Aliases for GABRR3 Gene
- Gamma-Aminobutyric Acid Type A Receptor Rho3 Subunit (Gene/Pseudogene) 2 3 5
- Gamma-Aminobutyric Acid (GABA) A Receptor, Rho 3 2 3
- GABA(A) Receptor Subunit Rho-3 3 4
- GABA(C) Receptor 3 4
- Gamma-Aminobutyric Acid (GABA) A Receptor, Rho 3 (Gene/Pseudogene) 2
- Gamma-Aminobutyric Acid Receptor Subunit Rho-3 3
- Gamma-Aminobutyric Acid (GABA) Receptor, Rho 3 2
- GABA(A) Receptor, Rho 3 2
External Ids for GABRR3 Gene
Previous GeneCards Identifiers for GABRR3 Gene
The neurotransmitter gamma-aminobutyric acid (GABA) functions in the central nervous system to regulate synaptic transmission of neurons. This gene encodes one of three related subunits, which combine as homo- or hetero-pentamers to form GABA(C) receptors. In humans, some individuals contain a single-base polymorphism (dbSNP rs832032) that is predicted to inactivate the gene product. [provided by RefSeq, Jan 2012]
GeneCards Summary for GABRR3 Gene
GABRR3 (Gamma-Aminobutyric Acid Type A Receptor Rho3 Subunit (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are GABA receptor activation and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and extracellular ligand-gated ion channel activity. An important paralog of this gene is GABRR1.
UniProtKB/Swiss-Prot for GABRR3 Gene
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
GABAA-rho receptors, previously known as GABAC receptors, are Cys-loop ionotropic ligand-gated ion channels mediating the fast synaptic inhibitory effects of GABA. Despite differing in pharmacology, physiology and biochemistry, they are viewed as a subclass of GABAA receptors.