This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008] See more...

Aliases for GADD45G Gene

Aliases for GADD45G Gene

  • Growth Arrest And DNA Damage Inducible Gamma 2 3 5
  • Growth Arrest And DNA Damage-Inducible Protein GADD45 Gamma 3 4
  • DNA Damage-Inducible Transcript 2 Protein 3 4
  • Cytokine-Responsive Protein CR6 3 4
  • Gadd-Related Protein, 17 KD 2 3
  • DDIT-2 3 4
  • DDIT2 3 4
  • CR6 3 4
  • Growth Arrest And DNA-Damage-Inducible, Gamma 2
  • Growth Arrest And DNA-Damage-Inducible Gamma 2
  • GADD45-Gamma 3
  • GADD45gamma 3
  • GRP17 3

External Ids for GADD45G Gene

Previous GeneCards Identifiers for GADD45G Gene

  • GC09P083195
  • GC09P084099
  • GC09P085804
  • GC09P087711
  • GC09P089449
  • GC09P091409
  • GC09P092219
  • GC09P062051

Summaries for GADD45G Gene

Entrez Gene Summary for GADD45G Gene

  • This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]

GeneCards Summary for GADD45G Gene

GADD45G (Growth Arrest And DNA Damage Inducible Gamma) is a Protein Coding gene. Diseases associated with GADD45G include Pituitary Adenoma and Retinal Microaneurysm. Among its related pathways are Endometrial cancer and Gastric cancer. An important paralog of this gene is GADD45A.

UniProtKB/Swiss-Prot Summary for GADD45G Gene

  • Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

Gene Wiki entry for GADD45G Gene

Additional gene information for GADD45G Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GADD45G Gene

Genomics for GADD45G Gene

GeneHancer (GH) Regulatory Elements for GADD45G Gene

Promoters and enhancers for GADD45G Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GADD45G on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GADD45G

Top Transcription factor binding sites by QIAGEN in the GADD45G gene promoter:
  • C/EBPalpha
  • CUTL1
  • GR
  • GR-alpha
  • HOXA3
  • NF-AT
  • NF-AT1
  • p53
  • Pax-5

Genomic Locations for GADD45G Gene

Genomic Locations for GADD45G Gene
chr9:89,605,012-89,606,555
(GRCh38/hg38)
Size:
1,544 bases
Orientation:
Plus strand
chr9:92,219,927-92,221,470
(GRCh37/hg19)
Size:
1,544 bases
Orientation:
Plus strand

Genomic View for GADD45G Gene

Genes around GADD45G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GADD45G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GADD45G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GADD45G Gene

Proteins for GADD45G Gene

  • Protein details for GADD45G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95257-GA45G_HUMAN
    Recommended name:
    Growth arrest and DNA damage-inducible protein GADD45 gamma
    Protein Accession:
    O95257
    Secondary Accessions:
    • Q5VZ87
    • Q9C076

    Protein attributes for GADD45G Gene

    Size:
    159 amino acids
    Molecular mass:
    17121 Da
    Quaternary structure:
    • Undergoes concentration-dependent homodimerization, which is required for growth inhibititory activity and enhances interaction with PCNA. Interacts with GADD45GIP1. Interacts with PCNA.

    Three dimensional structures from OCA and Proteopedia for GADD45G Gene

neXtProt entry for GADD45G Gene

Post-translational modifications for GADD45G Gene

No Post-translational modifications

Other Protein References for GADD45G Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for GADD45G
  • Boster Bio Antibodies for GADD45G

No data available for DME Specific Peptides for GADD45G Gene

Domains & Families for GADD45G Gene

Gene Families for GADD45G Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GADD45G Gene

Blocks:
  • Ribosomal protein L7Ae/L30e/S12e/Gadd45
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GADD45G Gene

GenScript: Design optimal peptide antigens:
  • DNA damage-inducible transcript 2 protein (GA45G_HUMAN)
  • Growth arrest and DNA-damage-inducible gamma (Q5MAI3_HUMAN)
  • cDNA, FLJ94278, Homo sapiens growth arrest and DNA-damage-inducible, gamma(GADD45G), mRNA (Q5VZ87_HUMAN)
  • GADD45G protein (Q6IAW6_HUMAN)
  • Gadd45-related protein (Q9UJS2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95257

UniProtKB/Swiss-Prot:

GA45G_HUMAN :
  • Two central helices mediate homodimerization through parallel packing.
  • Belongs to the GADD45 family.
Domain:
  • Two central helices mediate homodimerization through parallel packing.
Family:
  • Belongs to the GADD45 family.
genes like me logo Genes that share domains with GADD45G: view

Function for GADD45G Gene

Molecular function for GADD45G Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
GENATLAS Biochemistry:
growth arrest and DNA-damage inducible,gamma,involved in negative control of cell growth

Phenotypes From GWAS Catalog for GADD45G Gene

Gene Ontology (GO) - Molecular Function for GADD45G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12716909
genes like me logo Genes that share ontologies with GADD45G: view
genes like me logo Genes that share phenotypes with GADD45G: view

Animal Models for GADD45G Gene

MGI Knock Outs for GADD45G:

Animal Model Products

CRISPR Products

miRNA for GADD45G Gene

miRTarBase miRNAs that target GADD45G

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GADD45G Gene

Localization for GADD45G Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GADD45G gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GADD45G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9827804
GO:0005737 cytoplasm IDA,IBA 9827804
genes like me logo Genes that share ontologies with GADD45G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GADD45G Gene

