Aliases for GABPB2 Gene

Aliases for GABPB2 Gene

  • GA Binding Protein Transcription Factor Subunit Beta 2 2 3 5
  • GA Binding Protein Transcription Factor Beta Subunit 2 2 3
  • GA-Binding Protein Subunit Beta-2 3 4
  • GABP Subunit Beta-2 3 4
  • GABPB-2 3 4

External Ids for GABPB2 Gene

Previous GeneCards Identifiers for GABPB2 Gene

  • GC15U990021
  • GC15M048148
  • GC15M048285
  • GC15M048356
  • GC01P149310
  • GC01P151043
  • GC01P122420

Summaries for GABPB2 Gene

GeneCards Summary for GABPB2 Gene

GABPB2 (GA Binding Protein Transcription Factor Subunit Beta 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transcription regulatory region DNA binding. An important paralog of this gene is GABPB1.

UniProtKB/Swiss-Prot Summary for GABPB2 Gene

  • May function as transcription factor capable of interacting with purine rich repeats (GA repeats).

Additional gene information for GABPB2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GABPB2 Gene

Genomics for GABPB2 Gene

GeneHancer (GH) Regulatory Elements for GABPB2 Gene

Promoters and enhancers for GABPB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GABPB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GABPB2 gene promoter:
  • ATF-2
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Elk-1
  • HSF1 (long)
  • HSF1short

Genomic Locations for GABPB2 Gene

Genomic Locations for GABPB2 Gene
chr1:151,070,578-151,129,119
(GRCh38/hg38)
Size:
58,542 bases
Orientation:
Plus strand
chr1:151,043,054-151,098,018
(GRCh37/hg19)
Size:
54,965 bases
Orientation:
Plus strand

Genomic View for GABPB2 Gene

Genes around GABPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GABPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GABPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABPB2 Gene

Proteins for GABPB2 Gene

  • Protein details for GABPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAK5-GABP2_HUMAN
    Recommended name:
    GA-binding protein subunit beta-2
    Protein Accession:
    Q8TAK5
    Secondary Accessions:
    • B1AVJ8
    • D3DV14
    • Q8NAR5

    Protein attributes for GABPB2 Gene

    Size:
    448 amino acids
    Molecular mass:
    48650 Da
    Quaternary structure:
    • Heterotetramer of two alpha and two beta subunits. The C-terminal is necessary for the formation of a heterotetrameric GABP-alpha-2/beta-2 complex, and also facilitates homotypic dimerization. Interacts with ADGRB2.

neXtProt entry for GABPB2 Gene

Post-translational modifications for GABPB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GABPB2 Gene

Domains & Families for GABPB2 Gene

Gene Families for GABPB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GABPB2 Gene

Suggested Antigen Peptide Sequences for GABPB2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53938 (B4DXA3_HUMAN)
  • GA-binding protein subunit beta-2 (GABP2_HUMAN)
genes like me logo Genes that share domains with GABPB2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GABPB2 Gene

Function for GABPB2 Gene

Molecular function for GABPB2 Gene

UniProtKB/Swiss-Prot Function:
May function as transcription factor capable of interacting with purine rich repeats (GA repeats).
GENATLAS Biochemistry:
GA binding protein,beta subunit 2,component of the nuclear respiratory factor 2,interacting with GABPA form a high affinity DNA-binding complex recognizing an important site for herpes simplex virus type I activation,putatively involved in the activation of nuclear genes specifying mitochondrial function

Phenotypes From GWAS Catalog for GABPB2 Gene

Gene Ontology (GO) - Molecular Function for GABPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IEA --
GO:0044212 transcription regulatory region DNA binding IDA 9857059
GO:0046982 protein heterodimerization activity IDA 9857059
genes like me logo Genes that share ontologies with GABPB2: view
genes like me logo Genes that share phenotypes with GABPB2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GABPB2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GABPB2 Gene

Localization for GABPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABPB2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GABPB2 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GABPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9857059
genes like me logo Genes that share ontologies with GABPB2: view

Pathways & Interactions for GABPB2 Gene

PathCards logo

SuperPathways for GABPB2 Gene

No Data Available

SIGNOR curated interactions for GABPB2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for GABPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 9857059
genes like me logo Genes that share ontologies with GABPB2: view

No data available for Pathways by source for GABPB2 Gene

Drugs & Compounds for GABPB2 Gene

No Compound Related Data Available

Transcripts for GABPB2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GABPB2

Alternative Splicing Database (ASD) splice patterns (SP) for GABPB2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - - -
SP6: -
SP7: - - -

Relevant External Links for GABPB2 Gene

GeneLoc Exon Structure for
GABPB2
ECgene alternative splicing isoforms for
GABPB2

Expression for GABPB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GABPB2 Gene

Protein differential expression in normal tissues from HIPED for GABPB2 Gene

This gene is overexpressed in Liver, secretome (28.6), Peripheral blood mononuclear cells (10.0), CD4 Tcells (9.3), Lymph node (7.2), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GABPB2 Gene



Protein tissue co-expression partners for GABPB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GABPB2 Gene:

GABPB2

SOURCE GeneReport for Unigene cluster for GABPB2 Gene:

Hs.654699
genes like me logo Genes that share expression patterns with GABPB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GABPB2 Gene

Orthologs for GABPB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GABPB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GABPB2 33 32
  • 99.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GABPB2 33 32
  • 91.01 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GABPB2 33 32
  • 90.09 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gabpb2 17 33 32
  • 86.18 (n)
rat
(Rattus norvegicus)
Mammalia Gabpb2 32
  • 85.32 (n)
oppossum
(Monodelphis domestica)
Mammalia GABPB2 33
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GABPB2 33
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 33
  • 80 (a)
OneToMany
-- 33
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia GABPB2 33
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gabpb2b 33 32
  • 64.29 (n)
OneToMany
gabpb2a 33
  • 57 (a)
OneToMany
Dr.16630 32
fruit fly
(Drosophila melanogaster)
Insecta Atac3 33
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 35 (a)
OneToMany
Species where no ortholog for GABPB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GABPB2 Gene

ENSEMBL:
Gene Tree for GABPB2 (if available)
TreeFam:
Gene Tree for GABPB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GABPB2: view image

Paralogs for GABPB2 Gene

Paralogs for GABPB2 Gene

(5) SIMAP similar genes for GABPB2 Gene using alignment to 2 proteins:

  • GABP2_HUMAN
  • Q5SZG2_HUMAN
genes like me logo Genes that share paralogs with GABPB2: view

Variants for GABPB2 Gene

Sequence variations from dbSNP and Humsavar for GABPB2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000052352 -- 151,080,571(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000082523 -- 151,094,136(+) C/T intron_variant
rs1000101679 -- 151,086,793(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000140490 -- 151,069,110(+) C/T upstream_transcript_variant
rs1000156130 -- 151,071,936(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GABPB2 Gene

Variant ID Type Subtype PubMed ID
esv3587519 CNV loss 21293372
nsv1113178 CNV deletion 24896259
nsv1113179 CNV deletion 24896259
nsv472328 CNV novel sequence insertion 20440878
nsv522840 CNV gain 19592680

Variation tolerance for GABPB2 Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.47; 88.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GABPB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GABPB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GABPB2 Gene

Disorders for GABPB2 Gene

Additional Disease Information for GABPB2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GABPB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GABPB2 Gene

Publications for GABPB2 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 43 56
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. Molecular and genetic characterization of GABP beta. (PMID: 7958862) de la Brousse FC … McKnight SL (Genes & development 1994) 2 3 56
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56

Products for GABPB2 Gene

Sources for GABPB2 Gene