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Aliases for GAL3ST2 Gene

Aliases for GAL3ST2 Gene

  • Galactose-3-O-Sulfotransferase 2 2 3 3 5
  • Glycoprotein Beta-Gal 3-Sulfotransferase 2 3 4
  • Gal-Beta-1, 3-GalNAc 3-Sulfotransferase 2 3 4
  • Beta-Galactose-3-O-Sulfotransferase 2 3 4
  • GP3ST 3 4
  • Galbeta1-3GalNAc 3-Sulfotransferase 2 3
  • Gal 3-O-Sulphotransferase 3
  • EC 2.8.2.- 4
  • GAL3ST-2 3
  • Gal3ST-2 4

External Ids for GAL3ST2 Gene

Previous GeneCards Identifiers for GAL3ST2 Gene

  • GC11M068343
  • GC11M067490
  • GC11M066059
  • GC11M065585
  • GC02P243038
  • GC02P242436
  • GC02P242364
  • GC02P242716
  • GC02P234469

Summaries for GAL3ST2 Gene

Entrez Gene Summary for GAL3ST2 Gene

  • This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAL3ST2 Gene

GAL3ST2 (Galactose-3-O-Sulfotransferase 2) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and galactosylceramide sulfotransferase activity. An important paralog of this gene is GAL3ST4.

UniProtKB/Swiss-Prot for GAL3ST2 Gene

  • Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency.

Gene Wiki entry for GAL3ST2 Gene

Additional gene information for GAL3ST2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAL3ST2 Gene

Genomics for GAL3ST2 Gene

GeneHancer (GH) Regulatory Elements for GAL3ST2 Gene

Promoters and enhancers for GAL3ST2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J241775 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 663.1 -1.7 -1693 0.8 ARID4B DMAP1 DNMT3B RARA GLIS2 SCRT2 EGR2 SP5 NFYC ZBTB25 GAL3ST2 GC02M241775 GC02P241774 D2HGDH NEU4
GH02J241777 Promoter/Enhancer 0.9 EPDnew dbSUPER 650.7 -1.2 -1170 0.1 ZFHX2 EGR2 GAL3ST2 GC02M241775 GC02P241774
GH02J241776 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.7 0.0 -22 0.1 GAL3ST2 GC02M241775
GH02J241733 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 6.4 -41.8 -41814 2.1 HDGF MLX ARID4B SIN3A FEZF1 DMAP1 ZNF143 SP5 ZHX2 MXD4 D2HGDH ENSG00000215692 PIR35530 GC02P241738 ENSG00000223374 ENSG00000235351 SNED1 FARP2 DTYMK ING5
GH02J241769 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.9 -5.4 -5385 3.2 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 PAF1 LOC105373976 D2HGDH ENSG00000223374 GAL3ST2 NEU4 GC02P241774
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAL3ST2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GAL3ST2 gene promoter:
  • C/EBPalpha
  • Hlf
  • E4BP4

Genomic Locations for GAL3ST2 Gene

Genomic Locations for GAL3ST2 Gene
27,463 bases
Plus strand
27,463 bases
Plus strand

Genomic View for GAL3ST2 Gene

Genes around GAL3ST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAL3ST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAL3ST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAL3ST2 Gene

Proteins for GAL3ST2 Gene

  • Protein details for GAL3ST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Galactose-3-O-sulfotransferase 2
    Protein Accession:
    Secondary Accessions:
    • Q17RK0
    • Q57Z52

    Protein attributes for GAL3ST2 Gene

    398 amino acids
    Molecular mass:
    46110 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GAL3ST2 Gene

Post-translational modifications for GAL3ST2 Gene

  • Glycosylation at Asn360, Asn330, isoforms=287, isoforms=179, isoforms=132, and Asn79
  • Modification sites at PhosphoSitePlus

Other Protein References for GAL3ST2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAL3ST2 Gene

Domains & Families for GAL3ST2 Gene

Gene Families for GAL3ST2 Gene

Protein Domains for GAL3ST2 Gene

Suggested Antigen Peptide Sequences for GAL3ST2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the galactose-3-O-sulfotransferase family.
  • Belongs to the galactose-3-O-sulfotransferase family.
genes like me logo Genes that share domains with GAL3ST2: view

Function for GAL3ST2 Gene

Molecular function for GAL3ST2 Gene

UniProtKB/Swiss-Prot Function:
Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency.
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by Cu(2+) and Zn(2+).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.0-6.5.;

Enzyme Numbers (IUBMB) for GAL3ST2 Gene

Phenotypes From GWAS Catalog for GAL3ST2 Gene

Gene Ontology (GO) - Molecular Function for GAL3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001733 galactosylceramide sulfotransferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008146 sulfotransferase activity IDA 11029462
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with GAL3ST2: view
genes like me logo Genes that share phenotypes with GAL3ST2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAL3ST2

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAL3ST2 Gene

Localization for GAL3ST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAL3ST2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAL3ST2 gene
Compartment Confidence
golgi apparatus 4
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GAL3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane TAS 11029462
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with GAL3ST2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GAL3ST2 Gene

Pathways & Interactions for GAL3ST2 Gene

genes like me logo Genes that share pathways with GAL3ST2: view

Pathways by source for GAL3ST2 Gene

1 BioSystems pathway for GAL3ST2 Gene

UniProtKB/Swiss-Prot Q9H3Q3-G3ST2_HUMAN

  • Pathway: Protein modification; carbohydrate sulfation.