Pathways & Interactions for GADD45G Gene

genes like me logo Genes that share pathways with GADD45G: view

Pathways by source for GADD45G Gene

1 GeneGo (Thomson Reuters) pathway for GADD45G Gene
  • Immune response IL-12-induced IFN-gamma production
5 Qiagen pathways for GADD45G Gene
  • ATM Pathway
  • BRCA1 Pathway
  • DNA Repair Mechanisms
  • GADD45 Pathway
  • p53 Signaling
2 GeneTex pathways for GADD45G Gene

Gene Ontology (GO) - Biological Process for GADD45G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IDA 9827804
GO:0006915 apoptotic process IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0043065 positive regulation of apoptotic process IDA 9827804
genes like me logo Genes that share ontologies with GADD45G: view

No data available for SIGNOR curated interactions for GADD45G Gene

Drugs & Compounds for GADD45G Gene

No Compound Related Data Available

Transcripts for GADD45G Gene

mRNA/cDNA for GADD45G Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GADD45G Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6: -

Relevant External Links for GADD45G Gene

GeneLoc Exon Structure for
GADD45G

Expression for GADD45G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GADD45G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GADD45G Gene

This gene is overexpressed in Liver (x5.6), Heart - Atrial Appendage (x5.6), and Artery - Tibial (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GADD45G

SOURCE GeneReport for Unigene cluster for GADD45G Gene:

Hs.9701

Evidence on tissue expression from TISSUES for GADD45G Gene

  • Nervous system(4.6)
  • Lung(4.5)
  • Liver(2.4)
  • Muscle(2.3)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with GADD45G: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GADD45G Gene

Orthologs for GADD45G Gene

This gene was present in the common ancestor of chordates.

Orthologs for GADD45G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GADD45G 31 30
  • 99.58 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GADD45G 31 30
  • 89.1 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GADD45G 31 30
  • 88.89 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gadd45g 17 31 30
  • 88.26 (n)
rat
(Rattus norvegicus)
Mammalia Gadd45g 30
  • 88.26 (n)
oppossum
(Monodelphis domestica)
Mammalia GADD45G 31
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves GADD45B 30
  • 76.1 (n)
GADD45 31
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GADD45G 31
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gadd45g 30
  • 70.23 (n)
Str.6981 30
zebrafish
(Danio rerio)
Actinopterygii gadd45g 31 30
  • 67.3 (n)
OneToMany
GADD45G (1 of 3) 31
  • 49 (a)
OneToMany
GADD45G (3 of 3) 31
  • 30 (a)
OneToMany
Dr.11828 30
Species where no ortholog for GADD45G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GADD45G Gene

ENSEMBL:
Gene Tree for GADD45G (if available)
TreeFam:
Gene Tree for GADD45G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GADD45G: view image

Paralogs for GADD45G Gene

Paralogs for GADD45G Gene

(3) SIMAP similar genes for GADD45G Gene using alignment to 5 proteins:

  • GA45G_HUMAN
  • Q5MAI3_HUMAN
  • Q5VZ87_HUMAN
  • Q5VZ88_HUMAN
  • Q6IAW6_HUMAN
genes like me logo Genes that share paralogs with GADD45G: view

Variants for GADD45G Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GADD45G Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs3138505 - p.Gly112Ser

Additional dbSNP identifiers (rs#s) for GADD45G Gene

Structural Variations from Database of Genomic Variants (DGV) for GADD45G Gene

Variant ID Type Subtype PubMed ID
esv29434 CNV gain+loss 19812545
esv3621014 CNV gain 21293372
nsv1047460 CNV gain 25217958
nsv469563 CNV gain 16826518
nsv471662 CNV gain+loss 15918152
nsv509309 CNV insertion 20534489

Variation tolerance for GADD45G Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GADD45G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GADD45G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GADD45G Gene

Disorders for GADD45G Gene

MalaCards: The human disease database

(10) MalaCards diseases for GADD45G Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pituitary adenoma
  • adenoma of the pituitary gland
retinal microaneurysm
  • microaneurysm
chromium allergic contact dermatitis
severe nonproliferative diabetic retinopathy
  • high risk non proliferative diabetic retinopathy
gastric cardia adenocarcinoma
  • adenocarcinoma of cardia of stomach
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GADD45G

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GADD45G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GADD45G Gene

Publications for GADD45G Gene

  1. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. (PMID: 9827804) Takekawa M … Saito H (Cell 1998) 2 3 4 23 54
  2. Cytokine response gene 6 induces p21 and regulates both cell growth and arrest. (PMID: 10597261) Fan W … Smith KA (Oncogene 1999) 3 4 23 54
  3. Molecular cloning, expression, and mapping of a novel human cDNA, GRP17, highly homologous to human gadd45 and murine MyD118. (PMID: 10496071) Suzuki M … Tanigami A (Journal of human genetics 1999) 2 3 23 54
  4. Crystal structure of human Gadd45γ [corrected] reveals an active dimer. (PMID: 22058036) Zhang W … Rao Z (Protein & cell 2011) 3 4 54
  5. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D … Ferrucci L (PLoS genetics 2008) 3 41 54

Products for GADD45G Gene

Sources for GADD45G Gene