Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits eleva... See more...

Aliases for GAL3ST1 Gene

Aliases for GAL3ST1 Gene

  • Galactose-3-O-Sulfotransferase 1 2 3 5
  • CST 2 3 4
  • 3'-Phosphoadenosine-5'-Phosphosulfate:GalCer Sulfotransferase 3 4
  • Galactosylceramide Sulfotransferase 3 4
  • Cerebroside (3' Phosphoadenylylsulfate:Galactosylceramide 3') Sulfotransferase 2
  • Cerebroside (3'-Phosphoadenylylsulfate:Galactosylceramide 3') Sulfotransferase 3
  • 3'-Phosphoadenylylsulfate:Galactosylceramide 3'-Sulfotransferase 4
  • Cerebroside Sulfotransferase 4
  • GalCer Sulfotransferase 4
  • EC 2.8.2.11 4
  • GAL3ST1 5

External Ids for GAL3ST1 Gene

Previous GeneCards Identifiers for GAL3ST1 Gene

  • GC22M029276
  • GC22M029277
  • GC22M030950
  • GC22M013912

Summaries for GAL3ST1 Gene

Entrez Gene Summary for GAL3ST1 Gene

  • Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits elevated expression in ovarian epithelial carcinoma and the encoded enzyme exhibits elevated activity in renal cell carcinoma. Mutations in this gene may be associated with reduced insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for GAL3ST1 Gene

GAL3ST1 (Galactose-3-O-Sulfotransferase 1) is a Protein Coding gene. Diseases associated with GAL3ST1 include Metachromatic Leukodystrophy and Renal Cell Carcinoma, Nonpapillary. Among its related pathways are Acyl chain remodelling of PE and Metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and galactosylceramide sulfotransferase activity. An important paralog of this gene is GAL3ST4.

UniProtKB/Swiss-Prot Summary for GAL3ST1 Gene

  • Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro).

Gene Wiki entry for GAL3ST1 Gene

Additional gene information for GAL3ST1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GAL3ST1 Gene

Genomics for GAL3ST1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GAL3ST1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J030572 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 606.7 +0.1 82 4.5 HNRNPL CTCF POLR2A RBFOX2 REST ZNF600 SP1 JUND RBM22 NR2F2 GAL3ST1 SLC35E4 PES1 RF00951-099 SEC14L6
GH22J030559 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 600.4 +14.5 14450 1.4 GATAD2A ZBTB33 PKNOX1 ZNF24 IRF2 ZNF740 PBX2 CTCF KDM6A FOXP1 RF00951-099 GAL3ST1 SEC14L6 SFI1 SMTN
GH22J030564 Promoter/Enhancer 0.8 EPDnew Ensembl 607.8 +10.0 9964 0.6 NFIC ZFHX2 NFIB ZNF768 NFIA EGR2 GATA2 GAL3ST1 SLC35E4 RF00951-099 SEC14L6
GH22J030704 Enhancer 0.9 Ensembl ENCODE 10.3 -131.1 -131136 2.8 ZIC2 PKNOX1 TCF12 IKZF2 TRIM22 PBX2 CEBPA SCRT2 EED ARID3A lnc-SLC35E4-1 OSBP2 DUSP18 GAL3ST1 SEC14L6 ENSG00000249590 SEC14L2 SLC35E4 lnc-DUSP18-2 MORC2
GH22J030755 Enhancer 0.8 Ensembl ENCODE 11 -180.4 -180360 1.6 CTCF ZNF143 REST RAD21 TRIM22 IRF3 ZNF592 SMC3 NFYB SMARCA5 INPP5J SLC35E4 DUSP18 PES1 TCN2 ENSG00000223831 GAL3ST1 SELENOM piR-57137-013 lnc-SLC35E4-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAL3ST1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GAL3ST1

Top Transcription factor binding sites by QIAGEN in the GAL3ST1 gene promoter:
  • ATF-2
  • c-Myc
  • CRE-BP1
  • CREB
  • E47
  • Egr-1
  • ITF-2
  • Max
  • PPAR-alpha
  • Tal-1

Genomic Locations for GAL3ST1 Gene

Genomic Locations for GAL3ST1 Gene
chr22:30,554,635-30,574,665
(GRCh38/hg38)
Size:
20,031 bases
Orientation:
Minus strand
chr22:30,950,622-30,970,574
(GRCh37/hg19)
Size:
19,953 bases
Orientation:
Minus strand

