Aliases for GABRA2 Gene
- Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha2 2 3 5
- Gamma-Aminobutyric Acid Receptor Subunit Alpha-2 3 4
- GABA(A) Receptor Subunit Alpha-2 3 4
- Gamma-Aminobutyric Acid Type A Receptor Alpha2 Subunit 3
- Gamma-Aminobutyric Acid (GABA) A Receptor, Alpha 2 2
- GABA(A) Receptor, Alpha 2 2
- EIEE78 3
- GABRA2 5
- DEE78 3
External Ids for GABRA2 Gene
Previous GeneCards Identifiers for GABRA2 Gene
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for GABRA2 Gene
GABRA2 (Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha2) is a Protein Coding gene. Diseases associated with GABRA2 include Developmental And Epileptic Encephalopathy 78 and Alcohol Dependence. Among its related pathways are GABA receptor activation and Apoptosis Pathway. Gene Ontology (GO) annotations related to this gene include chloride channel activity and GABA-A receptor activity. An important paralog of this gene is GABRA1.
UniProtKB/Swiss-Prot Summary for GABRA2 Gene
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:29961870, PubMed:31032849). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:29961870, PubMed:31032849). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity).
GABAA receptors are members of the Cys-loop family of ligand-gated ion channels and, along with GABAB receptors, are responsible for mediating the inhibitory effects of GABA. They are pentameric proteins, consisting of five subunits belonging to different families.