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Aliases for GALNT10 Gene

Aliases for GALNT10 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 10 2 3 5
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 10 (GalNAc-T10) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 10 3 4
  • Polypeptide GalNAc Transferase 10 2 4
  • EC 2.4.1.41 4 56
  • Protein-UDP Acetylgalactosaminyltransferase 10 4
  • GalNAc Transferase 10 3
  • Pp-GaNTase 10 4
  • PPGALNACT10 3
  • PPGANTASE10 3
  • GalNAc-T10 4
  • GALNACT10 3

External Ids for GALNT10 Gene

Previous GeneCards Identifiers for GALNT10 Gene

  • GC05P153553
  • GC05P153598
  • GC05P153550
  • GC05P148711

Summaries for GALNT10 Gene

Entrez Gene Summary for GALNT10 Gene

  • This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010]

GeneCards Summary for GALNT10 Gene

GALNT10 (Polypeptide N-Acetylgalactosaminyltransferase 10) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and O-linked glycosylation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNTL6.

UniProtKB/Swiss-Prot for GALNT10 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.

Additional gene information for GALNT10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT10 Gene

Genomics for GALNT10 Gene

GeneHancer (GH) Regulatory Elements for GALNT10 Gene

Promoters and enhancers for GALNT10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I154189 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 560.4 -0.1 -80 2.4 HDGF PKNOX1 ARNT SIN3A ZNF2 ZBTB7B POLR2B ZNF213 ZNF207 ZNF143 GALNT10 GC05M154138 GC05M154064 MFAP3
GH05I154191 Enhancer 0.3 ENCODE 550.8 +1.2 1206 0.2 ZBTB17 GALNT10 PIR61110 GC05M154138 MFAP3
GH05I154276 Enhancer 0.9 Ensembl ENCODE 20.1 +86.5 86502 2.4 HDAC1 ZNF316 BRD9 POLR2A FOSL2 FOS NFE2 ATF7 MAFK CEBPB GALNT10 GC05M154291 GC05M154138 PIR61110
GH05I154272 Enhancer 0.8 Ensembl ENCODE 22.5 +82.8 82843 2.9 ATF1 TEAD2 MAFG GABPA MAFF ZNF316 GATA3 POLR2A GABPB1 IKZF1 GALNT10 GC05M154291 GC05M154138 PIR61110
GH05I154219 Enhancer 0.8 Ensembl ENCODE 22.1 +30.6 30550 3.5 FOSL1 JUND ZNF316 POLR2A ZFP36 FOSL2 FOS MAFK ZNF7 GALNT10 PIR61110 GC05M154138 GC05M154291 MFAP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GALNT10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GALNT10 gene promoter:

Genomic Locations for GALNT10 Gene

Genomic Locations for GALNT10 Gene
chr5:154,190,730-154,420,984
(GRCh38/hg38)
Size:
230,255 bases
Orientation:
Plus strand
chr5:153,570,290-153,800,544
(GRCh37/hg19)

Genomic View for GALNT10 Gene

Genes around GALNT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALNT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALNT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT10 Gene

Proteins for GALNT10 Gene

  • Protein details for GALNT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SR1-GLT10_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 10
    Protein Accession:
    Q86SR1
    Secondary Accessions:
    • B3KXC9
    • Q6IN56
    • Q86VP8
    • Q8IXJ2
    • Q8TEJ2
    • Q96IV2
    • Q9H8E1
    • Q9Y4M4

    Protein attributes for GALNT10 Gene

    Size:
    603 amino acids
    Molecular mass:
    68992 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14676.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GALNT10 Gene

    Alternative splice isoforms for GALNT10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNT10 Gene

Selected DME Specific Peptides for GALNT10 Gene

Q86SR1:
  • LLRTVHS
  • DCHSMKGNQL
  • WREDIRPG
  • MAGGLFA
  • SPVTLYDCH
  • IVCPMID
  • IWGGEQYE
  • SLARNLKRVAE
  • FWELGGYD
  • AYRENGFNI
  • AEYIYQRRPEYRHLS
  • VHSVLNRSPP
  • LNRSLPD
  • LPNTSIIIPFHNEGW
  • SFKVWMCGG
  • FLDSHCE
  • SDREHLK
  • NCKSFKWFM
  • RVAEVWMD
  • QAGDAMRGAFDWEMYYKRIPIPPELQ
  • KREGLIR
  • PCSRVGH

Post-translational modifications for GALNT10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GALNT10 Gene

Domains & Families for GALNT10 Gene

Gene Families for GALNT10 Gene

Graphical View of Domain Structure for InterPro Entry

Q86SR1

UniProtKB/Swiss-Prot:

GLT10_HUMAN :
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNT10: view

Function for GALNT10 Gene

Molecular function for GALNT10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.

