This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates.... See more...

Aliases for GAL3ST4 Gene

Aliases for GAL3ST4 Gene

  • Galactose-3-O-Sulfotransferase 4 2 3 4 5
  • Gal-Beta-1,3-GalNAc 3'-Sulfotransferase 3 4
  • Beta-Galactose-3-O-Sulfotransferase 4 3 4
  • EC 2.8.2.- 4
  • GAL3ST-4 3
  • FLJ12116 2
  • Gal3ST-4 4
  • GAL3ST4 5

External Ids for GAL3ST4 Gene

Previous GeneCards Identifiers for GAL3ST4 Gene

  • GC07M099369
  • GC07M099401
  • GC07M099594
  • GC07M099757
  • GC07M094391
  • GC07M099758
  • GC07M099760
  • GC07M099770
  • GC07M099790

Summaries for GAL3ST4 Gene

Entrez Gene Summary for GAL3ST4 Gene

  • This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAL3ST4 Gene

GAL3ST4 (Galactose-3-O-Sulfotransferase 4) is a Protein Coding gene. Diseases associated with GAL3ST4 include Fanconi Anemia, Complementation Group G and Scoliosis. Among its related pathways are Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include galactosylceramide sulfotransferase activity and proteoglycan sulfotransferase activity. An important paralog of this gene is GAL3ST2.

UniProtKB/Swiss-Prot Summary for GAL3ST4 Gene

  • Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc.

Gene Wiki entry for GAL3ST4 Gene

Additional gene information for GAL3ST4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GAL3ST4 Gene

Genomics for GAL3ST4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GAL3ST4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J100171 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -3.1 -3083 1.8 ARHGAP35 PRDM10 ZNF512 IKZF1 MTA2 PRDM1 PKNOX1 PATZ1 KLF9 SP2 GAL3ST4 PILRA PVRIG piR-58020 GPC2 lnc-GAL3ST4-2
GH07J100165 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 600.7 +0.4 358 4.7 ARHGAP35 CTCF PRDM10 ZNF512 LEF1 IKZF1 ZNF692 JUND PRDM1 DDX20 GAL3ST4 lnc-GPC2-1 piR-58020 ZSCAN25 TRIM4 ZNF3 AP4M1 ZNF655 ENSG00000228335 PCOLCE
GH07J099929 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 9.8 +238.9 238914 1 CTCF PRDM10 TFE3 IKZF1 ZIC2 RBFOX2 PKNOX1 PATZ1 REST IRF2 ENSG00000237640 GJC3 ZNF3 TRIM4 ZSCAN25 ENSG00000228335 ZSCAN21 ZNF655 STAG3L5P GIGYF1
GH07J100364 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -199.5 -199452 6.7 SP1 CREB1 PRDM10 POLR2A BACH1 JUND LARP7 ZNF143 PATZ1 TCF12 PILRA PILRB MEPCE AP4M1 SRRT PPP1R35 GIGYF1 ZCWPW1 ZSCAN25 MOSPD3
GH07J100199 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 11.9 -32.2 -32184 1.6 LEF1 IKZF1 JUND PHF21A PKNOX1 MTA1 NR2C1 ZNF740 IKZF2 SP1 piR-54685-004 PVRIG GPC2 STAG3 GAL3ST4 MAP11 LAMTOR4 piR-43590 CASTOR3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAL3ST4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GAL3ST4

Top Transcription factor binding sites by QIAGEN in the GAL3ST4 gene promoter:
  • AREB6
  • c-Myc
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Max1
  • Sp1

Genomic Locations for GAL3ST4 Gene

Genomic Locations for GAL3ST4 Gene
chr7:100,159,244-100,168,617
(GRCh38/hg38)
Size:
9,374 bases
Orientation:
Minus strand
chr7:99,756,865-99,766,373
(GRCh37/hg19)
Size:
9,509 bases
Orientation:
Minus strand

