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This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2. [provided by RefSeq, Jul 2008]
GAL3ST2 (Galactose-3-O-Sulfotransferase 2) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and galactosylceramide sulfotransferase activity. An important paralog of this gene is GAL3ST4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001733 | galactosylceramide sulfotransferase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008146 | sulfotransferase activity | IDA | 11029462 |
GO:0016740 | transferase activity | IEA | -- |
GO:0050694 | galactose 3-O-sulfotransferase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0016020 | membrane | TAS | 11029462 |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0032580 | Golgi cisterna membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008150 | biological_process | ND | -- |
GO:0009101 | glycoprotein biosynthetic process | IBA | 21873635 |
GO:0009247 | glycolipid biosynthetic process | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP13: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GAL3ST2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GAL3ST2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GAL3ST2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gm9994 30 31 |
|
OneToMany | |
Gal3st2 17 31 |
|
OneToMany | |||
Gm6086 31 |
|
OneToMany | |||
Gal3st2b 17 |
|
||||
Gal3st2c 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Gal3st2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | GAL3ST2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | GAL3ST2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GAL3ST2 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | LOC556126 30 |
|
||
CABZ01079005.1 31 |
|
ManyToMany | |||
si:dkey-246m18.2 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs372108744 | Likely Pathogenic: not provided | 241,801,858(+) |
C/T NM_022134.3(GAL3ST2):c.197C>T (p.Thr66Met) |
MISSENSE | |
rs78620448 | Conflicting Interpretations: not specified; not provided | 241,776,985(+) |
G/A NM_022134.3(GAL3ST2):c.29+1G>A |
SPLICE_DONOR | |
rs12469459 | - |
p.Met4Leu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv165e55 | CNV | loss | 17911159 |
dgv4200n100 | CNV | loss | 25217958 |
dgv4201n100 | CNV | gain | 25217958 |
esv3594840 | CNV | loss | 21293372 |
esv3594841 | CNV | loss | 21293372 |
esv3594842 | CNV | gain | 21293372 |
esv3893578 | CNV | loss | 25118596 |
nsv1002941 | CNV | gain | 25217958 |
nsv1006733 | CNV | gain | 25217958 |
nsv10232 | CNV | gain+loss | 18304495 |
nsv584982 | CNV | loss | 21841781 |
nsv955300 | CNV | deletion | 24416366 |
nsv955301 | CNV | deletion | 24416366 |
nsv997984 | CNV | gain | 25217958 |
No disorders were found for GAL3ST2 Gene.