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Aliases for GAGE6 Gene

Aliases for GAGE6 Gene

  • G Antigen 6 2 3 4
  • Cancer/Testis Antigen Family 4, Member 6 2 3
  • Cancer/Testis Antigen 4.6 3 4
  • GAGE-6 3 4
  • CT4.6 3 4

External Ids for GAGE6 Gene

Previous GeneCards Identifiers for GAGE6 Gene

  • GC0XP047421
  • GC0XP048026
  • GC0XP048254
  • GC0XP048259
  • GC0XP049030
  • GC0XP049035
  • GC0XP049212
  • GC0XP049356
  • GC0XP049365

Summaries for GAGE6 Gene

Entrez Gene Summary for GAGE6 Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAGE6 Gene

GAGE6 (G Antigen 6) is a Protein Coding gene. Among its related pathways are Innate Lymphoid Cell Differentiation Pathways.

Additional gene information for GAGE6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE6 Gene

Genomics for GAGE6 Gene

Genomic Locations for GAGE6 Gene

Genomic Locations for GAGE6 Gene
Unknown strand

Genomic View for GAGE6 Gene

Cytogenetic band:
  • Xp11.4-p11.2 not on reference assembly by HGNC
  • Xp11.4-p11.2 by Entrez Gene
GeneLoc Logo Gene Density

No data available for GeneHancer (GH) Regulatory Elements and RefSeq DNA sequence for GAGE6 Gene

Proteins for GAGE6 Gene

  • Protein details for GAGE6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G antigen 6
    Protein Accession:

    Protein attributes for GAGE6 Gene

    117 amino acids
    Molecular mass:
    12892 Da
    Quaternary structure:
    No Data Available
    • This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE6 Gene

Post-translational modifications for GAGE6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE6 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for GAGE6 Gene

Domains & Families for GAGE6 Gene

Gene Families for GAGE6 Gene


Protein Domains for GAGE6 Gene


Suggested Antigen Peptide Sequences for GAGE6 Gene

GenScript: Design optimal peptide antigens:
  • Cancer/testis antigen 4.6 (GAGE6_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE6: view

Function for GAGE6 Gene

Phenotypes for GAGE6 Gene

genes like me logo Genes that share phenotypes with GAGE6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAGE6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAGE6 Gene

Localization for GAGE6 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GAGE6 Gene

Pathways & Interactions for GAGE6 Gene

PathCards logo

SuperPathways for GAGE6 Gene

genes like me logo Genes that share pathways with GAGE6: view

Pathways by source for GAGE6 Gene

1 R&D Systems pathway for GAGE6 Gene

Interacting Proteins for GAGE6 Gene

Selected Interacting proteins: Q13070-GAGE6_HUMAN for GAGE6 Gene via UniProtKB

Gene Ontology (GO) - Biological Process for GAGE6 Gene


No data available for SIGNOR curated interactions for GAGE6 Gene

Drugs & Compounds for GAGE6 Gene

No Compound Related Data Available

Transcripts for GAGE6 Gene

Unigene Clusters for GAGE6 Gene

G antigen 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAGE6

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE6 Gene

No ASD Table

Relevant External Links for GAGE6 Gene

ECgene alternative splicing isoforms for

Expression for GAGE6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAGE6 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAGE6 Gene:


SOURCE GeneReport for Unigene cluster for GAGE6 Gene:


mRNA Expression by UniProt/SwissProt for GAGE6 Gene:

Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except testis.
genes like me logo Genes that share expression patterns with GAGE6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAGE6 Gene

Orthologs for GAGE6 Gene

No data available for Orthologs and Evolution for GAGE6 Gene

Paralogs for GAGE6 Gene

(27) SIMAP similar genes for GAGE6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAGE6: view

No data available for Paralogs for GAGE6 Gene

Variants for GAGE6 Gene

Structural Variations from Database of Genomic Variants (DGV) for GAGE6 Gene

Variant ID Type Subtype PubMed ID
dgv4237n106 CNV duplication 24896259
esv28941 CNV gain+loss 19812545
esv3364710 CNV duplication 20981092
esv3380090 CNV duplication 20981092
esv3435089 CNV duplication 20981092
esv3449504 CNV duplication 20981092
nsv1077583 CNV duplication 25765185
nsv1077584 CNV duplication 25765185
nsv1129078 CNV duplication 24896259
nsv1147303 CNV duplication 26484159
nsv1152758 CNV duplication 26484159
nsv820429 CNV deletion 20802225
nsv953412 CNV duplication 24416366

Additional Variant Information for GAGE6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for GAGE6 Gene

Disorders for GAGE6 Gene

Additional Disease Information for GAGE6

No disorders were found for GAGE6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE6 Gene

Publications for GAGE6 Gene

  1. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PMID: 7544395) Van den Eynde B … Boon T (The Journal of experimental medicine 1995) 2 3 4 58
  2. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff MF … Ditzel HJ (Tissue antigens 2008) 3 4 58
  3. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PMID: 10397259) De Backer O … van der Bruggen P (Cancer research 1999) 3 4 58
  4. Vault RNAs partially induces drug resistance of human tumor cells MCF-7 by binding to the RNA/DNA-binding protein PSF and inducing oncogene GAGE6. (PMID: 29346433) Chen J … Liu S (PloS one 2018) 3 58
  5. Isolation and characterization of PAGE-1 and GAGE-7. New genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PMID: 9651357) Chen ME … Sikes RA (The Journal of biological chemistry 1998) 3 58

Products for GAGE6 Gene

Sources for GAGE6 Gene

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