Genomic View for GAL3ST4 Gene

Genes around GAL3ST4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAL3ST4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAL3ST4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAL3ST4 Gene

Proteins for GAL3ST4 Gene

  • Protein details for GAL3ST4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RP7-G3ST4_HUMAN
    Recommended name:
    Galactose-3-O-sulfotransferase 4
    Protein Accession:
    Q96RP7
    Secondary Accessions:
    • A4D2A8
    • B4DWL8
    • D6W5U5
    • Q8N3P7
    • Q8WZ17
    • Q96E33
    • Q9HA78

    Protein attributes for GAL3ST4 Gene

    Size:
    486 amino acids
    Molecular mass:
    54166 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GAL3ST4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAL3ST4 Gene

Post-translational modifications for GAL3ST4 Gene

  • Glycosylation at Asn374
  • Modification sites at PhosphoSitePlus

Other Protein References for GAL3ST4 Gene

No data available for DME Specific Peptides for GAL3ST4 Gene

Domains & Families for GAL3ST4 Gene

Gene Families for GAL3ST4 Gene

Protein Domains for GAL3ST4 Gene

InterPro:
Blocks:
  • Galactose-3-O-sulfotransferase
ProtoNet:

Suggested Antigen Peptide Sequences for GAL3ST4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54945, highly similar to Galactose-3-O-sulfotransferase 4 (EC 2.8.2.-) (B4DWL8_HUMAN)
  • Gal-beta-1,3-GalNAc 3'-sulfotransferase (G3ST4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96RP7

UniProtKB/Swiss-Prot:

G3ST4_HUMAN :
  • Belongs to the galactose-3-O-sulfotransferase family.
Family:
  • Belongs to the galactose-3-O-sulfotransferase family.
genes like me logo Genes that share domains with GAL3ST4: view

Function for GAL3ST4 Gene

Molecular function for GAL3ST4 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6-7.;

Enzyme Numbers (IUBMB) for GAL3ST4 Gene

Phenotypes From GWAS Catalog for GAL3ST4 Gene

Gene Ontology (GO) - Molecular Function for GAL3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001733 galactosylceramide sulfotransferase activity IEA --
GO:0008146 sulfotransferase activity IBA 21873635
GO:0016740 transferase activity IEA --
GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding NAS 11333265
GO:0050694 galactose 3-O-sulfotransferase activity IDA 11333265
genes like me logo Genes that share ontologies with GAL3ST4: view
genes like me logo Genes that share phenotypes with GAL3ST4: view

Animal Model Products

CRISPR Products

miRNA for GAL3ST4 Gene

miRTarBase miRNAs that target GAL3ST4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAL3ST4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAL3ST4 Gene

Localization for GAL3ST4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAL3ST4 Gene

Golgi apparatus, Golgi stack membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAL3ST4 gene
Compartment Confidence
extracellular 4
golgi apparatus 4
endoplasmic reticulum 1
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GAL3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA,IDA 11333265
GO:0016021 integral component of membrane IEA,NAS 11333265
GO:0032580 Golgi cisterna membrane IEA --
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with GAL3ST4: view

Pathways & Interactions for GAL3ST4 Gene

PathCards logo

SuperPathways for GAL3ST4 Gene

genes like me logo Genes that share pathways with GAL3ST4: view

Pathways by source for GAL3ST4 Gene

1 BioSystems pathway for GAL3ST4 Gene

UniProtKB/Swiss-Prot Q96RP7-G3ST4_HUMAN

  • Pathway: Protein modification; carbohydrate sulfation.