Interacting Proteins for GAL3ST2 Gene

Selected Interacting proteins: Q9H3Q3-G3ST2_HUMAN for GAL3ST2 Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for GAL3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0009247 glycolipid biosynthetic process IEA --
genes like me logo Genes that share ontologies with GAL3ST2: view

No data available for SIGNOR curated interactions for GAL3ST2 Gene

Drugs & Compounds for GAL3ST2 Gene

No Compound Related Data Available

Transcripts for GAL3ST2 Gene

mRNA/cDNA for GAL3ST2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(38) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GAL3ST2 Gene

Galactose-3-O-sulfotransferase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAL3ST2

Alternative Splicing Database (ASD) splice patterns (SP) for GAL3ST2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12a · 12b
SP1: - - - - - - - -
SP2: - -
SP4: - - - - - - -
SP5: - - -
SP6: -
SP7: - - - -
SP8: - - -
SP9: - - - - - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - -

Relevant External Links for GAL3ST2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GAL3ST2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAL3ST2 Gene

mRNA differential expression in normal tissues according to GTEx for GAL3ST2 Gene

This gene is overexpressed in Colon - Transverse (x21.4).

Protein differential expression in normal tissues from HIPED for GAL3ST2 Gene

This gene is overexpressed in Oral epithelium (63.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GAL3ST2 Gene

Protein tissue co-expression partners for GAL3ST2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAL3ST2 Gene:


SOURCE GeneReport for Unigene cluster for GAL3ST2 Gene:


mRNA Expression by UniProt/SwissProt for GAL3ST2 Gene:

Tissue specificity: Ubiquitous. Detected in heart, stomach, colon, liver and spleen, in epithelial cells lining the lower to middle layer of the crypts in colonic mucosa, hepatocytes surrounding the central vein of the liver, extravillous cytotrophoblasts in the basal plate of the septum of the placenta, renal tubules of the kidney, and neuronal cells of the cerebral cortex.

Evidence on tissue expression from TISSUES for GAL3ST2 Gene

  • Intestine(4.4)
genes like me logo Genes that share expression patterns with GAL3ST2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAL3ST2 Gene

Orthologs for GAL3ST2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAL3ST2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GAL3ST2 34 33
  • 99.03 (n)
(Canis familiaris)
Mammalia GAL3ST2 34 33
  • 83.8 (n)
(Bos Taurus)
Mammalia GAL3ST2 34 33
  • 82.24 (n)
(Mus musculus)
Mammalia Gm9994 34 33
  • 73.63 (n)
Gal3st2 34
  • 68 (a)
Gm6086 34
  • 67 (a)
Gal3st2c 16
(Rattus norvegicus)
Mammalia Gal3st2 33
  • 73.43 (n)
(Monodelphis domestica)
Mammalia GAL3ST2 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
-- 34
  • 43 (a)
(Gallus gallus)
Aves GAL3ST2 34 33
  • 62.67 (n)
(Anolis carolinensis)
Reptilia GAL3ST2 34
  • 50 (a)
(Danio rerio)
Actinopterygii LOC556126 33
  • 56.63 (n)
CABZ01079005.1 34
  • 33 (a)
si:dkey-246m18.2 34
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
-- 34
  • 33 (a)
-- 34
  • 25 (a)
Species where no ortholog for GAL3ST2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAL3ST2 Gene

Gene Tree for GAL3ST2 (if available)
Gene Tree for GAL3ST2 (if available)
Evolutionary constrained regions (ECRs) for GAL3ST2: view image

Paralogs for GAL3ST2 Gene

Paralogs for GAL3ST2 Gene

(2) SIMAP similar genes for GAL3ST2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAL3ST2: view

Variants for GAL3ST2 Gene

Sequence variations from dbSNP and Humsavar for GAL3ST2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs372108744 likely-pathogenic, not provided 241,801,858(+) C/T coding_sequence_variant, missense_variant
rs78620448 uncertain-significance, not specified 241,776,985(+) G/A splice_donor_variant
rs1000026073 -- 241,798,307(+) C/T intron_variant
rs1000152829 -- 241,803,511(+) G/A coding_sequence_variant, missense_variant
rs1000301134 -- 241,800,655(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GAL3ST2 Gene

Variant ID Type Subtype PubMed ID
dgv165e55 CNV loss 17911159
dgv4200n100 CNV loss 25217958
dgv4201n100 CNV gain 25217958
esv3594840 CNV loss 21293372
esv3594841 CNV loss 21293372
esv3594842 CNV gain 21293372
esv3893578 CNV loss 25118596
nsv1002941 CNV gain 25217958
nsv1006733 CNV gain 25217958
nsv10232 CNV gain+loss 18304495
nsv584982 CNV loss 21841781
nsv955300 CNV deletion 24416366
nsv955301 CNV deletion 24416366
nsv997984 CNV gain 25217958

Variation tolerance for GAL3ST2 Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.73; 73.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAL3ST2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAL3ST2 Gene

Disorders for GAL3ST2 Gene

Additional Disease Information for GAL3ST2

No disorders were found for GAL3ST2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAL3ST2 Gene

Publications for GAL3ST2 Gene

  1. Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Gal beta 1-3/1-4GlcNAc-R) oligosaccharides. (PMID: 11029462) Honke K … Taniguchi N (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. Gal3ST-2 involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrins. (PMID: 15921657) Shi BZ … Wu XZ (Biochemical and biophysical research communications 2005) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Recurrent cis-SAGe chimeric RNA, D2HGDH-GAL3ST2, in prostate cancer. (PMID: 27322736) Qin F … Li H (Cancer letters 2016) 3 58
  5. GAL3ST2 from mammary gland epithelial cells affects differentiation of 3T3-L1 preadipocytes. (PMID: 25532485) Guerra LN … Calvo JC (Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2015) 3 58

Products for GAL3ST2 Gene

Sources for GAL3ST2 Gene

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