Aliases for GAGE2D Gene

Aliases for GAGE2D Gene

  • G Antigen 2D 2 3 4
  • Cancer/Testis Antigen 4.8 3 4
  • GAGE-2D 3 4
  • GAGE-8 3 4
  • CT4.8 3 4
  • GAGE8 2 3
  • G Antigen 8 4

External Ids for GAGE2D Gene

Previous GeneCards Identifiers for GAGE2D Gene

  • GC0XP049096
  • GC0XP049098
  • GC0XP049099
  • GC0XP049191
  • GC0XP049206
  • GC0XP049209
  • GC0XP049219
  • GC0XP049229
  • GC0XP049236
  • GC0XP049246
  • GC0XP049252
  • GC0XP049257
  • GC0XP049262
  • GC0XP049561

Summaries for GAGE2D Gene

GeneCards Summary for GAGE2D Gene

GAGE2D (G Antigen 2D) is a Protein Coding gene.

Additional gene information for GAGE2D Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GAGE2D Gene

Genomics for GAGE2D Gene

Genomic Locations for GAGE2D Gene

Genomic Locations for GAGE2D Gene
Unknown strand
7,305 bases
Plus strand

Genomic View for GAGE2D Gene

Cytogenetic band:
GeneLoc Logo Gene Density

No data available for GeneHancer (GH) Regulatory Elements and RefSeq DNA sequence for GAGE2D Gene

Proteins for GAGE2D Gene

  • Protein details for GAGE2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G antigen 2D
    Protein Accession:
    Secondary Accessions:
    • A6NG46
    • A6NNR8
    • B7ZL76
    • Q4V325

    Protein attributes for GAGE2D Gene

    116 amino acids
    Molecular mass:
    12764 Da
    Quaternary structure:
    No Data Available
    • This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE2D Gene

Post-translational modifications for GAGE2D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE2D Gene

REFSEQ proteins:

No data available for DME Specific Peptides for GAGE2D Gene

Domains & Families for GAGE2D Gene

Gene Families for GAGE2D Gene


Protein Domains for GAGE2D Gene

  • GAGE

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE2D: view

No data available for Suggested Antigen Peptide Sequences for GAGE2D Gene

Function for GAGE2D Gene

Gene Ontology (GO) - Molecular Function for GAGE2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with GAGE2D: view

Animal Model Products

CRISPR Products

miRNA for GAGE2D Gene

miRTarBase miRNAs that target GAGE2D

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAGE2D

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAGE2D Gene

Localization for GAGE2D Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GAGE2D Gene

Pathways & Interactions for GAGE2D Gene

PathCards logo

SuperPathways for GAGE2D Gene

No Data Available

Interacting Proteins for GAGE2D Gene

Gene Ontology (GO) - Biological Process for GAGE2D Gene


No data available for Pathways by source and SIGNOR curated interactions for GAGE2D Gene

Drugs & Compounds for GAGE2D Gene

No Compound Related Data Available

Transcripts for GAGE2D Gene

mRNA/cDNA for GAGE2D Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAGE2D

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE2D Gene

No ASD Table

Expression for GAGE2D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAGE2D Gene

mRNA differential expression in normal tissues according to GTEx for GAGE2D Gene

This gene is overexpressed in Testis (x49.5).

mRNA Expression by UniProt/SwissProt for GAGE2D Gene:

Tissue specificity: Not expressed in normal tissues, except in testis, but expressed by a large proportion of tumors of various histological origins.
genes like me logo Genes that share expression patterns with GAGE2D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAGE2D Gene

Orthologs for GAGE2D Gene

No data available for Orthologs and Evolution for GAGE2D Gene

Paralogs for GAGE2D Gene

(25) SIMAP similar genes for GAGE2D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAGE2D: view

No data available for Paralogs for GAGE2D Gene

Variants for GAGE2D Gene

Structural Variations from Database of Genomic Variants (DGV) for GAGE2D Gene

Variant ID Type Subtype PubMed ID
esv3399100 CNV duplication 20981092
esv3408787 CNV duplication 20981092
nsv1129077 CNV duplication 24896259
nsv515202 CNV gain 21397061
nsv6897 CNV insertion 18451855

Variation tolerance for GAGE2D Gene

Gene Damage Index Score: 5.67; 72.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAGE2D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Additional dbSNP identifiers (rs#s) for GAGE2D Gene

Disorders for GAGE2D Gene

Additional Disease Information for GAGE2D

No disorders were found for GAGE2D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE2D Gene

Publications for GAGE2D Gene

  1. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff MF … Ditzel HJ (Tissue antigens 2008) 3 4
  2. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PMID: 10397259) De Backer O … van der Bruggen P (Cancer research 1999) 3 4
  3. Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones. (PMID: 28515276) Malinová A … Verheggen C (The Journal of cell biology 2017) 3
  4. A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. (PMID: 28625976) Hou P … Huang J (Cancer research 2017) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for GAGE2D Gene

Sources for GAGE2D Gene