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This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstrea... See more...
Aliases for GADD45B Gene
Aliases for GADD45B Gene
External Ids for GADD45B Gene
- HGNC: 4096
- Entrez Gene: 4616
- Ensembl: ENSG00000099860
- OMIM: 604948
- UniProtKB: O75293
Previous HGNC Symbols for GADD45B Gene
- MYD118
Previous GeneCards Identifiers for GADD45B Gene
- GC19P002538
- GC19P002416
- GC19P002427
- GC19P002247
Summaries for GADD45B Gene
-
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
GeneCards Summary for GADD45B Gene
GADD45B (Growth Arrest And DNA Damage Inducible Beta) is a Protein Coding gene. Diseases associated with GADD45B include Lung Cancer and Hepatocellular Carcinoma. Among its related pathways are ATM Pathway and Transcriptional misregulation in cancer. An important paralog of this gene is GADD45A.
UniProtKB/Swiss-Prot Summary for GADD45B Gene
-
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
Additional gene information for GADD45B Gene
- HGNC(4096)
- Entrez Gene(4616)
- Ensembl(ENSG00000099860)
- OMIM(604948)
- UniProtKB(O75293)
- Open Targets Platform(ENSG00000099860)
- Monarch Initiative
- Search for GADD45B at DataMed
- Search for GADD45B at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GADD45B Gene
Genomics for GADD45B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GADD45B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GADD45B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GADD45B
- Top Transcription factor binding sites by QIAGEN in the GADD45B gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- c-Rel
- MyoD
Genomic Locations for GADD45B Gene
Genomic Locations for GADD45B Gene
- chr19:2,476,122-2,478,259
- (GRCh38/hg38)
- Size:
- 2,138 bases
- Orientation:
- Plus strand
- chr19:2,476,120-2,478,257
- (GRCh37/hg19)
- Size:
- 2,138 bases
- Orientation:
- Plus strand
Genomic View for GADD45B Gene
Genes around GADD45B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by HGNC
- 19p13.3 by Entrez Gene
- 19p13.3 by Ensembl
GADD45B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GADD45B Gene
Proteins for GADD45B Gene
-
Protein details for GADD45B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75293-GA45B_HUMAN
- Recommended name:
- Growth arrest and DNA damage-inducible protein GADD45 beta
- Protein Accession:
- O75293
- A8KAM2
- O75960
- Q17R46
Protein attributes for GADD45B Gene
- Size:
- 160 amino acids
- Molecular mass:
- 17818 Da
- Quaternary structure:
-
- Interacts with GADD45GIP1.
Post-translational modifications for GADD45B Gene
Other Protein References for GADD45B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GADD45B Antibody
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-
Abcam antibodies for GADD45B
- Invitrogen Antibodies for GADD45B (AFLGC-GADD45B)
- antibodies-online: Show 4 available GADD45B Antibodies ranked by validation data
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- 12 IF (p) Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 10 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for GADD45B
-
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Protein Products
- G Biosciences Human GADD45B/MYD118, Lyophilized
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-
ProSci Proteins for GADD45B
-
Abcam proteins for GADD45B
Assay Products
-
Signalway ELISA kits for GADD45B
No data available for DME Specific Peptides for GADD45B Gene
Domains & Families for GADD45B Gene
Gene Families for GADD45B Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GADD45B Gene
- InterPro:
- Blocks:
-
- Ribosomal protein L7Ae/L30e/S12e/Gadd45
- ProtoNet:
Suggested Antigen Peptide Sequences for GADD45B Gene
- GenScript: Design optimal peptide antigens:
-
- Negative growth regulatory protein MyD118 (GA45B_HUMAN)
- Growth arrest and DNA-damage-inducible beta (Q6IX74_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O75293- Family:
-
- Belongs to the GADD45 family.
