This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstrea... See more...

Aliases for GADD45B Gene

Aliases for GADD45B Gene

  • Growth Arrest And DNA Damage Inducible Beta 2 3 5
  • Growth Arrest And DNA Damage-Inducible Protein GADD45 Beta 3 4
  • Myeloid Differentiation Primary Response Protein MyD118 3 4
  • Negative Growth Regulatory Protein MyD118 3 4
  • MYD118 3 4
  • Growth Arrest And DNA-Damage-Inducible, Beta 2
  • Growth Arrest And DNA-Damage-Inducible Beta 2
  • Myeloid Differentiation Primary Response 2
  • GADD45BETA 3

External Ids for GADD45B Gene

Previous HGNC Symbols for GADD45B Gene

  • MYD118

Previous GeneCards Identifiers for GADD45B Gene

  • GC19P002538
  • GC19P002416
  • GC19P002427
  • GC19P002247

Summaries for GADD45B Gene

Entrez Gene Summary for GADD45B Gene

  • This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

GeneCards Summary for GADD45B Gene

GADD45B (Growth Arrest And DNA Damage Inducible Beta) is a Protein Coding gene. Diseases associated with GADD45B include Lung Cancer and Hepatocellular Carcinoma. Among its related pathways are Endometrial cancer and Gastric cancer. An important paralog of this gene is GADD45A.

UniProtKB/Swiss-Prot Summary for GADD45B Gene

  • Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

Gene Wiki entry for GADD45B Gene

Additional gene information for GADD45B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GADD45B Gene

Genomics for GADD45B Gene

GeneHancer (GH) Regulatory Elements for GADD45B Gene

Promoters and enhancers for GADD45B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GADD45B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GADD45B

Top Transcription factor binding sites by QIAGEN in the GADD45B gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • c-Rel
  • MyoD

Genomic Locations for GADD45B Gene

Genomic Locations for GADD45B Gene
chr19:2,476,122-2,478,259
(GRCh38/hg38)
Size:
2,138 bases
Orientation:
Plus strand
chr19:2,476,120-2,478,257
(GRCh37/hg19)
Size:
2,138 bases
Orientation:
Plus strand

Genomic View for GADD45B Gene

Genes around GADD45B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GADD45B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GADD45B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GADD45B Gene

Proteins for GADD45B Gene

  • Protein details for GADD45B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75293-GA45B_HUMAN
    Recommended name:
    Growth arrest and DNA damage-inducible protein GADD45 beta
    Protein Accession:
    O75293
    Secondary Accessions:
    • A8KAM2
    • O75960
    • Q17R46

    Protein attributes for GADD45B Gene

    Size:
    160 amino acids
    Molecular mass:
    17818 Da
    Quaternary structure:
    • Interacts with GADD45GIP1.

neXtProt entry for GADD45B Gene

Post-translational modifications for GADD45B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GADD45B Gene

No data available for DME Specific Peptides for GADD45B Gene

Domains & Families for GADD45B Gene

Gene Families for GADD45B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GADD45B Gene

Blocks:
  • Ribosomal protein L7Ae/L30e/S12e/Gadd45
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GADD45B Gene

GenScript: Design optimal peptide antigens:
  • Negative growth regulatory protein MyD118 (GA45B_HUMAN)
  • Growth arrest and DNA-damage-inducible beta (Q6IX74_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75293

UniProtKB/Swiss-Prot:

GA45B_HUMAN :
  • Belongs to the GADD45 family.
Family:
  • Belongs to the GADD45 family.
genes like me logo Genes that share domains with GADD45B: view

Function for GADD45B Gene

Molecular function for GADD45B Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
GENATLAS Biochemistry:
growth arrest and DNA-damage-inducible,beta,ubiquitously expressed,activating MEKK4

Phenotypes From GWAS Catalog for GADD45B Gene

Gene Ontology (GO) - Molecular Function for GADD45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12052864
genes like me logo Genes that share ontologies with GADD45B: view
genes like me logo Genes that share phenotypes with GADD45B: view

Animal Models for GADD45B Gene

MGI Knock Outs for GADD45B:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GADD45B Gene

Localization for GADD45B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GADD45B gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GADD45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9827804
GO:0005737 cytoplasm IBA,IDA 9827804
genes like me logo Genes that share ontologies with GADD45B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GADD45B Gene

Pathways & Interactions for GADD45B Gene

genes like me logo Genes that share pathways with GADD45B: view

Pathways by source for GADD45B Gene

3 GeneGo (Thomson Reuters) pathways for GADD45B Gene
  • Development_TGF-beta receptor signaling
  • DNA damage_ATM/ATR regulation of G1/S checkpoint
  • Immune response IL-12-induced IFN-gamma production
5 Qiagen pathways for GADD45B Gene
  • ATM Pathway
  • BRCA1 Pathway
  • DNA Repair Mechanisms
  • GADD45 Pathway
  • p53 Signaling

Gene Ontology (GO) - Biological Process for GADD45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IDA 9827804
GO:0000186 activation of MAPKK activity IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0006915 apoptotic process IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with GADD45B: view

No data available for SIGNOR curated interactions for GADD45B Gene

Drugs & Compounds for GADD45B Gene

No Compound Related Data Available

Transcripts for GADD45B Gene

mRNA/cDNA for GADD45B Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GADD45B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - -

Relevant External Links for GADD45B Gene

GeneLoc Exon Structure for
GADD45B

Expression for GADD45B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GADD45B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GADD45B

SOURCE GeneReport for Unigene cluster for GADD45B Gene:

Hs.110571

Evidence on tissue expression from TISSUES for GADD45B Gene

  • Nervous system(4.8)
  • Lung(4.1)
  • Liver(3.4)
  • Spleen(3.1)
  • Bone marrow(3)
  • Intestine(3)
  • Heart(2.9)
  • Kidney(2.6)
  • Blood(2.5)
  • Eye(2.5)
  • Lymph node(2.5)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with GADD45B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GADD45B Gene

Orthologs for GADD45B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GADD45B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GADD45B 31 30
  • 99.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GADD45B 31 30
  • 92.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GADD45B 31 30
  • 91.25 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gadd45b 17 31 30
  • 86.25 (n)
oppossum
(Monodelphis domestica)
Mammalia GADD45B 31
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gadd45b 30
  • 85.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GADD45B 31
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859853 30
  • 76.54 (n)
GADD45B 31
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gadd45b 30
  • 62.24 (n)
zebrafish
(Danio rerio)
Actinopterygii gadd45bb 31 30
  • 70.06 (n)
OneToMany
gadd45ba 31
  • 69 (a)
OneToMany
sbcb196 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10915 30
Species where no ortholog for GADD45B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GADD45B Gene

ENSEMBL:
Gene Tree for GADD45B (if available)
TreeFam:
Gene Tree for GADD45B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GADD45B: view image

Paralogs for GADD45B Gene

Paralogs for GADD45B Gene

(3) SIMAP similar genes for GADD45B Gene using alignment to 4 proteins:

  • GA45B_HUMAN
  • K7EM97_HUMAN
  • K7EPQ8_HUMAN
  • Q6IX74_HUMAN
genes like me logo Genes that share paralogs with GADD45B: view

Variants for GADD45B Gene

Additional dbSNP identifiers (rs#s) for GADD45B Gene

Structural Variations from Database of Genomic Variants (DGV) for GADD45B Gene

Variant ID Type Subtype PubMed ID
nsv1064930 CNV gain 25217958
nsv953944 CNV deletion 24416366

Variation tolerance for GADD45B Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.88; 96.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GADD45B Gene

Human Gene Mutation Database (HGMD)
GADD45B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GADD45B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GADD45B Gene

Disorders for GADD45B Gene

MalaCards: The human disease database

(2) MalaCards diseases for GADD45B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GADD45B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GADD45B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GADD45B Gene

Publications for GADD45B Gene

  1. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. (PMID: 9827804) Takekawa M … Saito H (Cell 1998) 2 3 4 23 54
  2. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PMID: 19064572) Palmieri RT … Australian Ovarian Cancer Study Group (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 41 54
  3. GADD45B inhibits MKK7-induced cardiac hypertrophy and the polymorphisms of GADD45B is associated with inter-ventricular septum hypertrophy. (PMID: 18515079) Wang J … Hui R (Biochemical and biophysical research communications 2008) 3 23 54
  4. Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta. (PMID: 15546867) Ungefroren H … Fändrich F (The Journal of biological chemistry 2005) 3 23 54
  5. Co-activation of ERK, NF-kappaB, and GADD45beta in response to ionizing radiation. (PMID: 15642734) Wang T … Li JJ (The Journal of biological chemistry 2005) 3 23 54

Products for GADD45B Gene

Sources for GADD45B Gene