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Aliases for GAL3ST4 Gene

Aliases for GAL3ST4 Gene

  • Galactose-3-O-Sulfotransferase 4 2 3 3 5
  • Gal-Beta-1,3-GalNAc 3-Sulfotransferase 3 4
  • Beta-Galactose-3-O-Sulfotransferase 4 3 4
  • EC 2.8.2.- 4
  • GAL3ST-4 3
  • Gal3ST-4 4

External Ids for GAL3ST4 Gene

Previous GeneCards Identifiers for GAL3ST4 Gene

  • GC07M099369
  • GC07M099401
  • GC07M099594
  • GC07M099757
  • GC07M094391
  • GC07M099758
  • GC07M099760
  • GC07M099770
  • GC07M099790

Summaries for GAL3ST4 Gene

Entrez Gene Summary for GAL3ST4 Gene

  • This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAL3ST4 Gene

GAL3ST4 (Galactose-3-O-Sulfotransferase 4) is a Protein Coding gene. Diseases associated with GAL3ST4 include Pectus Excavatum. Among its related pathways are Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include galactosylceramide sulfotransferase activity and proteoglycan sulfotransferase activity. An important paralog of this gene is GAL3ST2.

UniProtKB/Swiss-Prot for GAL3ST4 Gene

  • Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc.

Gene Wiki entry for GAL3ST4 Gene

Additional gene information for GAL3ST4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAL3ST4 Gene

Genomics for GAL3ST4 Gene

GeneHancer (GH) Regulatory Elements for GAL3ST4 Gene

Promoters and enhancers for GAL3ST4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J100165 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.8 781 4.1 HDGF PKNOX1 SMAD1 FOXA2 ARNT SIN3A ZNF2 POLR2B ZNF766 E2F8 GAL3ST4 PIR52019 ZSCAN25 TRIM4 ZNF3 AP4M1 ZNF655 LOC100131859 PCOLCE SRRT
GH07J100171 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 650.7 -2.7 -2678 0.7 KLF1 SP3 SP2 KLF14 ZNF335 GLIS2 POLR2A PATZ1 KLF9 ZNF24 GAL3ST4 PILRA PVRIG PIR52019 GPC2
GH07J100364 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -202.2 -202219 12.5 HDGF PKNOX1 ATF1 YBX1 ZBTB7B ZNF121 POLR2B E2F8 ZNF207 ZNF143 PILRA ZCWPW1 MEPCE MOSPD3 LAMTOR4 C7orf43 PVRIG ENSG00000241357 STAG3 GPC2
GH07J099929 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 9.8 +239.0 239047 1 HDAC1 PKNOX1 ARID4B SIN3A ZBTB40 ZNF48 RAD21 ZNF335 GLIS2 ZNF366 ENSG00000237640 GJC3 ZNF3 TRIM4 ZSCAN25 LOC100131859 ZSCAN21 ZNF655 STAG3L5P GIGYF1
GH07J100343 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -176.3 -176282 3 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 E2F8 ZNF207 ZNF143 FOS PILRA C7orf43 MBLAC1 ZCWPW1 MEPCE FAM200A LAMTOR4 ENSG00000241357 GPC2 GAL3ST4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAL3ST4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GAL3ST4 gene promoter:
  • E2F
  • Sp1
  • AREB6
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • c-Myc
  • Max1

Genomic Locations for GAL3ST4 Gene

Genomic Locations for GAL3ST4 Gene
chr7:100,159,242-100,168,750
(GRCh38/hg38)
Size:
9,509 bases
Orientation:
Minus strand
chr7:99,756,865-99,766,373
(GRCh37/hg19)
Size:
9,509 bases
Orientation:
Minus strand

Genomic View for GAL3ST4 Gene

Genes around GAL3ST4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAL3ST4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAL3ST4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAL3ST4 Gene

Proteins for GAL3ST4 Gene

  • Protein details for GAL3ST4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RP7-G3ST4_HUMAN
    Recommended name:
    Galactose-3-O-sulfotransferase 4
    Protein Accession:
    Q96RP7
    Secondary Accessions:
    • A4D2A8
    • B4DWL8
    • D6W5U5
    • Q8N3P7
    • Q8WZ17
    • Q96E33
    • Q9HA78

    Protein attributes for GAL3ST4 Gene

    Size:
    486 amino acids
    Molecular mass:
    54166 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GAL3ST4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAL3ST4 Gene

Post-translational modifications for GAL3ST4 Gene

  • Glycosylation at Asn374
  • Modification sites at PhosphoSitePlus

Other Protein References for GAL3ST4 Gene

No data available for DME Specific Peptides for GAL3ST4 Gene

Domains & Families for GAL3ST4 Gene

Gene Families for GAL3ST4 Gene

Protein Domains for GAL3ST4 Gene

Suggested Antigen Peptide Sequences for GAL3ST4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96RP7

UniProtKB/Swiss-Prot:

G3ST4_HUMAN :
  • Belongs to the galactose-3-O-sulfotransferase family.
Family:
  • Belongs to the galactose-3-O-sulfotransferase family.
genes like me logo Genes that share domains with GAL3ST4: view

Function for GAL3ST4 Gene

Molecular function for GAL3ST4 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6-7.;

