Aliases for GALNT10 Gene
External Ids for GALNT10 Gene
Previous GeneCards Identifiers for GALNT10 Gene
This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010]
GeneCards Summary for GALNT10 Gene
GALNT10 (Polypeptide N-Acetylgalactosaminyltransferase 10) is a Protein Coding gene. Diseases associated with GALNT10 include Postural Orthostatic Tachycardia Syndrome. Among its related pathways are O-linked glycosylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNTL6.
UniProtKB/Swiss-Prot Summary for GALNT10 Gene
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.