Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GAGE5 Gene

Aliases for GAGE5 Gene

  • G Antigen 5 2 3 4
  • Cancer/Testis Antigen Family 4, Member 5 2 3
  • Cancer/Testis Antigen 4.5 3 4
  • GAGE-5 3 4
  • CT4.5 3 4

External Ids for GAGE5 Gene

Previous GeneCards Identifiers for GAGE5 Gene

  • GC0XP048025
  • GC0XP048253
  • GC0XP048258
  • GC0XP049029
  • GC0XP049034
  • GC0XP049105
  • GC0XP049089
  • GC0XP049215
  • GC0XP049354
  • GC0XP049364

Summaries for GAGE5 Gene

Entrez Gene Summary for GAGE5 Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAGE5 Gene

GAGE5 (G Antigen 5) is a Protein Coding gene.

Additional gene information for GAGE5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE5 Gene

Genomics for GAGE5 Gene

Genomic Locations for GAGE5 Gene

Genomic Locations for GAGE5 Gene
Unknown strand

Genomic View for GAGE5 Gene

Cytogenetic band:
  • Xp11.4-p11.2 not on reference assembly by HGNC
  • Xp11.4-p11.2 by Entrez Gene
GeneLoc Logo Gene Density

No data available for GeneHancer (GH) Regulatory Elements and RefSeq DNA sequence for GAGE5 Gene

Proteins for GAGE5 Gene

  • Protein details for GAGE5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G antigen 5
    Protein Accession:
    Secondary Accessions:
    • Q6FG72

    Protein attributes for GAGE5 Gene

    117 amino acids
    Molecular mass:
    12924 Da
    Quaternary structure:
    No Data Available
    • This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE5 Gene

Post-translational modifications for GAGE5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE5 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for GAGE5 Gene

Domains & Families for GAGE5 Gene

Gene Families for GAGE5 Gene


Protein Domains for GAGE5 Gene


Suggested Antigen Peptide Sequences for GAGE5 Gene

GenScript: Design optimal peptide antigens:
  • Cancer/testis antigen 4.5 (GAGE5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE5: view

Function for GAGE5 Gene

Gene Ontology (GO) - Molecular Function for GAGE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with GAGE5: view
genes like me logo Genes that share phenotypes with GAGE5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAGE5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAGE5 Gene

Localization for GAGE5 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GAGE5 Gene

Pathways & Interactions for GAGE5 Gene

PathCards logo

SuperPathways for GAGE5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GAGE5 Gene


No data available for Pathways by source and SIGNOR curated interactions for GAGE5 Gene

Drugs & Compounds for GAGE5 Gene

No Compound Related Data Available

Transcripts for GAGE5 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAGE5

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE5 Gene

No ASD Table

Relevant External Links for GAGE5 Gene

ECgene alternative splicing isoforms for

Expression for GAGE5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAGE5 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAGE5 Gene:


mRNA Expression by UniProt/SwissProt for GAGE5 Gene:

Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except testis.
genes like me logo Genes that share expression patterns with GAGE5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAGE5 Gene

Orthologs for GAGE5 Gene

No data available for Orthologs and Evolution for GAGE5 Gene

Paralogs for GAGE5 Gene

(27) SIMAP similar genes for GAGE5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAGE5: view

No data available for Paralogs for GAGE5 Gene

Variants for GAGE5 Gene

Structural Variations from Database of Genomic Variants (DGV) for GAGE5 Gene

Variant ID Type Subtype PubMed ID
dgv4237n106 CNV duplication 24896259
esv28941 CNV gain+loss 19812545
esv3364710 CNV duplication 20981092
esv3380090 CNV duplication 20981092
esv3435089 CNV duplication 20981092
esv3449504 CNV duplication 20981092
nsv1077583 CNV duplication 25765185
nsv1077584 CNV duplication 25765185
nsv1129078 CNV duplication 24896259
nsv1147303 CNV duplication 26484159
nsv1152758 CNV duplication 26484159
nsv820429 CNV deletion 20802225
nsv953412 CNV duplication 24416366

Additional Variant Information for GAGE5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for GAGE5 Gene

Disorders for GAGE5 Gene

Additional Disease Information for GAGE5

No disorders were found for GAGE5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE5 Gene

Publications for GAGE5 Gene

  1. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PMID: 7544395) Van den Eynde B … Boon T (The Journal of experimental medicine 1995) 2 3 4 58
  2. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff MF … Ditzel HJ (Tissue antigens 2008) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PMID: 10397259) De Backer O … van der Bruggen P (Cancer research 1999) 3 4 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for GAGE5 Gene

Sources for GAGE5 Gene

Loading form....