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Aliases for GAGE12C Gene

Aliases for GAGE12C Gene

  • G Antigen 12C 2 3 5
  • G Antigen 12B/C/D/E 3 4
  • GAGE-12B 3 4
  • GAGE-12C 3 4
  • G Antigen 12C/D/E 3
  • GAGE-12D 4
  • GAGE-12E 4

External Ids for GAGE12C Gene

Previous GeneCards Identifiers for GAGE12C Gene

  • GC0XU900713
  • GC0XP049115
  • GC0XP049184
  • GC0XP049178
  • GC0XP049300

Summaries for GAGE12C Gene

GeneCards Summary for GAGE12C Gene

GAGE12C (G Antigen 12C) is a Protein Coding gene. An important paralog of this gene is GAGE12D.

Additional gene information for GAGE12C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE12C Gene

Genomics for GAGE12C Gene

GeneHancer (GH) Regulatory Elements for GAGE12C Gene

Promoters and enhancers for GAGE12C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ049532 Promoter 0.5 EPDnew 600.7 0.0 -14 0.1 GAGE12C GAGE2E
GH0XJ049341 Promoter 0.6 Ensembl 0.1 -190.6 -190576 0.4 RB1 GAGE12B GAGE2E GAGE12C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAGE12C on UCSC Golden Path with GeneCards custom track

Genomic Locations for GAGE12C Gene

Genomic Locations for GAGE12C Gene
7,365 bases
Plus strand
7,365 bases
Plus strand

Genomic View for GAGE12C Gene

Genes around GAGE12C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAGE12C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAGE12C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE12C Gene

Proteins for GAGE12C Gene

  • Protein details for GAGE12C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G antigen 12B/C/D/E
    Protein Accession:
    Secondary Accessions:
    • A6NHF1
    • B7ZL74

    Protein attributes for GAGE12C Gene

    117 amino acids
    Molecular mass:
    12925 Da
    Quaternary structure:
    No Data Available
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE12C Gene

Post-translational modifications for GAGE12C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE12C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAGE12C Gene

Domains & Families for GAGE12C Gene

Gene Families for GAGE12C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GAGE12C Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE12C: view

No data available for Suggested Antigen Peptide Sequences for GAGE12C Gene

Function for GAGE12C Gene

Gene Ontology (GO) - Molecular Function for GAGE12C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GAGE12C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAGE12C

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAGE12C Gene

Localization for GAGE12C Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Golgi apparatus (1)
  • Plasma membrane (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GAGE12C Gene

Pathways & Interactions for GAGE12C Gene

PathCards logo

SuperPathways for GAGE12C Gene

No Data Available

Interacting Proteins for GAGE12C Gene

Gene Ontology (GO) - Biological Process for GAGE12C Gene


No data available for Pathways by source and SIGNOR curated interactions for GAGE12C Gene

Drugs & Compounds for GAGE12C Gene

No Compound Related Data Available

Transcripts for GAGE12C Gene

mRNA/cDNA for GAGE12C Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAGE12C

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE12C Gene

No ASD Table

Relevant External Links for GAGE12C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GAGE12C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAGE12C Gene

mRNA differential expression in normal tissues according to GTEx for GAGE12C Gene

This gene is overexpressed in Testis (x53.0).

NURSA nuclear receptor signaling pathways regulating expression of GAGE12C Gene:

genes like me logo Genes that share expression patterns with GAGE12C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAGE12C Gene

Orthologs for GAGE12C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE12C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 93 (a)
Species where no ortholog for GAGE12C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE12C Gene

Gene Tree for GAGE12C (if available)
Gene Tree for GAGE12C (if available)

Paralogs for GAGE12C Gene

(23) SIMAP similar genes for GAGE12C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAGE12C: view

Variants for GAGE12C Gene

Sequence variations from dbSNP and Humsavar for GAGE12C Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs11091259 -- 49,535,667(+) A/C intron_variant
rs1156535419 -- 49,537,021(+) G/A intron_variant
rs1156897200 -- 49,533,953(+) C/A coding_sequence_variant, missense_variant
rs1158939653 -- 49,530,767(+) C/A upstream_transcript_variant
rs1159075702 -- 49,538,328(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GAGE12C Gene

Variant ID Type Subtype PubMed ID
dgv4237n106 CNV duplication 24896259
esv28941 CNV gain+loss 19812545
esv3363500 CNV duplication 20981092
esv3364710 CNV duplication 20981092
esv3373509 CNV duplication 20981092
esv3374855 CNV duplication 20981092
esv3393529 CNV duplication 20981092
esv3407218 CNV duplication 20981092
esv3434123 CNV duplication 20981092
esv3435089 CNV duplication 20981092
esv3445396 CNV duplication 20981092
esv3446455 CNV duplication 20981092
esv3449504 CNV duplication 20981092
esv3450031 CNV duplication 20981092
esv3451132 CNV duplication 20981092
esv3451692 CNV duplication 20981092
nsv1075724 CNV deletion 25765185
nsv1075725 CNV deletion 25765185
nsv1075726 CNV deletion 25765185
nsv1076708 CNV duplication 25765185
nsv1077583 CNV duplication 25765185
nsv1077584 CNV duplication 25765185
nsv1129078 CNV duplication 24896259
nsv1141677 CNV duplication 24896259
nsv1147303 CNV duplication 26484159
nsv1151845 CNV duplication 26484159
nsv515203 CNV gain 21397061
nsv6899 CNV insertion 18451855
nsv6900 CNV deletion 18451855
nsv820429 CNV deletion 20802225
nsv953412 CNV duplication 24416366

Additional Variant Information for GAGE12C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GAGE12C Gene

Disorders for GAGE12C Gene

Additional Disease Information for GAGE12C

No disorders were found for GAGE12C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE12C Gene

Publications for GAGE12C Gene

  1. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff MF … Ditzel HJ (Tissue antigens 2008) 3 4 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for GAGE12C Gene

Sources for GAGE12C Gene

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