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Aliases for GABARAPL3 Gene

Aliases for GABARAPL3 Gene

  • GABA Type A Receptor Associated Protein Like 3 Pseudogene 2 3 5
  • GABA(A) Receptors Associated Protein Like 3, Pseudogene 2 3
  • GABA(A) Receptors Associated Protein Like 3 (Pseudogene) 2
  • GABA(A) Receptors Associated Protein Like 3 2
  • GABA(A) Receptor-Associated Protein-Like 3 4
  • ATG8D 3

External Ids for GABARAPL3 Gene

Previous GeneCards Identifiers for GABARAPL3 Gene

  • GC15P087280
  • GC15M084397
  • GC15M088476
  • GC15M088621
  • GC15M088693
  • GC15M090893
  • GC15M067002

Summaries for GABARAPL3 Gene

GeneCards Summary for GABARAPL3 Gene

GABARAPL3 (GABA Type A Receptor Associated Protein Like 3 Pseudogene) is a Pseudogene. Among its related pathways are Autophagy Pathway and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include microtubule binding and GABA receptor binding.

UniProtKB/Swiss-Prot for GABARAPL3 Gene

  • Ubiquitin-like modifier involved in autophagosome formation. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).

Additional gene information for GABARAPL3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABARAPL3 Gene

Genomics for GABARAPL3 Gene

GeneHancer (GH) Regulatory Elements for GABARAPL3 Gene

Promoters and enhancers for GABARAPL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I090263 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 +83.7 83698 3.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF766 CIB1 ENSG00000275674 NGRN ENSG00000228998 TTLL13P ARPIN RPL36AP43 NIFKP5 GDPGP1 GABARAPL3
GH15I090398 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -54.4 -54354 11.2 HDGF PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A FEZF1 ZNF766 FOS JUNB IQGAP1 ZNF774 CRTC3 RPL36AP43 ENSG00000259212 GABARAPL3 VPS33B ARPIN CIB1 ZNF710
GH15I090157 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +185.9 185905 12.2 CLOCK MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 UNC45A CIB1 ENSG00000259314 POLG RCCD1 SEMA4B LOC100631255 RPL36AP43 GDPGP1 NGRN
GH15I090647 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -299.9 -299906 4.7 HDGF PKNOX1 SMAD1 ARNT YY1 POLR2B ZNF766 ZNF213 E2F8 ZNF207 ENSG00000278370 ENSG00000259314 UNC45A ENSG00000259212 BLM CRTC3 ENSG00000200677 GABARAPL3 ZNF774 FES
GH15I090153 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.1 +194.5 194524 1.9 PKNOX1 FOXA2 ZNF133 ARID4B NEUROD1 FEZF1 ZNF2 YY1 GLIS2 ATF7 CIB1 GDPGP1 NGRN GABARAPL3 ZNF774 SEMA4B IDH2 GC15M090124
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GABARAPL3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GABARAPL3 Gene

Genomic Locations for GABARAPL3 Gene
chr15:90,346,527-90,349,447
(GRCh38/hg38)
Size:
2,921 bases
Orientation:
Minus strand
chr15:90,889,759-90,892,679
(GRCh37/hg19)

Genomic View for GABARAPL3 Gene

Genes around GABARAPL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GABARAPL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GABARAPL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABARAPL3 Gene

Proteins for GABARAPL3 Gene

  • Protein details for GABARAPL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY60-GBRL3_HUMAN
    Recommended name:
    Gamma-aminobutyric acid receptor-associated protein-like 3
    Protein Accession:
    Q9BY60

    Protein attributes for GABARAPL3 Gene

    Size:
    117 amino acids
    Molecular mass:
    13976 Da
    Quaternary structure:
    • Interacts with GABRG2 and beta-tubulin.

neXtProt entry for GABARAPL3 Gene

Post-translational modifications for GABARAPL3 Gene

  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL3-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes (By similarity).

No data available for DME Specific Peptides for GABARAPL3 Gene

Domains & Families for GABARAPL3 Gene

Protein Domains for GABARAPL3 Gene

Suggested Antigen Peptide Sequences for GABARAPL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY60

UniProtKB/Swiss-Prot:

GBRL3_HUMAN :
  • Belongs to the ATG8 family.
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with GABARAPL3: view

No data available for Gene Families for GABARAPL3 Gene

Function for GABARAPL3 Gene

Molecular function for GABARAPL3 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier involved in autophagosome formation. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).

