Aliases for GABRG1 Gene
External Ids for GABRG1 Gene
Previous GeneCards Identifiers for GABRG1 Gene
The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. [provided by RefSeq, Jul 2008]
GeneCards Summary for GABRG1 Gene
GABRG1 (Gamma-Aminobutyric Acid Type A Receptor Gamma1 Subunit) is a Protein Coding gene. Diseases associated with GABRG1 include Alcohol Dependence and Autism. Among its related pathways are Akt Signaling and GABAergic synapse. Gene Ontology (GO) annotations related to this gene include chloride channel activity and GABA-A receptor activity. An important paralog of this gene is GABRG2.
UniProtKB/Swiss-Prot for GABRG1 Gene
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
GABAA receptors are members of the Cys-loop family of ligand-gated ion channels and, along with GABAB receptors, are responsible for mediating the inhibitory effects of GABA. They are pentameric proteins, consisting of five subunits belonging to different families.