Function for GADD45B Gene
Molecular function for GADD45B Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
- GENATLAS Biochemistry:
- growth arrest and DNA-damage-inducible,beta,ubiquitously expressed,activating MEKK4
Phenotypes From GWAS Catalog for GADD45B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 12052864 |
Phenotypes for GADD45B Gene
- MGI mutant phenotypes for GADD45B:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for GADD45B:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability in glioblastoma multiforme (GBM) lineage
- Decreased epidermal growth factor (EGF) endocytosis
Animal Models for GADD45B Gene
Animal Model Products
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CRISPR Products
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Cell Line Products
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Horizon Cell Lines for GADD45B
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GADD45B Gene
Localization for GADD45B Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| cytosol | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 9827804 |
| GO:0005737 | cytoplasm | IBA,IDA | 9827804 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for GADD45B Gene
Pathways & Interactions for GADD45B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Endometrial cancer |
.36
|
|
| 2 | Gastric cancer |
.62
.62
|
|
| 3 | Glioma |
.49
|
.46
|
| 4 | DNA Damage Response | ||
| 5 | p53 Signaling |
.46
|
p53 Signaling
.46
|
Pathways by source for GADD45B Gene
1 Sino Biological pathway for GADD45B Gene
5 BioSystems pathways for GADD45B Gene
23 KEGG pathways for GADD45B Gene
3 GeneGo (Thomson Reuters) pathways for GADD45B Gene
- Development_TGF-beta receptor signaling
- DNA damage_ATM/ATR regulation of G1/S checkpoint
- Immune response IL-12-induced IFN-gamma production
5 Qiagen pathways for GADD45B Gene
- ATM Pathway
- BRCA1 Pathway
- DNA Repair Mechanisms
- GADD45 Pathway
- p53 Signaling
Interacting Proteins for GADD45B Gene
Selected Interacting proteins:
O75293-GA45B_HUMAN
ENSP00000215631
for GADD45B Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for GADD45B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000185 | activation of MAPKKK activity | IDA | 9827804 |
| GO:0000186 | activation of MAPKK activity | IEA | -- |
| GO:0006469 | negative regulation of protein kinase activity | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for SIGNOR curated interactions for GADD45B Gene
Drugs & Compounds for GADD45B Gene
No Compound Related Data Available
Drug Products
- G Biosciences Human GADD45B/MYD118, Lyophilized
Transcripts for GADD45B Gene
mRNA/cDNA for GADD45B Gene
- 1 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000215631 1371 nts (view in UCSC)
- ENST00000585359 750 nts (view in UCSC)
- ENST00000586759 517 nts (view in UCSC)
- ENST00000587345 765 nts (view in UCSC)
- ENST00000587887 276 nts (view in UCSC)
CRISPR Products
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-
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
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| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||
| SP7: | - | - |
Relevant External Links for GADD45B Gene
- GeneLoc Exon Structure for
- GADD45B
Expression for GADD45B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
-
Epithelial Cells
- Duct Cells Pancreatic Ducts
- Bone (Muscoskeletal System)
-
Prostate (Endocrine System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Adipose (Muscoskeletal System)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GADD45B
SOURCE GeneReport for Unigene cluster for GADD45B Gene:
Hs.110571Evidence on tissue expression from TISSUES for GADD45B Gene
- Nervous system(4.9)
- Lung(4.2)
- Liver(3.6)
- Heart(3.3)
- Spleen(3.3)
- Intestine(3.3)
- Bone marrow(3.2)
- Kidney(3.1)
- Muscle(3)
- Lymph node(2.9)
- Blood(2.8)
- Eye(2.8)
- Skin(2.5)
- Adrenal gland(2.5)
- Pancreas(2.5)
- Thyroid gland(2.4)
- Stomach(2.3)
Primer Products
-
OriGene qPCR primer pairs for GADD45B
-
OriGene qPCR primer pairs and template standards for GADD45B
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GADD45B Gene
Orthologs for GADD45B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GADD45B 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GADD45B 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GADD45B 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gadd45b 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | GADD45B 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gadd45b 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GADD45B 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LOC100859853 30 |
|
||
| GADD45B 31 |
|
OneToOne | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gadd45b 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | gadd45bb 30 31 |
|
OneToMany | |
| gadd45ba 31 |
|
OneToMany | |||
| sbcb196 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10915 30 |
|
- Species where no ortholog for GADD45B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for GADD45B Gene
- ENSEMBL:
- Gene Tree for GADD45B (if available)
- TreeFam:
- Gene Tree for GADD45B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GADD45B: view image
Paralogs for GADD45B Gene
Variants for GADD45B Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1064930 | CNV | gain | 25217958 |
| nsv953944 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
14.88;
96.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GADD45B Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GADD45B Gene
Disorders for GADD45B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lung cancer |
|
|
| hepatocellular carcinoma |
|
|
Search GADD45B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GADD45B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GADD45B Gene
Publications for GADD45B Gene
- A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. (PMID: 9827804) Takekawa M … Saito H (Cell 1998) 2 3 4 23
- Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PMID: 19064572) Palmieri RT … Australian Ovarian Cancer Study Group (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 41
- GADD45B inhibits MKK7-induced cardiac hypertrophy and the polymorphisms of GADD45B is associated with inter-ventricular septum hypertrophy. (PMID: 18515079) Wang J … Hui R (Biochemical and biophysical research communications 2008) 3 23
- Co-activation of ERK, NF-kappaB, and GADD45beta in response to ionizing radiation. (PMID: 15642734) Wang T … Li JJ (The Journal of biological chemistry 2005) 3 23
- Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta. (PMID: 15546867) Ungefroren H … Fändrich F (The Journal of biological chemistry 2005) 3 23
ExternalLinks
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Sources for GADD45B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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