Genomic View for GAL3ST1 Gene

Genes around GAL3ST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAL3ST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAL3ST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAL3ST1 Gene

Proteins for GAL3ST1 Gene

  • Protein details for GAL3ST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99999-G3ST1_HUMAN
    Recommended name:
    Galactosylceramide sulfotransferase
    Protein Accession:
    Q99999
    Secondary Accessions:
    • Q96C63

    Protein attributes for GAL3ST1 Gene

    Size:
    423 amino acids
    Molecular mass:
    48764 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GAL3ST1 Gene

Post-translational modifications for GAL3ST1 Gene

  • Glycosylation at Asn66 and Asn312
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GAL3ST1 Gene

Domains & Families for GAL3ST1 Gene

Gene Families for GAL3ST1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GAL3ST1 Gene

InterPro:
Blocks:
  • Galactose-3-O-sulfotransferase
ProtoNet:

Suggested Antigen Peptide Sequences for GAL3ST1 Gene

GenScript: Design optimal peptide antigens:
  • Cerebroside sulfotransferase (G3ST1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99999

UniProtKB/Swiss-Prot:

G3ST1_HUMAN :
  • Belongs to the galactose-3-O-sulfotransferase family.
Family:
  • Belongs to the galactose-3-O-sulfotransferase family.
genes like me logo Genes that share domains with GAL3ST1: view

Function for GAL3ST1 Gene

Molecular function for GAL3ST1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine = adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine; Xref=Rhea:RHEA:20613, ChEBI:CHEBI:15378, ChEBI:CHEBI:18390, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:75956; EC=2.8.2.11;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:41744, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:78428, ChEBI:CHEBI:78429; EC=2.8.2.11;.

Enzyme Numbers (IUBMB) for GAL3ST1 Gene

Phenotypes From GWAS Catalog for GAL3ST1 Gene

Gene Ontology (GO) - Molecular Function for GAL3ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001733 galactosylceramide sulfotransferase activity IEA,IBA 21873635
GO:0008146 sulfotransferase activity TAS,IBA 21873635
GO:0016740 transferase activity IEA --
GO:0050694 galactose 3-O-sulfotransferase activity IBA 21873635
genes like me logo Genes that share ontologies with GAL3ST1: view
genes like me logo Genes that share phenotypes with GAL3ST1: view

Animal Models for GAL3ST1 Gene

MGI Knock Outs for GAL3ST1:

Animal Model Products

CRISPR Products

miRNA for GAL3ST1 Gene

miRTarBase miRNAs that target GAL3ST1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAL3ST1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GAL3ST1 Gene

Localization for GAL3ST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAL3ST1 Gene

Golgi apparatus membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAL3ST1 gene
Compartment Confidence
plasma membrane 4
golgi apparatus 4
extracellular 2
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GAL3ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005887 integral component of plasma membrane TAS 9030544
GO:0016020 membrane TAS 9030544
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GAL3ST1: view

Pathways & Interactions for GAL3ST1 Gene

genes like me logo Genes that share pathways with GAL3ST1: view

Pathways by source for GAL3ST1 Gene

2 BioSystems pathways for GAL3ST1 Gene

UniProtKB/Swiss-Prot Q99999-G3ST1_HUMAN

  • Pathway: Lipid metabolism; sphingolipid metabolism.

Gene Ontology (GO) - Biological Process for GAL3ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006487 protein N-linked glycosylation TAS 9030544
GO:0006629 lipid metabolic process IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0006682 galactosylceramide biosynthetic process IEA,IBA 21873635
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with GAL3ST1: view

No data available for SIGNOR curated interactions for GAL3ST1 Gene

Drugs & Compounds for GAL3ST1 Gene

(5) Drugs for GAL3ST1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3'-phospho-5'-adenylyl sulfate Experimental Pharma 0
Adenosine 3',5'-diphosphate Experimental Pharma 0

(39) Additional Compounds for GAL3ST1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
genes like me logo Genes that share compounds with GAL3ST1: view

Transcripts for GAL3ST1 Gene

mRNA/cDNA for GAL3ST1 Gene

15 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAL3ST1

Alternative Splicing Database (ASD) splice patterns (SP) for GAL3ST1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i · 7j · 7k · 7l
SP1: - - - - - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - - - -
SP10: - - -
SP11: - - -
SP12:

Relevant External Links for GAL3ST1 Gene

GeneLoc Exon Structure for
GAL3ST1

Expression for GAL3ST1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAL3ST1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAL3ST1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.4), Brain - Substantia nigra (x4.4), and Nerve - Tibial (x4.3).

