Aliases for GADD45G Gene
External Ids for GADD45G Gene
Previous GeneCards Identifiers for GADD45G Gene
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
GeneCards Summary for GADD45G Gene
GADD45G (Growth Arrest And DNA Damage Inducible Gamma) is a Protein Coding gene. Diseases associated with GADD45G include Pituitary Adenoma and Retinal Microaneurysm. Among its related pathways are Apoptosis Modulation and Signaling and Gastric cancer. An important paralog of this gene is GADD45A.
UniProtKB/Swiss-Prot Summary for GADD45G Gene
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.