Enzyme Numbers (IUBMB) for GAL3ST4 Gene

Phenotypes From GWAS Catalog for GAL3ST4 Gene

Gene Ontology (GO) - Molecular Function for GAL3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001733 galactosylceramide sulfotransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0050656 3-phosphoadenosine 5-phosphosulfate binding NAS 11333265
GO:0050694 galactose 3-O-sulfotransferase activity IDA 11333265
GO:0050698 proteoglycan sulfotransferase activity NAS 11333265
genes like me logo Genes that share ontologies with GAL3ST4: view
genes like me logo Genes that share phenotypes with GAL3ST4: view

Animal Model Products

miRNA for GAL3ST4 Gene

miRTarBase miRNAs that target GAL3ST4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAL3ST4 Gene

Localization for GAL3ST4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAL3ST4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAL3ST4 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GAL3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IDA,IEA 11333265
GO:0016021 integral component of membrane NAS,IEA 11333265
GO:0032580 Golgi cisterna membrane IEA --
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with GAL3ST4: view

Pathways & Interactions for GAL3ST4 Gene

genes like me logo Genes that share pathways with GAL3ST4: view

Pathways by source for GAL3ST4 Gene

1 BioSystems pathway for GAL3ST4 Gene

UniProtKB/Swiss-Prot Q96RP7-G3ST4_HUMAN

  • Pathway: Protein modification; carbohydrate sulfation.

Interacting Proteins for GAL3ST4 Gene

Gene Ontology (GO) - Biological Process for GAL3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006790 sulfur compound metabolic process NAS 11333265
GO:0007267 cell-cell signaling NAS 11333265
GO:0009100 glycoprotein metabolic process NAS 11333265
GO:0009247 glycolipid biosynthetic process IEA --
GO:0009311 oligosaccharide metabolic process NAS 11333265
genes like me logo Genes that share ontologies with GAL3ST4: view

No data available for SIGNOR curated interactions for GAL3ST4 Gene

Drugs & Compounds for GAL3ST4 Gene

(1) Drugs for GAL3ST4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 37
genes like me logo Genes that share compounds with GAL3ST4: view

Transcripts for GAL3ST4 Gene

mRNA/cDNA for GAL3ST4 Gene

Unigene Clusters for GAL3ST4 Gene

Galactose-3-O-sulfotransferase 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAL3ST4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3:

Relevant External Links for GAL3ST4 Gene

GeneLoc Exon Structure for
GAL3ST4
ECgene alternative splicing isoforms for
GAL3ST4

Expression for GAL3ST4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAL3ST4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAL3ST4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.6) and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for GAL3ST4 Gene

This gene is overexpressed in Heart (47.4), Placenta (9.7), and Pancreas (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GAL3ST4 Gene



Protein tissue co-expression partners for GAL3ST4 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAL3ST4 Gene:

GAL3ST4

SOURCE GeneReport for Unigene cluster for GAL3ST4 Gene:

Hs.44856

mRNA Expression by UniProt/SwissProt for GAL3ST4 Gene:

Q96RP7-G3ST4_HUMAN
Tissue specificity: Expressed mainly in placenta, thymus, testis, ovary, spinal cord, trachea and adrenal gland and at low levels in brain, lung, spleen, prostate, small intestine, colon, stomach thyroid and lymph node.

Evidence on tissue expression from TISSUES for GAL3ST4 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GAL3ST4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GAL3ST4 Gene

Orthologs for GAL3ST4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAL3ST4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAL3ST4 34 33
  • 99.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GAL3ST4 34 33
  • 87.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GAL3ST4 34 33
  • 87.58 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gal3st4 33
  • 81.35 (n)
mouse
(Mus musculus)
Mammalia Gal3st4 16 34 33
  • 80.65 (n)
oppossum
(Monodelphis domestica)
Mammalia GAL3ST4 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves GAL3ST4 34
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAL3ST4 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gal3st4 33
  • 56.88 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC565556 33
  • 51.01 (n)
GAL3ST4 34
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
Species where no ortholog for GAL3ST4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAL3ST4 Gene

ENSEMBL:
Gene Tree for GAL3ST4 (if available)
TreeFam:
Gene Tree for GAL3ST4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GAL3ST4: view image

Paralogs for GAL3ST4 Gene

Paralogs for GAL3ST4 Gene

Pseudogenes.org Pseudogenes for GAL3ST4 Gene

genes like me logo Genes that share paralogs with GAL3ST4: view

Variants for GAL3ST4 Gene

Sequence variations from dbSNP and Humsavar for GAL3ST4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000444312 -- 100,170,683(-) A/G upstream_transcript_variant
rs1000518460 -- 100,162,630(-) A/G intron_variant
rs1000622990 -- 100,159,645(-) G/T 3_prime_UTR_variant
rs1000700344 -- 100,166,132(-) C/G intron_variant
rs1000731078 -- 100,168,954(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GAL3ST4 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv428180 CNV gain 18775914
nsv607931 CNV loss 21841781

Variation tolerance for GAL3ST4 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAL3ST4 Gene

Human Gene Mutation Database (HGMD)
GAL3ST4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAL3ST4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAL3ST4 Gene

Disorders for GAL3ST4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GAL3ST4 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
pectus excavatum
  • funnel chest
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GAL3ST4

genes like me logo Genes that share disorders with GAL3ST4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAL3ST4 Gene

Publications for GAL3ST4 Gene

  1. Molecular cloning and characterization of a novel human galactose 3-O-sulfotransferase that transfers sulfate to gal beta 1-->3galNAc residue in O-glycans. (PMID: 11333265) Seko A … Yamashita K (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58

Products for GAL3ST4 Gene

Sources for GAL3ST4 Gene

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