Enzyme Numbers (IUBMB) for GALNT10 Gene

Phenotypes From GWAS Catalog for GALNT10 Gene

Gene Ontology (GO) - Molecular Function for GALNT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT10: view
genes like me logo Genes that share phenotypes with GALNT10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GALNT10

miRNA for GALNT10 Gene

miRTarBase miRNAs that target GALNT10

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GALNT10 Gene

Localization for GALNT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT10 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GALNT10 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GALNT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GALNT10: view

Pathways & Interactions for GALNT10 Gene

genes like me logo Genes that share pathways with GALNT10: view

Pathways by source for GALNT10 Gene

UniProtKB/Swiss-Prot Q86SR1-GLT10_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for GALNT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006493 protein O-linked glycosylation IDA 12417297
GO:0016266 O-glycan processing IDA,TAS --
genes like me logo Genes that share ontologies with GALNT10: view

No data available for SIGNOR curated interactions for GALNT10 Gene

Drugs & Compounds for GALNT10 Gene

(3) Drugs for GALNT10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Manganese Approved Nutra 37
Uridine-5'-Diphosphate Experimental Pharma 0

(3) Additional Compounds for GALNT10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lactosamine
  • 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-Amino-2-deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
13000-25-4
UDP-N-acetyl-alpha-D-galactosamine
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT10: view

Transcripts for GALNT10 Gene

mRNA/cDNA for GALNT10 Gene

Unigene Clusters for GALNT10 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for GALNT10 Gene

GeneLoc Exon Structure for
GALNT10
ECgene alternative splicing isoforms for
GALNT10

Expression for GALNT10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GALNT10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GALNT10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.2), Adipocyte (10.5), and Ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GALNT10 Gene



NURSA nuclear receptor signaling pathways regulating expression of GALNT10 Gene:

GALNT10

SOURCE GeneReport for Unigene cluster for GALNT10 Gene:

Hs.631797

mRNA Expression by UniProt/SwissProt for GALNT10 Gene:

Q86SR1-GLT10_HUMAN
Tissue specificity: Widely expressed. Expressed at high level in small intestine, and at intermediate levels in stomach, pancreas, ovary, thyroid gland and spleen. Weakly expressed in other tissues.

Evidence on tissue expression from TISSUES for GALNT10 Gene

  • Nervous system(4.5)
  • Kidney(4.2)
  • Spleen(4.2)
  • Skin(4.1)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with GALNT10: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GALNT10 Gene

Orthologs for GALNT10 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNT10 33 34
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia GALNT10 33 34
  • 91.87 (n)
cow
(Bos Taurus)
Mammalia GALNT10 33 34
  • 90.71 (n)
mouse
(Mus musculus)
Mammalia Galnt10 33 16 34
  • 88.67 (n)
rat
(Rattus norvegicus)
Mammalia Galnt10 33
  • 88.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT10 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GALNT10 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves GALNT10 33 34
  • 80.1 (n)
lizard
(Anolis carolinensis)
Reptilia GALNT10 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt10 33
  • 70.56 (n)
zebrafish
(Danio rerio)
Actinopterygii Dr.12540 33
fruit fly
(Drosophila melanogaster)
Insecta pgant6 33 34
  • 56.59 (n)
pgant4 34
  • 39 (a)
ManyToMany
CG31776 34
  • 33 (a)
ManyToMany
pgant8 34
  • 33 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010367 33
  • 52.04 (n)
worm
(Caenorhabditis elegans)
Secernentea gly-10 33 34
  • 54.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToMany
Species where no ortholog for GALNT10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT10 Gene

ENSEMBL:
Gene Tree for GALNT10 (if available)
TreeFam:
Gene Tree for GALNT10 (if available)

Paralogs for GALNT10 Gene

Variants for GALNT10 Gene

Sequence variations from dbSNP and Humsavar for GALNT10 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000006629 -- 154,406,601(+) A/AA intron_variant
rs1000009747 -- 154,246,494(+) T/C intron_variant
rs1000017424 -- 154,383,886(+) ACTGCCTGAGACTG/ACTG intron_variant
rs1000055865 -- 154,349,007(+) C/T intron_variant
rs1000117184 -- 154,355,236(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GALNT10 Gene

Variant ID Type Subtype PubMed ID
dgv5820n100 CNV gain 25217958
esv23918 CNV loss 19812545
esv2582402 CNV insertion 19546169
esv2662546 CNV deletion 23128226
esv2730934 CNV deletion 23290073
esv2730935 CNV deletion 23290073
esv3323048 CNV insertion 20981092
esv3360575 CNV insertion 20981092
esv3444196 CNV duplication 20981092
esv3575889 CNV gain 25503493
esv3575890 CNV gain 25503493
esv3607239 CNV loss 21293372
nsv1015362 CNV gain 25217958
nsv1137536 CNV deletion 24896259
nsv475805 CNV novel sequence insertion 20440878
nsv5079 CNV insertion 18451855
nsv5080 CNV insertion 18451855
nsv521696 CNV loss 19592680
nsv524343 CNV loss 19592680
nsv830520 CNV loss 17160897
nsv964964 CNV duplication 23825009

Variation tolerance for GALNT10 Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GALNT10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GALNT10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT10 Gene

Disorders for GALNT10 Gene

Additional Disease Information for GALNT10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GALNT10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALNT10 Gene

Publications for GALNT10 Gene

  1. Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10. (PMID: 12417297) Cheng L … Narimatsu H (FEBS letters 2002) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Prognostic role of N-Acetylgalactosaminyltransferase 10 in metastatic renal cell carcinoma. (PMID: 28122358) Liu L … Guo J (Oncotarget 2017) 3 58

Products for GALNT10 Gene

Sources for GALNT10 Gene

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