Free for academic non-profit institutions. Other users need a Commercial license
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
GADD45B (Growth Arrest And DNA Damage Inducible Beta) is a Protein Coding gene. Diseases associated with GADD45B include Lung Cancer and Hepatocellular Carcinoma. Among its related pathways are ATM Pathway and Transcriptional misregulation in cancer. An important paralog of this gene is GADD45A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 12052864 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 9827804 |
GO:0005737 | cytoplasm | IBA,IDA | 9827804 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Endometrial cancer |
.36
|
|
2 | Gastric cancer |
.62
.62
|
|
3 | Glioma |
.49
|
.46
|
4 | DNA Damage Response | ||
5 | p53 Signaling |
.46
|
p53 Signaling
.46
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000185 | activation of MAPKKK activity | IDA | 9827804 |
GO:0000186 | activation of MAPKK activity | IEA | -- |
GO:0006469 | negative regulation of protein kinase activity | IEA | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||
SP7: | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GADD45B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GADD45B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GADD45B 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gadd45b 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GADD45B 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gadd45b 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | GADD45B 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LOC100859853 30 |
|
||
GADD45B 31 |
|
OneToOne | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gadd45b 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | gadd45bb 30 31 |
|
OneToMany | |
gadd45ba 31 |
|
OneToMany | |||
sbcb196 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10915 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1064930 | CNV | gain | 25217958 |
nsv953944 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
lung cancer |
|
|
hepatocellular carcinoma |
|
|