Aliases for GADD45G Gene
External Ids for GADD45G Gene
Previous GeneCards Identifiers for GADD45G Gene
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
GeneCards Summary for GADD45G Gene
GADD45G (Growth Arrest And DNA Damage Inducible Gamma) is a Protein Coding gene. Diseases associated with GADD45G include Pituitary Adenoma. Among its related pathways are Endometrial cancer and DNA Damage Response. An important paralog of this gene is GADD45A.
UniProtKB/Swiss-Prot Summary for GADD45G Gene
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.