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Aliases for GAGE12I Gene

Aliases for GAGE12I Gene

  • G Antigen 12I 2 3
  • G Antigen 7B 2 3
  • Cancer/Testis Antigen 4.7 3
  • G Antigen 12F/G/I 3
  • GAGE-12I 4
  • GAGE-7B 3
  • GAGE7B 3
  • CT4.7 3
  • AL4 3

External Ids for GAGE12I Gene

Previous HGNC Symbols for GAGE12I Gene

  • GAGE7B

Previous GeneCards Identifiers for GAGE12I Gene

  • GC0XP049085
  • GC0XP049110
  • GC0XP049179
  • GC0XP049223
  • GC0XP049228
  • GC0XP049237
  • GC0XP049247
  • GC0XP049253
  • GC0XP049258
  • GC0XP049263
  • GC0XP049341

Summaries for GAGE12I Gene

Entrez Gene Summary for GAGE12I Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAGE12I Gene

GAGE12I (G Antigen 12I) is a Protein Coding gene. An important paralog of this gene is GAGE12C.

Additional gene information for GAGE12I Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE12I Gene

Genomics for GAGE12I Gene

Genomic Locations for GAGE12I Gene

Genomic Locations for GAGE12I Gene
Unknown strand

Genomic View for GAGE12I Gene

Cytogenetic band:
GeneLoc Logo Gene Density

No data available for GeneHancer (GH) Regulatory Elements and RefSeq DNA sequence for GAGE12I Gene

Proteins for GAGE12I Gene

  • Protein details for GAGE12I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G antigen 12I
    Protein Accession:
    Secondary Accessions:
    • Q66I50

    Protein attributes for GAGE12I Gene

    117 amino acids
    Molecular mass:
    12978 Da
    Quaternary structure:
    • Forms tetramers.
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE12I Gene

Post-translational modifications for GAGE12I Gene

No Post-translational modifications

Other Protein References for GAGE12I Gene

REFSEQ proteins:

No data available for DME Specific Peptides for GAGE12I Gene

Domains & Families for GAGE12I Gene

Protein Domains for GAGE12I Gene


Suggested Antigen Peptide Sequences for GAGE12I Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE12I: view

No data available for Gene Families for GAGE12I Gene

Function for GAGE12I Gene

Gene Ontology (GO) - Molecular Function for GAGE12I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GAGE12I: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAGE12I Gene

Localization for GAGE12I Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GAGE12I Gene

Pathways & Interactions for GAGE12I Gene

SuperPathways for GAGE12I Gene

No Data Available

Interacting Proteins for GAGE12I Gene

Selected Interacting proteins: P0CL82-GG12I_HUMAN for GAGE12I Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for GAGE12I Gene


No data available for Pathways by source and SIGNOR curated interactions for GAGE12I Gene

Drugs & Compounds for GAGE12I Gene

No Compound Related Data Available

Transcripts for GAGE12I Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE12I Gene

No ASD Table

Relevant External Links for GAGE12I Gene

ECgene alternative splicing isoforms for

Expression for GAGE12I Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAGE12I Gene

mRNA differential expression in normal tissues according to GTEx for GAGE12I Gene

This gene is overexpressed in Testis (x50.6).

NURSA nuclear receptor signaling pathways regulating expression of GAGE12I Gene:

genes like me logo Genes that share expression patterns with GAGE12I: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAGE12I Gene

Orthologs for GAGE12I Gene

No data available for Orthologs and Evolution for GAGE12I Gene

Paralogs for GAGE12I Gene

Paralogs for GAGE12I Gene

genes like me logo Genes that share paralogs with GAGE12I: view

Variants for GAGE12I Gene

Structural Variations from Database of Genomic Variants (DGV) for GAGE12I Gene

Variant ID Type Subtype PubMed ID
nsv953412 CNV duplication 24416366
nsv820429 CNV deletion 20802225
nsv1152758 CNV duplication 26484159
nsv1147303 CNV duplication 26484159
nsv1129078 CNV duplication 24896259
nsv1077584 CNV duplication 25765185
nsv1077583 CNV duplication 25765185
esv3449504 CNV duplication 20981092
esv3435089 CNV duplication 20981092
esv3380090 CNV duplication 20981092
esv3364710 CNV duplication 20981092
esv28941 CNV gain+loss 19812545
dgv4237n106 CNV duplication 24896259

Additional Variant Information for GAGE12I Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for GAGE12I Gene

Disorders for GAGE12I Gene

Additional Disease Information for GAGE12I

No disorders were found for GAGE12I Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE12I Gene

Publications for GAGE12I Gene

  1. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PMID: 10397259) De Backer O … van der Bruggen P (Cancer research 1999) 2 3 22 58
  2. GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL). (PMID: 23029259) Gjerstorff MF … Ditzel HJ (PloS one 2012) 2 3 58
  3. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff MF … Ditzel HJ (Tissue antigens 2008) 3 4 58
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  5. Isolation and characterization of PAGE-1 and GAGE-7. New genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PMID: 9651357) Chen ME … Sikes RA (The Journal of biological chemistry 1998) 3 22 58

Products for GAGE12I Gene

Sources for GAGE12I Gene

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