Aliases for GABARAPL3 Gene

Aliases for GABARAPL3 Gene

  • GABA Type A Receptor Associated Protein Like 3 Pseudogene 2 3 5
  • GABA(A) Receptors Associated Protein Like 3, Pseudogene 2 3
  • ATG8D 2 3
  • Gamma-Aminobutyric Acid Receptor-Associated Protein-Like 3 4
  • GABA(A) Receptors Associated Protein Like 3 (Pseudogene) 2
  • GABA(A) Receptors Associated Protein Like 3 2
  • GABA(A) Receptor-Associated Protein-Like 3 4
  • GABARAPL3 5

External Ids for GABARAPL3 Gene

Previous GeneCards Identifiers for GABARAPL3 Gene

  • GC15P087280
  • GC15M084397
  • GC15M088476
  • GC15M088621
  • GC15M088693
  • GC15M090893
  • GC15M067002

Summaries for GABARAPL3 Gene

GeneCards Summary for GABARAPL3 Gene

GABARAPL3 (GABA Type A Receptor Associated Protein Like 3 Pseudogene) is a Pseudogene. Among its related pathways are Cellular Senescence (REACTOME) and Macroautophagy. Gene Ontology (GO) annotations related to this gene include microtubule binding and GABA receptor binding.

UniProtKB/Swiss-Prot Summary for GABARAPL3 Gene

  • Ubiquitin-like modifier involved in autophagosome formation. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).

Additional gene information for GABARAPL3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GABARAPL3 Gene

Genomics for GABARAPL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GABARAPL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GABARAPL3 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for GABARAPL3 Gene

Genomic Locations for GABARAPL3 Gene
chr15:90,346,527-90,349,447
(GRCh38/hg38)
Size:
2,921 bases
Orientation:
Minus strand
chr15:90,889,759-90,892,679
(GRCh37/hg19)
Size:
2,921 bases
Orientation:
Minus strand

Genomic View for GABARAPL3 Gene

Genes around GABARAPL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GABARAPL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GABARAPL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABARAPL3 Gene

Proteins for GABARAPL3 Gene

  • Protein details for GABARAPL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY60-GBRL3_HUMAN
    Recommended name:
    Gamma-aminobutyric acid receptor-associated protein-like 3
    Protein Accession:
    Q9BY60

    Protein attributes for GABARAPL3 Gene

    Size:
    117 amino acids
    Molecular mass:
    13976 Da
    Quaternary structure:
    • Interacts with GABRG2 and beta-tubulin.

neXtProt entry for GABARAPL3 Gene

Post-translational modifications for GABARAPL3 Gene

  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL3-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes (By similarity).

No data available for DME Specific Peptides for GABARAPL3 Gene

Domains & Families for GABARAPL3 Gene

Protein Domains for GABARAPL3 Gene

InterPro:
Blocks:
  • Light chain 3 (LC3)
ProtoNet:

Suggested Antigen Peptide Sequences for GABARAPL3 Gene

GenScript: Design optimal peptide antigens:
  • GABA(A) receptor-associated protein-like 3 (GBRL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BY60

UniProtKB/Swiss-Prot:

GBRL3_HUMAN :
  • Belongs to the ATG8 family.
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with GABARAPL3: view

No data available for Gene Families for GABARAPL3 Gene

Function for GABARAPL3 Gene

Molecular function for GABARAPL3 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier involved in autophagosome formation. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).

Phenotypes From GWAS Catalog for GABARAPL3 Gene

Gene Ontology (GO) - Molecular Function for GABARAPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IBA 21873635
GO:0050811 GABA receptor binding IBA 21873635
genes like me logo Genes that share ontologies with GABARAPL3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GABARAPL3 Gene

Localization for GABARAPL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABARAPL3 Gene

Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome membrane. Lipid-anchor.

