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Aliases for GAGE12D Gene

Aliases for GAGE12D Gene

  • G Antigen 12D 2 3 5
  • GAGE-12B 3 4
  • GAGE-12D 3 4
  • G Antigen 12B/C/D/E 3
  • G Antigen 12C/D/E 3
  • GAGE-12C 4
  • GAGE-12E 4

External Ids for GAGE12D Gene

Previous GeneCards Identifiers for GAGE12D Gene

  • GC0XP049075
  • GC0XP049055
  • GC0XP049067
  • GC0XP049185
  • GC0XP049197
  • GC0XP049306

Summaries for GAGE12D Gene

GeneCards Summary for GAGE12D Gene

GAGE12D (G Antigen 12D) is a Protein Coding gene. An important paralog of this gene is GAGE12E.

Additional gene information for GAGE12D Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE12D Gene

Genomics for GAGE12D Gene

Genomic Locations for GAGE12D Gene

Genomic Locations for GAGE12D Gene
chrX:49,541,722-49,549,107
(GRCh38/hg38)
Size:
7,386 bases
Orientation:
Plus strand
chrX:49,306,325-49,313,710
(GRCh37/hg19)
Size:
7,386 bases
Orientation:
Plus strand

Genomic View for GAGE12D Gene

Genes around GAGE12D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAGE12D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAGE12D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE12D Gene

No data available for GeneHancer (GH) Regulatory Elements for GAGE12D Gene

Proteins for GAGE12D Gene

  • Protein details for GAGE12D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L429-GG12C_HUMAN
    Recommended name:
    G antigen 12B/C/D/E
    Protein Accession:
    A1L429
    Secondary Accessions:
    • A6NHF1
    • B7ZL74

    Protein attributes for GAGE12D Gene

    Size:
    117 amino acids
    Molecular mass:
    12925 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE12D Gene

Post-translational modifications for GAGE12D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE12D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAGE12D Gene

Domains & Families for GAGE12D Gene

Gene Families for GAGE12D Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GAGE12D Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A1L429

UniProtKB/Swiss-Prot:

GG12C_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE12D: view

No data available for Suggested Antigen Peptide Sequences for GAGE12D Gene

Function for GAGE12D Gene

Gene Ontology (GO) - Molecular Function for GAGE12D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GAGE12D: view

Animal Model Products

CRISPR Products

miRNA for GAGE12D Gene

miRTarBase miRNAs that target GAGE12D

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAGE12D

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAGE12D Gene

Localization for GAGE12D Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Golgi apparatus (1)
  • Plasma membrane (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GAGE12D Gene

Pathways & Interactions for GAGE12D Gene

PathCards logo

SuperPathways for GAGE12D Gene

No Data Available

Interacting Proteins for GAGE12D Gene

Selected Interacting proteins: A1L429-GG12C_HUMAN for GAGE12D Gene via IID

Symbol External ID(s) Details
GMCL1
GMCL2

Gene Ontology (GO) - Biological Process for GAGE12D Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAGE12D Gene

Drugs & Compounds for GAGE12D Gene

No Compound Related Data Available

Transcripts for GAGE12D Gene

mRNA/cDNA for GAGE12D Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for GAGE12D Gene

G antigen 12D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAGE12D

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE12D Gene

No ASD Table

Relevant External Links for GAGE12D Gene

GeneLoc Exon Structure for
GAGE12D
ECgene alternative splicing isoforms for
GAGE12D

Expression for GAGE12D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAGE12D Gene

NURSA nuclear receptor signaling pathways regulating expression of GAGE12D Gene:

GAGE12D

SOURCE GeneReport for Unigene cluster for GAGE12D Gene:

Hs.645554
genes like me logo Genes that share expression patterns with GAGE12D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAGE12D Gene

Orthologs for GAGE12D Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE12D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 93 (a)
OneToMany
Species where no ortholog for GAGE12D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE12D Gene

ENSEMBL:
Gene Tree for GAGE12D (if available)
TreeFam:
Gene Tree for GAGE12D (if available)

Paralogs for GAGE12D Gene

(23) SIMAP similar genes for GAGE12D Gene using alignment to 1 proteins:

  • GG12C_HUMAN
genes like me logo Genes that share paralogs with GAGE12D: view

Variants for GAGE12D Gene

Sequence variations from dbSNP and Humsavar for GAGE12D Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1168647813 -- 49,543,433(+) C/A intron_variant
rs1170942005 -- 49,543,625(+) C/T intron_variant
rs1174970546 -- 49,543,893(+) G/T intron_variant
rs1178504441 -- 49,543,728(+) T/C intron_variant
rs1186880266 -- 49,543,441(+) A/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for GAGE12D Gene

Variant ID Type Subtype PubMed ID
dgv4237n106 CNV duplication 24896259
esv28941 CNV gain+loss 19812545
esv3334428 CNV duplication 20981092
esv3363500 CNV duplication 20981092
esv3364710 CNV duplication 20981092
esv3365328 CNV duplication 20981092
esv3373509 CNV duplication 20981092
esv3374855 CNV duplication 20981092
esv3380090 CNV duplication 20981092
esv3383847 CNV duplication 20981092
esv3393529 CNV duplication 20981092
esv3399100 CNV duplication 20981092
esv3407218 CNV duplication 20981092
esv3408787 CNV duplication 20981092
esv3434123 CNV duplication 20981092
esv3435089 CNV duplication 20981092
esv3445396 CNV duplication 20981092
esv3446455 CNV duplication 20981092
esv3449504 CNV duplication 20981092
esv3450031 CNV duplication 20981092
esv3451132 CNV duplication 20981092
esv3451692 CNV duplication 20981092
nsv1075724 CNV deletion 25765185
nsv1075725 CNV deletion 25765185
nsv1075726 CNV deletion 25765185
nsv1076708 CNV duplication 25765185
nsv1077583 CNV duplication 25765185
nsv1077584 CNV duplication 25765185
nsv1129077 CNV duplication 24896259
nsv1129078 CNV duplication 24896259
nsv1141677 CNV duplication 24896259
nsv1147303 CNV duplication 26484159
nsv1151845 CNV duplication 26484159
nsv1152758 CNV duplication 26484159
nsv515202 CNV gain 21397061
nsv515203 CNV gain 21397061
nsv6896 CNV insertion 18451855
nsv6897 CNV insertion 18451855
nsv6899 CNV insertion 18451855
nsv6900 CNV deletion 18451855
nsv820429 CNV deletion 20802225
nsv953412 CNV duplication 24416366

Additional Variant Information for GAGE12D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAGE12D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GAGE12D Gene

Disorders for GAGE12D Gene

Additional Disease Information for GAGE12D

No disorders were found for GAGE12D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE12D Gene

Publications for GAGE12D Gene

  1. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff MF … Ditzel HJ (Tissue antigens 2008) 3 4 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for GAGE12D Gene

Sources for GAGE12D Gene

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