Phenotypes From GWAS Catalog for GABARAPL3 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GABARAPL3 Gene

Localization for GABARAPL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABARAPL3 Gene

Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GABARAPL3 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GABARAPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IBA --
GO:0005829 cytosol IBA --
GO:0005874 microtubule IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with GABARAPL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GABARAPL3 Gene

Pathways & Interactions for GABARAPL3 Gene

genes like me logo Genes that share pathways with GABARAPL3: view

Pathways by source for GABARAPL3 Gene

2 Reactome pathways for GABARAPL3 Gene

Interacting Proteins for GABARAPL3 Gene

Selected Interacting proteins: Q9BY60-GBRL3_HUMAN for GABARAPL3 Gene via IID

Gene Ontology (GO) - Biological Process for GABARAPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0000422 autophagy of mitochondrion IBA --
GO:0006995 cellular response to nitrogen starvation IBA --
genes like me logo Genes that share ontologies with GABARAPL3: view

No data available for SIGNOR curated interactions for GABARAPL3 Gene

Drugs & Compounds for GABARAPL3 Gene

No Compound Related Data Available

Transcripts for GABARAPL3 Gene

mRNA/cDNA for GABARAPL3 Gene

(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GABARAPL3 Gene

GABA(A) receptors associated protein like 3, pseudogene:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GABARAPL3 Gene

No ASD Table

Relevant External Links for GABARAPL3 Gene

GeneLoc Exon Structure for
GABARAPL3
ECgene alternative splicing isoforms for
GABARAPL3

Expression for GABARAPL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GABARAPL3 Gene

mRNA differential expression in normal tissues according to GTEx for GABARAPL3 Gene

This gene is overexpressed in Testis (x11.6).

NURSA nuclear receptor signaling pathways regulating expression of GABARAPL3 Gene:

GABARAPL3

SOURCE GeneReport for Unigene cluster for GABARAPL3 Gene:

Hs.592014

mRNA Expression by UniProt/SwissProt for GABARAPL3 Gene:

Q9BY60-GBRL3_HUMAN
Tissue specificity: Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine.

Evidence on tissue expression from TISSUES for GABARAPL3 Gene

  • Nervous system(4.9)
  • Lung(3.2)
  • Heart(3.1)
  • Kidney(2.9)
  • Muscle(2.4)
  • Liver(2.3)
  • Eye(2.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with GABARAPL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GABARAPL3 Gene

Orthologs for GABARAPL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GABARAPL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GABARAPL3 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GABARAPL1 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GABARAPL3 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gabarapl1 34
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GABARAPL3 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves GABARAPL3 34
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GABARAPL3 34
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12334 35
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea lgg-1 35
  • 74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 34
  • 52 (a)
OneToMany
Species where no ortholog for GABARAPL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GABARAPL3 Gene

ENSEMBL:
Gene Tree for GABARAPL3 (if available)
TreeFam:
Gene Tree for GABARAPL3 (if available)

Paralogs for GABARAPL3 Gene

(9) SIMAP similar genes for GABARAPL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GABARAPL3: view

No data available for Paralogs for GABARAPL3 Gene

Variants for GABARAPL3 Gene

Sequence variations from dbSNP and Humsavar for GABARAPL3 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000068961 -- 90,349,950(-) C/T upstream_transcript_variant
rs1000395556 -- 90,349,697(-) G/A upstream_transcript_variant
rs1001002462 -- 90,347,274(-) T/C intron_variant
rs1002083956 -- 90,346,833(-) A/C/G/T intron_variant
rs1002375211 -- 90,348,079(-) G/T non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GABARAPL3 Gene

Variant ID Type Subtype PubMed ID
nsv833087 CNV loss 17160897
nsv570395 CNV loss 21841781
nsv570394 CNV gain 21841781
nsv457246 CNV gain 19166990
esv2761843 CNV gain 21179565
esv2751541 CNV gain 17911159
dgv4705n54 CNV gain 21841781
dgv2659n100 CNV gain 25217958
dgv2658n100 CNV gain 25217958

Variation tolerance for GABARAPL3 Gene

Gene Damage Index Score: 4.50; 64.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GABARAPL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GABARAPL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GABARAPL3 Gene

Disorders for GABARAPL3 Gene

Additional Disease Information for GABARAPL3

No disorders were found for GABARAPL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GABARAPL3 Gene

Publications for GABARAPL3 Gene

  1. Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. (PMID: 11414770) Xin Y … Zhao S (Genomics 2001) 2 3 4 22 58
  2. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PMID: 22446963) Okada Y … Yamamoto K (Nature genetics 2012) 3 58

Products for GABARAPL3 Gene

Sources for GABARAPL3 Gene

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