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Aliases for GAGE2B Gene

Aliases for GAGE2B Gene

  • G Antigen 2B 2 3
  • Cancer/Testis Antigen 4.2 3 4
  • GAGE-2B 3 4
  • CT4.2 3 4
  • G Antigen 2A/2B 3
  • G Antigen 2B/2C 3
  • G Antigen 2C 4
  • GAGE-2C 4
  • GAGE-2 3
  • GAGE2 4

External Ids for GAGE2B Gene

Previous GeneCards Identifiers for GAGE2B Gene

  • GC0XU900862
  • GC0XP049123
  • GC0XP049124
  • GC0XP049235
  • GC0XP049234

Summaries for GAGE2B Gene

GeneCards Summary for GAGE2B Gene

GAGE2B (G Antigen 2B) is a Protein Coding gene.

UniProtKB/Swiss-Prot for GAGE2B Gene

  • Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes.

Additional gene information for GAGE2B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE2B Gene

Genomics for GAGE2B Gene

GeneHancer (GH) Regulatory Elements for GAGE2B Gene

Promoters and enhancers for GAGE2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI049331 Promoter 0.5 EPDnew 550.8 0.0 -21 0.1 GAGE13 GAGE2B PIR40119
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GAGE2B on UCSC Golden Path with GeneCards custom track

Genomic Locations for GAGE2B Gene

Genomic Locations for GAGE2B Gene
7,319 bases
Plus strand

Genomic View for GAGE2B Gene

Genes around GAGE2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAGE2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAGE2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for GAGE2B Gene

Proteins for GAGE2B Gene

  • Protein details for GAGE2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G antigen 2B/2C
    Protein Accession:
    Secondary Accessions:
    • C9K0W9
    • Q4V322

    Protein attributes for GAGE2B Gene

    116 amino acids
    Molecular mass:
    12786 Da
    Quaternary structure:
    No Data Available
    • This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE2B Gene

Post-translational modifications for GAGE2B Gene

No Post-translational modifications

Other Protein References for GAGE2B Gene

REFSEQ proteins:

No data available for DME Specific Peptides for GAGE2B Gene

Domains & Families for GAGE2B Gene

Protein Domains for GAGE2B Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE2B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for GAGE2B Gene

Function for GAGE2B Gene

Molecular function for GAGE2B Gene

UniProtKB/Swiss-Prot Function:
Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes.

Gene Ontology (GO) - Molecular Function for GAGE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GAGE2B: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAGE2B Gene

Localization for GAGE2B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAGE2B gene
Compartment Confidence
nucleus 3
extracellular 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GAGE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with GAGE2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GAGE2B Gene

Pathways & Interactions for GAGE2B Gene

SuperPathways for GAGE2B Gene

No Data Available

Interacting Proteins for GAGE2B Gene

Selected Interacting proteins: Q13066-GAG2B_HUMAN for GAGE2B Gene via UniProtKB

Gene Ontology (GO) - Biological Process for GAGE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GAGE2B: view

No data available for Pathways by source and SIGNOR curated interactions for GAGE2B Gene

Drugs & Compounds for GAGE2B Gene

No Compound Related Data Available

Transcripts for GAGE2B Gene

mRNA/cDNA for GAGE2B Gene

(1) REFSEQ mRNAs :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE2B Gene

No ASD Table

Relevant External Links for GAGE2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GAGE2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAGE2B Gene

mRNA differential expression in normal tissues according to GTEx for GAGE2B Gene

This gene is overexpressed in Testis (x53.0).

NURSA nuclear receptor signaling pathways regulating expression of GAGE2B Gene:


SOURCE GeneReport for Unigene cluster for GAGE2B Gene:


mRNA Expression by UniProt/SwissProt for GAGE2B Gene:

Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except testis.
genes like me logo Genes that share expression patterns with GAGE2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAGE2B Gene

Orthologs for GAGE2B Gene

No data available for Orthologs and Evolution for GAGE2B Gene

Paralogs for GAGE2B Gene

genes like me logo Genes that share paralogs with GAGE2B: view

No data available for Paralogs for GAGE2B Gene

Variants for GAGE2B Gene

Structural Variations from Database of Genomic Variants (DGV) for GAGE2B Gene

Variant ID Type Subtype PubMed ID
dgv4237n106 CNV duplication 24896259
esv28941 CNV gain+loss 19812545
esv3327960 CNV duplication 20981092
esv3364710 CNV duplication 20981092
esv3392575 CNV duplication 20981092
esv3407218 CNV duplication 20981092
nsv1075727 CNV deletion 25765185
nsv1153207 CNV duplication 26484159
nsv515203 CNV gain 21397061
nsv6899 CNV insertion 18451855
nsv6900 CNV deletion 18451855
nsv820429 CNV deletion 20802225
nsv953412 CNV duplication 24416366

Variation tolerance for GAGE2B Gene

Gene Damage Index Score: 0.00; 0.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAGE2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GAGE2B Gene

Disorders for GAGE2B Gene

Additional Disease Information for GAGE2B

No disorders were found for GAGE2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE2B Gene

Publications for GAGE2B Gene

  1. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff MF … Ditzel HJ (Tissue antigens 2008) 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PMID: 7544395) Van den Eynde B … Boon T (The Journal of experimental medicine 1995) 3 4 58
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 58

Products for GAGE2B Gene

Sources for GAGE2B Gene

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