Protein differential expression in normal tissues from HIPED for GAL3ST1 Gene

This gene is overexpressed in Gallbladder (35.0), Urine (18.6), and Testis (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GAL3ST1 Gene



Protein tissue co-expression partners for GAL3ST1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GAL3ST1

SOURCE GeneReport for Unigene cluster for GAL3ST1 Gene:

Hs.17958

mRNA Expression by UniProt/SwissProt for GAL3ST1 Gene:

Q99999-G3ST1_HUMAN
Tissue specificity: Expressed in kidney proximal tubule, gastric mucosa and adenocarcinoma. Highly expressed in renal cell carcinoma cell lines.

Evidence on tissue expression from TISSUES for GAL3ST1 Gene

  • Kidney(4.6)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with GAL3ST1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GAL3ST1 Gene

Orthologs for GAL3ST1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAL3ST1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GAL3ST1 30 31
  • 99.53 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GAL3ST1 30
  • 91.19 (n)
CST 31
  • 89 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia GAL3ST1 30 31
  • 90.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gal3st1 30
  • 83.97 (n)
Mouse
(Mus musculus)
Mammalia Gal3st1 30 17 31
  • 83.49 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 74 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia GAL3ST1 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GAL3ST1 30 31
  • 77.06 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 70 (a)
OneToMany
-- 31
  • 70 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gal3st1 30
  • 57.43 (n)
Zebrafish
(Danio rerio)
Actinopterygii gal3st1 30 31
  • 62.98 (n)
OneToMany
GAL3ST1 (2 of 2) 31
  • 50 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
Species where no ortholog for GAL3ST1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GAL3ST1 Gene

ENSEMBL:
Gene Tree for GAL3ST1 (if available)
TreeFam:
Gene Tree for GAL3ST1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GAL3ST1: view image

Paralogs for GAL3ST1 Gene

Paralogs for GAL3ST1 Gene

(2) SIMAP similar genes for GAL3ST1 Gene using alignment to 17 proteins:

  • G3ST1_HUMAN
  • C9J2M1_HUMAN
  • C9J2X7_HUMAN
  • C9J3S3_HUMAN
  • C9J4I2_HUMAN
  • C9J6M2_HUMAN
  • C9J993_HUMAN
  • C9JE31_HUMAN
  • C9JGL4_HUMAN
  • C9JIS3_HUMAN
  • C9JKD7_HUMAN
  • C9JLB5_HUMAN
  • C9JN55_HUMAN
  • C9JTV3_HUMAN
  • C9JU54_HUMAN
  • C9JYD7_HUMAN
  • C9K037_HUMAN

Pseudogenes.org Pseudogenes for GAL3ST1 Gene

genes like me logo Genes that share paralogs with GAL3ST1: view

Variants for GAL3ST1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GAL3ST1 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs2267161 - p.Val29Met

Additional dbSNP identifiers (rs#s) for GAL3ST1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GAL3ST1 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv588887 CNV loss 21841781
nsv829171 CNV loss 20364138

Variation tolerance for GAL3ST1 Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.20; 87.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAL3ST1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAL3ST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAL3ST1 Gene

Disorders for GAL3ST1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GAL3ST1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
metachromatic leukodystrophy
  • mld
renal cell carcinoma, nonpapillary
  • rcc
leukodystrophy
  • leukodystrophies
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with GAL3ST1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAL3ST1 Gene

Publications for GAL3ST1 Gene

  1. Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase. (PMID: 9030544) Honke K … Wada Y (The Journal of biological chemistry 1997) 2 3 4 23
  2. Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene. (PMID: 10785389) Tsuda M … Honke K (European journal of biochemistry 2000) 3 4 23
  3. Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells. (PMID: 8830034) Honke K … Makita A (Journal of biochemistry 1996) 3 4 23
  4. A variation in the cerebroside sulfotransferase gene is linked to exercise-modified insulin resistance and to type 2 diabetes. (PMID: 19587831) Roeske-Nielsen A … Lindblad U (Experimental diabetes research 2009) 3 23
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4

Products for GAL3ST1 Gene

Sources for GAL3ST1 Gene