Aliases for GABARAP Gene
External Ids for GABARAP Gene
Previous GeneCards Identifiers for GABARAP Gene
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]
GeneCards Summary for GABARAP Gene
GABARAP (GABA Type A Receptor-Associated Protein) is a Protein Coding gene. Diseases associated with GABARAP include Stiff-Person Syndrome and Machado-Joseph Disease. Among its related pathways are Apelin signaling pathway and Pathways of neurodegeneration - multiple diseases. Gene Ontology (GO) annotations related to this gene include microtubule binding and GABA receptor binding. An important paralog of this gene is GABARAPL1.
UniProtKB/Swiss-Prot Summary for GABARAP Gene
Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (PubMed:9892355). Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:15169837, PubMed:20562859, PubMed:22948227). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538). Involved in apoptosis (PubMed:15977068).