Aliases for GAL3ST1 Gene
- Galactose-3-O-Sulfotransferase 1 2 3 5
- 3-Phosphoadenosine-5-Phosphosulfate:GalCer Sulfotransferase 3 4
- CST 3 4
- Cerebroside (3-Phosphoadenylylsulfate:Galactosylceramide 3) Sulfotransferase 3
- Cerebroside (3 Phosphoadenylylsulfate:Galactosylceramide 3) Sulfotransferase 2
- 3-Phosphoadenylylsulfate:Galactosylceramide 3-Sulfotransferase 4
External Ids for GAL3ST1 Gene
Previous GeneCards Identifiers for GAL3ST1 Gene
Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits elevated expression in ovarian epithelial carcinoma and the encoded enzyme exhibits elevated activity in renal cell carcinoma. Mutations in this gene may be associated with reduced insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for GAL3ST1 Gene
GAL3ST1 (Galactose-3-O-Sulfotransferase 1) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and galactosylceramide sulfotransferase activity. An important paralog of this gene is GAL3ST4.
UniProtKB/Swiss-Prot for GAL3ST1 Gene
Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro).