Aliases for GADD45B Gene
External Ids for GADD45B Gene
Previous HGNC Symbols for GADD45B Gene
Previous GeneCards Identifiers for GADD45B Gene
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
GeneCards Summary for GADD45B Gene
GADD45B (Growth Arrest And DNA Damage Inducible Beta) is a Protein Coding gene. Diseases associated with GADD45B include Lung Cancer and Hepatocellular Carcinoma. Among its related pathways are ATM Pathway and Transcriptional misregulation in cancer. An important paralog of this gene is GADD45A.
UniProtKB/Swiss-Prot Summary for GADD45B Gene
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.