT14
-
Santa Cruz Biotechnology (SCBT) Antibodies for GALNT14
Protein Products
-
OriGene Purified Proteins for GALNT14
- Search Origene for MassSpec and Protein Over-expression Lysates for GALNT14
- Origene Custom Protein Services for GALNT14
- antibodies-online: Show 10 available GALNT14 Proteins ranked by validation data
- Compare Top GALNT14 Proteins
-
Quality Products:
-
Signalway Proteins for GALNT14
-
Abcam proteins for GALNT14
Domains & Families for GALNT14 Gene
Gene Families for GALNT14 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for GALNT14 Gene
- InterPro:
- Blocks:
-
- Ricin B lectin domain
- Glycosyl transferase, family 2
- ProtoNet:
Suggested Antigen Peptide Sequences for GALNT14 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ16272 fis, clone NT2NE2018916, highly similar to Polypeptide N-acetylgalactosaminyltransferase 14 (EC 2.4.1.41) (B3KV89_HUMAN)
- UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14 (GLT14_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96FL9UniProtKB/Swiss-Prot:
GLT14_HUMAN :- There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
- Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
- Domain:
-
- There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
- The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
- Family:
-
- Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Function for GALNT14 Gene
Molecular function for GALNT14 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Evidence={ECO:0000269|PubMed:12507512};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Evidence={ECO:0000269|PubMed:12507512};.
Enzyme Numbers (IUBMB) for GALNT14 Gene
Phenotypes From GWAS Catalog for GALNT14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
| GO:0030246 | carbohydrate binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for GALNT14 Gene
- MGI mutant phenotypes for GALNT14:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GALNT14:
Animal Models for GALNT14 Gene
- MGI Knock Outs for GALNT14:
-
- Galnt14 Galnt14<tm1Lex>
Animal Model Products
-
Taconic Biosciences Mouse Models for GALNT14
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GALNT14 - Select products 50% OFF >
- * GALNT14 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GALNT14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GALNT14
-
Santa Cruz Biotechnology (SCBT) CRISPR for GALNT14
miRNA for GALNT14 Gene
- miRTarBase miRNAs that target GALNT14
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GALNT14
- Browse OriGene Inhibitory RNA Products For GALNT14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALNT14
Clone Products
- Applied Biological Materials (abm): Clones for GALNT14 - Select products 50% OFF >
- * GALNT14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GALNT14
- Addgene plasmids for GALNT14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GALNT14
Cell Line Products
- ESI BIO PureStem ES-209, Meso-prx/latp Progenitor for GALNT14
-
Horizon Cell Lines for GALNT14
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GALNT14 Gene
Localization for GALNT14 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GALNT14 Gene
- Golgi apparatus membrane. Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| plasma membrane | 3 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Golgi apparatus (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for GALNT14 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Mucin type O-glycan biosynthesis | ||
| 2 | Metabolism of proteins | ||
| 3 | O-linked glycosylation | ||
| 4 | Metabolism | ||
Pathways by source for GALNT14 Gene
4 Reactome pathways for GALNT14 Gene
3 KEGG pathways for GALNT14 Gene
UniProtKB/Swiss-Prot Q96FL9-GLT14_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for GALNT14 Gene
GPS-Prot Interaction Network for GALNT14
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IEA | -- |
| GO:0016266 | O-glycan processing | TAS | -- |
No data available for SIGNOR curated interactions for GALNT14 Gene
Drugs & Compounds for GALNT14 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cisplatin | Approved | Pharma | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 3412 | ||
| Fluorouracil | Approved | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor | 2338 | ||
| Mitoxantrone | Approved, Investigational | Pharma | 299 | |||
| Sorafenib | Approved, Investigational | Pharma | Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 779 | ||
| Manganese | Approved | Nutra | 56 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Lactosamine |
|
13000-25-4 |
|
|||
| UDP-N-acetyl-alpha-D-galactosamine |
|
|
||||
| Uridine diphosphate-N-acetylgalactosamine |
|
7277-98-7 |
|
Transcripts for GALNT14 Gene
mRNA/cDNA for GALNT14 Gene
- 6 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000324589 2169 nts (view in UCSC)
- ENST00000349752 2447 nts (view in UCSC)
- ENST00000406653 2496 nts (view in UCSC)
- ENST00000424136 735 nts (view in UCSC)
- ENST00000430167 1619 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GALNT14 - Select products 50% OFF >
- * GALNT14 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GALNT14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GALNT14
-
Santa Cruz Biotechnology (SCBT) CRISPR for GALNT14
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GALNT14
- Browse OriGene Inhibitory RNA Products For GALNT14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALNT14
Clone Products
- Applied Biological Materials (abm): Clones for GALNT14 - Select products 50% OFF >
- * GALNT14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GALNT14
- Addgene plasmids for GALNT14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GALNT14
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 21b | · | 21c |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: |
Relevant External Links for GALNT14 Gene
- GeneLoc Exon Structure for
- GALNT14
Expression for GALNT14 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
- Eye (Sensory Organs)
-
Spinal Cord (Nervous System)
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for GALNT14 Gene
This gene is overexpressed in Whole Blood (x10.2), Kidney - Cortex (x9.6), and Esophagus - Mucosa (x5.1).
