This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated ... See more...

Aliases for GALNT10 Gene

Aliases for GALNT10 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 10 2 3 4 5
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 10 (GalNAc-T10) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 10 3 4
  • Polypeptide GalNAc Transferase 10 2 4
  • EC 2.4.1.41 4 51
  • GalNAc-T10 2 4
  • Protein-UDP Acetylgalactosaminyltransferase 10 4
  • GalNAc Transferase 10 3
  • Pp-GaNTase 10 4
  • PPGALNACT10 3
  • PPGANTASE10 3
  • GALNACT10 3
  • GALNT10 5

External Ids for GALNT10 Gene

Previous GeneCards Identifiers for GALNT10 Gene

  • GC05P153553
  • GC05P153598
  • GC05P153550
  • GC05P148711

Summaries for GALNT10 Gene

Entrez Gene Summary for GALNT10 Gene

  • This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010]

GeneCards Summary for GALNT10 Gene

GALNT10 (Polypeptide N-Acetylgalactosaminyltransferase 10) is a Protein Coding gene. Diseases associated with GALNT10 include Postural Orthostatic Tachycardia Syndrome. Among its related pathways are O-linked glycosylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNTL6.

UniProtKB/Swiss-Prot Summary for GALNT10 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GALNT10 Gene

Genomics for GALNT10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GALNT10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J154189 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 260.3 0.0 -29 3.4 TBP ZBTB10 CEBPA MNT IKZF1 SMAD5 ZNF217 BHLHE40 ZBTB7B ELF1 GALNT10 lnc-FAM114A2-2 MFAP3 lnc-MFAP3-1
GH05J154037 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 250.1 -151.6 -151629 3 CHD2 TBP ZBTB10 MXD4 SIX5 NR2C1 MNT SMAD5 ETS1 MBD2 FAM114A2 HSALNG0045989 MFAP3 lnc-HAND1-8-002 lnc-MFAP3-1 GALNT10 HSALNG0045991
GH05J154272 Enhancer 0.9 Ensembl ENCODE 22.6 +84.2 84170 7.4 IKZF1 MAFF GABPA ZNF316 PRDM10 MAFK EHMT2 JUND NFE2 MAFG GALNT10 HSALNG0046001 lnc-HAND1-7 SAP30L
GH05J154237 Enhancer 0.9 Ensembl ENCODE 22.5 +49.4 49371 8.2 EBF1 SMARCA5 REST ZNF24 ZNF664 TCF7 ATF2 ZMYM3 GATA2 ZNF217 GALNT10 piR-60985-099 HSALNG0046000 SAP30L
GH05J154219 Enhancer 0.8 Ensembl ENCODE 22.8 +31.2 31171 6.2 ZNF316 FOSL1 JUND MAFK LCORL ZFP36 ZNF350 NFIB ZNF561 NFIA HSALNG0046000 GALNT10 LARP1 SAP30L-AS1 LOC107986465 piR-60985-099 MFAP3 lnc-MFAP3-1 SAP30L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GALNT10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GALNT10

Top Transcription factor binding sites by QIAGEN in the GALNT10 gene promoter:
  • AREB6
  • ARP-1
  • Brachyury
  • c-Ets-1
  • GATA-1
  • GATA-6
  • HOXA3
  • p53
  • S8

Genomic Locations for GALNT10 Gene

Latest Assembly
chr5:154,190,730-154,420,984
(GRCh38/hg38)
Size:
230,255 bases
Orientation:
Plus strand

Previous Assembly
chr5:153,570,293-153,800,544
(GRCh37/hg19 by Entrez Gene)
Size:
230,252 bases
Orientation:
Plus strand

chr5:153,570,290-153,800,544
(GRCh37/hg19 by Ensembl)
Size:
230,255 bases
Orientation:
Plus strand

Genomic View for GALNT10 Gene

Genes around GALNT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALNT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALNT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT10 Gene

Proteins for GALNT10 Gene

  • Protein details for GALNT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SR1-GLT10_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 10
    Protein Accession:
    Q86SR1
    Secondary Accessions:
    • B3KXC9
    • Q6IN56
    • Q86VP8
    • Q8IXJ2
    • Q8TEJ2
    • Q96IV2
    • Q9H8E1
    • Q9Y4M4

    Protein attributes for GALNT10 Gene

    Size:
    603 amino acids
    Molecular mass:
    68992 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14676.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GALNT10 Gene

    Alternative splice isoforms for GALNT10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNT10 Gene

Selected DME Specific Peptides for GALNT10 Gene

Q86SR1:
  • LLRTVHS
  • DCHSMKGNQL
  • WREDIRPG
  • MAGGLFA
  • SPVTLYDCH
  • IVCPMID
  • IWGGEQYE
  • SLARNLKRVAE
  • FWELGGYD
  • AYRENGFNI
  • AEYIYQRRPEYRHLS
  • VHSVLNRSPP
  • LNRSLPD
  • LPNTSIIIPFHNEGW
  • SFKVWMCGG
  • FLDSHCE
  • SDREHLK
  • NCKSFKWFM
  • RVAEVWMD
  • QAGDAMRGAFDWEMYYKRIPIPPELQ
  • KREGLIR
  • PCSRVGH

Post-translational modifications for GALNT10 Gene

  • Glycosylation at Thr39, Ser43, Thr62, Asn124, Asn146, and Asn593
  • Modification sites at PhosphoSitePlus

Other Protein References for GALNT10 Gene

Domains & Families for GALNT10 Gene

Gene Families for GALNT10 Gene

Protein Domains for GALNT10 Gene

InterPro:
Blocks:
  • Ricin B lectin domain
  • Glycosyl transferase, family 2
ProtoNet:

Suggested Antigen Peptide Sequences for GALNT10 Gene

GenScript: Design optimal peptide antigens:
  • UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10), isoform CRA_d (D3DQI7_HUMAN)
  • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10 (GLT10_HUMAN)
  • GALNT10 protein (Q4G0E1_HUMAN)
  • UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase (Q58A70_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86SR1

UniProtKB/Swiss-Prot:

GLT10_HUMAN :
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNT10: view

Function for GALNT10 Gene

Molecular function for GALNT10 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.41; Evidence={ECO:0000269|PubMed:12417297};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:52424, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:87075; EC=2.4.1.41; Evidence={ECO:0000269|PubMed:12417297};.

Enzyme Numbers (IUBMB) for GALNT10 Gene

Phenotypes From GWAS Catalog for GALNT10 Gene

Gene Ontology (GO) - Molecular Function for GALNT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IDA 12417297
GO:0005515 protein binding IPI --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with GALNT10: view
genes like me logo Genes that share phenotypes with GALNT10: view

Animal Models for research

  • Taconic Biosciences Mouse Models for GALNT10

miRNA for GALNT10 Gene

miRTarBase miRNAs that target GALNT10

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALNT10

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GALNT10 Gene

Localization for GALNT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT10 Gene

Golgi apparatus membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GALNT10 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
peroxisome 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GALNT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GALNT10: view

Pathways & Interactions for GALNT10 Gene

genes like me logo Genes that share pathways with GALNT10: view

UniProtKB/Swiss-Prot Q86SR1-GLT10_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for GALNT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006493 protein O-linked glycosylation IDA 12417297
GO:0016266 O-glycan processing TAS --
GO:0018215 protein phosphopantetheinylation IEA --
genes like me logo Genes that share ontologies with GALNT10: view

No data available for SIGNOR curated interactions for GALNT10 Gene

Drugs & Compounds for GALNT10 Gene

(3) Drugs for GALNT10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 64
Uridine 5'-diphosphate Experimental Pharma 0
Calcium Nutra 6876

(3) Additional Compounds for GALNT10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lactosamine
  • 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-Amino-2-deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
13000-25-4
UDP-N-acetyl-alpha-D-galactosamine
  • (2R,3R,4R,5R,6R)-3-(Acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name)
  • UDP-GalNac
  • URIDINE-diphosphATE-N-acetylgalactosamine
  • (2R,3R,4R,5R,6R)-3-(Acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphoric acid (non-preferred name)
  • URIDINE-diphosphoric acid-N-acetylgalactosamine
Uridine diphosphate-N-acetylgalactosamine
  • Uridine diphosphoric acid-N-acetylgalactosamine
  • N-[2-({[({[3,4-dihydroxy-5-(4-hydroxy-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]ethanimidate
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT10: view

Transcripts for GALNT10 Gene

mRNA/cDNA for GALNT10 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GALNT10

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for GALNT10 Gene

GeneLoc Exon Structure for
GALNT10

Expression for GALNT10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GALNT10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GALNT10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.2), Adipocyte (10.5), and Ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GALNT10 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GALNT10

SOURCE GeneReport for Unigene cluster for GALNT10 Gene:

Hs.631797

mRNA Expression by UniProt/SwissProt for GALNT10 Gene:

Q86SR1-GLT10_HUMAN
Tissue specificity: Widely expressed. Expressed at high level in small intestine, and at intermediate levels in stomach, pancreas, ovary, thyroid gland and spleen. Weakly expressed in other tissues.

