Aliases for GABRA6 Gene
- Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha6 2 3 5
- Gamma-Aminobutyric Acid (GABA) A Receptor, Alpha 6 2 3
- Gamma-Aminobutyric Acid Receptor Subunit Alpha-6 3 4
- GABA(A) Receptor Subunit Alpha-6 3 4
- GABA(A) Receptor, Alpha 6 2 3
- Gamma-Aminobutyric Acid Type A Receptor Alpha6 Subunit 3
- GABA Subunit A Receptor Alpha 6 3
- GABRA6 5
External Ids for GABRA6 Gene
Previous GeneCards Identifiers for GABRA6 Gene
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for GABRA6 Gene
GABRA6 (Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha6) is a Protein Coding gene. Diseases associated with GABRA6 include Childhood Absence Epilepsy and Intraventricular Meningioma. Among its related pathways are GABA receptor activation and Apoptosis Pathway. Gene Ontology (GO) annotations related to this gene include chloride channel activity and GABA-A receptor activity. An important paralog of this gene is GABRA4.
UniProtKB/Swiss-Prot Summary for GABRA6 Gene
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
GABAA receptors are members of the Cys-loop family of ligand-gated ion channels and, along with GABAB receptors, are responsible for mediating the inhibitory effects of GABA. They are pentameric proteins, consisting of five subunits belonging to different families.