Interacting Proteins for GAL3ST4 Gene

Gene Ontology (GO) - Biological Process for GAL3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006790 sulfur compound metabolic process NAS 11333265
GO:0007267 cell-cell signaling NAS 11333265
GO:0009100 glycoprotein metabolic process NAS 11333265
GO:0009101 glycoprotein biosynthetic process IDA 11333265
GO:0009247 glycolipid biosynthetic process IEA --
genes like me logo Genes that share ontologies with GAL3ST4: view

No data available for SIGNOR curated interactions for GAL3ST4 Gene

Drugs & Compounds for GAL3ST4 Gene

(1) Drugs for GAL3ST4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 56
genes like me logo Genes that share compounds with GAL3ST4: view

Transcripts for GAL3ST4 Gene

mRNA/cDNA for GAL3ST4 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAL3ST4

Alternative Splicing Database (ASD) splice patterns (SP) for GAL3ST4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3:

Relevant External Links for GAL3ST4 Gene

GeneLoc Exon Structure for
GAL3ST4

Expression for GAL3ST4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAL3ST4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAL3ST4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.6) and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for GAL3ST4 Gene

This gene is overexpressed in Heart (47.4), Placenta (9.7), and Pancreas (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GAL3ST4 Gene



Protein tissue co-expression partners for GAL3ST4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GAL3ST4

SOURCE GeneReport for Unigene cluster for GAL3ST4 Gene:

Hs.44856

mRNA Expression by UniProt/SwissProt for GAL3ST4 Gene:

Q96RP7-G3ST4_HUMAN
Tissue specificity: Expressed mainly in placenta, thymus, testis, ovary, spinal cord, trachea and adrenal gland and at low levels in brain, lung, spleen, prostate, small intestine, colon, stomach thyroid and lymph node.

Evidence on tissue expression from TISSUES for GAL3ST4 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with GAL3ST4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GAL3ST4 Gene

Orthologs for GAL3ST4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAL3ST4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GAL3ST4 30 31
  • 99.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GAL3ST4 30 31
  • 87.72 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GAL3ST4 30 31
  • 87.58 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gal3st4 30
  • 81.35 (n)
Mouse
(Mus musculus)
Mammalia Gal3st4 30 17 31
  • 80.65 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GAL3ST4 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GAL3ST4 31
  • 40 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GAL3ST4 31
  • 41 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gal3st4 30
  • 56.88 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC565556 30
  • 51.01 (n)
GAL3ST4 31
  • 40 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 32 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
Species where no ortholog for GAL3ST4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GAL3ST4 Gene

ENSEMBL:
Gene Tree for GAL3ST4 (if available)
TreeFam:
Gene Tree for GAL3ST4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GAL3ST4: view image

Paralogs for GAL3ST4 Gene

Paralogs for GAL3ST4 Gene

Pseudogenes.org Pseudogenes for GAL3ST4 Gene

genes like me logo Genes that share paralogs with GAL3ST4: view

Variants for GAL3ST4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GAL3ST4 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
714353 Likely Benign: not provided 100,160,676(-) G/C MISSENSE_VARIANT
715811 Likely Benign: not provided 100,166,617(-) A/G MISSENSE_VARIANT
737176 Likely Benign: not provided 100,160,522(-) C/T NONSENSE
773744 Benign: not provided 100,160,331(-) C/T MISSENSE_VARIANT
774659 Benign: not provided 100,160,417(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for GAL3ST4 Gene

Structural Variations from Database of Genomic Variants (DGV) for GAL3ST4 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv428180 CNV gain 18775914
nsv607931 CNV loss 21841781

Variation tolerance for GAL3ST4 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAL3ST4 Gene

Human Gene Mutation Database (HGMD)
GAL3ST4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAL3ST4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAL3ST4 Gene

Disorders for GAL3ST4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GAL3ST4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fanconi anemia, complementation group g
  • fancg
scoliosis
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with GAL3ST4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAL3ST4 Gene

Publications for GAL3ST4 Gene

  1. Molecular cloning and characterization of a novel human galactose 3-O-sulfotransferase that transfers sulfate to gal beta 1-->3galNAc residue in O-glycans. (PMID: 11333265) Seko A … Yamashita K (The Journal of biological chemistry 2001) 2 3 4 23
  2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4

Products for GAL3ST4 Gene

Sources for GAL3ST4 Gene