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Aliases for GAGE8 Gene

Aliases for GAGE8 Gene

  • G Antigen 8 2 3 4
  • Cancer/Testis Antigen Family 4, Member 8 2 3
  • Cancer/Testis Antigen 4.8 3 4
  • G Antigen 2D 3 4
  • GAGE-8 3 4
  • CT4.8 3 4
  • GAGE-2D 4

External Ids for GAGE8 Gene

Previous GeneCards Identifiers for GAGE8 Gene

  • GC0XP047423
  • GC0XP048217
  • GC0XP048273
  • GC0XP049059
  • GC0XP049060
  • GC0XP049047
  • GC0XP049066
  • GC0XP049097
  • GC0XP049189
  • GC0XP049190
  • GC0XP049201
  • GC0XP049220

Summaries for GAGE8 Gene

Entrez Gene Summary for GAGE8 Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAGE8 Gene

GAGE8 (G Antigen 8) is a Protein Coding gene.

Additional gene information for GAGE8 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE8 Gene

Genomics for GAGE8 Gene

Genomic Locations for GAGE8 Gene

Genomic Locations for GAGE8 Gene
Unknown strand

Genomic View for GAGE8 Gene

Cytogenetic band:
GeneLoc Logo Gene Density

No data available for GeneHancer (GH) Regulatory Elements and RefSeq DNA sequence for GAGE8 Gene

Proteins for GAGE8 Gene

  • Protein details for GAGE8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G antigen 2D
    Protein Accession:
    Secondary Accessions:
    • A6NG46
    • A6NNR8
    • B7ZL76
    • Q4V325

    Protein attributes for GAGE8 Gene

    116 amino acids
    Molecular mass:
    12764 Da
    Quaternary structure:
    No Data Available
    • This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE8 Gene

Post-translational modifications for GAGE8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE8 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for GAGE8 Gene

Domains & Families for GAGE8 Gene

Gene Families for GAGE8 Gene


Protein Domains for GAGE8 Gene


Suggested Antigen Peptide Sequences for GAGE8 Gene

GenScript: Design optimal peptide antigens:
  • G antigen 8 (GGE2D_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE8: view

Function for GAGE8 Gene

Molecular function for GAGE8 Gene

GENATLAS Biochemistry:
G antigen 8,expressed in testis and in several tumors

Gene Ontology (GO) - Molecular Function for GAGE8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with GAGE8: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAGE8 Gene

Localization for GAGE8 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GAGE8 Gene

Pathways & Interactions for GAGE8 Gene

PathCards logo

SuperPathways for GAGE8 Gene

No Data Available

Interacting Proteins for GAGE8 Gene

Gene Ontology (GO) - Biological Process for GAGE8 Gene


No data available for Pathways by source and SIGNOR curated interactions for GAGE8 Gene

Drugs & Compounds for GAGE8 Gene

No Compound Related Data Available

Transcripts for GAGE8 Gene

mRNA/cDNA for GAGE8 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE8 Gene

No ASD Table

Relevant External Links for GAGE8 Gene

ECgene alternative splicing isoforms for

Expression for GAGE8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAGE8 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAGE8 Gene:


mRNA Expression by UniProt/SwissProt for GAGE8 Gene:

Tissue specificity: Not expressed in normal tissues, except in testis, but expressed by a large proportion of tumors of various histological origins.
genes like me logo Genes that share expression patterns with GAGE8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAGE8 Gene

Orthologs for GAGE8 Gene

No data available for Orthologs and Evolution for GAGE8 Gene

Paralogs for GAGE8 Gene

(25) SIMAP similar genes for GAGE8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAGE8: view

No data available for Paralogs for GAGE8 Gene

Variants for GAGE8 Gene

Structural Variations from Database of Genomic Variants (DGV) for GAGE8 Gene

Variant ID Type Subtype PubMed ID
esv3399100 CNV duplication 20981092
esv3408787 CNV duplication 20981092
nsv1129077 CNV duplication 24896259
nsv515202 CNV gain 21397061
nsv6897 CNV insertion 18451855

Additional Variant Information for GAGE8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for GAGE8 Gene

Disorders for GAGE8 Gene

Additional Disease Information for GAGE8

No disorders were found for GAGE8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE8 Gene

Publications for GAGE8 Gene

  1. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PMID: 10397259) De Backer O … van der Bruggen P (Cancer research 1999) 2 3 4 58
  2. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff MF … Ditzel HJ (Tissue antigens 2008) 3 4 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for GAGE8 Gene

Sources for GAGE8 Gene

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