Evidence on tissue expression from TISSUES for GALNT10 Gene

  • Nervous system(4.6)
  • Spleen(4.3)
  • Skin(4.3)
  • Kidney(4.2)
  • Lung(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with GALNT10: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GALNT10 Gene

Orthologs for GALNT10 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GALNT10 30 31
  • 99.52 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GALNT10 30 31
  • 91.87 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GALNT10 30 31
  • 90.71 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Galnt10 30 17 31
  • 88.67 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Galnt10 30
  • 88.5 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia GALNT10 31
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GALNT10 31
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GALNT10 30 31
  • 80.1 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GALNT10 31
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia galnt10 30
  • 70.56 (n)
Zebrafish
(Danio rerio)
Actinopterygii Dr.12540 30
Fruit Fly
(Drosophila melanogaster)
Insecta pgant6 30 31
  • 56.59 (n)
ManyToMany
pgant4 31
  • 39 (a)
ManyToMany
pgant8 31
  • 33 (a)
ManyToMany
CG31776 31
  • 33 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010367 30
  • 52.04 (n)
Worm
(Caenorhabditis elegans)
Secernentea gly-10 30 31
  • 54.61 (n)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 54 (a)
OneToMany
Species where no ortholog for GALNT10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GALNT10 Gene

ENSEMBL:
Gene Tree for GALNT10 (if available)
TreeFam:
Gene Tree for GALNT10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GALNT10: view image

Paralogs for GALNT10 Gene

(24) SIMAP similar genes for GALNT10 Gene using alignment to 5 proteins:

  • GLT10_HUMAN
  • C9JGD4_HUMAN
  • D3DQI7_HUMAN
  • F2Z2M7_HUMAN
  • Q4G0E1_HUMAN
genes like me logo Genes that share paralogs with GALNT10: view

Variants for GALNT10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GALNT10 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
982122 Benign: not specified 154,297,802(+) G/C
NM_198321.4(GALNT10):c.263-139G>C
INTRON
982123 Benign: not specified 154,297,803(+) A/T
NM_198321.4(GALNT10):c.263-138A>T
INTRON
rs142635658 Likely Benign: not provided 154,412,893(+) G/A
NM_198321.4(GALNT10):c.1391G>A (p.Arg464Gln)
MISSENSE
rs35405339 Benign: not provided 154,415,905(+) G/A
NM_198321.4(GALNT10):c.1626G>A (p.Lys542=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GALNT10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GALNT10 Gene

Variant ID Type Subtype PubMed ID
dgv5820n100 CNV gain 25217958
esv23918 CNV loss 19812545
esv2582402 CNV insertion 19546169
esv2662546 CNV deletion 23128226
esv2730934 CNV deletion 23290073
esv2730935 CNV deletion 23290073
esv3323048 CNV insertion 20981092
esv3360575 CNV insertion 20981092
esv3444196 CNV duplication 20981092
esv3575889 CNV gain 25503493
esv3575890 CNV gain 25503493
esv3607239 CNV loss 21293372
nsv1015362 CNV gain 25217958
nsv1137536 CNV deletion 24896259
nsv475805 CNV novel sequence insertion 20440878
nsv5079 CNV insertion 18451855
nsv5080 CNV insertion 18451855
nsv521696 CNV loss 19592680
nsv524343 CNV loss 19592680
nsv830520 CNV loss 17160897
nsv964964 CNV duplication 23825009

Variation tolerance for GALNT10 Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GALNT10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GALNT10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT10 Gene

Disorders for GALNT10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GALNT10 Gene - From: COP

Disorder Aliases PubMed IDs
postural orthostatic tachycardia syndrome
  • familial orthostatic tachycardia due to norepinephrine transporter deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GALNT10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GALNT10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GALNT10 Gene

Publications for GALNT10 Gene

  1. Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10. (PMID: 12417297) Cheng L … Narimatsu H (FEBS letters 2002) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

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