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Aliases for GAGE10 Gene

Aliases for GAGE10 Gene

  • G Antigen 10 2 3 4 5
  • GAGE-10 3 4

External Ids for GAGE10 Gene

Previous GeneCards Identifiers for GAGE10 Gene

  • GC0XP049048
  • GC0XP049063
  • GC0XP049064
  • GC0XP049160
  • GC0XP046817

Summaries for GAGE10 Gene

GeneCards Summary for GAGE10 Gene

GAGE10 (G Antigen 10) is a Protein Coding gene. An important paralog of this gene is GAGE13.

Additional gene information for GAGE10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE10 Gene

Genomics for GAGE10 Gene

GeneHancer (GH) Regulatory Elements for GAGE10 Gene

Promoters and enhancers for GAGE10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ049219 Enhancer 0.4 Ensembl 4.5 -83.8 -83845 0.8 ZNF121 ZNF513 GPKOW GAGE10 CACNA1F SYP
GH0XJ049308 Enhancer 0.7 ENCODE 0.4 +5.8 5820 2.3 SP1 PRDM1 IKZF1 IKZF2 RFX1 MGA EGR1 NR2C2 ZFHX2 IRF2 GAGE13 GAGE10 GAGE12J
GH0XJ049315 Enhancer 0.6 Ensembl 0.4 +12.1 12055 1.4 TRIM24 IKZF1 ZNF512 ZNF24 SOX6 ATF2 DPF2 TCF12 ATF1 TAL1 GAGE13 PQBP1 GAGE12J GAGE10
GH0XJ049305 Enhancer 0.2 Ensembl 0.7 +2.1 2055 0.2 GAGE10 GAGE12J
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAGE10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GAGE10 gene promoter:
  • Arnt
  • Egr-4
  • GR
  • GR-alpha
  • GR-beta
  • HNF-4alpha1
  • MZF-1
  • PPAR-gamma1
  • PPAR-gamma2
  • TBP

Genomic Locations for GAGE10 Gene

Genomic Locations for GAGE10 Gene
16,199 bases
Plus strand
16,176 bases
Plus strand

Genomic View for GAGE10 Gene

Genes around GAGE10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAGE10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAGE10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE10 Gene

Proteins for GAGE10 Gene

  • Protein details for GAGE10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G antigen 10
    Protein Accession:

    Protein attributes for GAGE10 Gene

    116 amino acids
    Molecular mass:
    12651 Da
    Quaternary structure:
    No Data Available
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE10 Gene

Post-translational modifications for GAGE10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAGE10 Gene

Domains & Families for GAGE10 Gene

Gene Families for GAGE10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GAGE10 Gene


Suggested Antigen Peptide Sequences for GAGE10 Gene

GenScript: Design optimal peptide antigens:
  • G antigen 10 (GAG10_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE10: view

Function for GAGE10 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAGE10

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAGE10 Gene

Localization for GAGE10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAGE10 gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Golgi apparatus (1)
  • Plasma membrane (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GAGE10 Gene

Pathways & Interactions for GAGE10 Gene

PathCards logo

SuperPathways for GAGE10 Gene

No Data Available

Interacting Proteins for GAGE10 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
Selected Interacting proteins: A6NGK3-GAG10_HUMAN ENSP00000385415 for GAGE10 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for GAGE10 Gene


No data available for Pathways by source and SIGNOR curated interactions for GAGE10 Gene

Drugs & Compounds for GAGE10 Gene

No Compound Related Data Available

Transcripts for GAGE10 Gene

mRNA/cDNA for GAGE10 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAGE10

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE10 Gene

No ASD Table

Relevant External Links for GAGE10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GAGE10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAGE10 Gene

mRNA differential expression in normal tissues according to GTEx for GAGE10 Gene

This gene is overexpressed in Testis (x7.9) and Pituitary (x7.1).

NURSA nuclear receptor signaling pathways regulating expression of GAGE10 Gene:

genes like me logo Genes that share expression patterns with GAGE10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAGE10 Gene

Orthologs for GAGE10 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GAGE10 34
  • 96.26 (n)
-- 35
  • 91 (a)
Species where no ortholog for GAGE10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE10 Gene

Gene Tree for GAGE10 (if available)
Gene Tree for GAGE10 (if available)

Paralogs for GAGE10 Gene

(26) SIMAP similar genes for GAGE10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAGE10: view

Variants for GAGE10 Gene

Sequence variations from dbSNP and Humsavar for GAGE10 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs111602038 -- 49,315,479(+) G/A intron_variant
rs111622823 -- 49,315,072(+) C/A intron_variant
rs111674184 -- 49,315,529(+) G/A intron_variant
rs111851556 -- 49,304,192(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GAGE10 Gene

Variant ID Type Subtype PubMed ID
esv3392254 CNV duplication 20981092
esv3451555 CNV duplication 20981092
esv3573952 CNV loss 25503493
nsv469734 CNV gain+loss 16826518
nsv471602 CNV gain 15918152
nsv6896 CNV insertion 18451855

Variation tolerance for GAGE10 Gene

Residual Variation Intolerance Score: 68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAGE10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAGE10 Gene

Disorders for GAGE10 Gene

Additional Disease Information for GAGE10

No disorders were found for GAGE10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE10 Gene

Publications for GAGE10 Gene

  1. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff MF … Ditzel HJ (Tissue antigens 2008) 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for GAGE10 Gene

Sources for GAGE10 Gene

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