Aliases for GAGE12F Gene

Aliases for GAGE12F Gene

  • G Antigen 12F 2 3 4 5
  • GAGE-12F 3 4
  • Cancer/Testis Antigen 4.7 3
  • OTTHUMG00000024147 2
  • G Antigen 12F/G/I 3
  • G Antigen 12G 3
  • G Antigen 12I 3
  • G Antigen 7 3
  • GAGE-7B 3
  • GAGE12F 5
  • GAGE-7 3
  • GAGE-8 3
  • GAGE7B 3
  • CT4.7 3
  • GAGE7 3
  • AL4 3

External Ids for GAGE12F Gene

Previous GeneCards Identifiers for GAGE12F Gene

  • GC00U922120
  • GC0XP049051
  • GC0XP049194
  • GC0XP049203
  • GC0XP049217
  • GC0XP049205
  • GC0XP049298
  • GC0XP049299
  • GC0XP049307
  • GC0XP049326
  • GC0XP049560

Summaries for GAGE12F Gene

GeneCards Summary for GAGE12F Gene

GAGE12F (G Antigen 12F) is a Protein Coding gene. Diseases associated with GAGE12F include Febrile Seizures, Familial, 9 and Familial Febrile Seizures. An important paralog of this gene is GAGE12G.

Additional gene information for GAGE12F Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GAGE12F Gene

Genomics for GAGE12F Gene

Genomic Locations for GAGE12F Gene

Genomic Locations for GAGE12F Gene
16,941 bases
Plus strand
7,330 bases
Plus strand

Genomic View for GAGE12F Gene

Genes around GAGE12F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAGE12F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAGE12F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE12F Gene

No data available for GeneHancer (GH) Regulatory Elements for GAGE12F Gene

Proteins for GAGE12F Gene

  • Protein details for GAGE12F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G antigen 12F
    Protein Accession:
    Secondary Accessions:
    • Q66I50

    Protein attributes for GAGE12F Gene

    117 amino acids
    Molecular mass:
    12978 Da
    Quaternary structure:
    • Forms tetramers.
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

    Alternative splice isoforms for GAGE12F Gene


neXtProt entry for GAGE12F Gene

Post-translational modifications for GAGE12F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE12F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAGE12F Gene

Domains & Families for GAGE12F Gene

Gene Families for GAGE12F Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GAGE12F Gene


Suggested Antigen Peptide Sequences for GAGE12F Gene

GenScript: Design optimal peptide antigens:
  • G antigen 12F (GG12F_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE12F: view

Function for GAGE12F Gene

Gene Ontology (GO) - Molecular Function for GAGE12F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with GAGE12F: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAGE12F

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAGE12F Gene

Localization for GAGE12F Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAGE12F gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GAGE12F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with GAGE12F: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GAGE12F Gene

Pathways & Interactions for GAGE12F Gene

PathCards logo

SuperPathways for GAGE12F Gene

No Data Available

Interacting Proteins for GAGE12F Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000404123 P0CL80-GG12F_HUMAN for GAGE12F Gene via STRING IID

Gene Ontology (GO) - Biological Process for GAGE12F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GAGE12F: view

No data available for Pathways by source and SIGNOR curated interactions for GAGE12F Gene

Drugs & Compounds for GAGE12F Gene

No Compound Related Data Available

Transcripts for GAGE12F Gene

mRNA/cDNA for GAGE12F Gene

12 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAGE12F

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE12F Gene

No ASD Table

Relevant External Links for GAGE12F Gene

GeneLoc Exon Structure for

Expression for GAGE12F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAGE12F Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GAGE12F

SOURCE GeneReport for Unigene cluster for GAGE12F Gene:

genes like me logo Genes that share expression patterns with GAGE12F: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAGE12F Gene

Orthologs for GAGE12F Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE12F Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 31
  • 94 (a)
Species where no ortholog for GAGE12F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for GAGE12F Gene

Gene Tree for GAGE12F (if available)
Gene Tree for GAGE12F (if available)

Paralogs for GAGE12F Gene

(26) SIMAP similar genes for GAGE12F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAGE12F: view

Variants for GAGE12F Gene

Additional dbSNP identifiers (rs#s) for GAGE12F Gene

Structural Variations from Database of Genomic Variants (DGV) for GAGE12F Gene

Variant ID Type Subtype PubMed ID
dgv4237n106 CNV duplication 24896259
esv28941 CNV gain+loss 19812545
esv3363500 CNV duplication 20981092
esv3364710 CNV duplication 20981092
esv3373509 CNV duplication 20981092
esv3374855 CNV duplication 20981092
esv3380090 CNV duplication 20981092
esv3393529 CNV duplication 20981092
esv3434123 CNV duplication 20981092
esv3435089 CNV duplication 20981092
esv3445396 CNV duplication 20981092
esv3446455 CNV duplication 20981092
esv3449504 CNV duplication 20981092
esv3450031 CNV duplication 20981092
esv3451132 CNV duplication 20981092
nsv1075724 CNV deletion 25765185
nsv1075725 CNV deletion 25765185
nsv1076708 CNV duplication 25765185
nsv1077583 CNV duplication 25765185
nsv1077584 CNV duplication 25765185
nsv1129078 CNV duplication 24896259
nsv1141677 CNV duplication 24896259
nsv1147303 CNV duplication 26484159
nsv1151845 CNV duplication 26484159
nsv1152758 CNV duplication 26484159
nsv820429 CNV deletion 20802225
nsv953412 CNV duplication 24416366

Additional Variant Information for GAGE12F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for GAGE12F Gene

Disorders for GAGE12F Gene

MalaCards: The human disease database

(2) MalaCards diseases for GAGE12F Gene - From: DISEASES

Disorder Aliases PubMed IDs
febrile seizures, familial, 9
  • feb9
familial febrile seizures
  • familial febrile convulsions
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GAGE12F

genes like me logo Genes that share disorders with GAGE12F: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAGE12F Gene

Publications for GAGE12F Gene

  1. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff MF … Ditzel HJ (Tissue antigens 2008) 3 4
  2. GAGE7B promotes tumor metastasis and growth via activating the p38δ/pMAPKAPK2/pHSP27 pathway in gastric cancer. (PMID: 30871606) Shi DB … Gao P (Journal of experimental & clinical cancer research : CR 2019) 3
  3. A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. (PMID: 28625976) Hou P … Huang J (Cancer research 2017) 3
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for GAGE12F Gene

Sources for GAGE12F Gene