Aliases for GALM Gene
External Ids for GALM Gene
Previous GeneCards Identifiers for GALM Gene
This gene encodes an enzyme that catalyzes the epimerization of hexose sugars such as glucose and galactose. The encoded protein is expressed in the cytoplasm and has a preference for galactose. The encoded protein may be required for normal galactose metabolism by maintaining the equilibrium of alpha and beta anomers of galactose.[provided by RefSeq, Mar 2009]
GeneCards Summary for GALM Gene
GALM (Galactose Mutarotase) is a Protein Coding gene. Diseases associated with GALM include Galactosemia Iv and Disorder Of Galactose Metabolism. Among its related pathways are Galactose metabolism and Fructose metabolism. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and aldose 1-epimerase activity.
UniProtKB/Swiss-Prot Summary for GALM Gene
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism (PubMed:12753898). Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase) (PubMed:30451973). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1 (PubMed:12753898). Also active on D-glucose although shows a preference for galactose over glucose (PubMed:12753898).