Gene Ontology (GO) - Cellular Components for GABARAPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IBA 21873635
GO:0005776 autophagosome IBA 21873635
GO:0005829 cytosol IBA 21873635
GO:0005874 microtubule IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with GABARAPL3: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for GABARAPL3 Gene

Pathways & Interactions for GABARAPL3 Gene

PathCards logo

SuperPathways for GABARAPL3 Gene

genes like me logo Genes that share pathways with GABARAPL3: view

Pathways by source for GABARAPL3 Gene

2 Reactome pathways for GABARAPL3 Gene

Interacting Proteins for GABARAPL3 Gene

Selected Interacting proteins: Q9BY60-GBRL3_HUMAN for GABARAPL3 Gene via IID

Gene Ontology (GO) - Biological Process for GABARAPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA 21873635
GO:0000422 autophagy of mitochondrion IBA 21873635
GO:0006995 cellular response to nitrogen starvation IBA 21873635
GO:0016236 macroautophagy IBA 21873635
genes like me logo Genes that share ontologies with GABARAPL3: view

No data available for SIGNOR curated interactions for GABARAPL3 Gene

Drugs & Compounds for GABARAPL3 Gene

No Compound Related Data Available

Transcripts for GABARAPL3 Gene

mRNA/cDNA for GABARAPL3 Gene

1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for GABARAPL3 Gene

No ASD Table

Relevant External Links for GABARAPL3 Gene

GeneLoc Exon Structure for
GABARAPL3

Expression for GABARAPL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GABARAPL3 Gene

mRNA differential expression in normal tissues according to GTEx for GABARAPL3 Gene

This gene is overexpressed in Testis (x11.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GABARAPL3

SOURCE GeneReport for Unigene cluster for GABARAPL3 Gene:

Hs.592014

mRNA Expression by UniProt/SwissProt for GABARAPL3 Gene:

Q9BY60-GBRL3_HUMAN
Tissue specificity: Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine.
genes like me logo Genes that share expression patterns with GABARAPL3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GABARAPL3 Gene

Orthologs for GABARAPL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GABARAPL3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GABARAPL3 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia GABARAPL3 31
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia GABARAPL1 31
  • 93 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gabarapl1 31
  • 93 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 91 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia GABARAPL3 31
  • 90 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GABARAPL3 31
  • 81 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii GABARAPL3 31
  • 57 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG12334 32
  • 67 (a)
Worm
(Caenorhabditis elegans)
Secernentea lgg-1 32
  • 74 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 31
  • 52 (a)
OneToMany
Species where no ortholog for GABARAPL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for GABARAPL3 Gene

ENSEMBL:
Gene Tree for GABARAPL3 (if available)
TreeFam:
Gene Tree for GABARAPL3 (if available)

Paralogs for GABARAPL3 Gene

(9) SIMAP similar genes for GABARAPL3 Gene using alignment to 1 proteins:

  • GBRL3_HUMAN
genes like me logo Genes that share paralogs with GABARAPL3: view

No data available for Paralogs for GABARAPL3 Gene

Variants for GABARAPL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for GABARAPL3 Gene

Variant ID Type Subtype PubMed ID
dgv2658n100 CNV gain 25217958
dgv2659n100 CNV gain 25217958
dgv4705n54 CNV gain 21841781
esv2751541 CNV gain 17911159
esv2761843 CNV gain 21179565
nsv457246 CNV gain 19166990
nsv570394 CNV gain 21841781
nsv570395 CNV loss 21841781
nsv833087 CNV loss 17160897

Variation tolerance for GABARAPL3 Gene

Gene Damage Index Score: 4.50; 64.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GABARAPL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GABARAPL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Additional dbSNP identifiers (rs#s) for GABARAPL3 Gene

Disorders for GABARAPL3 Gene

Additional Disease Information for GABARAPL3

No disorders were found for GABARAPL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GABARAPL3 Gene

Publications for GABARAPL3 Gene

  1. Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. (PMID: 11414770) Xin Y … Zhao S (Genomics 2001) 2 3 4 23
  2. Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer. (PMID: 30652415) Liu Y … Chen L (Cancer medicine 2019) 3
  3. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PMID: 22446963) Okada Y … Yamamoto K (Nature genetics 2012) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for GABARAPL3 Gene

Sources for GABARAPL3 Gene