This gene is overexpressed in Skin (60.3) and Peripheral blood mononuclear cells (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GALNT14 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GALNT14
SOURCE GeneReport for Unigene cluster for GALNT14 Gene:
Hs.468058mRNA Expression by UniProt/SwissProt for GALNT14 Gene:
Q96FL9-GLT14_HUMAN
Tissue specificity:
Detected in renal tubules (at protein level). Highly expressed in fetal and adult kidney. Widely expressed at low level. Weakly expressed in whole brain, cerebellum, thymus, lung, mammary gland, liver, stomach, small intestine, colon, pancreas, spleen, bladder, uterus, placenta, testis, ovary, skeletal muscle, leukocyte, B-cell, bone marrow, fetal brain, fetal thymus, fetal lung, fetal liver, fetal small intestine, fetal spleen, fetal skeletal and fetus. Detected in renal tubules (at protein level).
Evidence on tissue expression from TISSUES for GALNT14 Gene
- Nervous system(4.7)
- Stomach(4.3)
- Eye(4.2)
- Kidney(4)
- Liver(2.4)
- Intestine(2.2)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for GALNT14
-
OriGene qPCR primer pairs and template standards for GALNT14
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GALNT14 Gene
Orthologs for GALNT14 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GALNT14 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | GALNT14 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GALNT14 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Galnt14 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Galnt14 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GALNT14 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | GALNT14 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | GALNT14 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GALNT14 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | galnt14 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | galnt14 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | pgant2 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | gly-4 31 |
|
ManyToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10774 31 |
|
OneToMany |
- Species where no ortholog for GALNT14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for GALNT14 Gene
- ENSEMBL:
- Gene Tree for GALNT14 (if available)
- TreeFam:
- Gene Tree for GALNT14 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GALNT14: view image
Paralogs for GALNT14 Gene
Paralogs for GALNT14 Gene
(23) SIMAP similar genes for GALNT14 Gene using alignment to 5 proteins:
- GLT14_HUMAN
- F5H263_HUMAN
- H7C168_HUMAN
- H7C1E3_HUMAN
- J3KQQ5_HUMAN
Variants for GALNT14 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GALNT14 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 777990 | Benign: not provided | 30,955,678(-) | G/A | SYNONYMOUS_VARIANT | |
| 782736 | Benign: not provided | 30,955,749(-) | G/A | INTRON_VARIANT | |
| 788391 | Benign: not provided | 30,912,229(-) | G/A | MISSENSE_VARIANT,SYNONYMOUS_VARIANT | |
| 788392 | Benign: not provided | 30,992,932(-) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
| rs201118996 | Likely Pathogenic: Non-immune hydrops fetalis | 30,924,226(-) | G/A | NONSENSE,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1880n106 | CNV | deletion | 24896259 |
| dgv690e199 | CNV | deletion | 23128226 |
| esv1683223 | CNV | deletion | 17803354 |
| esv22531 | CNV | loss | 19812545 |
| esv2674441 | CNV | deletion | 23128226 |
| esv2719868 | CNV | deletion | 23290073 |
| esv2719869 | CNV | deletion | 23290073 |
| esv2719870 | CNV | deletion | 23290073 |
| esv2719871 | CNV | deletion | 23290073 |
| esv2845014 | CNV | deletion | 24192839 |
| esv3554489 | CNV | deletion | 23714750 |
| esv3567 | CNV | loss | 18987735 |
| esv3590211 | CNV | loss | 21293372 |
| esv3590212 | CNV | loss | 21293372 |
| esv3590213 | CNV | loss | 21293372 |
| esv3590215 | CNV | loss | 21293372 |
| nsv1071985 | CNV | deletion | 25765185 |
| nsv1127717 | CNV | deletion | 24896259 |
| nsv833659 | CNV | gain | 17160897 |
| nsv955061 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.65;
86.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GALNT14 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT14 Gene
Disorders for GALNT14 Gene
Additional Disease Information for GALNT14
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for GALNT14 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALNT14 Gene
Publications for GALNT14 Gene
- Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14. (PMID: 12507512) Wang H … Narimatsu H (Biochemical and biophysical research communications 2003) 2 3 4
- Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa JR … Partners in Prevention HSV/HIV Transmission Study Team (PloS one 2011) 3 41
- Development of immunohistochemistry assays to assess GALNT14 and FUT3/6 in clinical trials of dulanermin and drozitumab. (PMID: 20179215) Stern HM … Ashkenazi A (Clinical cancer research : an official journal of the American Association for Cancer Research 2010) 3 4
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
ExternalLinks
Products for GALNT14 Gene
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- Biorbyt antibodies for GALNT14
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Sources for GALNT14 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (44) Atlas
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- (48) IMGT
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- (50) miRBase
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- (53) PubMed
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- (55) TGDB
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- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
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- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
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- (100) DGIdb
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- (104) diseasecard
- (105) NIH Rare Diseases
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- (178) MirGeneDB